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Nineteen cases of persistent pruritic nodules and contact allergy to aluminium after injection of commonly used aluminium-adsorbed vaccines.

Artikel i vetenskaplig tidskrift
Författare Elisabet Bergfors
Cecilia Björkelund
Birger Trollfors
Publicerad i European journal of pediatrics
Volym 164
Nummer/häfte 11
Sidor 691-7
ISSN 0340-6199
Publiceringsår 2005
Publicerad vid Institutionen för samhällsmedicin, Avdelningen för allmänmedicin
Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik
Sidor 691-7
Språk en
Länkar dx.doi.org/10.1007/s00431-005-1704-...
Ämnesord Adsorbed vaccines, persistent itching nodules, aluminium hypersensitivity
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

Rare cases of persistent pruritic nodules, sometimes associated with aluminium (Al) allergy, have been reported after the use of several Al adsorbed vaccines. During vaccine trials in the 1990s a high incidence of pruritic nodules (645 cases/76,000 recipients), in 77% associated with Al allergy, was observed after the administration of diphtheria-tetanus / acellular pertussis (DT/aP) vaccines from a single producer. In the present report 19 children with pruritic nodules after vaccination with Al hydroxide-adsorbed DTaP/polio+Hib (Infanrix, Pentavac) are described. The children had intensely itching nodules at the injection site, often aggravated during upper respiratory tract infections, and local skin alterations. So far, the symptoms have persisted for up to 7 years. The median time between vaccination and onset of symptoms was 1 month. 16 children were epicutaneously tested for Al, all with positive reactions indicating delayed hypersensitivity to Al. The condition is not commonly known but is important to recognise, as the child and the family may suffer considerably. Future vaccinations with Al-adsorbed vaccines may cause aggravation of the symptoms and the Al allergy. Al-containing skin products, such as antiperspirants, may cause contact dermatitis. Nodules may be mistaken for tumours. Even though the incidence of itching nodules and Al allergy after administration of Infanrix, Pentavac and other Al-adsorbed vaccines is probably low, research to replace Al adjuvants seems appropriate. We conclude that intensely itching subcutaneous nodules, lasting for many years, and hypersensitivity to aluminium may occur after DTaP/polio+Hib vaccination of infants.

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