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Analysis of linkage and linkage disequilibrium for eight X-STR markers

Artikel i vetenskaplig tidskrift
Författare Andreas O Tillmar
Petter Mostad
Thore Egeland
Bertil Lindblom
Gunilla Holmlund
Kerstin Montelius
Publicerad i Forensic Science International: Genetics
Publiceringsår 2008
Publicerad vid Institutionen för matematiska vetenskaper, matematisk statistik
Språk en
Länkar dx.doi.org/10.1016/j.fsigen.2008.09...
Ämnesord X-chromosomal STR Linkage Linkage disequilibrium Recombination Likelihood ratios Sweden
Ämneskategorier Rättsgenetik, Matematisk statistik

Sammanfattning

X-chromosomal short tandem repeats (X-STR) have proven to be informative and useful in complex relationship testing. Themain feature of X-STR markers, compared to autosomal forensicmarkers, is that all loci are located on the same chromosome. Thus, linkage and linkage disequilibrium may occur. The aim of this work was to study population genetic parameters of eight X-STR markers, located in four linkage groups. We present haplotype frequencies, based on 718 Swedish males, for the four linkage groups included in the Argus X-8 kit. Forensic efficiency parameters have been calculated as well as the allelic association between the tested markers for detection of linkage disequilibrium. To study the occurrences of recombination between the loci, both Swedish and Somali families were typed. A mathematical model for the estimation of recombination frequencies is presented and applied on the family samples. Our study showed that the tested markers all have highly informative forensic values and that there is a significant degree of linkage disequilibrium between the STR markers within the four linkage groups. Furthermore, based on the tested families, we also demonstrated that two of the linkage groups are partially linked. A consequence of these findings is that both linkage and linkage disequilibrium should be accounted for when producing likelihood ratios in relationship testing with XSTR markers.

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