Avhandling för medicine doktorsexamen vid Sahlgrenska akademin, Institutionen för neurovetenskap och fysiologi, Sektionen för fysiologi
Opponent: Associate Professor James Ernest Blevins, Diabetes Research Center, University of Washington, Washington, USA
Betygsnämnd: docent Cristina Maglio, professor Bodil Ohlsson (LU) och docent Petronella Kettunen
Disputationen hålls på engelska.
Det går bra att delta på distans, disputationen kommer att streamas via Zoom Webinar. En länk publiceras senast dagen innan disputationen. Frågor tas endast emot från publiken på plats.
This thesis investigates how hormones like oxytocin and glucagon-like peptide-1 (GLP-1) regulate appetite and metabolism, with a focus on differences between males and females.
In rodent studies, peripheral oxytocin activation reduced food intake without centrally mediated side effects, while oxytocin receptors in the vagus nerve were shown to be critical for normal esophageal motility and swallowing, particularly in males. The adrenal glands were identified as a new oxytocin source post-meal, and brainstem GLP-1 activation reduced food intake, with effects on motivation seen primarily in females.
These discoveries highlight potential hormone-based therapies for obesity tailored by sex.