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Irradiation of myxoid/round cell liposarcoma induces volume reduction and lipoma-like morphology.

Artikel i vetenskaplig tidskrift
Författare Katarina Engström
Peter Bergh
C. G. Cederlund
Ragnar Hultborn
Helena Willen
Pierre Åman
Lars-Gunnar Kindblom
Jeanne Meis-Kindblom
Publicerad i Acta oncologica (Stockholm, Sweden)
Volym 46
Nummer/häfte 6
Sidor 838-45
ISSN 0284-186X
Publiceringsår 2007
Publicerad vid Institutionen för biomedicin, avdelningen för patologi
Institutionen för kliniska vetenskaper
Sidor 838-45
Språk en
Länkar dx.doi.org/10.1080/0284186060108041...
Ämneskategorier Medicin och Hälsovetenskap, Ortopedi

Sammanfattning

The aim of the study was to investigate the clinical and morphological effects of radiotherapy in the treatment of myxoid/round cell liposarcoma (MLS/RCLS). Thirty-three primary and metastatic MLS/RCLS tumours in 15 patients were treated with radiation therapy. Twenty-seven of the 33 tumours were surgically removed after preoperative radiation (34-46 Gy) while six tumours were treated with radiotherapy alone (44-60 Gy). The pretreatment diagnosis was established in all 15 patients based on fine needle aspirates or histological findings. Tumour size was measured by CT or MRI before and after radiotherapy in 30 tumours. Thirteen tumours from 11 patients were genetically characterised before and/or after radiation therapy. Twenty-three of 30 irradiated tumours showed a median reduction in tumour volume of 52% and seven lesions a median progression of 36%. All 27 surgically removed tumours revealed histological features of radiation response. The most striking morphological changes were lipoma-like appearance, paucicellularity and hyalinisation. Twelve of 13 tumours analysed before and/or after radiation therapy showed the FUS-DDIT3 translocation. Radiation therapy of MLS/RCLS induces histopathologic accumulation of mature lipoma-like areas and tumour volume reduction that may facilitate resectability.

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