Detta är en digital seminarieserie i kondenserade materiens fysik och atomfysik, med syfte att koppla samman forskare från olika nordiska universitet. Samtalen är informella och ska inspirera till diskussioner och interaktioner.
Collective structural arrangements and cell migration are important physical processes underlying tissue development and regeneration. Understanding the complexity of cell-cell interactions and the emergence of collective behavior at the tissue scale presents formidable challenges both experimentally and theoretically. In this talk, I will discuss recent theoretical work on the dynamical patterns that emerge at the tissue scale from localised rearrangements and topological defects. Using a multi-phase field model, we demonstrate that tissue fluidity stems from cell neighbor exchanges, serving as transient sources of vortical flow. This flow emerges from the relative dispersion of cells at a rate proportional to the frequency of rearrangements. Balancing collective migration with relative cell motion appears to be essential for maintaining tissue shape and fluidity. Using a cell-based model, we study the tissue's response to the presence of a vortex. While solid-like behavior tends toward conical shapes, localised fluidisation triggers the transition to a tube, which is fundamental in biological tissues.
Zoom-länk: https://nordita.org/zoom/nvcms