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Validation of the Retinopathy of Prematurity Activity Scale (ROP-ActS) using retrospective clinical data

Artikel i vetenskaplig tidskrift
Författare Aldina Pivodic
Staffan Nilsson
A. Stahl
L. E. H. Smith
Ann Hellström
Publicerad i Acta Ophthalmologica
Sidor 6
ISSN 1755-375X
Publiceringsår 2020
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för biomedicin
Sidor 6
Språk en
Länkar dx.doi.org/10.1111/aos.14532
Ämnesord retinopathy of prematurity, ROP activity scale, ROP-ActS, ROP stage, ROP, zone, Ophthalmology
Ämneskategorier Oftalmologi

Sammanfattning

Purpose The International Neonatal Consortium recently published a proposed retinopathy of prematurity (ROP) activity scale intended for use in clinical trials after validation. The aim of this study was to validate the ROP activity scale (ROP-ActS) in a ROP screened cohort with protocol based collected data by evaluating the ability of the ROP-Act scores to predict ROP treatment. In addition, we aimed to evaluate the scale's sensitivity characteristic of disease severity by studying association with gestational age (GA) in comparison with conventionally used ROP stage and zone. Methods A cohort of 535 preterm infants with 3324 ROP examinations with an end-point of ROP treatment or end of screening in Gothenburg, Sweden, was included. Median GA was 28.1 weeks, 47.5% were girls, and 74 (13.8%) infants were treated for ROP. The validation was performed by estimating probabilities for ROP treatment, and by applying logistic and linear regression. Results The original ROP-ActS was overall well-ordered with respect to ability to predict ROP treatment but could be improved by re-ordering score 3 (zone II stage 1) and 5 (zone III stage 3) based on our clinical cohort data. The modified ROP-ActS was superior to ROP stage and zone in the prediction analysis of ROP treatment. Modified ROP-ActS was more strongly related to GA than currently used ROP stage, but not zone. Conclusion In the studied cohort, the modified ROP-ActS could better predict ROP treatment compared to ROP stage and zone. Retinopathy of Prematurity Activity Scale (ROP-ActS) had a superior sensitivity characteristic studied through association to GA than conventionally used ROP stage.

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