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An Imbalance of the Immune System Instead of a Disease Behind Marginal Bone Loss Around Oral Implants: Position Paper

Artikel i vetenskaplig tidskrift
Författare Tomas Albrektsson
Christer Dahlin
David Reinedahl
Pentti Tengvall
Ricardo Trindade
Ann Wennerberg
Publicerad i The International journal of oral & maxillofacial implants
Volym 35
Nummer/häfte 3
Sidor 495-502
Publiceringsår 2020
Publicerad vid Institutionen för odontologi
Institutionen för odontologi, sektion 2
Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Sidor 495-502
Språk en
Länkar https://doi.org/10.11607/jomi.8218
Ämnesord biomaterials, failure analysis, immunologic reactions, peri-implantitis, review (narrative)
Ämneskategorier Biomaterialvetenskap, Medicinsk bioteknologi, Medicinska grundvetenskaper

Sammanfattning

PURPOSE: The purpose of this paper is to present evidence that supports the notion that the primary reason behind marginal bone loss and implant failure is immune-based and that bacterial actions in the great majority of problematic cases are of a secondary nature. MATERIALS AND METHODS: The paper is written as a narrative review. RESULTS: Evidence is presented that commercially pure titanium is not biologically inert, but instead activates the innate immune system of the body. For its function, the clinical implant is dependent on an immune/inflammatory defense against bacteria. Biologic models such as ligature studies have incorrectly assumed that the primary response causing marginal bone loss is due to bacterial action. In reality, bacterial actions are secondary to an imbalance of the innate immune system caused by the combination of titanium implants and ligatures, ie, nonself. This immunologic imbalance may lead to marginal bone resorption even in the absence of bacteria. CONCLUSION: Marginal bone loss and imminent oral implant failure cannot be properly analyzed without a clear understanding of immunologically caused tissue responses.

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