Grupp Volkan Sayin

Sammanfattning av forskning

Sayin lab positionerar sig i korsningen mellan behandlingsmetoder för lungcancer samt cancerämnesomsättning och redoxbiologi. Vi bygger en plattform för precisionsmedicin, där vi kombinerar de senaste teknologierna inom lungcancerforskning och metabolomik för att etablera en omfattande lungcancergrupp på Sahlgrenska Center for Cancer Research.

För mer information om vår forskning, se engelsk version av sidan.

Nuvarande gruppmedlemmar

Volkan Sayin, PhD, Docent, Forskargruppledare
Sama Sayin, MD, PhD, Senior forskare
Martin Dankis, PhD, Postdoc
Maria Schwarz, PhD, Postdoc
Ella Äng, MD, Doktorand
Kevin Ali, MSc, Doktorand
Angana Patel, MSc, Doktorand
Jozefina Dzanan, MSc, Doktorand

Utvalda publikationer

1. Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids.
   LeBoeuf SE, Wu WL, Karakousi TR, Karadal B, Jackson SR, Davidson SM, Wong KK, Koralov SB, Sayin VI, Papagiannakopoulos T. Cell Metab. 2019 Nov 28. pii: S1550-4131(19)30619-9. doi: 10.1016/j.cmet.2019.11.012.
    
2. Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions.
   Akula MK, Ibrahim MX, Ivarsson EG, Khan OM, Kumar IT, Erlandsson M, Karlsson C, Xu X, Brisslert M, Brakebusch C, Wang D, Bokarewa M, Sayin VI, Bergo MO. Nat Commun. 2019 Sep 4;10(1):3975. doi: 10.1038/s41467-019-11606-x.
    
3. BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis.
   Wiel C, Le Gal K, Ibrahim MX, Jahangir CA, Kashif M, Yao H, Ziegler DV, Xu X, Ghosh T, Mondal T, Kanduri C, Lindahl P, Sayin VI*, Bergo MO. Cell. 2019 Jul 11;178(2):330-345.e22. doi: 10.1016/j.cell.2019.06.005. Epub 2019 Jun 27.*Co-Corresponding
    
4. Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.
   Lignitto L, LeBoeuf SE, Homer H, Jiang S, Askenazi M, Karakousi TR, Pass HI, Bhutkar AJ, Tsirigos A, Ueberheide B, Sayin VI, Papagiannakopoulos T, Pagano M. Cell. 2019 Jul 11;178(2):316-329.e18. doi: 10.1016/j.cell.2019.06.003. Epub 2019 Jun 27.
    
5. Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.
   Romero R*, Sayin VI*, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Sánchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, Thomas CJ, Goparaju C, Davies A, Dolgalev I, Heguy A, Allaj V, Poirier JT, Moreira AL, Rudin CM, Pass HI, Vander Heiden MG, Jacks T, Papagiannakopoulos T. Nature Medicine 2017 Nov;23(11):1362-1368. doi: 10.1038/nm.4407. Epub 2017 Oct 2. *Co-First
    
6. Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.
   Sayin VI, LeBoeuf SE, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, Possemato R, Vander Heiden MG, Papagiannakopoulos T. Elife. 2017 Oct 2;6. pii: e28083. doi: 10.7554/eLife.28083.
    
7. Targeting Metabolic Bottlenecks in Lung Cancer.
   Sayin VI, LeBoeuf SE, Papagiannakopoulos T. Trends in Cancer. 2019 Aug;5(8):457-459. doi: 10.1016/j.trecan.2019.06.001. Epub 2019 Jun 27.
    

Fler publikationer från grupp Volkan Sayin på PubMed