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Pulmonary net release of tissue-type plasminogen activator during porcine primary and secondary acute lung injury.

Artikel i vetenskaplig tidskrift
Författare Annette Nyberg
Anneli Fagerberg
Marita Ahlqvist
Christina Jern
Heléne Seeman-Lodding
Anders Åneman
Publicerad i Acta anaesthesiologica Scandinavica
Volym 48
Nummer/häfte 7
Sidor 845-50
ISSN 0001-5172
Publiceringsår 2004
Publicerad vid Institutionen för klinisk neurovetenskap
Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård
Sidor 845-50
Språk en
Länkar dx.doi.org/10.1111/j.1399-6576.2004...
Ämnesord Animals, Female, Lung, secretion, Male, Respiratory Distress Syndrome, Adult, metabolism, Swine, Tissue Plasminogen Activator, blood, secretion, Tumor Necrosis Factor-alpha, analysis
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

BACKGROUND: Tissue-type plasminogen activator (tPA) is a key mediator of fibrinolysis. Matching of pulmonary perfusion and ventilation is a critical denominator of oxygenation in acute lung injury (ALI). This study investigates pulmonary venoarterial plasma tPA gradients in association with acute ALI induced by bronchoalveolar lavage (BAL) and endotoxinemia (ETX). METHODS: Twenty-one anaesthetized, ventilated pigs were allocated to control (CTRL, n=5), bronchoalveolar saline lavage (BAL, n=8) or infusion of Escherichia coli endotoxin (ETX, n=8). Total tPA was analyzed in plasma (ELISA calibrated for porcine tPA). The inflammatory response was assessed by TNFa levels (ELISA). All variables were assessed at baseline and 2 h following ALI. RESULTS: Bronchoalveolar lavage and ETX induced similar increases in pulmonary shunt whereas pulmonary vascular resistance was significantly more increased in ETX animals. Cardiac output remained stable in BAL animals but decreased in ETX animals. The pulmonary venoarterial tPA plasma gradient increased in ETX animals, yielding a positive pulmonary net flux of tPA, which was absent in BAL animals. TNFalpha levels increased in ETX, but not in BAL, animals. A significant correlation was observed between TNFalpha and tPA plasma levels in ETX animals. All variables remained unchanged in CTRL animals. CONCLUSION: Plasma changes of tPA levels support a pulmonary release of tPA in early experimental ALI induced by acute ETX but not lavage, and are related to the inflammatory response. Despite increased vascular fibrinolytic capacity in ETX animals, pulmonary dysfunction was not different from BAL animals. The results demonstrate the close relation between inflammation and coagulation in early ALI.

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