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Potential impact on tumor control and organ preservation with cisplatin and 5-fluorouracil for patients with advanced tumors of the paranasal sinuses and nasal fossa. A prospective pilot study

Artikel i vetenskaplig tidskrift
Författare Thomas Björk-Eriksson
Claes Mercke
Björn Petruson
Sven Ekholm
Publicerad i Cancer
Volym 70
Nummer/häfte 11
Sidor 2615-20
ISSN 0008-543X (Print)
Publiceringsår 1992
Publicerad vid Institutionen för särskilda specialiteter, Avdelningen för onkologi
Institutionen för särskilda specialiteter, Avdelningen för öron, näs- och halssjukdomar
Institutionen för särskilda specialiteter, Avdelningen för radiologi
Sidor 2615-20
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Actuarial Analysis, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/*therapeutic use, Carcinoma, Squamous Cell/*drug therapy/radiotherapy/surgery, Cisplatin/administration & dosage, Combined Modality Therapy, Drug Administration Schedule, Fluorouracil/administration & dosage, Humans, Male, Middle Aged, Nose/drug effects, Nose Neoplasms/*drug therapy/radiotherapy/surgery, Paranasal Sinus Neoplasms/*drug therapy/radiotherapy/surgery, Pilot Projects, Prospective Studies
Ämneskategorier Cancer och onkologi

Sammanfattning

METHODS. Twelve patients with advanced epithelial nonadenocarcinoma of the paranasal sinuses and nasal fossa were treated with three cycles of cisplatin (100 mg/m2, day 1) and 5-fluorouracil (1000 mg/m2/24 hours on days 1-5 by continuous infusion), followed by preoperative external radiation therapy of 48 Gy and limited surgery, clearing the paranasal sinuses and nasal fossa. RESULTS. After chemotherapy, 11 of 12 patients were free of the previous symptoms of disease. Clinical response rates were different, however, with an overall response rate of approximately 70% with no complete responses. Histopathologic analysis of resected specimens showed no vital tumor in eight patients, minimal microscopic disease in three patients, and infiltrating tumor in one patient. Local control was achieved in 11 of 12 patients. Ten patients are alive with no evidence of disease (mean follow-up, 27 months). Surgical mutilation was avoided, with no functional or cosmetic loss. CONCLUSIONS. The results of this small pilot study seem to indicate a high chemosensitivity of carcinomas of the paranasal sinuses and nasal fossa, which, in this study, has meant significant relief of symptoms and an unusually high rate of local control (90%) without mutilation.

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