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Ulf Smith
Seniorforskare
Avd för molekylär och kliniskOm Ulf Smith
Ulf Smith är forskningschef på Lundberglaboratoriet för diabetes forskning som ligger under Avdelningen för molekylär och klinisk medicin, Göteborgs universitet.
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Altered H3K4me3 profile at the TFAM promoter causes mitochondrial alterations in preadipocytes from first-degree relatives of type 2
diabetics
Michele Longo, Federica Zatterale, Rosa Spinelli, Jamal Naderi, Luca Parrillo, Pasqualina Florese, Cecilia Nigro, Alessia Leone, Augusta Moccia, Antonella Desiderio, Gregory A. Raciti, Claudia Miele, Ulf Smith, Francesco Beguinot
CLINICAL EPIGENETICS - 2023 -
Report on the 11th international workshop on the CCN family of genes, Nice, October 20-24,
2022
Havard Attramadal, Sushanta K. Banerjee, Brahim Chaqour, Gary Fisher, Lester Lau, Bernard Perbal, Ulf Smith, Herman Yeger
JOURNAL OF CELL COMMUNICATION AND SIGNALING - 2023 -
The impact of cellular senescence in human adipose
tissue
Annika Nerstedt, Ulf Smith
Journal of Cell Communication and Signaling - 2023 -
Cardiac arrhythmias and conduction abnormalities in patients with type 2
diabetes
Araz Rawshani, D. K. McGuire, Elmir Omerovic, N. Sattar, J. J. V. McMurray, Ulf Smith, Björn Redfors, Lennart Bergfeldt, Björn Eliasson, Jan Borén, D. L. Bhatt, Göran Bergström, Aidin Rawshani
Scientific Reports - 2023 -
Increased cell senescence in human metabolic
disorders
Rosa Spinelli, Ritesh Baboota, Silvia Gogg, F. Beguinot, M. Bluher, Annika Nerstedt, Ulf Smith
Journal of Clinical Investigation - 2023 -
BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of
NAFLD/NASH
Ritesh Baboota, Aidin Rawshani, Laurianne Bonnet, X. Y. Li, H. Yang, A. Mardinoglu, T. Tchkonia, J. L. Kirkland, A. Hoffmann, A. Dietrich, Jeremie Boucher, M. Bluher, Ulf Smith
Nature Metabolism - 2022 -
Left-Sided Degenerative Valvular Heart Disease in Type 1 and Type 2
Diabetes
Araz Rawshani, N. Sattar, D. K. McGuire, Oskar Wallström, Ulf Smith, Jan Borén, Göran Bergström, Elmir Omerovic, Annika Rosengren, Björn Eliasson, D. L. Bhatt, Aidin Rawshani
Circulation - 2022 -
Chronic hyperinsulinemia promotes human hepatocyte
senescence.
Ritesh Baboota, Rosa Spinelli, Malin Erlandsson, Bruna B Brandao, Marsel Lino, Hong Yang, Adil Mardinoglu, Maria Bokarewa, Jeremie Boucher, C Ronald Kahn, Ulf Smith
Molecular metabolism - 2022 -
Epigenetic Dysregulation of the Homeobox A5 (HOXA5) Gene Associates with Subcutaneous Adipocyte Hypertrophy in Human
Obesity
L. Parrillo, R. Spinelli, M. Costanzo, P. Florese, S. Cabaro, A. Desiderio, I. Prevenzano, G. A. Raciti, Ulf Smith, C. Miele, P. Formisano, R. Napoli, F. Beguinot
Cells - 2022 -
ZMAT3 hypomethylation contributes to early senescence of preadipocytes from healthy first-degree relatives of type 2
diabetics
R. Spinelli, P. Florese, L. Parrillo, F. Zatterale, M. Longo, V. D'Esposito, A. Desiderio, Annika Nerstedt, Birgit Gustafson, P. Formisano, C. Miele, G. A. Raciti, R. Napoli, Ulf Smith, F. Beguinot
Aging Cell - 2022 -
Cellular senescence in hepatocytes contributes to metabolic disturbances in
NASH
Laurianne Bonnet, Ida Alexandersson, Ritesh Baboota, Tobias Kroon, J. Oscarsson, Ulf Smith, Jeremie Boucher
Frontiers in Endocrinology - 2022 -
Type 2 Diabetes, Independent of Obesity and Age, Is Characterized by Senescent and Dysfunctional Mature Human Adipose
Cells
Birgit Gustafson, Annika Nerstedt, R. Spinelli, F. Beguinot, Ulf Smith
Diabetes - 2022 -
Metabolite Signature of Albuminuria Involves Amino Acid Pathways in 8661 Finnish Men Without
Diabetes
L. F. Silva, J. Vangipurapu, Ulf Smith, M. Laakso
Journal of Clinical Endocrinology & Metabolism - 2021 -
Adipocyte precursor cells from first degree relatives of type 2 diabetic patients feature changes in hsa-mir-23a-5p, -193a-5p, and -193b-5p and insulin-like growth factor 2
expression
P. Mirra, A. Desiderio, R. Spinelli, C. Nigro, M. Longo, L. Parrillo, V. D'Esposito, A. Carissimo, Shahram Hedjazifar, Ulf Smith, P. Formisano, C. Miele, G. A. Raciti, F. Beguinot
FASEB Journal - 2021 -
Emerging Role of Bone Morphogenetic Protein 4 in Metabolic
Disorders
Ritesh Baboota, M. Bluher, Ulf Smith
Diabetes - 2021 -
Identification of markers that distinguish adipose tissue and glucose and insulin metabolism using a multi-modal machine learning
approach
Josefin Henninger, Björn Eliasson, Ulf Smith, Aidin Rawshani
Scientific Reports - 2021 -
Cellular senescence and its role in white adipose
tissue
Ulf Smith, Q. Li, M. Ryden, K. L. Spalding
International Journal of Obesity - 2021 -
Impact of the Uncoupling Protein 1 on Cardiovascular Risk in Patients with Rheumatoid
Arthritis
Lovisa Lyngfelt, Malin Erlandsson, Mitra Nadali, Shahram Hedjazifar, Rille Pullerits, Karin Andersson, Petra Brembeck, Sofia Töyrä Silfverswärd, Ulf Smith, Maria Bokarewa
Cells - 2021 -
Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the
liver
Roxana Khatib Shahidi, Jenny M Hoffmann, Shahram Hedjazifar, Laurianne Bonnet, Ritesh Baboota, S. Heasman, C. Church, I. Elias, F. Bosch, Jeremie Boucher, Ann Hammarstedt, Ulf Smith
PLoS ONE - 2021 -
Adipose tissue morphology, imaging and metabolomics predicting cardiometabolic risk and family history of type 2 diabetes in non-obese
men
Aidin Rawshani, Björn Eliasson, Araz Rawshani, Josefin Henninger, A. Mardinoglu, Åsa Carlsson, Maja Sohlin, Maria Ljungberg, Ann Hammarstedt, Annika Rosengren, Ulf Smith
Scientific Reports - 2020 -
Microbiota-Related Metabolites and the Risk of Type 2
Diabetes
J. Vangipurapu, L. F. Silva, T. Kuulasmaa, Ulf Smith, M. Laakso
Diabetes care - 2020 -
Altered PTPRD DNA methylation associates with restricted adipogenesis in healthy first-degree relatives of Type 2 diabetes
subjects
L. Parrillo, R. Spinelli, M. Longo, A. Desiderio, P. Mirra, C. Nigro, F. Fiory, Shahram Hedjazifar, M. Mutarelli, A. Carissimo, P. Formisano, C. Miele, Ulf Smith, G. A. Raciti, F. Beguinot
Epigenomics - 2020 -
BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese
mice
Jenny M Hoffmann, John Grünberg, Ann Hammarstedt, T. Kroon, Thomas U. Greiner, S. Maurer, I. Elias, Vilborg Palsdottir, F. Bosch, Jeremie Boucher, Shahram Hedjazifar, Ulf Smith
Molecular Metabolism - 2020 -
The European medical information framework: A novel ecosystem for sharing healthcare data across
Europe
S. Lovestone, B. Vannieuwenhuyse, P. J. Visser, I. Bos, S. Vos, J. Streffer, Ulf Smith, D. Waterworth, J. van der Lei, P. Rijnbeek, J. L. Oliveira, M. Van Speybroeck, R. Verbeeck, D. Kalra, N. Lea, E. Molero, M. Lewi, M. Alexander, G. James, C. Sage, J. Praet, P. Egger, G. Singh, N. Hughes
Learning Health Systems - 2020 -
Mannose is an insulin-regulated metabolite reflecting whole-body insulin sensitivity in
man
E. Ferrannini, Maria Bokarewa, Petra Brembeck, Ritesh Baboota, Shahram Hedjazifar, S. Baldi, B. Campi, E. Muscelli, A. Saba, I. Sterner, Caroline Wasén, Ulf Smith
Metabolism: Clinical and Experimental - 2020 -
The Novel Adipokine Gremlin 1 Antagonizes Insulin Action and Is Increased in Type 2 Diabetes and
NAFLD/NASH
Shahram Hedjazifar, Roxana Khatib Shahidi, Ann Hammarstedt, Laurianne Bonnet, C. Church, Jeremie Boucher, M. Bluher, Ulf Smith
Diabetes - 2020 -
Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish
Men
J. Vangipurapu, A. Stancakova, Ulf Smith, J. Kuusisto, M. Laakso
Diabetes - 2019 -
Human adipose tissue microvascular endothelial cells secrete PPARγ ligands and regulate adipose tissue lipid
uptake.
Silvia Gogg, Annika Nerstedt, Jan Borén, Ulf Smith
JCI insight - 2019 -
Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor
cells
Birgit Gustafson, Annika Nerstedt, Ulf Smith
Nature Communications - 2019 -
Integrative Personal Omics Profiles during Periods of Weight Gain and
Loss
B. D. Piening, W. Y. Zhou, K. Contrepois, H. Rost, G. J. G. Urban, T. Mishra, B. M. Hanson, E. J. Bautista, S. Leopold, C. Y. Yeh, D. Spakowicz, I. Banerjee, C. Chen, K. Kukurba, D. Perelman, C. Craig, E. Colbert, D. Salins, S. Rego, S. Lee, C. Zhang, J. Wheeler, M. R. Sailani, L. Liang, C. Abbott, M. Gerstein, A. Mardinoglu, Ulf Smith, D. L. Rubin, S. Pitteri, E. Sodergren, T. L. McLaughlin, G. M. Weinstock, M. P. Snyder
Cell Systems - 2018 -
Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic
Acids
Ann Hammarstedt, I. Syed, A. Vijayakumar, Björn Eliasson, Silvia Gogg, B. B. Kahn, Ulf Smith
Scientific Reports - 2018 -
Methodological Issues in Studying PAHSA Biology: Masking PAHSA
Effects.
Ismail Syed, Jennifer Lee, Odile D Peroni, Mark M Yore, Pedro M Moraes-Vieira, Anna Santoro, Kerry Wellenstein, Ulf Smith, Timothy E McGraw, Alan Saghatelian, Barbara B Kahn
Cell metabolism - 2018 -
Impaired Adipogenesis and Dysfunctional Adipose Tissue in Human Hypertrophic
Obesity
Ann Hammarstedt, Silvia Gogg, Shahram Hedjazifar, Annika Nerstedt, Ulf Smith
Physiological Reviews - 2018 -
Systems biology in hepatology: approaches and
applications
A. Mardinoglu, Jan Borén, Ulf Smith, M. Uhlen, J. Nielsen
Nature Reviews Gastroenterology & Hepatology - 2018 -
CCN5/WISP2 and metabolic
diseases
J. R. Grunberg, Johannes Elvin, A. Paul, Shahram Hedjazifar, Ann Hammarstedt, Ulf Smith
Journal of Cell Communication and Signaling - 2018 -
Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2
Diabetes
A. Mardinoglu, Silvia Gogg, L. A. Lotta, A. Stancakova, Annika Nerstedt, Jan Borén, M. Bluher, E. Ferrannini, C. Langenberg, N. J. Wareham, M. Laakso, Ulf Smith
Ebiomedicine - 2018 -
Epigenetic modifications of the Zfp/ZNF423 gene control murine adipogenic commitment and are dysregulated in human hypertrophic
obesity.
Michele Longo, Gregory A Raciti, Federica Zatterale, Luca Parrillo, Antonella Desiderio, Rosa Spinelli, Ann Hammarstedt, Shahram Hedjazifar, Jenny M Hoffmann, Cecilia Nigro, Paola Mirra, Francesca Fiory, Pietro Formisano, Claudia Miele, Ulf Smith, Francesco Beguinot
Diabetologia - 2018 -
TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of
GSK3β
M. Romero, A. Sabaté-Pérez, V. A. Francis, I. Castrillón-Rodriguez, Á Díaz-Ramos, M. Sánchez-Feutrie, X. Durán, M. Palacín, J. M. Moreno-Navarrete, Birgit Gustafson, Ann Hammarstedt, J. M. Fernández-Real, J. Vendrell, Ulf Smith, A. Zorzano
Nature Cell Biology - 2018 -
Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male
mice.
Claes Ohlsson, Ann Hammarstedt, Liesbeth Vandenput, Niina Saarinen, Henrik Ryberg, Sara H Windahl, Helen H. Farman, John-Olov Jansson, Sofia Movérare-Skrtic, Ulf Smith, Fu-Ping Zhang, Matti Poutanen, Shahram Hedjazifar, Klara Sjögren
American journal of physiology. Endocrinology and metabolism - 2017 -
Network analyses identify liver-specific targets for treating liver
diseases.
Sunjae Lee, Cheng Zhang, Zhengtao Liu, Martina Klevstig, Bani Mukhopadhyay, Mattias Bergentall, Resat Cinar, Marcus Ståhlman, Natasha Sikanic, Joshua K Park, Sumit Deshmukh, Azadeh M Harzandi, Tim Kuijpers, Morten Grøtli, Simon J Elsässer, Brian D Piening, Michael Snyder, Ulf Smith, Jens Nielsen, Fredrik Bäckhed, George Kunos, Mathias Uhlen, Jan Borén, Adil Mardinoglu
Molecular systems biology - 2017 -
BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose
Tissue.
Jenny M Hoffmann, John Grünberg, Christopher Church, Ivet Elias, Vilborg Palsdottir, John-Olov Jansson, Fatima Bosch, Ann Hammarstedt, Shahram Hedjazifar, Ulf Smith
Cell reports - 2017 -
Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular
Disease.
Adil Mardinoglu, Alena Stančáková, Luca A Lotta, Johanna Kuusisto, Jan Borén, Matthias Blüher, Nicholas J Wareham, Ele Ferrannini, Per Henrik Groop, Markku Laakso, Claudia Langenberg, Ulf Smith
Cell metabolism - 2017 -
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes
Variants
A. R. Wood, A. Jonsson, A. U. Jackson, N. Wang, N. van Leewen, N. D. Palmer, S. Kobes, J. Deelen, L. Boquete-Vilarino, J. Paananen, A. Stancakova, D. I. Boomsma, E. J. C. de Geus, E. M. W. Eekhoff, A. Fritsche, M. Kramer, G. Nijpels, A. Simonis-Bik, T. W. van Haeften, A. Mahajan, M. Boehnke, R. N. Bergman, J. Tuomilehto, F. S. Collins, K. L. Mohlke, K. Banasik, C. J. Groves, M. I. McCarthy, E. R. Pearson, A. Natali, A. Mari, T. A. Buchanan, K. D. Taylor, A. H. Xiang, A. P. Gjesing, N. Grarup, H. Eiberg, O. Pedersen, Y. D. Chen, M. Laakso, J. M. Norris, Ulf Smith, L. E. Wagenknecht, L. Baier, D. W. Bowden, T. Hansen, M. Walker, R. M. Watanabe, L. M. t Hart, R. L. Hanson, T. M. Frayling
Diabetes - 2017 -
Personal model-assisted identification of NAD(+) and glutathione metabolism as intervention target in
NAFLD
A. Mardinoglu, Elias Björnson, C. Zhang, Martina Klevstig, S. Soderlund, Marcus Ståhlman, Martin Adiels, A. Hakkarainen, N. Lundbom, M. Kilicarslan, B. M. Hallstrom, J. Lundbom, B. Verges, P. H. R. Barrett, G. F. Watts, M. J. Serlie, J. Nielsen, M. Uhlen, Ulf Smith, Hanns-Ulrich Marschall, M. R. Taskinen, Jan Borén
Molecular Systems Biology - 2017 -
Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin
resistance.
John Grünberg, Jenny M Hoffmann, Shahram Hedjazifar, Annika Nerstedt, Lachmi E Jenndahl, Johannes Elvin, John Castellot, Lan Wei, Sofia Movérare-Skrtic, Claes Ohlsson, Louise Mannerås Holm, Fredrik Bäckhed, Ismail Syed, Fatima Bosch, Alan Saghatelian, Barbara B Kahn, Ann Hammarstedt, Ulf Smith
Scientific reports - 2017 -
Cephalic phase of insulin secretion in response to a meal is unrelated to family history of type 2
diabetes
Björn Eliasson, Araz Rawshani, Mette Axelsen, Ann Hammarstedt, Ulf Smith
Plos One - 2017 -
The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's
pathology.
Sarah Westwood, Benjamine Liu, Alison L Baird, Sneha Anand, Alejo J Nevado-Holgado, Danielle Newby, Maria Pikkarainen, Merja Hallikainen, Johanna Kuusisto, Johannes R Streffer, Gerald Novak, Kaj Blennow, Ulf Andreasson, Henrik Zetterberg, Ulf Smith, Markku Laakso, Hilkka Soininen, Simon Lovestone
Alzheimer's research & therapy - 2017 -
Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin
Resistance
S. Lee, C. Zhang, M. Kilicarslan, B. D. Piening, Elias Björnson, B. M. Hallstrom, A. K. Groen, E. Ferrannini, M. Laakso, M. Snyder, M. Bluher, M. Uhlen, Jens B. Nielsen, Ulf Smith, M. J. Serlie, Jan Borén, Adil Mardinoglu
Cell Metabolism - 2016 -
Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel
lipids
Ulf Smith, B. B. Kahn
Journal of Internal Medicine - 2016 -
High plasma osteocalcin is associated with low blood haemoglobin in elderly men: the MrOS Sweden
Study
Catharina Lewerin, Helena Johansson, M. K. Karlsson, Mattias Lorentzon, Ulf H Lerner, Jenny Kindblom, Claes Ohlsson, Ulf Smith, Dan Mellström
Journal of Internal Medicine - 2016 -
A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty
acids.
Tejia Zhang, Shili Chen, Ismail Syed, Marcus Ståhlman, Matthew J Kolar, Edwin A Homan, Qian Chu, Ulf Smith, Jan Borén, Barbara B Kahn, Alan Saghatelian
Nature Protocols - 2016 -
Is leptin coming back? A short introduction to the presentations in this symposium session at the 2015 annual meeting of the
EASD.
Ulf Smith
Diabetologia - 2016 -
Confounding effects of metformin on the human gut microbiome in Type 2
diabetes
Adil Mardinoglu, Jan Borén, Ulf Smith
Cell Metabolism - 2016 -
Exenatide improves β-cell function up to 3 years of treatment in patients with type 2 diabetes: a randomised controlled
trial.
Daniël H van Raalte, Mathijs C Bunck, Mark M Smits, T Hoekstra, Anja Cornér, Michaela Diamant, Björn Eliasson, Marja-RiittaTaskinen, Robert J Heine, Ulf Smith, HanneleYki-Järvinen, Andrea Mari
European journal of endocrinology - 2016 -
Genome-wide association study of the modified stumvoll insulin sensitivity index identifies BCL2 and FAM19A2 as novel insulin sensitivity
loci
G. A. Walford, S. Gustafsson, D. Rybin, A. Stancáková, H. Chen, C. T. Liu, J. Hong, R. A. Jensen, K. Rice, A. P. Morris, R. Mägi, A. Tönjes, I. Prokopenko, M. E. Kleber, G. Delgado, G. Silbernagel, A. U. Jackson, E. V. Appel, N. Grarup, J. P. Lewis, M. E. Montasser, C. Landenvall, H. Staiger, J. Luan, T. M. Frayling, M. N. Weedon, W. Xie, S. Morcillo, M. T. Martínez-Larrad, M. L. Biggs, Y. D. I. Chen, A. Corbaton-Anchuelo, K. Færch, J. M. Gómez-Zumaquero, M. O. Goodarzi, J. R. Kizer, H. A. Koistinen, A. Leong, L. Lind, C. Lindgren, F. Machicao, A. K. Manning, G. M. Martín-Núñez, G. Rojo-Martínez, J. I. Rotter, D. S. Siscovick, J. M. Zmuda, Z. Zhang, M. Serrano-Rios, Ulf Smith, F. Soriguer, T. Hansen, T. J. JØrgensen, A. Linnenberg, O. Pedersen, M. Walker, C. Langenberg, R. A. Scott, N. J. Wareham, A. Fritsche, H. U. Häring, N. Stefan, L. Groop, J. R. O'Connell, M. Boehnke, R. N. Bergman, F. S. Collins, K. L. Mohlke, J. Tuomilehto, W. März, P. Kovacs, M. Stumvoll, B. M. Psaty, J. Kuusisto, M. Laakso, J. B. Meigs, J. Dupuis, E. Ingelsson, J. C. Florez
Diabetes - 2016 -
Effect of 3 Years of Treatment With Exenatide on Postprandial Glucagon
Levels.
Mark M Smits, Mathijs C Bunck, Michaela Diamant, Anja Corner, Björn Eliasson, Robert J Heine, Ulf Smith, Hannele Yki-Järvinen, Daniël H van Raalte
Diabetes care - 2016 -
High serum adiponectin is associated with low blood haemoglobin in elderly men: the Swedish MrOS
study
Catharina Lewerin, Helena Johansson, Ulf H Lerner, M.K Karlsson, Mattias Lorentzon, E Barrett-Connor, Ulf Smith, Claes Ohlsson, Dan Mellström
Journal of Internal Medicine - 2015 -
Regulation of white adipogenesis and its relation to ectopic fat accumulation and cardiovascular
risk.
Birgit Gustafson, Ulf Smith
Atherosclerosis - 2015 -
BMP4 and BMP antagonists regulate human white and beige
adipogenesis.
Birgit Gustafson, Ann Hammarstedt, Shahram Hedjazifar, Jenny M Hoffmann, Per-Arne Svensson, Joseph Grimsby, Cristina Rondinone, Ulf Smith
Diabetes - 2015 -
Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes
Model
Manoj Amrutkar, Emmelie Cansby, Urszula Chursa, Esther Nuñez Durán, Belén Chanclón, Marcus Ståhlman, Vincent Fridén, Louise Mannerås Holm, Anna Wickman, Ulf Smith, Fredrik Bäckhed, Jan Borén, B. W. Howell, Margit Mahlapuu
Diabetes - 2015 -
Abdominal obesity - a marker of ectopic fat
accumulation
Ulf Smith
Journal of Clinical Investigation - 2015 -
Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and
NASH
Manoj Amrutkar, Emmelie Cansby, Esther Nuñez Durán, Carlo Pirazzi, Marcus Ståhlman, Elin Stenfeldt, Ulf Smith, Jan Borén, Margit Mahlapuu
Faseb Journal - 2015 -
Insulin resistance and impaired
adipogenesis
Birgit Gustafson, Shahram Hedjazifar, Silvia Gogg, Ann Hammarstedt, Ulf Smith
Trends in endocrinology and metabolism - 2015 -
Family history of type 2 diabetes increases the risk of both obesity and its complications: is type 2 diabetes a disease of inappropriate lipid
storage?
Hanna Cederberg, A. Stancakova, J. Kuusisto, Markku Laakso, Ulf Smith
Journal of Internal Medicine - 2015 -
Amelioration of insulin resistance by rosiglitazone is associated with increased adipose cell size in obese type 2 diabetic
patients
Björn Eliasson, Ulf Smith, S Mullen, S.W Cushman, A.S Sherman, J Yang
Adipocyte - 2014 -
Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory
Effects
M. M. Yore, I. Syed, P. M. Moraes-Vieira, T. J. Zhang, M. A. Herman, E. A. Homan, R. T. Patel, J. Lee, S. L. Chen, O. D. Peroni, A. S. Dhaneshwar, Ann Hammarstedt, Ulf Smith, T. E. McGraw, A. Saghatelian, B. B. Kahn
Cell - 2014 -
Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is
maintained
Emmelie Cansby, Annika Nerstedt, Manoj Amrutkar, Esther Nuñez Durán, Ulf Smith, Margit Mahlapuu
Molecular and Cellular Endocrinology - 2014 -
The effect of alogliptin and pioglitazone combination therapy on various aspects of beta-cell function in patients with recent-onset type 2
diabetes.
Daniël H van Raalte, Renate E van Genugten, Björn Eliasson, Diane Laurence Möller-Goede, Andrea Mari, Andrea Tura, Craig Wilson, Penny Fleck, Marja-Riita Taskinen, Ulf Smith, Michaela Diamant
European journal of endocrinology / European Federation of Endocrine Societies - 2014 -
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic
heterogeneity.
Antigone S Dimas, Vasiliki Lagou, Adam Barker, Joshua W Knowles, Reedik Mägi, Marie-France Hivert, Andrea Benazzo, Denis Rybin, Anne U Jackson, Heather M Stringham, Ci Song, Antje Fischer-Rosinsky, Trine Welløv Boesgaard, Niels Grarup, Fahim A Abbasi, Themistocles L Assimes, Ke Hao, Xia Yang, Cécile Lecoeur, Inês Barroso, Lori L Bonnycastle, Yvonne Böttcher, Suzannah Bumpstead, Peter S Chines, Michael R Erdos, Jurgen Graessler, Peter Kovacs, Mario A Morken, Narisu Narisu, Felicity Payne, Alena Stancakova, Amy J Swift, Anke Tönjes, Stefan R Bornstein, Stéphane Cauchi, Philippe Froguel, David Meyre, Peter E H Schwarz, Hans-Ulrich Häring, Ulf Smith, Michael Boehnke, Richard N Bergman, Francis S Collins, Karen L Mohlke, Jaakko Tuomilehto, Thomas Quertemous, Lars Lind, Torben Hansen, Oluf Pedersen, Mark Walker, Andreas F H Pfeiffer, Joachim Spranger, Michael Stumvoll, James B Meigs, Nicholas J Wareham, Johanna Kuusisto, Markku Laakso, Claudia Langenberg, Josée Dupuis, Richard M Watanabe, Jose C Florez, Erik Ingelsson, Mark I McCarthy, Inga Prokopenko, MAGIC Investigators
Diabetes - 2014 -
Advanced glycation end products, dementia, and
diabetes.
Simon Lovestone, Ulf Smith
Proceedings of the National Academy of Sciences of the United States of America - 2014 -
The Novel Secreted Adipokine WNT1-Inducible-Signaling Pathway Protein2/Wisp2 is a Mesenchymal Cell Activator of Canonical
Wnt
John Grünberg, Ann Hammarstedt, Shahram Hedjazifar, Ulf Smith
Journal of Biological Chemistry - 2014 -
WISP2 Regulates Preadipocyte Commitment and PPARgamma Activation by
BMP4
Ann Hammarstedt, Shahram Hedjazifar, Lachmi E Jenndahl, Silvia Gogg, John Grünberg, Birgit Gustafson, Eva Klimcakova, Vladimir Stich, Dominique Langin, Markku Laakso, Ulf Smith
Proceedings of the National Academy of Science of the United States of America - 2013 -
Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat
diet.
Emmelie Cansby, Manoj Amrutkar, Louise Mannerås Holm, Annika Nerstedt, Azadeh Reyahi, Elin Stenfeldt, Jan Borén, Peter Carlsson, Ulf Smith, Juleen R Zierath, Margit Mahlapuu
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2013 -
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2
diabetes.
Hanieh Yaghootkar, Claudia Lamina, Robert A Scott, Zari Dastani, Marie-France Hivert, Liling L Warren, Alena Stancáková, Sarah G Buxbaum, Leo-Pekka Lyytikäinen, Peter Henneman, Ying Wu, Chloe Y Y Cheung, James S Pankow, Anne U Jackson, Stefan Gustafsson, Jing Hua Zhao, Christie M Ballantyne, Weijia Xie, Richard N Bergman, Michael Boehnke, Fatiha el Bouazzaoui, Francis S Collins, Sandra H Dunn, Josee Dupuis, Nita G Forouhi, Christopher Gillson, Andrew T Hattersley, Jaeyoung Hong, Mika Kähönen, Johanna Kuusisto, Lyudmyla Kedenko, Florian Kronenberg, Alessandro Doria, Themistocles L Assimes, Ele Ferrannini, Torben Hansen, Ke Hao, Hans Häring, Joshua W Knowles, Cecilia M Lindgren, John J Nolan, Jussi Paananen, Oluf Pedersen, Thomas Quertermous, Ulf Smith, the GENESIS Consortium, the RISC Consortium, Terho Lehtimäki, Ching-Ti Liu, Ruth J F Loos, Mark I McCarthy, Andrew D Morris, Ramachandran S Vasan, Tim D Spector, Tanya M Teslovich, Jaakko Tuomilehto, Ko Willems van Dijk, Jorma S Viikari, Na Zhu, Claudia Langenberg, Erik Ingelsson, Robert K Semple, Alan R Sinaiko, Colin N A Palmer, Mark Walker, Karen S L Lam, Bernhard Paulweber, Karen L Mohlke, Cornelia van Duijn, Olli T Raitakari, Aurelian Bidulescu, Nick J Wareham, Markku Laakso, Dawn M Waterworth, Debbie A Lawlor, James B Meigs, J Brent Richards, Timothy M Frayling
Diabetes - 2013 -
A standardized vascular disease health check in Europe: a cost-effectiveness
analysis
C.A Schuetz, P Alperin, S Guda, A van Herick, B Cariou, D Eddy, J Gumprecht, A Nicolucci, P.E Schwarz, N Wareham, D.R Witte, Ulf Smith
PLoS ONE - 2013 -
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2
diabetes
Weijia Xie, Andrew Wood, Valeriya Lyssenko, Michael Weedon, Joshua Knowles, Sami Alkayyali, Themistocles Assimes, Thomas Quertermous, Fahim Abbasi, Jussi Paananen, Hans Häring, Torben Hansen, Oluf Pedersen, Ulf Smith, Markku Laakso, Jacqueline Dekker, John Nolan, Leif Groop, Ele Ferrannini, Klaus-Peter Adam, Walter E Gall, Timothy M Frayling, Mark Walker
Diabetes - 2013 -
Restricted Adipogenesis in Hypertrophic Obesity The Role of WISP2, WNT, and
BMP4
Birgit Gustafson, Ann Hammarstedt, Shahram Hedjazifar, Ulf Smith
Diabetes - 2013 -
Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human
hepatocytes
Annika Nerstedt, Emmelie Cansby, Manoj Amrutkar, Ulf Smith, Margit Mahlapuu
Molecular and Cellular Endocrinology - 2013 -
Non-Cholesterol Sterol Levels Predict Hyperglycemia and Conversion to Type 2 Diabetes in Finnish
Men
H. Cederberg, H. Gylling, T. A. Miettinen, J. Paananen, J. Vangipurapu, J. Pihlajamaki, T. Kuulasmaa, A. Stancakova, Ulf Smith, J. Kuusisto, M. Laakso
Plos One - 2013 -
A new paradigm for improved co-ordination and efficacy of European biomedical research: taking diabetes as a
model
Philippe Halban, Andrew Boulton, Ulf Smith
Diabetologia - 2013 -
Lowering of postprandial lipids in individuals with type 2 diabetes treated with alogliptin and/or pioglitazone: a randomised double-blind placebo-controlled
study.
Björn Eliasson, D Möller-Goede, Katarina Eeg-Olofsson, C Wilson, J Cederholm, P Fleck, M Diamant, M-R Taskinen, Ulf Smith
Diabetologia - 2012 -
The Size of Large Adipose Cells Is a Predictor of Insulin Resistance in First-Degree Relatives of Type 2 Diabetic
Patients
Jian Yang, Björn Eliasson, Ulf Smith, Samuel W Cushman, Arthur S Sherman
Obesity - 2012 -
PTEN - Linking Metabolism, Cell Growth, and
Cancer
Ulf Smith
New England Journal of Medicine - 2012 -
High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS)
Sweden.
Helena Johansson, Anders Odén, Ulf H Lerner, Hans Jutberger, Mattias Lorentzon, Elizabeth Barrett-Connor, Magnus K Karlsson, Östen Ljunggren, Ulf Smith, Eugene McCloskey, John A Kanis, Claes Ohlsson, Dan Mellström
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 2012 -
Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in
vitro
V. D'Esposito, F. Passaretti, Ann Hammarstedt, D. Liguoro, D. Terracciano, G. Molea, L. Canta, C. Miele, Ulf Smith, F. Beguinot, P. Formisano
Diabetologia - 2012 -
The many facets of the HbA1c
test
Ulf Smith
Journal of Internal Medicine - 2012 -
The WNT inhibitor Dickkopf-Related Protein 1 and Bone Morphogenetic Protein 4 rescue adipogenesis in hypertrophic obesity in
man.
Birgit Gustafson, Ulf Smith
Diabetes - 2012 -
Retinol-Binding Protein 4 Inhibits Insulin Signaling in Adipocytes by Inducing Proinflammatory Cytokines in Macrophages through a c-Jun N-Terminal Kinase- and Toll-Like Receptor 4-Dependent and Retinol-Independent
Mechanism
J. Norseen, T. Hosooka, Ann Hammarstedt, M. M. Yore, S. Kant, P. Aryal, U. A. Kiernan, D. A. Phillips, H. Maruyama, B. J. Kraus, A. Usheva, R. J. Davis, Ulf Smith, B. B. Kahn
Molecular and Cellular Biology - 2012 -
Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal
muscle
Annika Nerstedt, Emmelie Cansby, Christian X Andersson, M. Laakso, A. Stancakova, M. Bluher, Ulf Smith, Margit Mahlapuu
Diabetologia - 2012 -
Adipocyte mitochondrial genes and the forkhead factor FOXC2 are decreased in type 2 diabetes patients and normalized in response to
rosiglitazone.
Joakim Håkansson, Björn Eliasson, Ulf Smith, Sven Enerbäck
Diabetology & metabolic syndrome - 2011 -
Resistin and insulin/insulin-like growth factor signaling in rheumatoid
arthritis.
Elisabeth Almer Boström, Mattias Svensson, Sofia E M Andersson, Ing-Marie Jonsson, Anna-Karin H Ekwall, Thomas Eisler, Leif E Dahlberg, Ulf Smith, Maria Bokarewa
Arthritis and rheumatism - 2011 -
Anti-inflammatory effect of insulin in the human hepatoma cell line HepG2 involves decreased transcription of IL-6 target genes and nuclear exclusion of
FOXO1
Emelie Wallerstedt, Madelene Sandqvist, Ulf Smith, Christian X Andersson
Molecular and Cellular Biochemistry - 2011 -
Genetic predisposition for Type 2 diabetes, but not for overweight/obesity, is associated with a restricted
adipogenesis
P. Arner, E. Arner, Ann Hammarstedt, Ulf Smith
PLoS One - 2011 -
Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and
CDKN2B
M. L. Hribal, I. Presta, T. Procopio, M. A. Marini, A. Stancakova, J. Kuusisto, F. Andreozzi, Ann Hammarstedt, Per-Anders Jansson, N. Grarup, T. Hansen, M. Walker, N. Stefan, A. Fritsche, H. U. Haring, O. Pedersen, Ulf Smith, M. Laakso, G. Sesti
Diabetologia - 2011 -
Exenatide treatment did not affect bone mineral density despite body weight reduction in patients with type 2
diabetes
M. C. Bunck, Björn Eliasson, A. Corner, R. J. Heine, R. M. Shaginian, M. R. Taskinen, H. Yki-Jarvinen, Ulf Smith, M. Diamant
Diabetes, obesity & metabolism - 2011 -
Effects of Exenatide on Measures of {beta}-Cell Function After 3 Years in Metformin-Treated Patients With Type 2
Diabetes.
Mathijs C Bunck, Anja Cornér, Björn Eliasson, Robert J Heine, Rimma M Shaginian, Marja-Riitta Taskinen, Ulf Smith, Hannele Yki-Järvinen, Michaela Diamant
Diabetes care - 2011 -
AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3
(STAT3)
Annika Nerstedt, Aino Johansson, Christian X Andersson, Emmelie Cansby, Ulf Smith, Margit Mahlapuu
Diabetologia - 2010 -
Linking diabetes and cancer: a consensus on
complexity
A. Renehan, Ulf Smith, M. S. Kirkman
Lancet - 2010 -
Cancer and diabetes: are we ready for prime
time?
Ulf Smith, E. A. Gale
Diabetologia - 2010 -
Exenatide affected circulating cardiovascular risk biomarkers independently of changes in body
composition
M. C. Bunck, M. Diamant, Björn Eliasson, A. Corner, R. M. Shaginian, R. J. Heine, Marja-Riitta Taskinen, Hannele Yki-Järvinen, Ulf Smith
Diabetes Care - 2010 -
Activation of Canonical Wingless-type MMTV Integration Site Family (Wnt) Signaling in Mature Adipocytes Increases Beta-Catenin Levels and Leads to Cell Dedifferentiation and Insulin
Resistance
Birgit Gustafson, Ulf Smith
The Journal of Biological Chemistry - 2010 -
Protein kinase C-δ is involved in the inflammatory effect of IL-6 in mouse adipose
cells
Emelie Wallerstedt, Ulf Smith, Christian X Andersson
Diabetologia - 2010 -
Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) inhibitor Dickkopf-1 in adipocytes: a link with
osteogenesis
Birgit Gustafson, Björn Eliasson, Ulf Smith
Diabetologia - 2010 -
One-year treatment with exenatide vs. insulin glargine: effects on postprandial glycemia, lipid profiles, and oxidative
stress.
Mathijs C Bunck, Anja Cornér, Björn Eliasson, Robert J Heine, Rimma M Shaginian, Yan Wu, Ping Yan, Ulf Smith, Hannele Yki-Järvinen, Michaela Diamant, Marja-Riitta Taskinen
Atherosclerosis - 2010 -
Antagonistic effects of thiazolidinediones and cytokines in
lipotoxicity.
Ulf Smith, Ann Hammarstedt
BBA - Molecular and Cell Biology of Lipids - 2010 -
Insulin and free oestradiol are independent risk factors for benign prostatic
hyperplasia.
J Hammarsten, Jan-Erik Damber, M Karlsson, Tomas Knutson, O Ljunggren, Claes Ohlsson, Ralph Peeker, Ulf Smith, Dan Mellström
Prostate cancer and prostatic diseases - 2009 -
One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled
trial
M. C. Bunck, M. Diamant, A. Corner, Björn Eliasson, J. L. Malloy, R. M. Shaginian, W. Deng, D. M. Kendall, M. R. Taskinen, Ulf Smith, H. Yki-Jarvinen, R. J. Heine
Diabetes Care - 2009 -
Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2
study
T. W. Boesgaard, A. P. Gjesing, N. Grarup, J. Rutanen, Per-Anders Jansson, M. L. Hribal, G. Sesti, A. Fritsche, N. Stefan, H. Staiger, H. Haring, Ulf Smith, M. Laakso, O. Pedersen, T. Hansen
PLoS One - 2009 -
Acute hyperinsulinemia differentially regulates interstitial and circulating adiponectin oligomeric pattern in lean and insulin-resistant, obese
individuals
Giuseppe Murdolo, Ann Hammarstedt, M. Schmelz, Per-Anders Jansson, Ulf Smith
J Clin Endocrinol Metab - 2009 -
Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of
endothelin-1
Silvia Gogg, Ulf Smith, Per-Anders Jansson
Diabetes - 2009 -
Inflammation and impaired adipogenesis in hypertrophic obesity in
man
Birgit Gustafson, Silvia Gogg, Shahram Hedjazifar, Lachmi E Jenndahl, Ann Hammarstedt, Ulf Smith
Am J Physiol Endocrinol Metab - 2009 -
Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and
inflammation
Petter Isakson, Ann Hammarstedt, Birgit Gustafson, Ulf Smith
Diabetes - 2009 -
Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish
men
Jenny Kindblom, Claes Ohlsson, O. Ljunggren, M. K. Karlsson, Åsa Tivesten, Ulf Smith, Dan Mellström
Journal of bone and mineral research - 2009 -
Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human
genetics
H. Koutnikova, M. Laakso, L. Lu, R. Combe, J. Paananen, T. Kuulasmaa, J. Kuusisto, H. U. Haring, T. Hansen, O. Pedersen, Ulf Smith, M. Hanefeld, R. W. Williams, J. Auwerx
PLoS Genet - 2009 -
Does diabetes therapy influence the risk of
cancer?
Ulf Smith, E. A. Gale
Diabetologia - 2009 -
Incretin-based therapy: how do incretin mimetics and DPP-4 inhibitors fit into treatment algorithms for type 2 diabetic
patients?
M. Nauck, Ulf Smith
Best Pract Res Clin Endocrinol Metab - 2009 -
Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM
studies
B. Friedrich, P. Weyrich, A. Stancakova, J. Wang, J. Kuusisto, M. Laakso, G. Sesti, E. Succurro, Ulf Smith, T. Hansen, O. Pedersen, F. Machicao, S. Schafer, F. Lang, T. Risler, S. Ullrich, N. Stefan, A. Fritsche, H. U. Haring
PLoS One - 2008 -
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose
tolerance
A. Stancakova, J. Pihlajamaki, J. Kuusisto, N. Stefan, A. Fritsche, H. Haring, F. Andreozzi, E. Succurro, G. Sesti, T. W. Boesgaard, T. Hansen, O. Pedersen, Per-Anders Jansson, Ann Hammarstedt, Ulf Smith, M. Laakso
Journal of Clinical Endocrinology & Metabolism - 2008 -
High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naive type 2 diabetic
subjects
Ann Hammarstedt, J. Pihlajamaki, T. E. Graham, S. Kainulainen, B. B. Kahn, M. Laakso, Ulf Smith
Journal of Internal Medicine - 2008 -
Inflamed adipose tissue, insulin resistance and vascular
injury
Christian X Andersson, Birgit Gustafson, Ann Hammarstedt, Shahram Hedjazifar, Ulf Smith
Diabetes/Metabolism Research and Reviews - 2008 -
[Reply on new drugs against type 2 diabetes: important to gain experience and
knowledge]
Ake Sjöholm, Carl-David Agardh, Kerstin Brismar, Suad Efendic, Björn Eliasson, Jan W Eriksson, Anders Frid, Leif Groop, Jan Holmgren, Martin Ridderstråle, Ulf Smith
Läkartidningen - 2008 -
Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in
mice
S. Franckhauser, I. Elias, Victoria Rotter Sopasakis, T. Ferre, Ivan Nagaev, Christian X Andersson, J. Agudo, J. Ruberte, F. Bosch, Ulf Smith
Diabetologia - 2008 -
A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2
study
H. Staiger, A. Stancakova, J. Zilinskaite, M. Vanttinen, T. Hansen, M. A. Marini, Ann Hammarstedt, Per-Anders Jansson, G. Sesti, Ulf Smith, O. Pedersen, M. Laakso, N. Stefan, A. Fritsche, H. U. Haring
Diabetes - 2008 -
The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2
study
T. W. Boesgaard, J. Zilinskaite, M. Vanttinen, M. Laakso, Per-Anders Jansson, Ann Hammarstedt, Ulf Smith, N. Stefan, A. Fritsche, H. Haring, M. Hribal, G. Sesti, D. P. Zobel, O. Pedersen, T. Hansen
Diabetologia - 2008 -
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2
study
M. Laakso, J. Zilinskaite, T. Hansen, T. W. Boesgaard, M. Vanttinen, A. Stancakova, Per-Anders Jansson, F. Pellme, J. J. Holst, T. Kuulasmaa, M. L. Hribal, G. Sesti, N. Stefan, A. Fritsche, H. Haring, O. Pedersen, Ulf Smith
Diabetologia - 2008 -
WNT signalling is both an inducer and effector of glucagon-like
peptide-1
Birgit Gustafson, Ulf Smith
Diabetologia - 2008 -
Order! Order! Order in the House! DIAMAP: a road map for European diabetes
research
P. A. Halban, Ulf Smith
Diabetologia - 2008 -
Weight loss and metabolic effects of topiramate in overweight and obese type 2 diabetic patients: randomized double-blind placebo-controlled
trial
Björn Eliasson, Soffia Gudbjörnsdottir, J. Cederholm, Y. Liang, F. Vercruysse, Ulf Smith
Int J Obes (Lond) - 2007 -
Androgens and Glucuronidated Androgen Metabolites are Associated with Metabolic Risk Factors in
Men.
Liesbeth Vandenput, Dan Mellström, Mattias Lorentzon, Charlotte Swanson, M. K. Karlsson, John Brandberg, Lars Lönn, Eric Orwoll, Ulf Smith, F Labrie, O. Ljunggren, Åsa Tivesten, Claes Ohlsson
Journal of clinical endocrinology and metabolism - 2007 -
Inflamed Adipose Tissue: A Culprit Underlying the Metabolic Syndrome and
Atherosclerosis
Birgit Gustafson, Ann Hammarstedt, Christian X Andersson, Ulf Smith
Arterioscler Thromb Vasc Biol - 2007 -
Insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3T3-L1
adipocytes
Christian X Andersson, Victoria Rotter Sopasakis, Emelie Wallerstedt, Ulf Smith
J Biol Chem - 2007 -
Monocyte chemoattractant protein-1 in subcutaneous abdominal adipose tissue: characterization of interstitial concentration and regulation of gene expression by
insulin
Giuseppe Murdolo, Ann Hammarstedt, Madelene Sandqvist, M. Schmelz, C. Herder, Ulf Smith, Per-Anders Jansson
J Clin Endocrinol Metab - 2007 -
Insulin differentially modulates the peripheral endocannabinoid system in human subcutaneous abdominal adipose tissue from lean and obese
individuals.
Giuseppe Murdolo, K Kempf, Ann Hammarstedt, C. Herder, Ulf Smith, Per-Anders Jansson
Journal of endocrinological investigation - 2007 -
Wnt-signaling is maintained and adipogenesis inhibited by TNFalpha but not MCP-1 and
resistin
Ann Hammarstedt, Petter Isakson, Birgit Gustafson, Ulf Smith
Biochem Biophys Res Commun - 2007 -
The UDP Glucuronosyltransferase 2B15 D85Y and 2B17 Deletion Polymorphisms Predict the Glucuronidation Pattern of Androgens and Fat Mass in
Men.
Charlotte Swanson, Dan Mellström, Mattias Lorentzon, Liesbeth Vandenput, Jenny Jakobsson, Anders Rane, Magnus K Karlsson, Östen Ljunggren, Ulf Smith, Anna-Lena Eriksson, Alain Bélanger, Fernand Labrie, Claes Ohlsson
Journal of clinical endocrinology and metabolism - 2007 -
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose
metabolism
E. Pirinen, T. Kuulasmaa, M. Pietila, S. Heikkinen, M. Tusa, P. Itkonen, S. Boman, J. Skommer, A. Virkamaki, E. Hohtola, M. Kettunen, S. Fatrai, E. Kansanen, S. Koota, K. Niiranen, J. Parkkinen, A. L. Levonen, S. Yla-Herttuala, J. K. Hiltunen, L. Alhonen, Ulf Smith, J. Janne, M. Laakso
Mol Cell Biol - 2007 -
Introduction: Symposium on diabetes, inflammation and cardiovascular
disease
Ulf Smith
J Intern Med - 2007 -
Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the
answer?
Xiao Lin Yang, Ulf Smith
Diabetologia - 2007 -
TCF7L2 and type 2 diabetes-we WNT to
know
Ulf Smith
Diabetologia - 2007 -
Plasma cells and Fc receptors in human adipose tissue--lipogenic and anti-inflammatory effects of immunoglobulins on
adipocytes
Jenny Palming, Britt G. Gabrielsson, Eva Jennische, Ulf Smith, Björn Carlsson, Lena M S Carlsson, Malin Lönn
Biochem Biophys Res Commun - 2006 -
Increased levels of acylation-stimulating protein in interleukin-6-deficient (IL-6(-/-))
mice
Ingrid Wernstedt, Bob Olsson, Margareta Jernås, S. Paglialunga, Lena M S Carlsson, Ulf Smith, K. Cianflone, Kristina Wallenius, Ville Wallenius
Endocrinology - 2006 -
Human Resistin Is a Systemic Immune-Derived Proinflammatory Cytokine Targeting both Leukocytes and
Adipocytes
Ivan Nagaev, Maria Bokarewa, Andrej Tarkowski, Ulf Smith
PLoS ONE - 2006 -
Pathogenesis and treatment of diabetic vascular disease - illustrated by two
cases
Ulf Smith, M. Laakso, Björn Eliasson, Christian Wesslau, Jan Borén, Olov Wiklund, Stig Attvall
J Intern Med - 2006 -
Visfatin is an adipokine, but it is not regulated by
thiazolidinediones
Ann Hammarstedt, J. Pihlajamaki, Victoria Rotter Sopasakis, Silvia Gogg, Per-Anders Jansson, M. Laakso, Ulf Smith
J Clin Endocrinol Metab - 2006 -
Postprandial interstitial insulin concentrations in type 2 diabetes
relatives
Madelene Sandqvist, Else Hellebö Johanson, B. Ahren, Mette Axelsen, M. Schmelz, Ulf Smith, Per-Anders Jansson
Eur J Clin Invest - 2006 -
Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic
subjects
T. E. Graham, Q. Yang, M. Bluher, Ann Hammarstedt, T. P. Ciaraldi, R. R. Henry, C. J. Wason, A. Oberbach, Per-Anders Jansson, Ulf Smith, B. B. Kahn
N Engl J Med - 2006 -
Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1
preadipocytes
Birgit Gustafson, Ulf Smith
J Biol Chem - 2006 -
The dysregulated adipose tissue: a connecting link between insulin resistance, type 2 diabetes mellitus and
atherosclerosis
Giuseppe Murdolo, Ulf Smith
Nutr Metab Cardiovasc Dis - 2006 -
Low adipocyte IRS-1 protein expression is associated with an increased arterial stiffness in non-diabetic
males
Madelene Sandqvist, Gunnar Nyberg, Ann Hammarstedt, Natalia Klintland, Silvia Gogg, Kenneth Caidahl, Bo Ahrén, Ulf Smith, Per-Anders Jansson
Atherosclerosis - 2005 -
Resistin, an adipokine with potent proinflammatory
properties
Maria Bokarewa, Ivan Nagaev, L. Dahlberg, Ulf Smith, Andrej Tarkowski
J Immunol - 2005 -
The effect of PPARgamma ligands on the adipose tissue in insulin
resistance
Ann Hammarstedt, Christian X Andersson, Victoria Rotter Sopasakis, Ulf Smith
Prostaglandins Leukot Essent Fatty Acids - 2005 -
No acute effect of nateglinide on postprandial lipid and lipoprotein responses in subjects at risk for type 2
diabetes
Else Hellebö Johanson, Per-Anders Jansson, Birgit Gustafson, Madelene Sandqvist, M. R. Taskinen, Ulf Smith, Mette Axelsen
Diabetes Metab Res Rev - 2005 -
Improved insulin sensitivity and adipose tissue dysregulation after short-term treatment with pioglitazone in non-diabetic, insulin-resistant
subjects
Ann Hammarstedt, Victoria Rotter Sopasakis, Silvia Gogg, Per-Anders Jansson, Ulf Smith
Diabetologia - 2005 -
Effect of the interleukin-6 (-174) g/c promoter polymorphism on adiponectin and insulin
sensitivity
Xiao Lin Yang, Per-Anders Jansson, F. Pellme, M. Laakso, Ulf Smith
Obes Res - 2005 -
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled
trial
J. A. Dormandy, B. Charbonnel, D. J. Eckland, E. Erdmann, M. Massi-Benedetti, I. K. Moules, A. M. Skene, M. H. Tan, P. J. Lefebvre, G. D. Murray, E. Standl, R. G. Wilcox, L. Wilhelmsen, J. Betteridge, K. Birkeland, A. Golay, R. J. Heine, L. Koranyi, M. Laakso, M. Mokan, A. Norkus, V. Pirags, T. Podar, A. Scheen, W. Scherbaum, G. Schernthaner, O. Schmitz, J. Skrha, Ulf Smith, J. Taton
Lancet - 2005 -
Cytokine release from adipose tissue of nonobese
individuals
Victoria Rotter Sopasakis, Ivan Nagaev, Ulf Smith
Int J Obes (Lond) - 2005 -
Evidence of impaired adipogenesis in insulin
resistance
Xiao Lin Yang, Per-Anders Jansson, Ivan Nagaev, M. M. Jack, Eugénia Carvalho, Katharina Stibrant Sunnerhagen, M. C. Cam, S. W. Cushman, Ulf Smith
Biochem Biophys Res Commun - 2004 -
The prospective pioglitazone clinical trial in macrovascular events
(PROactive)
B. Charbonnel, E. Erdmann, Ulf Smith
Diabetes Care - 2004 -
Early alterations in the postprandial VLDL1 apoB-100 and apoB-48 metabolism in men with strong heredity for type 2
diabetes
Else Hellebö Johanson, Per-Anders Jansson, Birgit Gustafson, Lars Lönn, Ulf Smith, M. R. Taskinen, Mette Axelsen
J Intern Med - 2004 -
High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine
regulator
Victoria Rotter Sopasakis, Madelene Sandqvist, Birgit Gustafson, Ann Hammarstedt, M. Schmelz, Xiao Lin Yang, Per-Anders Jansson, Ulf Smith
Obes Res - 2004 -
Short-term infusion of interleukin-6 does not induce insulin resistance in vivo or impair insulin signalling in
rats
Victoria Rotter Sopasakis, Britt-Mari Larsson, Aino Johansson, Agneta Holmäng, Ulf Smith
Diabetologia - 2004 -
Predictors of weight loss in adults with topiramate-treated
epilepsy.
Elinor Ben-Menachem, Mette Axelsen, Else Hellebö Johanson, Anna Stagge, Ulf Smith
Obesity research - 2003 -
Fat distribution, lipid accumulation in the liver, and exercise capacity do not explain the insulin resistance in healthy males with a family history for type 2
diabetes.
Else H Johanson, Per-Anders Jansson, Lars Lönn, Yuji Matsuzawa, Tohru Funahashi, Marja-Riitta Taskinen, Ulf Smith, Mette Axelsen
The Journal of clinical endocrinology and metabolism - 2003 -
Nicotine infusion acutely impairs insulin sensitivity in type 2 diabetic patients but not in healthy
subjects
T. Axelsson, Per-Anders Jansson, Ulf Smith, Björn Eliasson
J Intern Med - 2001 -
Impaired phosphorylation and insulin-stimulated translocation to the plasma membrane of protein kinase B/Akt in adipocytes from Type II diabetic
subjects
Eugénia Carvalho, Björn Eliasson, Christian Wesslau, Ulf Smith
Diabetologia - 2000 -
Dietary fibre, lente carbohydrates and the insulin-resistant
diseases.
D J Jenkins, Mette Axelsen, C W Kendall, L S Augustin, V Vuksan, Ulf Smith
The British journal of nutrition - 2000 -
Suppression of nocturnal fatty acid concentrations by bedtime carbohydrate supplement in type 2 diabetes: effects on insulin sensitivity, lipids, and glycemic
control.
Mette Axelsen, Peter Lönnroth, Ragnhild Arvidsson Lenner, M R Taskinen, Ulf Smith
The American journal of clinical nutrition - 2000 -
Insulin signaling and action in fat cells: associations with insulin resistance and type 2
diabetes.
Ulf Smith, Mette Axelsen, Eugénia Carvalho, Björn Eliasson, Per-Anders Jansson, Christian Wesslau
Annals of the New York Academy of Sciences - 1999 -
Leptin levels in smokers and long-term users of nicotine
gum
Björn Eliasson, Ulf Smith
Eur J Clin Invest - 1999 -
Postprandial hypertriglyceridemia and insulin resistance in normoglycemic first-degree relatives of patients with type 2
diabetes.
Mette Axelsen, Ulf Smith, Jan W Eriksson, M R Taskinen, Per-Anders Jansson
Annals of internal medicine - 1999 -
Low cellular IRS 1 gene and protein expression predict insulin resistance and
NIDDM.
Eugénia Carvalho, Per-Anders Jansson, Mette Axelsen, Jan Erik Eriksson, X Huang, L Groop, Cristina Rondinone, Lars Sjöström, Ulf Smith
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1999 -
Bedtime uncooked cornstarch supplement prevents nocturnal hypoglycaemia in intensively treated type 1 diabetes
subjects.
Mette Axelsen, Christian Wesslau, Peter Lönnroth, Ragnhild Arvidsson Lenner, Ulf Smith
Journal of internal medicine - 1999 -
Breakfast glycaemic response in patients with type 2 diabetes: effects of bedtime dietary
carbohydrates.
Mette Axelsen, Ragnhild Arvidsson Lenner, Peter Lönnroth, Ulf Smith
European journal of clinical nutrition - 1999 -
Postprandial elevation of ApoB-48-containing triglyceride-rich particles and retinyl esters in normolipemic males who
smoke
N. Mero, M. Syvanne, Björn Eliasson, Ulf Smith, M. R. Taskinen
Arterioscler Thromb Vasc Biol - 1997 -
The insulin resistance syndrome and postprandial lipid intolerance in
smokers
Björn Eliasson, N. Mero, M. R. Taskinen, Ulf Smith
Atherosclerosis - 1997 -
Smoking cessation improves insulin sensitivity in healthy middle-aged
men
Björn Eliasson, Stig Attvall, M. R. Taskinen, Ulf Smith
Eur J Clin Invest - 1997 -
No acute effects of smoking and nicotine nasal spray on lipolysis measured by subcutaneous
microdialysis
Björn Eliasson, Ulf Smith, Peter Lönnroth
Eur J Clin Invest - 1997 -
Suppression of the nocturnal free fatty acid levels by bedtime cornstarch in NIDDM
subjects.
Mette Axelsen, Peter Lönnroth, Ragnhild Arvidsson Lenner, Ulf Smith
European journal of clinical investigation - 1997 -
Long-term use of nicotine gum is associated with hyperinsulinemia and insulin
resistance
Björn Eliasson, M. R. Taskinen, Ulf Smith
Circulation - 1996 -
Hyperinsulinaemia impairs gastrointestinal motility and slows carbohydrate
absorption
Björn Eliasson, Einar Björnsson, V. Urbanavicius, H. Andersson, Jesper Fowelin, Stig Attvall, H. Abrahamsson, Ulf Smith
Diabetologia - 1995 -
Effects of insulin and beta-adrenergic blockade on the migrating motor complex in
humans
Einar Björnsson, V. Urbanavicius, Björn Eliasson, Stig Attvall, Ulf Smith, H. Abrahamsson
Scand J Gastroenterol - 1995 -
Lipid intolerance in
smokers
Mette Axelsen, Björn Eliasson, E. Joheim, Ragnhild Arvidsson Lenner, M. R. Taskinen, Ulf Smith
J Intern Med - 1995 -
[Cigarette smoking causes insulin resistance. New findings on metabolic effects of
tobacco]
Björn Eliasson, Ulf Smith
Lakartidningen - 1995 -
The insulin resistance syndrome in smokers is related to smoking
habits
Björn Eliasson, Stig Attvall, M. R. Taskinen, Ulf Smith
Arterioscler Thromb - 1994 -
Effects of hyperglycemia on interdigestive gastrointestinal motility in
humans
E. S. Bjornsson, V. Urbanavicius, Björn Eliasson, Stig Attvall, Ulf Smith, H. Abrahamsson
Scand J Gastroenterol - 1994 -
Family history of diabetes in relation to different types of obesity and change of obesity during 12-yr period. Results from prospective population study of women in Göteborg,
Sweden
L Lapidus, Calle Bengtsson, Lauren Lissner, Ulf Smith
Diabetes Care - 1992