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Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy

Artikel i vetenskaplig tidskrift
Författare N. Chatron
F. Becker
H. Morsy
M. Schmidts
K. Hardies
B. Tuysuz
Sandra Roselli
M. Najafi
D. U. Alkaya
F. Ashrafzadeh
A. Nabil
T. Omar
R. Maroofian
E. G. Karimiani
H. Hussien
F. Kok
L. Ramos
N. Gunes
K. Bilguvar
A. Labalme
E. Alix
D. Sanlaville
J. de Bellescize
A. L. Poulat
Ali-Reza Moslemi
H. Lerche
P. May
G. Lesca
S. Weckhuysen
H. Tajsharghi
R. E. S. Consortium A. R. Wo EuroEpinomics
Publicerad i Brain
Volym 143
Nummer/häfte 5
Sidor 1447-1461
ISSN 0006-8950
Publiceringsår 2020
Publicerad vid Institutionen för biomedicin
Institutionen för kliniska vetenskaper
Sidor 1447-1461
Språk en
Länkar dx.doi.org/10.1093/brain/awaa085
Ämnesord GAD1, suppression-burst, hypsarrhythmia, arthrogryposis, omphalocele, cleft palate, glutamic-acid decarboxylase, gamma-aminobutyric-acid, de-novo mutations, cleft-palate, 67-kda isoform, gene, mice, schizophrenia, classification, association, Neurosciences & Neurology
Ämneskategorier Neurovetenskaper

Sammanfattning

Developmental and epileptic encephalopathies are a heterogeneous group of early-onset epilepsy syndromes dramatically impairing neurodevelopment. Modern genomic technologies have revealed a number of monogenic origins and opened the door to therapeutic hopes. Here we describe a new syndromic developmental and epileptic encephalopathy caused by bi-allelic loss-of-function variants in GAD1, as presented by 11 patients from six independent consanguineous families. Seizure onset occurred in the first 2 months of life in all patients. All 10 patients, from whom early disease history was available, presented with seizure onset in the first month of life, mainly consisting of epileptic spasms or myoclonic seizures. Early EEG showed suppression-burst or pattern of burst attenuation or hypsarrhythmia if only recorded in the post-neonatal period. Eight patients had joint contractures and/or pes equinovarus. Seven patients presented a cleft palate and two also had an omphalocele, reproducing the phenotype of the knockout Gad1(-/-) mouse model. Four patients died before 4 years of age. GAD1 encodes the glutamate decarboxylase enzyme GAD67, a critical actor of the c-aminobutyric acid (GABA) metabolism as it catalyses the decarboxylation of glutamic acid to form GABA. Our findings evoke a novel syndrome related to GAD67 deficiency, characterized by the unique association of developmental and epileptic encephalopathies, cleft palate, joint contractures and/or omphalocele.

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