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- Thaher Pelaseyed
Thaher Pelaseyed
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Avd för medicinsk kemi och cellbiologiOm Thaher Pelaseyed
Bacteria in our intestine exceed 10 trillions. In healthy individuals, an impermeable layer of secreted mucins separates bacteria from host intestinal cells.
In diseases such as Inflammatory bowel disease, bacteria breach the mucus barrier and reach epithelial cells covered with bottlebrush-like glycoproteins called transmembrane mucins. Despite the fact that transmembrane mucins extend up to 1 μm into the intestinal lumen and are ideal docking sites for penetrating bacteria, their biological function is unknown.
Our goal is to determine how transmembrane mucins sense bacteria and induce intestinal cell protection against bacterial infections.
Current funding and support: - Swedish Society for Medical Research, Start grant #S17-0005 (2018-2023) - NIH/NIAID/MIST Scholar Award in Mucosal Immunity (2018-2020) - Sahlgrenska Academy PhD Training Grant #U2018/162 (2019-2023) - The Wenner-Gren Foundations, Starting grant #FT2017-0002 (2017-2019) - The Wenner-Gren Foundations, International Postdoc Training grant, #UPD2018-0065 (2018-2020) - Åke Wiberg's Foundation, Research grant, #M17-0062 (2018-2019) - The Jeansson Foundations, Startup grant #JS2017-0003 (2018-2019)
Read more about our research and open positions here.
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BPP43_05035 is a Brachyspira pilosicoli cell surface adhesin that weakens the integrity of the epithelial barrier during
infection
Anandi Rajan, Pablo Gallego, Brendan Dolan, Piyush Patel, Chinmay Dwibedi, Ana S. Luis, Sergio Trillo-Muyo, Liisa Arike, Sjoerd van der Post, Magnus Simrén, Thaher Pelaseyed
GUT MICROBES - 2024 -
Discovery of a MUC3B gene reconstructs the membrane mucin gene cluster on human chromosome
7.
Tiange Lang, Thaher Pelaseyed
PloS one - 2022 -
IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during
weaning
Elena Layunta, Sofia Jäverfelt, Brendan Dolan, Liisa Arike, Thaher Pelaseyed
Cell Reports - 2021 -
Membrane mucins of the intestine at a
glance
Thaher Pelaseyed, Gunnar C. Hansson
Journal of Cell Science - 2020 -
The human transmembrane mucin MUC17 responds to TNF alpha by increased presentation at the plasma
membrane
Hannah Schneider, Evelin Berger, Brendan Dolan, Beatriz Martinez Abad, Liisa Arike, Thaher Pelaseyed, Gunnar C. Hansson
Biochemical Journal - 2019 -
Regulation of actin-based apical structures on epithelial
cells
Thaher Pelaseyed, Anthony Bretscher
Journal of Cell Science - 2018 -
Study of mucin turnover in the small intestine by in vivo
labeling
Hannah Schneider, Thaher Pelaseyed, Frida Svensson, Malin E V Johansson
Scientific Reports - 2018 -
Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge
mechanism.
Thaher Pelaseyed, Raghuvir Viswanatha, Cécile Sauvanet, Joshua J Filter, Michael L Goldberg, Anthony Bretscher
eLife - 2017 -
Murine Butyrophilin-Like 1 and BtnI6 Form Heteromeric Complexes in Small Intestinal Epithelial Cells and Promote Proliferation of Local T
Lymphocytes
Cristina Lebrero-Fernandez, Joakim H. Bergström, Thaher Pelaseyed, Anna Bas-Forsberg
Frontiers in Immunology - 2016 -
Structure, regulation, and functional diversity of microvilli on the apical domain of epithelial
cells.
Cécile Sauvanet, Jessica Wayt, Thaher Pelaseyed, Anthony Bretscher
Annual review of cell and developmental biology - 2015 -
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune
system
Thaher Pelaseyed, Joakim H. Bergström, Jenny K Gustafsson, Anna Ermund, George M. H. Birchenough, André Schütte, Sjoerd van der Post, Frida Svensson, Ana María Rodríguez-Piñeiro, Elisabeth E. L. Nyström, Catharina Wising, Malin E V Johansson, Gunnar C. Hansson
Immunological Reviews - 2014 -
Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in
enterocytes.
Thaher Pelaseyed, Jenny K Gustafsson, Ida J Gustafsson, Anna Ermund, Gunnar C. Hansson
American journal of physiology. Cell physiology - 2013 -
Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell-protective
device.
Thaher Pelaseyed, Michael Zäch, Asa C Petersson, Frida Svensson, Denny G A Johansson, Gunnar C. Hansson
The FEBS journal - 2013 -
The Relationship between Transmembrane Mucins, Ion Channels and PDZ Adaptor Proteins in the Small
Intestine
Thaher Pelaseyed
2012 -
Composition and functional role of the mucus layers in the
intestine.
Malin E V Johansson, Daniel Ambort, Thaher Pelaseyed, André Schütte, Jenny K Gustafsson, Anna Ermund, Durai B Subramani, Jessica Holmén Larsson, Kristina A Thomsson, Joakim H. Bergström, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Henrik Sjövall, Malin Bäckström, Gunnar C. Hansson
Cellular and Molecular Life Sciences - 2011 -
CFTR anion channel modulates expression of human transmembrane mucin MUC3 through the PDZ protein
GOPC.
Thaher Pelaseyed, Gunnar C. Hansson
Journal of cell science - 2011 -
The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small
intestine
Emily Malmberg, Thaher Pelaseyed, Åsa Petersson, Ursula E. Seidler, Hugo de Jonge, John R. Riordan, Gunnar C. Hansson
Biochemical Journal - 2008