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Free radical scavenging enzymes and G protein mediated receptor signalling systems in ischaemically preconditioned porcine myocardium.

Artikel i vetenskaplig tidskrift
Författare Michael Fu
K A Kirkebøen
Qi-Ming Liang
Klas-Göran Sjögren
Åke Hjalmarson
A Ilebekk
Publicerad i Cardiovascular research
Volym 27
Nummer/häfte 4
Sidor 612-6
ISSN 0008-6363
Publiceringsår 1993
Publicerad vid Wallenberglaboratoriet
Sidor 612-6
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Disease Models, Animal, Female, Free Radical Scavengers, GTP-Binding Proteins, metabolism, Male, Myocardial Infarction, prevention & control, Myocardial Ischemia, enzymology, metabolism, Myocardial Reperfusion, Myocardial Reperfusion Injury, prevention & control, Myocardium, enzymology, metabolism, Receptors, Adrenergic, beta, metabolism, Receptors, Cell Surface, metabolism, Receptors, Endothelin, metabolism, Receptors, Muscarinic, metabolism, Signal Transduction, physiology, Swine
Ämneskategorier Fysiologi

Sammanfattning

OBJECTIVE: Increased antioxidant defence and altered G protein mediated receptor signalling systems could be expected in myocardial preconditioning. The myocardial antioxidant defence and the integrity of the G protein mediated receptor signalling systems were therefore examined in normal and preconditioned myocardium. METHODS: Preconditioning in the porcine heart was induced by two occlusions of the mid left anterior descending coronary artery for 10 min, with a 30 min reperfusion interval. Left ventricular biopsies were obtained from control and preconditioned regions 30 min after the last occlusion. RESULTS: In biopsies from the preconditioning region, neither the activities of superoxide dismutase of glutathione peroxidase, nor the content of malondialdehyde were changed. There were no alterations in either the number of receptors (beta adrenergic, muscarinic and endothelin receptors) or the amount of G proteins. Furthermore, the activity of adenylyl cyclase remained unchanged. CONCLUSIONS: No change in the antioxidant defence was demonstrated in preconditioned myocardium. This finding does not support the hypothesis that increased antioxidant defence could contribute to the cardioprotection of preconditioning. Additionally, an intact G protein mediated receptor signalling system was found in preconditioned myocardium with regard to beta adrenergic, muscarinic, and endothelin receptors.

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