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A novel in vivo method for quantifying the interfacial biochemical bond strenth of bone implants

Artikel i vetenskaplig tidskrift
Författare Young-Taeg Sul
Carina B. Johansson
Tomas Albrektsson
Publicerad i Journal of The Royal Society Interface
Volym 7
Nummer/häfte 42
Sidor 81-90
ISSN 1742-5662
Publiceringsår 2010
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Sidor 81-90
Språk en
Länkar dx.doi.org/10.1098/rsif.2009.0060
Ämnesord Bone implant interface, interfacial biochemical bond, bonding strength measurement, titanium, metal plasma source ion implantation (MePSII), surface property.
Ämneskategorier Industriell bioteknik, Kemi, Biomaterial

Sammanfattning

Quantifying the in vivo interfacial biochemical bond strength of bone implants is a biological challenge. We have developed a new and novel in vivo method to identify an interfacial biochemical bond in bone implants and measure its bonding strength. This method, named BBM (biochemical bond measurement), involves a combination of the implant devices to truly measure interfacial bond strength and surface property controls, and thus enables to distinguish the contributions of mechanical interlocking and biochemical bonding from the measured strength values. We applied the BBM method to a rabbit model, and observed great differences in bone integration between the oxygen (control group) and magnesium (test group) plasma immersion ion implanted titanium implants (0.046 vs. 0.086 MPa, n = 10, P = 0.005). The biochemical bond in the test implants resulted in superior interfacial behavior of the implants to bone: i) close contact to approximately 2 μm thin amorphous interfacial tissue; ii) pronounced mineralization of the interfacial tissue; iii) rapid bone healing in contact; iv) strong integration to bone. The BBM method can be applied to in vivo experimental model not only to validate the presence of a biochemical bond at bone-implant interface but also to measure the relative quantity of biochemical bond strength. The present study may provide new avenues for better understanding the role of a biochemical bond involved in integration of bone implants.

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