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Terodiline in the treatment of children with unstable bladders.

Artikel i vetenskaplig tidskrift
Författare Anna-Lena Hellström
Kelm Hjälmås
Ulf Jodal
Publicerad i British journal of urology
Volym 63
Nummer/häfte 4
Sidor 358-62
ISSN 0007-1331
Publiceringsår 1989
Publicerad vid Institutionen för pediatrik
Sidor 358-62
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adolescent, Butylamines, therapeutic use, Child, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Male, Parasympatholytics, therapeutic use, Urinary Incontinence, drug therapy
Ämneskategorier Fysiologi, Omvårdnad, Barn

Sammanfattning

A double-blind study of terodiline compared with placebo was performed in 58 children aged 6 to 14 years with urgency or urge incontinence. All had an unstable bladder at cystometry. A bladder regimen was emphasised during the study. Continence was improved according to micturition charting and a pad test in both groups. Terodiline at 25 mg/day, however, gave significantly better results than placebo. In patients with a subnormal bladder capacity (less than or equal to 150 ml), a significant increase in capacity was recorded on cystometry during medication with terodiline but not with placebo. The improved continence seen in the placebo group was probably due to the non-specific bladder training achieved by the child's increased awareness and adult involvement during treatment. The even better results attained in the terodiline group shows this drug to be a valuable adjunct to a bladder regimen in children with urge incontinence, particularly since no important adverse effects were noted during an 8-week period.

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