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Evidence for an adrenergic innervation of the adrenal cortical blood vessels in rats.

Artikel i vetenskaplig tidskrift
Författare S Carlsson
Ingibjörg H Jonsdottir
J O Skarphedinsson
Peter Thorén
Publicerad i Acta physiologica Scandinavica
Volym 149
Nummer/häfte 1
Sidor 23-30
ISSN 0001-6772
Publiceringsår 1993
Publicerad vid Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi
Sidor 23-30
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adrenal Cortex, blood supply, innervation, Adrenal Medulla, drug effects, physiology, Animals, Blood Vessels, innervation, Electric Stimulation, Guanethidine, pharmacology, Laser-Doppler Flowmetry, Male, Nerve Fibers, physiology, Prazosin, pharmacology, Rats, Rats, Wistar, Regional Blood Flow, drug effects, physiology, Splanchnic Nerves, physiology, Sympathetic Nervous System, physiology, Trimethaphan, pharmacology
Ämneskategorier Fysiologi

Sammanfattning

The aim of this study was to investigate the blood flow in the adrenal cortex of the rat. Relative changes in the adrenal cortical blood flow were continuously measured by Laser Doppler flowmetry in 33 chloralose-anaesthetized artificially ventilated rats during electrical stimulation (1 ms, 5 V) of the left great splanchnic nerve (LGSN), which conveys both pre- and post-ganglionic nerve fibres to the adrenal gland. Laser Doppler flux (LDF) was decreased and regional resistance (RR) was increased by augmenting nerve stimulation at increasingly higher frequencies (2, 4, 8, 20 and 40 Hz). The decrease in LDF, when compared to pre-drug stimulations at 4 Hz was partially or totally inhibited by the adrenergic blocking agents trimethaphan (TRIM), guanethidine (GUA) and alpha 1-blockade with prazosin (PRAZ). Furthermore, both the decrease in LDF and the increase in RR were either completely or partially blocked by stimulation at 40 Hz after TRIM-treatment and GUA-treatment. It is concluded that the adrenal cortex in the rat is innervated by post-ganglionic adrenergic nerve fibres, which are involved in the regulation of blood flow in the adrenal cortex.

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