Avhandling för medicine doktorsexamen vid Sahlgrenska akademin, Institutionen för neurovetenskap och fysiologi, Sektionen för psykiatri och neurokemi
Opponent: professor Leslie Sombers, Department of Pharmacodynamics, University of Florida, Gainsville, USA
Betygsnämnd: professor Bo Söderpalm (ordf.), professor Åsa Konradsson Geuken (UU) och professor Pernilla Wittung Stafshede (Chalmers)
Disputationen hålls på engelska
Det går bra att delta på distans, disputationen kommer att streamas via Zoom Webinar: en länk publiceras senast dagen innan disputationen
Neurons in the brain and body communicate with each other, and with target cells, including muscles and glands, using special chemical signals or neurotransmitters. Among these, dopamine is widely recognized for its role in reward and motivation, while serotonin is known for its association with mood and depression. Other important neurotransmitters, such as acetylcholine and glutamate, play key roles in cognitive function and are affected in neuropsychiatric and neurodegenerative disorders, including Alzheimer's disease.
Alzheimer's disease, the leading cause of dementia, is characterized by impairments in both cholinergic (acetylcholine) and glutamatergic (glutamate) neurotransmission. The work described in this thesis focuses on studying neurotransmitter release using advanced high-speed electrochemical techniques to better understand disruptions in presynaptic neurotransmitter release dynamics in Alzheimer's disease.