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DendroPrime as an adhesion barrier on fracture fixation plates: an experimental study in rabbits

Artikel i vetenskaplig tidskrift
Författare J. von Kieseritzky
H. Alfort
V. Granskog
D. Hutchinson
P. Stenlund
Y. Bogestal
M. Arner
Joakim Håkansson
M. Malkoch
Publicerad i Journal of Hand Surgery-European Volume
Sidor 6
ISSN 1753-1934
Publiceringsår 2020
Publicerad vid Institutionen för biomedicin, avdelningen för laboratoriemedicin
Sidor 6
Språk en
Länkar dx.doi.org/10.1177/1753193420932477
Ämnesord Fracture, plate fixation, adhesion barrier, rabbit, flexor tendon, flexor tendon surgery, phalangeal fractures, peptide pxl01, zone-ii, osteosynthesis, complications, efficacy, mobility, removal, Orthopedics, Surgery
Ämneskategorier Ortopedi

Sammanfattning

We tested the anti-adhesional effect of a new thiol-ene-based coating in a rabbit model. In 12 New Zealand white rabbits, the periosteum and cortex of the proximal phalanx of the second toe of both hind paws was scratched. Stainless steel plates were fixated with screws. One plate was coated with DendroPrime and the other left bare. The non-operated second toes of both hind paws of an additional four rabbits served as controls. Seven weeks after surgery, the soft tissue adhesion to the plates was evaluated macroscopically, and joint mobility was measured biomechanically. Toe joint mobility was about 20% greater and statistically significant in specimens with coated plates compared with the bare plates. Soft tissue overgrowth and, in some cases, synovitis or adhesions between the plate and the tendon were observed on all bare plates but not on any of the coated plates. We conclude that the thiol-ene-based coating can improve joint mobility by about 20%. This material has a potential to reduce adhesion around plates in fracture surgery.

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