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Jörgen Engel
Anknuten till forskning
Sektionen för farmakologi-
Ghrelin activates the mesolimbic dopamine system via nitric oxide associated mechanisms in the ventral tegmental
area
Jörgen Engel, Erik Pålsson, Daniel Vallöf, Elisabeth Jerlhag
Nitric Oxide-Biology and Chemistry - 2023 -
The Leu72Met Polymorphism of the Prepro-ghrelin Gene is Associated With Alcohol Consumption and Subjective Responses to Alcohol: Preliminary
Findings
Petra Suchankova, J. Yan, M. L. Schwandt, B. L. Stangl, Elisabeth Jerlhag, Jörgen Engel, C. A. Hodgkinson, V. A. Ramchandani, L. Leggio
Alcohol and Alcoholism - 2017 -
Central administration of the anorexigenic peptide neuromedin U decreases alcohol intake and attenuates alcohol-induced reward in
rodents
Daniel Vallöf, Lisa Ulenius, Emil Egecioglu, Jörgen Engel, Elisabeth Jerlhag
Addiction Biology - 2017 -
The Anorexigenic Peptide Neuromedin U (NMU) Attenuates Amphetamine-Induced Locomotor Stimulation, Accumbal Dopamine Release and Expression of Conditioned Place Preference in
Mice
Daniel Vallöf, Jesper Vestlund, Jörgen Engel, Elisabeth Jerlhag
Plos One - 2016 -
The glucagon-like peptide 1 receptor agonist liraglutide attenuates the reinforcing properties of alcohol in
rodents.
Daniel Vallöf, Paola Maccioni, Giancarlo Colombo, Minja Mandrapa, Julia Winsa Jörnulf, Emil Egecioglu, Jörgen Engel, Elisabeth Jerlhag
Addiction Biology - 2016 -
Genetic variation of the growth hormone secretagogue receptor gene is associated with alcohol use disorders identification test scores and
smoking
Petra Suchankova, Staffan Nilsson, Bettina von der Pahlen, Pekka Santtila, Kenneth Sandnabba, Ada Johansson, Patrick Jern, Jörgen Engel, Elisabeth Jerlhag
Addiction Biology - 2016 -
Sub-chronic Ghrelin Receptor Blockade Attenuates Alcohol- and Amphetamine-Induced Locomotor Stimulation in
Mice.
Petra Suchankova, Jörgen Engel, Elisabeth Jerlhag
Alcohol and Alcoholism - 2016 -
The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol
dependence
Petra Suchankova, J. Yan, M. L. Schwandt, B. L. Stangl, E. C. Caparelli, R. Momenan, Elisabeth Jerlhag, Jörgen Engel, C. A. Hodgkinson, M. Egli, M. F. Lopez, H. C. Becker, D. Goldman, M. Heilig, V. A. Ramchandani, L. Leggio
Translational Psychiatry - 2015 -
Blockade of growth hormone secretagogue receptor 1A signaling by JMV 2959 attenuates the NMDAR antagonist, phencyclidine-induced impairments in prepulse
inhibition
Jörgen Engel, Elisabeth Jerlhag, Lennart Svensson, R. G. Smith, Emil Egecioglu
Psychopharmacology - 2015 -
A ghrelin receptor (GHS-R1A) antagonist attenuates the rewarding properties of morphine and increases opioid peptide levels in reward areas in
mice.
Jörgen Engel, Ingrid Nylander, Elisabeth Jerlhag
European Neuropsychopharmacology - 2015 -
Peripherally circulating ghrelin does not mediate alcohol-induced reward and alcohol intake in
rodents.
Elisabeth Jerlhag, Lisa Ivanoff, Axel Vater, Jörgen Engel
Alcoholism, clinical and experimental research - 2014 -
Alcohol: mechanisms along the mesolimbic dopamine
system
Jörgen Engel, Elisabeth Jerlhag
Dopamine, Edited by Marco Diana, Gaetano Di Chiara and Pierfranco Spano - 2014 -
Role of Appetite-Regulating Peptides in the Pathophysiology of Addiction: Implications for
Pharmacotherapy
Jörgen Engel, Elisabeth Jerlhag
Cns Drugs - 2014 -
Lagrådsremiss om missbruksvården är ett totalt
bottenapp
Lars Ahlin, Jörgen Engel, Claudia Fahlke, Marie Wedin
Bullentin , Sektionen Beroendemedicin - 2013 -
Förlegad syn på
missbruksvård
Lars Ahlin, Jörgen Engel, Claudia Fahlke, Marie Wedin
Svenska Dagbladet - 2013 -
Ghrelin receptor (GHS-R1A) antagonism suppresses both alcohol consumption and the alcohol deprivation effect in rats following long-term voluntary alcohol
consumption.
Petra Suchankova, Pia Steensland, Ida Fredriksson, Jörgen Engel, Elisabeth Jerlhag
PloS one - 2013 -
Genetic Variation of the Ghrelin Signalling System in Individuals with Amphetamine
Dependence
Petra Suchankova, Elisabeth Jerlhag, N. Jayaram-Lindström, Staffan Nilsson, Kjell Torén, Annika Rosengren, Jörgen Engel, J. Franck
PLoS ONE - 2013 -
The Glucagon-Like Peptide 1 Analogue Exendin-4 Attenuates the Nicotine-Induced Locomotor Stimulation, Accumbal Dopamine Release, Conditioned Place Preference as well as the Expression of Locomotor Sensitization in
Mice
Emil Egecioglu, Jörgen Engel, Elisabeth Jerlhag
Plos One - 2013 -
The Glucagon-Like Peptide 1 Analogue, Exendin-4, Attenuates the Rewarding Properties of Psychostimulant Drugs in
Mice
Emil Egecioglu, Jörgen Engel, Elisabeth Jerlhag
Plos One - 2013 -
The glucagon-like peptide 1 analogue Exendin-4 attenuates alcohol mediated behaviors in
rodents
Emil Egecioglu, P. Steensland, I. Fredriksson, K. Feltmann, Jörgen Engel, Elisabeth Jerlhag
Psychoneuroendocrinology - 2013 -
Concomitant Release of Ventral Tegmental Acetylcholine and Accumbal Dopamine by Ghrelin in
Rats
Elisabeth Jerlhag, A. C. Janson, S. Waters, Jörgen Engel
Plos One - 2012 -
Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in
rats.
Sara Landgren, JA Simms, P Hyytiä, Jörgen Engel, SE Bartlett, Elisabeth Jerlhag
Addiction biology - 2012 -
Neuroendocrine Assessment of Serotonergic, Dopaminergic, and Noradrenergic Functions in Alcohol-Dependent
Individuals.
Claudia Fahlke, Ulf Berggren, Kristina Berglund, Henrik Zetterberg, Kaj Blennow, Jörgen Engel, Jan Balldin
Alcoholism, clinical and experimental research - 2012 -
Reward-related genes and personality traits in alcohol-dependent individuals: a pilot case control
study.
Sara Landgren, Kristina Berglund, Elisabeth Jerlhag, Claudia Fahlke, Jan Balldin, Ulf Berggren, Henrik Zetterberg, Kaj Blennow, Jörgen Engel
Neuropsychobiology - 2011 -
Glutamatergic regulation of ghrelin-induced activation of the mesolimbic dopamine
system.
Elisabeth Jerlhag, Emil Egecioglu, Suzanne L. Dickson, Jörgen Engel
Addiction Biology - 2011 -
The role of the central ghrelin system in reward from food and chemical
drugs.
Suzanne L. Dickson, Emil Egecioglu, Sara Landgren, Karolina P Skibicka, Jörgen Engel, Elisabeth Jerlhag
Molecular and cellular endocrinology - 2011 -
L-lysine as adjunctive treatment in patients with schizophrenia: a single-blinded, randomized, cross-over pilot
study.
Caroline Wass, Daniel Klamer, Evangelos Katsarogiannis, Erik Pålsson, Lennart Svensson, Kim Fejgin, Inga-Britt Bogren, Jörgen Engel, Birgitta Rembeck
BMC medicine - 2011 -
Hedonic and incentive signals for body weight
control.
Emil Egecioglu, Karolina P Skibicka, Caroline Hansson, Mayte Alvarez-Crespo, P. Anders Friberg, Elisabeth Jerlhag, Jörgen Engel, Suzanne L. Dickson
Reviews in endocrine & metabolic disorders - 2011 -
The alcohol-induced locomotor stimulation and accumbal dopamine release is suppressed in ghrelin knockout
mice.
Elisabeth Jerlhag, Sara Landgren, Emil Egecioglu, Suzanne L. Dickson, Jörgen Engel
Alcohol - 2011 -
The ghrelin signalling system is involved in the consumption of
sweets.
Sara Landgren, JA Simms, Dag Thelle, Elisabeth Strandhagen, SE Bartlett, Jörgen Engel, Elisabeth Jerlhag
PLos One - 2011 -
Ghrelin receptor antagonism attenuates nicotine-induced locomotor stimulation, accumbal dopamine release and conditioned place preference in
mice.
Jörgen Engel, Elisabeth Jerlhag
Drug and Alcohol Dependence - 2011 -
Expression of the gene encoding the ghrelin receptor in rats selected for differential alcohol
preference.
Sara Landgren, Jörgen Engel, Petri Hyytiä, Henrik Zetterberg, Kaj Blennow, Elisabeth Jerlhag
Behavioural brain research - 2011 -
Ghrelin increases intake of rewarding food in
rodents.
Emil Egecioglu, Elisabeth Jerlhag, Nicolas Salomé, Karolina P Skibicka, David Haage, Mohammad Bohlooly-Yeganeh, Daniel Andersson, Mikael Bjursell, Daniel Perrissoud, Jörgen Engel, Suzanne L. Dickson
Addiction biology - 2010 -
[No, disulfiram (Antabus) is not the "odd
preparation"].
Jörgen Engel, Bo Söderpalm, Bengt Sternebring, Jan Hallgren, Lars Håkan Nilsson, Lars Blomström
Läkartidningen - 2010 -
Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place
preference.
Elisabeth Jerlhag, Emil Egecioglu, Suzanne L. Dickson, Jörgen Engel
Psychopharmacology - 2010 -
Blockade of central nicotine acetylcholine receptor signaling attenuate ghrelin-induced food intake in
rodents.
Suzanne L. Dickson, E Hrabovszky, Caroline Hansson, Elisabeth Jerlhag, Mayte Alvarez-Crespo, Karolina P Skibicka, C S Molnar, Z Liposits, Jörgen Engel, Emil Egecioglu
Neuroscience - 2010 -
Genetic variation of the ghrelin signaling system in females with severe alcohol
dependence
Sara Landgren, Elisabeth Jerlhag, Jarmila Hallman, Lars Oreland, Lauren Lissner, Elisabeth Strandhagen, Dag Thelle, Henrik Zetterberg, Kaj Blennow, Jörgen Engel
Alcoholism: Clinical and Experimental Research - 2010 -
Association of nAChR gene haplotypes with heavy alcohol use and body
mass.
Sara Landgren, Jörgen Engel, Malin E Andersson, Arturo Gonzalez-Quintela, Joaquin Campos, Staffan Nilsson, Henrik Zetterberg, Kaj Blennow, Elisabeth Jerlhag
Brain research - 2009 -
Requirement of central ghrelin signaling for alcohol
reward.
Elisabeth Jerlhag, Emil Egecioglu, Sara Landgren, Nicolas Salomé, Markus Heilig, Diederik Moechars, Rakesh Datta, Daniel Perrissoud, Suzanne L. Dickson, Jörgen Engel
Proceedings of the National Academy of Sciences of the United States of America - 2009 -
Effects of subunit selective nACh receptors on operant ethanol self-administration and relapse-like ethanol-drinking
behavior.
Alexander Kuzmin, Elisabeth Jerlhag, Sture Liljequist, Jörgen Engel
Psychopharmacology - 2009 -
Association of Pro-Ghrelin and GHS-R1A Gene Polymorphisms and Haplotypes With Heavy Alcohol Use and Body
Mass.
Sara Landgren, Elisabeth Jerlhag, Henrik Zetterberg, Arturo Gonzalez-Quintela, Joauquin Campos, Ulrica Olofsson, Staffan Nilsson, Kaj Blennow, Jörgen Engel
Alcoholism, clinical and experimental research - 2008 -
Nitric oxide synthase inhibition attenuates phencyclidine-induced disruption of cognitive
flexibility.
Caroline Wass, Lennart Svensson, Kim Fejgin, Erik Pålsson, Trevor Archer, Jörgen Engel, Daniel Klamer
Pharmacology, biochemistry, and behavior - 2008 -
Systemic adminstration of Phencyclidine increases Nitric oxide levels in the rat medial prefrontal
cortex
Daniel Klamer, Kim Fejgin, Erik Pålsson, Niall J Finnerty, Caroline Wass, Jörgen Engel, Lennart Svensson, John P Lowry
Presented at EWCBR. March, 2008, Les Arcs, France - 2008 -
Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors are involved in mediating the ghrelin-induced locomotor stimulation and dopamine overflow in nucleus
accumbens.
Elisabeth Jerlhag, Emil Egecioglu, Suzanne L. Dickson, Lennart Svensson, Jörgen Engel
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 2008 -
Cognitive dysfunctions in schizophrenia: focus on the nitric oxide pathway in rodent
models
Daniel Klamer, Kim Fejgin, Caroline Wass, Niall J Finnerty, John P Lowry, Jörgen Engel, Lennart Svensson, Erik Pålsson
Presented at Cognitive Dysfunctions in Disease: Mechanisms and Therapies. Stockholm, Sweden. April 2008 - 2008 -
Nitric oxide and GABAB-sensitive mechanisms in the prefrontal cortex are important for the disruptive effects of phencyclidine on prepulse
inhibition
Kim Fejgin, Erik Pålsson, Caroline Wass, Jörgen Engel, Lennart Svensson, Daniel Klamer
Presented at Cognitive Dysfunctions in Disease: Mechanisms and Therapies. April 2008, Stockholm, Sweden, - 2008 -
The atypical antipsychotic, aripiprazole, blocks phencyclidine-induced disruption of prepulse inhibition in
mice.
Kim Fejgin, Sergej Safonov, Erik Pålsson, Caroline Wass, Jörgen Engel, Lennart Svensson, Daniel Klamer
Psychopharmacology - 2007 -
The amino acid L-lysine blocks the disruptive effect of phencyclidine on prepulse inhibition in
mice.
Erik Pålsson, Kim Fejgin, Caroline Wass, Jörgen Engel, Lennart Svensson, Daniel Klamer
Psychopharmacology - 2007 -
Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus
accumbens.
Elisabeth Jerlhag, Emil Egecioglu, Suzanne L. Dickson, Annika Douhan, Lennart Svensson, Jörgen Engel
Addiction biology - 2007 -
Role of the subunit composition of central nicotinic acetylcholine receptors for the stimulatory and dopamine-enhancing effects of
ethanol.
Elisabeth Jerlhag, Morten Grøtli, Kristina Luthman, Lennart Svensson, Jörgen Engel
Alcohol and Alcoholism - 2006 -
Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: implications for its involvement in brain
reward.
Elisabeth Jerlhag, Emil Egecioglu, Suzanne L. Dickson, Malin E Andersson, Lennart Svensson, Jörgen Engel
Addiction biology - 2006 -
Effects of phencyclidine on spatial learning and memory: nitric oxide-dependent
mechanisms
Caroline Wass, Trevor Archer, Erik Pålsson, Kim Fejgin, Daniel Klamer, Jörgen Engel, Lennart Svensson
Behav Brain Res - 2006 -
Phencyclidine affects memory in a nitric oxide-dependent manner: working and reference
memory
Caroline Wass, Trevor Archer, Erik Pålsson, Kim Fejgin, A. Alexandersson, Daniel Klamer, Jörgen Engel, Lennart Svensson
Behav Brain Res - 2006 -
Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old
mice.
Johan Svensson, M Diez, Jörgen Engel, Caroline Wass, Åsa Tivesten, John-Olov Jansson, Olle Isaksson, Trevor Archer, Tomas Hökfelt, Claes Ohlsson
The Journal of endocrinology - 2006 -
Inverse relationship between central serotonergic neurotransmission and blood pressure in alcohol-dependent male
subjects
Jan Balldin, Madelene Andersson, Ulf Berggren, Jörgen Engel, Matts Eriksson, Claudia Fahlke
Journal of Neural Transmission - 2006 -
Platelet monoamine oxidase B (MAO-B) activity and its relationship to DL-fenfluramine-induced prolactin response in healthy
men
Matts Eriksson, Ulf Berggren, Claudia Fahlke, Jörgen Engel, Jan Balldin
Journal of Neural Transmission - 2006 -
Voluntary ethanol intake increases extracellular acetylcholine levels in the ventral tegmental area in the
rat.
Anna Larsson, Lena Edström, Lennart Svensson, Bo Söderpalm, Jörgen Engel
Alcohol and Alcoholism - 2005 -
Stressas vi till
missbruk?
Bo Söderpalm, Jörgen Engel, Anna Söderpalm
Stress. Ed. Ekman R & Arnetz B - 2005 -
Antagonism of the nitric oxide synthase inhibitor, L-NAME, of the effects of phencyclidine on latent inhibition in taste aversion
conditioning
Daniel Klamer, Erik Pålsson, Caroline Wass, Trevor Archer, Jörgen Engel, Lennart Svensson
Behav Brain Res - 2005 -
The effects of phencyclidine on latent inhibition in taste aversion conditioning: differential effects of preexposure and
conditioning
Erik Pålsson, Daniel Klamer, Caroline Wass, Trevor Archer, Jörgen Engel, Lennart Svensson
Behav Brain Res - 2005 -
Activation of a nitric-oxide-sensitive cAMP pathway with phencyclidine: elevated hippocampal cAMP levels are temporally associated with deficits in prepulse
inhibition
Daniel Klamer, Erik Pålsson, Kim Fejgin, J. Zhang, Jörgen Engel, Lennart Svensson
Psychopharmacology (Berl) - 2005 -
Effects of phencyclidine on acoustic startle and prepulse inhibition in neuronal nitric oxide synthase deficient
mice
Daniel Klamer, Jörgen Engel, Lennart Svensson
Eur Neuropsychopharmacol - 2005 -
Selective interaction of nitric oxide synthase inhibition with phencyclidine: behavioural and NMDA receptor binding studies in the
rat
Daniel Klamer, J. Zhang, Jörgen Engel, Lennart Svensson
Behav Brain Res - 2005 -
Liver-derived IGF-I regulates exploratory activity in old
mice.
Johan Svensson, Bo Söderpalm, Klara Sjögren, Jörgen Engel, Claes Ohlsson
American journal of physiology. Endocrinology and metabolism - 2005 -
Phencyclidine-induced behaviour in mice prevented by methylene
blue
Daniel Klamer, Jörgen Engel, Lennart Svensson
Basic & Clinical Pharmacology & Toxicology - 2004 -
Habituation of acoustic startle is disrupted by psychotomimetic drugs: differential dependence on dopaminergic and nitric oxide modulatory
mechanisms
Daniel Klamer, Erik Pålsson, Aron Revesz, Jörgen Engel, Lennart Svensson
Psychopharmacology (Berl) - 2004 -
The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in
mice
Daniel Klamer, Jörgen Engel, Lennart Svensson
Eur J Pharmacol - 2004 -
Is an alpha-conotoxin MII-sensitive mechanism involved in the neurochemical, stimulatory, and rewarding effects of
ethanol?
Anna Larsson, Elisabeth Jerlhag, Lennart Svensson, Bo Söderpalm, Jörgen Engel
Alcohol - 2004 -
Neurochemical and behavioral studies on ethanol and nicotine
interactions.
Anna Larsson, Jörgen Engel
Neurosci Biobehav Rev - 2004 -
Ethanol elevates accumbal dopamine levels via indirect activation of ventral tegmental nicotinic acetylcholine
receptors.
Mia Ericson, Anna C Molander, Elin Löf, Jörgen Engel, Bo Söderpalm
European journal of pharmacology - 2003 -
Testosterone treatment induces behavioral disinhibition in adult male
rats.
Anders I Svensson, Pernilla Akesson, Jörgen Engel, Bo Söderpalm
Pharmacology, biochemistry, and behavior - 2003 -
Role of different nicotinic acetylcholine receptors in mediating behavioral and neurochemical effects of ethanol in
mice.
Anna Larsson, Lennart Svensson, Bo Söderpalm, Jörgen Engel
Alcohol - 2002 -
Neurobiological processes in alcohol
addiction.
A D Lê, K Kiianmaa, C L Cunningham, Jörgen Engel, Mia Ericson, Bo Söderpalm, G F Koob, A J Roberts, F Weiss, P Hyytiä, S Janhunen, J Mikkola, P Bäckström, I Ponomarev, J C Crabbe
Alcoholism, clinical and experimental research - 2001 -
Mechanisms of alcohol-nicotine interactions: alcoholics versus
smokers.
T Narahashi, Bo Söderpalm, Mia Ericson, Peter Olausson, Jörgen Engel, X Zhang, A Nordberg, W Marszalec, G L Aistrup, L G Schmidt, U Kalouti, M Smolka And, L Hedlund
Alcoholism, clinical and experimental research - 2001 -
Nicotine-induced behavioral disinhibition and ethanol preference correlate after repeated nicotine
treatment.
Peter Olausson, Mia Ericson, Elin Löf, Jörgen Engel, Bo Söderpalm
European journal of pharmacology - 2001 -
Neonatal herpes simplex virus type 1 brain infection affects the development of sensorimotor gating in
rats.
Jörgen Engel, Jianhua Zhang, Tomas Bergström, Nils Conradi, C Forkstam, A Liljeroth, Lennart Svensson
Brain research - 2000 -
Disinhibitory behavior and GABA(A) receptor function in serotonin-depleted adult male rats are reduced by
gonadectomy.
Anders I Svensson, A Berntsson, Jörgen Engel, Bo Söderpalm
Pharmacology, biochemistry, and behavior - 2000 -
Gonadectomy enhances shock-induced behavioral inhibition in adult male rats: implications for impulsive
behavior.
Anders I Svensson, Bo Söderpalm, Jörgen Engel
Pharmacology, biochemistry, and behavior - 2000 -
Involvement of the medial geniculate body in prepulse inhibition of acoustic
startle.
Jianhua Zhang, Jörgen Engel, Mia Ericson, Lennart Svensson
Psychopharmacology - 1999 -
Repeated administration of amphetamine induces sensitisation to its disruptive effect on prepulse inhibition in the
rat.
Jianhua Zhang, Jörgen Engel, Bo Söderpalm, Lennart Svensson
Psychopharmacology - 1998 -
Induction but not expression of behavioural sensitization to nicotine in the rat is dependent on
glucocorticoids.
D H Johnson, Anders I Svensson, Jörgen Engel, Bo Söderpalm
European journal of pharmacology - 1995 -
Serotonergic and dopaminergic involvement in ethanol
intake
Jörgen Engel, C Enerbäck, Claudia Fahlke
Novel pharmacological intervention for alcoholism - 1992