- Hem
- Om universitetet
- Hitta person
- Malin Johansson
Malin Johansson
Professor
Avd för medicinsk kemi och cellbiologiAvd-/Sektionschef, Inst
Avd för medicinsk kemi och cellbiologi-
GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut
microbiota
Thomas U. Greiner, Ara Koh, Eduard Peris, Mattias Bergentall, Malin E V Johansson, Gunnar C. Hansson, Daniel J. Drucker, Fredrik Bäckhed
MOLECULAR METABOLISM - 2024 -
Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in
mice.
Paola Paone, Dimitris Latousakis, Romano Terrasi, Didier Vertommen, Ching Jian, Valentina Borlandelli, Francesco Suriano, Malin E V Johansson, Anthony Puel, Caroline Bouzin, Nathalie M. Delzenne, Anne Salonen, Nathalie Juge, Bogdan I. Florea, Giulio G. Muccioli, Herman Overkleeft, Matthias Van Hul, Patrice D. Cani
Gut - 2024 -
The structure of the second CysD domain of MUC2 and role in mucin organization by transglutaminase-based
cross-linking
Christian V Recktenwald, Göran Karlsson, Maria-Jose Garcia-Bonete, Gergely Katona, Maja Jensen, Richard Lymer, Malin Bäckström, Malin E V Johansson, Gunnar C. Hansson, Sergio Trillo-Muyo
Cell Reports - 2024 -
Low-grade intestinal inflammation two decades after pelvic
radiotherapy.
Sravani Devarakonda, Annika Thorsell, Per Hedenström, Azar Rezapour, Lisen Heden, Sanghita Banerjee, Malin E V Johansson, George M. H. Birchenough, Amelie Toft Morén, Karin Gustavsson, Viktor Skokic, Victor L Pettersson, F. Sjöberg, Marie Kalm, Mohammad Al Masri, Michaela Ekh, Henrik Fagman, Mats Wolving, Rosie Perkins, Rodrigo A Morales, Francisca Castillo, Eduardo J Villablanca, Ulf Yrlid, Karin Bergmark, Gunnar Steineck, Cecilia Bull
EBioMedicine - 2023 -
The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming
mucins
Pablo Gallego, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Christian V Recktenwald, Malin E V Johansson, Gunnar C. Hansson
Nature communications - 2023 -
The role of goblet cells and mucus in intestinal
homeostasis
Jenny K Gustafsson, Malin E V Johansson
Nature Reviews Gastroenterology & Hepatology - 2022 -
Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier
protection
D. P. Yang, A. Jacobson, K. A. Meerschaert, J. J. Sifakis, M. Wu, X. Chen, T. D. Yang, Y. L. Zhou, P. V. Anekal, R. A. Rucker, D. Sharma, A. Sontheimer-Phelps, G. S. Wu, L. W. Deng, M. D. Anderson, S. Choi, D. Neel, N. C. L. Lee, D. L. Kasper, B. Jabri, J. R. Huh, Malin E V Johansson, J. R. Thiagarajah, S. J. Riesenfeld, I. M. Chiu
Cell - 2022 -
Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion
transport
Brendan Dolan, Anna Ermund, Beatriz Martinez Abad, M Johansson, Gunnar C. Hansson
Science Signaling - 2022 -
Human intelectin-2 (ITLN2) is selectively expressed by secretory Paneth
cells
E. B. Nonnecke, P. A. Castillo, Malin E V Johansson, E. J. Hollox, B. Shen, B. Lönnerdal, C. L. Bevins
FASEB Journal - 2022 -
A fiber-rich diet and radiation-induced injury in the murine intestinal
mucosa
Dilip Malipatlolla, Sravani Devarakonda, Piyush Patel, Fei Sjöberg, A. Rascón, Rita Grandér, Viktor Skokic, Marie Kalm, Jolie Danial, Eva Mehdin, Malin Warholm, Henrietta Norling, A. Stringer, Malin E V Johansson, M. Nyman, Gunnar Steineck, Cecilia Bull
International Journal of Molecular Sciences - 2022 -
Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus
layer
Jack D. A. Sharpen, Brendan Dolan, Elisabeth E. L. Nyström, George M. H. Birchenough, Liisa Arike, Beatriz Martinez Abad, Malin E V Johansson, Gunnar C. Hansson, Christian V Recktenwald
Nature Communications - 2022 -
Human intelectin-1 (ITLN1) genetic variation and intestinal
expression
E. B. Nonnecke, P. A. Castillo, A. E. Dugan, F. Almalki, M. A. Underwood, C. A. De La Motte, W. Yuan, W. Lu, B. Shen, Malin E V Johansson, L. L. Kiessling, E. J. Hollox, B. Lonnerdal, C. L. Bevins
Scientific Reports - 2021 -
The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide
bonds
Erik Ehrencrona, Sjoerd van der Post, Pablo Gallego, Christian V Recktenwald, Ana Rodriguez-Piñeiro, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Malin Bäckström, Gunnar C. Hansson, Malin E V Johansson
Journal of Biological Chemistry - 2021 -
An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier
function
Elisabeth E. L. Nyström, Beatriz Martinez Abad, Liisa Arike, George M. H. Birchenough, E. B. Nonnecke, P. A. Castillo, Frida Svensson, C. L. Bevins, Gunnar C. Hansson, Malin E V Johansson
Science - 2021 -
Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and
Microbiota
Liisa Arike, A. Seiman, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Anna Ermund, André Schütte, Fredrik Bäckhed, Malin E V Johansson, Gunnar C. Hansson
Cell Reports - 2020 -
The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or
function
Joana K. Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz Martinez Abad, Björn O. Schröder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, Malin E V Johansson, Gunnar C. Hansson, George M. H. Birchenough
Journal of Experimental Medicine - 2019 -
Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial
cells
Sinan Sharba, Nazanin Navabi, Médea Padra, Macarena P Quintana-Hayashi, Jenny K Gustafsson, Louis Szeponik, Vignesh Venkatakrishnan, A. Sjoling, Staffan Nilsson, Marianne Quiding-Järbrink, Malin E V Johansson, Sara K. Lindén
Virulence - 2019 -
Normal calcium-activated anion secretion in a mouse selectively lacking TMEM16A in intestinal
epithelium
Génesis Vega, Anita Guequén, Malin E V Johansson, Liisa Arike, Beatriz Martinez Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores
Frontiers in Physiology - 2019 -
Potential roles of gut microbiome and metabolites in modulating ALS in
mice
E. Blacher, S. Bashiardes, H. Shapiro, D. Rothschild, U. Mor, M. Dori-Bachash, C. Kleimeyer, C. Moresi, Y. Harnik, M. Zur, M. Zabari, R. B. Z. Brik, D. Kviatcovsky, N. Zmora, Y. Cohen, N. Bar, I. Levi, N. Amar, T. Mehlman, A. Brandis, I. Biton, Y. Kuperman, M. Tsoory, L. Alfahel, A. Harmelin, M. Schwartz, A. Israelson, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, M. Gotkine, E. Segal, E. Elinav
Nature - 2019 -
Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis
pathogenesis
Sjoerd van der Post, Karolina S. Jabbar, George M. H. Birchenough, Liisa Arike, Noreen Akhtar, Henrik Sjövall, Malin E V Johansson, Gunnar C. Hansson
Gut - 2019 -
Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing
properties
Elisabeth E. L. Nyström, Liisa Arike, Erik Ehrencrona, Gunnar C. Hansson, Malin E V Johansson
Journal of Biological Chemistry - 2019 -
Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus
Deterioration
Björn O. Schröder, George M. H. Birchenough, Marcus Ståhlman, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, Fredrik Bäckhed
Cell Host & Microbe - 2018 -
The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between
individuals
Frida Svensson, T. G. Lang, Malin E V Johansson, Gunnar C. Hansson
Scientific Reports - 2018 -
Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic
Activity
Elisabeth E. L. Nyström, George M. H. Birchenough, Sjoerd van der Post, Liisa Arike, A. D. Gruber, Gunnar C. Hansson, Malin E V Johansson
Ebiomedicine - 2018 -
Study of mucin turnover in the small intestine by in vivo
labeling
Hannah Schneider, Thaher Pelaseyed, Frida Svensson, Malin E V Johansson
Scientific Reports - 2018 -
Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in
mice.
K Bergstrom, J Fu, Malin E V Johansson, X Liu, N Gao, Q Wu, J Song, J M McDaniel, S McGee, W Chen, J Braun, Gunnar C. Hansson, L Xia
Mucosal immunology - 2017 -
Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1
infection
George M. H. Birchenough, F. Dalgakiran, L. A. Witcomb, Malin E V Johansson, A. J. McCarthy, Gunnar C. Hansson, P. W. Taylor
Scientific Reports - 2017 -
Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein
ZG16.
Joakim H. Bergström, George M. H. Birchenough, Gergely Katona, Björn O. Schröder, André Schütte, Anna Ermund, Malin E V Johansson, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2016 -
Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and
FCGBP
Tiange Lang, Sofia Klasson, Erik Larsson, Malin E V Johansson, Gunnar C. Hansson, Tore Samuelsson
Molecular Biology and Evolution - 2016 -
A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2
secretion
George M. H. Birchenough, Elisabeth E. L. Nyström, Malin E V Johansson, Gunnar C. Hansson
Science - 2016 -
The
Mucins
Malin E V Johansson, Gunnar C. Hansson
Encyclopedia of Immunobiology - 2016 -
Immunological aspects of intestinal mucus and
mucins
Malin E V Johansson, Gunnar C. Hansson
Nature Reviews Immunology - 2016 -
The composition of the gut microbiota shapes the colon mucus
barrier.
Hedvig E Jakobsson, Ana María Rodríguez-Piñeiro, André Schütte, Anna Ermund, Preben Boysen, Mats Bemark, Felix Sommer, Fredrik Bäckhed, Gunnar C. Hansson, Malin E V Johansson
EMBO reports - 2015 -
Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial
Colonization
Malin E V Johansson, Hedvig E Jakobsson, Jessica Holmén Larsson, André Schütte, Anna Ermund, Ana María Rodríguez-Piñeiro, Liisa Arike, Catharina Wising, Frida Svensson, Fredrik Bäckhed, Gunnar C. Hansson
Cell Host & Microbe - 2015 -
Loss of NHE8 expression impairs intestinal mucosal
integrity
Aiping Wang, Jing Li, Yang Zhao, Malin E V Johansson, Hua Xu, Fayez K. Ghishan
American Journal of Physiology - Gastrointestinal and Liver Physiology - 2015 -
The colonic mucus protection depends on the
microbiota
Ana María Rodríguez-Piñeiro, Malin E V Johansson
Gut microbes - 2015 -
The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged
Mice
N. A. Erickson, Elisabeth E. L. Nyström, L. Mundhenk, Liisa Arike, R. Glauben, M. M. Heimesaat, A. Fischer, S. Bereswill, George M. H. Birchenough, A. D. Gruber, Malin E V Johansson
Plos One - 2015 -
New developments in goblet cell mucus secretion and
function
George M. H. Birchenough, Malin E V Johansson, Jenny K Gustafsson, Joakim H. Bergström, Gunnar C. Hansson
Mucosal Immunology - 2015 -
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative
colitis.
Malin E V Johansson, Jenny K Gustafsson, Jessica Holmén Larsson, Karolina S. Jabbar, Lijun Xia, Hua Xu, Fayez K Ghishan, Frederic A Carvalho, Andrew T Gewirtz, Henrik Sjövall, Gunnar C. Hansson
Gut - 2014 -
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune
system
Thaher Pelaseyed, Joakim H. Bergström, Jenny K Gustafsson, Anna Ermund, George M. H. Birchenough, André Schütte, Sjoerd van der Post, Frida Svensson, Ana María Rodríguez-Piñeiro, Elisabeth E. L. Nyström, Catharina Wising, Malin E V Johansson, Gunnar C. Hansson
Immunological Reviews - 2014 -
Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal
architecture.
Felix Sommer, Nina Adam, Malin E V Johansson, Lijun Xia, Gunnar C. Hansson, Fredrik Bäckhed
PloS one - 2014 -
Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative
colitis.
Ulf Alexander Wenzel, Maria K Magnusson, Anna Rydström, Caroline Jonstrand, Julia Hengst, Malin E V Johansson, Anna Velcich, Lena Öhman, Hans Strid, Henrik Sjövall, Gunnar C. Hansson, Mary Jo Wick
PloS one - 2014 -
Is the intestinal goblet cell a major immune
cell?
Malin E V Johansson, Gunnar C. Hansson
Cell host & microbe - 2014 -
AGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal
mucus.
Joakim H. Bergström, Katarina A Berg, Ana María Rodríguez-Piñeiro, Bärbel Stecher, Malin E V Johansson, Gunnar C. Hansson
PloS one - 2014 -
Mucus Layers in Inflammatory Bowel
Disease
Malin E V Johansson
Inflammatory Bowel Diseases - 2014 -
Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal
mucus
André Schütte, Anna Ermund, C. Becker-Pauly, Malin E V Johansson, Ana María Rodríguez-Piñeiro, Fredrik Bäckhed, S.C. Müller, D. Lottaz, J.S. Bond, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2014 -
Slc26a3 deficiency is associated with loss of colonic HCO3 (-) secretion, absence of a firm mucus layer, and barrier impairment in
mice.
Fang Xiao, Qin Yu, Junhua Li, Malin E V Johansson, Anurag Kumar Singh, Weiliang Xia, Brigitte Riederer, Regina Engelhardt, Marshall Montrose, Manoocher Soleimani, De-An Tian, Gang Xu, Gunnar C. Hansson, Ursula Seidler
Acta physiologica (Oxford, England) - 2014 -
Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease
(RgpB).
Sjoerd van der Post, Durai B Subramani, Malin Bäckström, Malin E V Johansson, Malene B Vester-Christensen, Ulla Mandel, Eric P Bennett, Henrik Clausen, Gunnar Dahlén, Aneta Sroka, Jan Potempa, Gunnar C. Hansson
The Journal of biological chemistry - 2013 -
Altered innate defenses in the neonatal gastrointestinal tract in response to colonization by neuropathogenic Escherichia
coli.
George M. H. Birchenough, Malin E V Johansson, Richard A Stabler, Fatma Dalgakiran, Gunnar C. Hansson, Brendan W Wren, J Paul Luzio, Peter W Taylor
Infection and immunity - 2013 -
Altered Innate Defenses in the Neonatal Gastrointestinal Tract in Response to Colonization by Neuropathogenic Escherichia
coli
George M. H. Birchenough, Malin E V Johansson, R. A. Stabler, F. Dalgakiran, Gunnar C. Hansson, B. W. Wren, J. P. Luzio, P. W. Taylor
Infection and Immunity - 2013 -
Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core
proteins.
Ana María Rodríguez-Piñeiro, Joakim H. Bergström, Anna Ermund, Jenny K Gustafsson, André Schütte, Malin E V Johansson, Gunnar C. Hansson
American journal of physiology. Gastrointestinal and liver physiology - 2013 -
Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's
patches.
Anna Ermund, André Schütte, Malin E V Johansson, Jenny K Gustafsson, Gunnar C. Hansson
American journal of physiology. Gastrointestinal and liver physiology - 2013 -
Mucus and the Goblet
Cell
Malin E V Johansson, Gunnar C. Hansson
Digestive Diseases - 2013 -
The gastrointestinal mucus system in health and
disease.
Malin E V Johansson, Henrik Sjövall, Gunnar C. Hansson
Nature reviews. Gastroenterology & hepatology - 2013 -
NHE8 plays an important role in mucosal protection via its effect on bacterial
adhesion.
Chang Liu, Hua Xu, Bo Zhang, Malin E V Johansson, Jing Li, Gunnar C. Hansson, Fayez K Ghishan
American journal of physiology. Cell physiology - 2013 -
Increased understanding of the biochemistry and biosynthesis of MUC2 and other gel-forming mucins through the recombinant expression of their protein
domains.
Malin Bäckström, Daniel Ambort, Elisabeth Thomsson, Malin E V Johansson, Gunnar C. Hansson
Molecular biotechnology - 2013 -
Helicobacter pylori Infection Impairs the Mucin Production Rate and Turnover in the Murine Gastric
Mucosa
Nazanin Navabi, Malin E V Johansson, Sukanya Raghavan, Sara K. Lindén
Infection and Immunity - 2013 -
The goblet cell: a key player in ischaemia-reperfusion
injury.
Malin E V Johansson, Gunnar C. Hansson
Gut - 2013 -
An ex vivo method for studying mucus formation, properties and thickness in human colonic biopsies and mouse small and large intestinal
explants.
Jenny K Gustafsson, Anna Ermund, Malin E V Johansson, André Schütte, Gunnar C. Hansson, Henrik Sjövall
American journal of physiology. Gastrointestinal and liver physiology - 2012 -
Analysis of assembly of secreted
mucins
Malin E V Johansson, Gunnar C. Hansson
Methods in Molecular Biology - 2012 -
Preservation of mucus in histological sections, immunostaining of mucins in fixed tissue, and localization of bacteria with
FISH.
Malin E V Johansson, Gunnar C. Hansson
Methods in molecular biology (Clifton, N.J.) - 2012 -
Perspectives on mucus properties and formation--lessons from the biochemical
world.
Daniel Ambort, Malin E V Johansson, Jenny K Gustafsson, Anna Ermund, Gunnar C. Hansson
Cold Spring Harbor perspectives in medicine - 2012 -
Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human
MUC2.
Kristina A Thomsson, Jessica Holmén, Jonas Ångström, Malin E V Johansson, Lijun Xia, Gunnar C. Hansson
Glycobiology - 2012 -
Fast renewal of the distal colonic mucus layers by the surface goblet cells as measured by in vivo labeling of mucin
glycoproteins.
Malin E V Johansson
PloS one - 2012 -
Proteomic study of the mucin granulae in an intestinal goblet cell
model.
Ana María Rodríguez-Piñeiro, Sjoerd van der Post, Malin E V Johansson, Kristina A Thomsson, Alexey I Nesvizhskii, Gunnar C. Hansson
Journal of proteome research - 2012 -
Calcium and pH-dependent packing and release of the gel-forming MUC2
mucin.
Daniel Ambort, Malin E V Johansson, Jenny K Gustafsson, Harriet E Nilsson, Anna Ermund, Bengt R Johansson, Philip J B Koeck, Hans Hebert, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2012 -
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus
phenotype.
Jenny K Gustafsson, Anna Ermund, Daniel Ambort, Malin E V Johansson, Harriet E Nilsson, Kaisa Thorell, Hans Hebert, Henrik Sjövall, Gunnar C. Hansson
The Journal of experimental medicine - 2012 -
Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient
Mice
F. A. Carvalho, O. Koren, J. K. Goodrich, Malin E V Johansson, I. Nalbantoglu, J. D. Aitken, Y. J. Su, B. Chassaing, W. A. Walters, A. Gonzalez, J. C. Clemente, T. C. Cullender, N. Barnich, A. Darfeuille-Michaud, M. Vijay-Kumar, R. Knight, R. E. Ley, A. T. Gewirtz
Cell Host & Microbe - 2012 -
Composition and functional role of the mucus layers in the
intestine.
Malin E V Johansson, Daniel Ambort, Thaher Pelaseyed, André Schütte, Jenny K Gustafsson, Anna Ermund, Durai B Subramani, Jessica Holmén Larsson, Kristina A Thomsson, Joakim H. Bergström, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Henrik Sjövall, Malin Bäckström, Gunnar C. Hansson
Cellular and Molecular Life Sciences - 2011 -
Microbiology. Keeping bacteria at a
distance.
Malin E V Johansson, Gunnar C. Hansson
Science (New York, N.Y.) - 2011 -
Function of the CysD domain of the gel-forming MUC2
mucin.
Daniel Ambort, Sjoerd van der Post, Malin E V Johansson, J. Mackenzie, Elisabeth Thomsson, Ute Krengel, Gunnar C. Hansson
Biochem Journal - 2011 -
Keeping Bacteria at a
Distance
Malin E V Johansson, Gunnar C. Hansson
Science - 2011 -
The two mucus layers of colon are organized by the MUC2 mucin – the outer layer is a legislator of host-microbial
interactions.
Malin E V Johansson, Jessica Holmén Larsson, Gunnar C. Hansson
Proc. Natl. Acad. Sci. USA - 2011 -
An Altered O-glycosylation Profile of the MUC2 Mucin Occurs in Active Ulcerative Colitis and is Associated with Increased
Inflammation.
Jessica Holmén Larsson, Hasse Karlsson, Jessica Gråberg Crespo, Malin E V Johansson, Lisbeth Eklund, Henrik Sjövall, Gunnar C. Hansson
Infl. Bowel Dis. - 2011 -
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial
interactions.
Malin E V Johansson, Jessica Holmén Larsson, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2011 -
Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased
inflammation.
Jessica Holmén Larsson, Hasse Karlsson, Jessica Gråberg Crespo, Malin E V Johansson, Lisbeth Eklund, Henrik Sjövall, Gunnar C. Hansson
Inflammatory bowel diseases - 2011 -
Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in
mice.
Jianxin Fu, Bo Wei, Tao Wen, Malin E V Johansson, Xiaowei Liu, Emily Bradford, Kristina A Thomsson, Samuel McGee, Lilah Mansour, Maomeng Tong, J Michael McDaniel, Thomas J Sferra, Jerrold R Turner, Hong Chen, Gunnar C. Hansson, Jonathan Braun, Lijun Xia
The Journal of clinical investigation - 2011 -
Lactobacillus and Bifidobacterium species do not secrete protease that cleaves the MUC2 mucin which organises the colon
mucus.
Durai B Subramani, Malin E V Johansson, Gunnar Dahlén, Gunnar C. Hansson
Beneficial microbes - 2010 -
Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis
model.
Malin E V Johansson, Jenny K Gustafsson, Karolina E Sjöberg, Joel Petersson, Lena Holm, Henrik Sjövall, Gunnar C. Hansson
PloS one - 2010 -
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of
bacteria.
Gunnar C. Hansson, Malin E V Johansson
Gut microbes - 2010 -
Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp
protein.
Malin E V Johansson, Kristina A Thomsson, Gunnar C. Hansson
Journal of proteome research - 2009 -
The MUC2 mucin -A network in the intestinal protective
mucus
Malin E V Johansson
2009 -
The gastric mucus layers: constituents and regulation of
accumulation.
Mia Phillipson, Malin E V Johansson, Johanna Henriksnäs, Joel Petersson, Sandra J. Gendler, Stellan Sandler, A Erik G Persson, Gunnar C. Hansson, Lena Holm
American journal of physiology. Gastrointestinal and liver physiology - 2008 -
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of
bacteria.
Malin E V Johansson, Mia Phillipson, Joel Petersson, Anna Velcich, Lena Holm, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2008 -
Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin
expression.
Emily Malmberg, Karin Noaksson, Mia Phillipson, Malin E V Johansson, Marina Hinojosa-Kurtzberg, Lena Holm, Sandra J. Gendler, Gunnar C. Hansson
American journal of physiology. Gastrointestinal and liver physiology - 2006 -
Biosynthesis and Secretion of Mucins, Especially the MUC2 Mucin, in Relation to Cystic
Fibrosis
Gunnar C. Hansson, Malin E V Johansson, Martin Lidell
Advances in Experimental Medicine and Biology - 2005 -
Novel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient
mice.
A Marina Hinojosa-Kurtzberg, Malin E V Johansson, Cathy S Madsen, Gunnar C. Hansson, Sandra J Gendler
American journal of physiology. Gastrointestinal and liver physiology - 2003 -
An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory
pathway.
Martin Lidell, Malin E V Johansson, Gunnar C. Hansson
The Journal of biological chemistry - 2003 -
The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T
cells.
Martin Lidell, Malin E V Johansson, Matthias Mörgelin, Noomi Asker, James R Gum, Young S Kim, Gunnar C. Hansson
The Biochemical journal - 2003 -
The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core
fragment.
Klaus Godl, Malin E V Johansson, Martin Lidell, Matthias Mörgelin, Hasse Karlsson, Fredrik J. Olson, James R Gum, Young S Kim, Gunnar C. Hansson
The Journal of biological chemistry - 2002 -
Blood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during a Nippostrongylus brasiliensis parasite
infection.
Fredrik J. Olson, Malin E V Johansson, Karin Klinga-Levan, Danièle Bouhours, Lennart Enerbäck, Gunnar C. Hansson, Niclas G. Karlsson
The Journal of biological chemistry - 2002 -
Lithium evokes a more pronounced natriuresis when administered orally than when given intravenously to salt-depleted
rats.
J Mu, Malin E V Johansson, Gunnar C. Hansson, Ove Lundgren
Pflügers Archiv : European journal of physiology - 1999 -
The glycosylation of rat intestinal Muc2 mucin varies between rat strains and the small and large intestine. A study of O-linked oligosaccharides by a mass spectrometric
approach.
Niclas G. Karlsson, A Herrmann, Hasse Karlsson, Malin E V Johansson, I Carlstedt, Gunnar C. Hansson
The Journal of biological chemistry - 1997 -
Molecular characterization of the large heavily glycosylated domain glycopeptide from the rat small intestinal Muc2
mucin.
Niclas G. Karlsson, Malin E V Johansson, Noomi Asker, Hasse Karlsson, S J Gendler, I Carlstedt, Gunnar C. Hansson
Glycoconjugate journal - 1996