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The glycine antagonist (+)-HA-966 injected into the nucleus accumbens stimulates locomotion in mice. (Rapid communication)

Artikel i vetenskaplig tidskrift
Författare Marie Nilsson
Maria L. Carlsson
Publicerad i J Neural Transm
Volym 104
Nummer/häfte 4-5
Sidor 419-25
ISSN 0300-9564 (Print)
Publiceringsår 1997
Publicerad vid Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi
Sidor 419-25
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Dose-Response Relationship, Drug, Glycine/*antagonists & inhibitors, Injections, Male, Mice, Mice, Inbred Strains, Motor Activity/*drug effects/*physiology, Nucleus Accumbens/*physiology, Pyrrolidinones/*pharmacology, Stereoisomerism
Ämneskategorier Farmakologi

Sammanfattning

We have previously observed that NMDA antagonists injected into the ventral striatum cause locomotor stimulation in both normal and monoamine-depleted mice. Since glycine receptor activation is claimed to be a prerequisite for NMDA receptor channel opening, also a glycine site antagonist injected into the ventral striatum should cause behavioural activation. The present study was aimed at investigating whether this is the case. The glycine site antagonist (+)-HA-966, as well as its (-)-enantiomer, were injected bilaterally into the nucleus accumbens of normal, habituated mice. (+)-HA-966, but not (-)-HA-966, was found to stimulate locomotion. The stereoselective response suggests that the underlying mechanism involves the NMDA receptor-coupled glycine site. The present results support the notion that a glycine agonist might be of value in the treatment of schizophrenia, whereas a glycine antagonist should be expected to have psychotogenic effects.

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