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Executive Dysfunction Related to Binge Drinking in Ischemic Stroke

Artikel i vetenskaplig tidskrift
Författare S. P. K. Laari
T. V. Kauranen
K. E. A. Turunen
S. M. Mustanoja
Turgut Tatlisumak
E. T. Poutiainen
Publicerad i Cognitive and Behavioral Neurology
Volym 33
Nummer/häfte 1
Sidor 23-32
ISSN 1543-3633
Publiceringsår 2020
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
Sidor 23-32
Språk en
Länkar dx.doi.org/10.1097/wnn.000000000000...
Ämnesord binge drinking, alcohol, executive functions, cognition, ischemic stroke, alcohol-consumption, cognitive performance, heavy drinking, use, disorders, young, risk, adolescents, impulsivity, drinkers, brain, Behavioral Sciences, Neurosciences & Neurology
Ämneskategorier Neurologi

Sammanfattning

Background: Recent evidence has shown that cognitive dysfunction is associated with a history of binge drinking in adolescents who do not have an alcohol use disorder. Most previous studies with adults, however, have failed to show a link between cognitive dysfunction and subdiagnostic binge drinking, nor have any studies investigated the additive cognitive effect of binge drinking to ischemic stroke. Objective: To examine whether a pattern of cognitive dysfunction, especially executive and memory dysfunction, in patients with a first-ever ischemic stroke is associated with a history of subdiagnostic binge drinking. Methods: We studied 206 first-ever ischemic stroke patients (18-65 years) and 50 healthy, demographically comparable adults-both groups with no alcohol use disorder. After exclusion by matching, 189 patients and 39 healthy participants were included in our study (228 participants). The binge-drinking group included 76 participants; the non-binge-drinking group included 152. A multivariate analysis of covariance was used to compare nine cognitive functions between the two groups, with age, education, and stroke severity used as covariates. Results: Binge drinking had a significant negative effect on executive functions (P<0.001). The non-binge-drinking group outperformed the binge-drinking group on the Stroop Test (P=0.001), Trail Making Test (P=0.002), and a phonemic fluency test (P=0.005). The BingexStroke Severity interaction (P=0.037) indicated that a history of binge drinking increased the negative effect of stroke on executive functions. Conclusions: Subdiagnostic binge drinking may exacerbate the adverse effects of ischemic stroke on executive dysfunction.

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