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| Författare |
Göran Stenman E Röijer Ulla Rüetschi A Dellsén Lars Rymo Sven Lindstedt |
|---|---|
| Publicerad i | Cytogenetics and cell genetics |
| Volym | 71 |
| Nummer/häfte | 4 |
| Sidor | 374-6 |
| ISSN | 0301-0171 |
| Publiceringsår | 1995 |
| Publicerad vid |
Institutionen för laboratoriemedicin , Avdelningen för patologi Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin |
| Sidor | 374-6 |
| Språk | en |
| Länkar |
www.ncbi.nlm.nih.gov/entrez/query.f... |
| Ämnesord | 4-Hydroxyphenylpyruvate Dioxygenase, genetics, Animals, Base Sequence, Blotting, Southern, Chromosome Mapping, Chromosomes, Human, Pair 12, genetics, ultrastructure, DNA, Complementary, Exons, genetics, Humans, In Situ Hybridization, Fluorescence, Mice, Molecular Sequence Data |
| Ämneskategorier | Cell- och molekylärbiologi |
Using a panel of human-rodent somatic cell hybrids, we have previously mapped the gene (HPD, previously called PPD) encoding 4-hydroxyphenylpyruvate dioxygenase to the distal half of the long arm of human chromosome 12, region q14-->qter. To obtain a genomic probe useful for fluorescence in situ hybridization (FISH) analysis we screened a human leukocyte genomic library and isolated a 13.4-kb phage clone, which by restriction fragment and sequence analyses was shown to contain exons 1-10 of HPD and approximately 2-kb upstream sequences. We now report the subregional localization of HPD to 12q24-->qter based on two color FISH analysis employing this clone.
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