Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän

The IGF system and longit… - Göteborgs universitet Till startsida
Till innehåll Läs mer om hur kakor används på gu.se

The IGF system and longitudinal growth in preterm infants in relation to gestational age, birth weight and gender

Artikel i vetenskaplig tidskrift
Författare Ann Hellström
J. Sigurdsson
Chatarina Löfqvist
Gunnel Hellgren
A. Kistner
Publicerad i Growth Hormone & Igf Research
Volym 51
Sidor 46-57
ISSN 1096-6374
Publiceringsår 2020
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för biomedicin
Institutionen för vårdvetenskap och hälsa
Sidor 46-57
Språk en
Länkar dx.doi.org/10.1016/j.ghir.2020.02.0...
Ämnesord Preterm children, IGF-I, IGF-II, IGFBP-I, ALS, acid-labile subunit, factor-i, binding protein-1, postnatal-growth, insulin, retinopathy, prematurity, leptin, deficiency, variables, Cell Biology, Endocrinology & Metabolism
Ämneskategorier Pediatrik, Neurologi


Objective: Growth factors in the blood of very preterm infants may reflect growth and contribute to the understanding of early development. We investigated postnatal levels of insulin-like growth factors (IGFs) in infants born very preterm and related them to early growth development. Design: Blood samples were analyzed weekly for IGF-I, IGF-II, IGF binding protein (BP)-1, IGFBP-3, and acid-label subunit (ALS). Methods: 73 children born very preterm (gestational age (GA) < 32 weeks) were divided according to their gender-specific birth weight standard deviation score (SDS) into either appropriate for GA (AGA) or small for GA (SGA). Fifty-two (71%) and forty-three (59%) infants completed follow-up with anthropometry at approximately 3 years and at 5 years of age respectively. Thirty-six subjects (49%) had blood sampling for IGF-I and IGFBP-3 measurements up to 3 years of age. Results: IGF-I, IGFBP-3, and ALS levels increased in all groups from week 31 to week 36, with generally lower levels in the SGAs, with a concomitant lower growth velocity. Postnatal ALS was strongly associated with IGF-I and IGFBP-3 in boys, girls and AGA infants. IGF-II was higher in earlier born preterms (GA < 27 weeks) at postmenstrual ages 27.5-29.9 weeks compared with SGAs and late GA (GA >= 27 weeks) preterms (p <.0001). IGF-II, in contrast to IGF-I, did not differ between SGAs and AGAs at weeks 31-36. Mean IGFBP-1 was highest in the SGAs compared to AGAs at mean week 28,5 and 31 (p=.001) and IGFBP-1 levels were elevated in relation to IGF-I in the SGAs at that period. At follow-up, the increase in IGF-I between week 31 and 33.5 was a significant positive determinant of height SDS at 3 and 5 years of age in forward multiple regression analysis, independent of target height. Conclusion: This is the first study to investigate postnatal ALS levels in preterm infants. In very preterm infants, IGF-II is less affected by size at birth during early postnatal weeks compared with IGF-I. Early elevated IGFBP-1 might protect the SGA infants from an intense metabolic rate. Our results indicate that anabolic and metabolic processes during weeks 31-36 predicts later height.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?