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  4. Christina Jern

Christina Jern

Professor/ Chief Physician

Department of Laboratory Medicine
Telephone
+46 709-83 16 16
Mail
christina.jern@gu.se
Visiting address
Medicinaregatan 3
41390 Göteborg
Room number
Plan 3
Postal address
Institutionen för Biomedicine, Box 445
S-40530 Göteborg

About Christina Jern

About Christina Jern

Professor of Neurology, Sahlgrenska Academy at University of Gothenburg

Christina Jern is Professor of Neurology at the Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, and Senior Consultant at the Department of Clinical Genetics and Genomics at the Sahlgrenska University Hospital, Västra Götalandsregionen. She obtained her medical degree at the University of Gothenburg, where she also completed her PhD and clinical training in Neurology and Clinical Genetics. Her main research interests lie in etiological subtypes of ischemic stroke and in post-stroke outcomes.

Her present research program is focused on studies of blood-based and neuroimaging biomarkers in ischemic stroke. This includes large clinical and longitudinal studies of carefully phenotyped study participants. Special research interests include genetic and protein biomarkers, the role of prothrombotic factors in cryptogenic stroke, and trajectories of different post-stroke outcomes such as cognitive functions and their predictors. She is a member of the Royal Society of Arts and Sciences in Gothenburg, a member of the Scientific Board of the Swedish Heart Lung Foundation, and a Fellow of the European Stroke Organisation.

Education & Degrees (selected)

2002 Visiting Scientist, Monash University, Melbourne, Australia

2000 Associate Professor (docent) in Neurology, University of Gothenburg, Sweden

1991 PhD, the Medical Faculty, University of Gothenburg, Sweden

1987 MD, University of Gothenburg, Sweden

Distinctions, Grants, etc. (selected)

2026-2028 Project grant, the Swedish Research Council (Vetenskapsrådet)

Title: On prothrombotic pathways and blood biomarkers in ischemic stroke.

 

2026-2028 Project grant, the Swedish Heart Lung Foundation (Hjärt-Lungfonden)

Title: On prothrombotic pathways and blood biomarkers in ischemic stroke

 

2025-2027 Project grant, the Swedish State (ALF)

Title: Blood-based biomarkers for stroke – Towards improved diagnostics and outcome prediction

 

2024-2027 Data Driven Life Science (DDLS) PhD student position, Knut and Alice Wallenbeg (KAW) Foundation

Title: Towards precision medicine for ischemic stroke: Integrating clinical, neuroimaging, and molecular omics data using deep and machine learning-based approaches

 

2018- Fellow, European Stroke Organisation (FESO)

 

2017- Member, Royal Society of Arts and Sciences in Gothenburg

 

1995-98 Swedish Society for Medical Research (Berth von Kantzows Stiftelse) Postdoctoral Fellowship

National and International Assignments of Importance (selected)

·     2025- Host, together with Assoc. Prof. Tara Stanne, for the 32nd International Stroke Genomics Consortium Workshop in Gothenburg/Marstrand, Sweden

·     2023- Member, the Scientific Board and the Evaluation Committee for research applications, Swedish Heart Lung Foundation

·     2021-2023 Member of the Steering Committee for the International Stroke Genomics Consortium

·     2019- Member of the Genomic Medicine Sweden (GMS) Complex Disease Coordinating Group, Sweden

·     2018-2022 Director of the Wallenberg Centre for Molecular and Translational Medicine (WCMTM), University of Gothenburg

·     2018- Member of the local organization committee for the European Stroke Organisation Conference (ESOC), Gothenburg, Sweden, with >4,000 registered participants

·     2015-2017 Vice dean (vice dekanus för ALF), the Sahlgrenska Academy

·     2013-2022 Chairman of the of the steering committee of the stroke research network Stroke Center West, University of Gothenburg

·     2008-2017 Chairman on a rotating basis (Alternerande Ordförande) together with the research director (Forskningdirektören) in Medi-SAM, the coordinating body for collaborations between the Sahlgrenska University Hospital and the Sahlgrenska Academy

·     2006-2012 Member of the Board of the Sahlgrenska Academy (Akademistyrelsen)

·     2005-2008 Member of the Board (Institutionsstyrelsen), the Institute of Clinical Neuroscience, University of Gothenburg

 

Group Members

(see main webpage, On prothrombotic pathways and blood biomarkers in ischemic stroke: an integrated clinical and experimental study | University of Gothenburg )

 

Networks

European Stroke Organisation ESO

International Stroke Genomics Consortium ISGC


SCALLOP consortium (Systematic and Combined AnaLysis of Olink Proteins) SCALLOP - genetic regulation of the proteome


CORAL consortium CORAL — Olink®


DDLS (Data Driven Life Science) Research School, co-supervisor to PhD student DDLS Research school - SciLifeLab

Genomic Medicine Sweden Genomics Medicine Sweden

 

LinkedIn: https://www.linkedin.com/in/christina-jern-341bb81b/

 

Key Publications

·     Granelli B, Angerfors A, Furutjäll S, Nguyen Larsson H, Brännmark C, Andersson B, Stanne TM, Jern C. Elevated acute-phase plasma levels of S100A12 [EN-RAGE] are associated with vascular recurrence after ischemic stroke. Eur Stroke Journal. 2026;11(1):23969873251384439.

·     Stanne TM, Gonzalez-Ortiz F, Brännmark C, Jood K, Karikari T, Blennow K, Jern C. Association of Plasma Brain-Derived Tau With Functional Outcome After Ischemic Stroke. Neurology. 2024;102(4):e209129.

·     Brennan SO, Kelly PJ, Gorey S, Synnott P, Gill D, Dichgans M, Georgakis MK, Dib MJ, Gagnon E, Mahon N, Blake GJ, Jern C, Markus HS, Whiteley W, McCabe JJ. Genetically predicted IL-18 inhibition and risk of cardiovascular events: a Mendelian Randomization study. Circulation. 2025;151(5):334-336.

·     Dorvall M, Pedersen A, Dumanski JP, Söderholm M, Lindgren AG, Stanne TM, Jern C. Mosaic loss of chromosome Y is associated with functional outcome after ischemic stroke. Stroke. 2023;54(9):2434-2437.

·     Stanne TM, Angerfors A, Andersson B, Brännmark C, Holmegaard L, Jern C. Longitudinal Study Reveals Long-Term Proinflammatory Proteomic Signature After Ischemic Stroke Across Subtypes. Stroke. 2022;53(9):2847-2858.

·     Mishra A, Malik R, [70 authors], Jern C, [63 authors]; COMPASS Consortium, INVENT Consortium, Dutch Parelsnoer Initative, Cerebrovascular Disease Study Group, Estonian Biobank, PRECISE4Q Consortium, FinnGen Consortium, NINDS Stroke Genetics Network, MEGASTROKE Consortium, SIREN Consortium, China Kadoorie Biobank Collaborative Group, VA Million Veteran Program, International Stroke Genetics Consortium, Biobank Japan, CHARGE Consortium, GIGASTROKE Consortium, [51 authors]; Dichgans M, Debette S. Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. 2022;611(7934):115-123.

·     Pedersen A, Stanne TM, Nilsson S, Klasson S, Rosengren L, Holmegaard L, Jood K, Blennow K, Zetterberg H, Jern C. Circulating neurofilament light in ischemic stroke: temporal profile and outcome prediction. J Neurol. 2019;266(11):2796-2806.

·     Söderholm M, Pedersen A, [27 authors], Maguire J, Lindgren A, Jern C. Genome-wide association meta-analysis of functional outcome after ischemic stroke. Neurology. 2019;92(12):e1271-e1283.

·     Pedersen A, Redfors P, Lundberg L, Gils A, Declerck PJ, Jood K, Nilsson S, Jern C. Haemostatic biomarkers are associated with long-term recurrent vascular events after ischaemic stroke. Thromb Haemost. 2016;116(3):537-43.

·     Hanson E, Jood K, Karlsson S, Nilsson S, Blomstrand C, Jern C. Plasma levels of von Willebrand factor in the etiologic subtypes of ischemic stroke. J Thromb Haemost. 2011;9(2):275-81.

·     Tjärnlund Wolf A, Medcalf R, Jern C. The t-PA 7,351C>T enhancer polymorphism decreases Sp1 and Sp3 protein binding affinity and transcriptional responsiveness to retinoic acid. Blood. 2005;105(3):1060-7.