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Exercise immunology: neuroendocrine regulation of NK-cells.

Forskningsöversiktsartikel
Författare Ingibjörg H Jonsdottir
Publicerad i International journal of sports medicine
Volym 21 Suppl 1
Sidor S20-3
ISSN 0172-4622
Publiceringsår 2000
Publicerad vid Institutionen för fysiologi och farmakologi
Sidor S20-3
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Afferent Pathways, immunology, Animals, Exercise, physiology, Humans, Hypothalamo-Hypophyseal System, immunology, Immunity, Natural, immunology, physiology, Killer Cells, Natural, immunology, physiology, Neuroimmunomodulation, physiology, Opioid Peptides, immunology, Pituitary-Adrenal System, immunology, Rats
Ämneskategorier Fysiologi

Sammanfattning

Natural immunity, including that of the natural killer (NK) cells, is strongly influenced by physical exercise, but the physiological significance of the reported changes in NK cells after exercise training is as yet unclear. The exercise effect is likely mediated by interactions between the central nervous and endocrine systems. Chronic activation of endogenous opioid systems augments natural cytotoxicity. We have investigated the possible involvement of opioids in the exercise-induced enhancement of NK cell function. The pathways by which the central nervous system may communicate with the periphery include neuroendocrine outflow via the hypothalamic-pituitary-adrenal axis and the autonomic nervous system (ANS) through direct nerve fiber connections with cells or the organs of the immune system. This review will discuss the role of various neuroendocrine factors such as growth hormone, catecholamines and glucocorticoids and the role of the ANS, in particular the sympathetic division, in modulating NK cell function in response to exercise.

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