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Anna Casselbrant
Forskare
Avd för kirurgiOm Anna Casselbrant
Head of Tissue Lab, Associate Professor
Thesis 2005: The nitric oxide and renin-angiotensin II system in the human esophagus
Om Anna Casselbrant
Forskningsområde:
Tarmens betydelse för metabol kontroll
Aktuell forskning
Huvudsyftet med projektet är att förstå mekanismer bakom de många hälsorelaterade effekter som uppkommer efter viktminskande kirurgi, så som Roux-en-Y Gastric Bypass (RYGB). Operationen leder till viktnedgång men många av effekter uppkommer redan innan viktnedgången har börjat. Eftersom det kirurgiska förfarandet är begränsat till övre-magtarmområdet kan det antas att interferensen med metabolisk kontroll är kopplad till matsmältnings/absorberande processer i tunntarmen.
Frågeställningar
1. Frisättning av mättnads- och insulinstimulerande tarmhormoner
2. Kalciumupptag
3. Glukosupptag
4. Tunntarmspermeabilitet
5. Tunntarmsmorfologi
Pågående doktorandprojekt:
· Erik Elebring: Intestinal ketogenes och dess inverkan på blodsockerreglering
· Jasmin Bagge: Protective intervention during the storage of intestinal graft
Bakgrund
Anna Casselbrant har en docentur i ämnet Biomedicinsk Laboratorievetenskap, vilket innebär att en stor del av arbetet har rört metodikutveckling inom laborativ fysiologi. Anna har arbetat med övre mag-tarmkanalen under mer är 15 år, och har genomgående studerat olika reglersystem på human-material vilket är en svårighet i sig. Ett bra exempel på detta är hennes avhandling som beskriver två reglersystem, båda med funktionell betydelse med titeln ”The nitric oxide and renin-angiotensin II system in the human esophagus”.
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Intestinal Ketogenesis and
Permeability
Anna Casselbrant, Erik Elias, Peter Hallersund, Erik Elebring, Jakob Cervin, Lars Fändriks, Ville Wallenius
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 2024 -
Role of FFAR3 in ketone body regulated glucagon-like peptide 1
secretion
Sara M.T. Persson, Anna Casselbrant, Aiham Alarai, Erik Elebring, Lars Fändriks, Ville Wallenius
BIOCHEMISTRY AND BIOPHYSICS REPORTS - 2024 -
βHB inhibits glucose-induced GLP-1 secretion in GLUTag and human jejunal
enteroids
Erik Elebring, Anna Casselbrant, Sara M.T. Persson, Lars Fändriks, Ville Wallenius
Journal of molecular endocrinology - 2023 -
Mucosal Recovery after Intestinal Transplantation in the Rat: A Sequential Histological and Molecular
Assessment
Jasmine Bagge, Arvind M. Padma, Anna Casselbrant, Mats Hellström, Mihai Oltean
European Surgical Research - 2023 -
Morphological Adaptation in the Jejunal Mucosa after Iso-Caloric High-Fat versus High-Carbohydrate Diets in Healthy Volunteers: Data from a Randomized Crossover
Study
Anna Casselbrant, Ville Wallenius, Erik Elebring, Hanns-Ulrich Marschall, Bengt R Johansson, Herbert F Helander, Lars Fändriks
Nutrients - 2022 -
A Fatty Diet Induces a Jejunal Ketogenesis Which Inhibits Local SGLT1-Based Glucose Transport via an Acetylation Mechanism-Results from a Randomized Cross-Over Study between Iso-Caloric High-Fat versus High-Carbohydrate Diets in Healthy
Volunteers
Erik Elebring, Ville Wallenius, Anna Casselbrant, N. G. Docherty, C. W. le Roux, Hanns-Ulrich Marschall, Lars Fändriks
Nutrients - 2022 -
Asymmetric mucosal structure, mesenteric versus antimesenteric, in mouse, rat, and human small
intestines
Anna Casselbrant, Herbert F Helander
Physiological Reports - 2022 -
The proteomic signature of intestinal acute rejection in the
mouse
Mihai Oltean, Jasmine Bagge, George Dindelegan, Diarmuid T. Kenny, Antonio Molinaro, Mats Hellström, Ola Nilsson, C. Sihlbom, Anna Casselbrant, Marcela Dávila López, Michael Olausson
Metabolites - 2022 -
Glycemic Control and Metabolic Adaptation in Response to High-Fat versus High-Carbohydrate Diets-Data from a Randomized Cross-Over Study in Healthy
Subjects.
Ville Wallenius, Erik Elebring, Anna Casselbrant, Anna Laurenius, Carel W le Roux, Neil G Docherty, Christina Biörserud, Niclas Björnfot, My Engström, Hanns-Ulrich Marschall, Lars Fändriks
Nutrients - 2021 -
Luminal polyethylene-glycol solution delays the onset of preservation injury in the human
intestine.
John M. Söfteland, Jasmine Bagge, Arvind M. Padma, Anna Casselbrant, Changlian Zhu, Yafeng Wang, Mats Hellström, Michael Olausson, Mihai Oltean
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 2021 -
Intestinal sodium/glucose cotransporter 3 expression is epithelial and downregulated in
obesity.
Matus Sotak, Anna Casselbrant, Tamara Zietek, Maria Strömstedt, Damilola D Adingupu, Daniel Karlsson, Maria Fritsch Fredin, Peter Ergang, Jiří Pácha, Anna Batorsky, Charles E Alpers, Emma Börgeson, Pernille Hansen, Anette Ericsson, Anna Björnson Granqvist, Ville Wallenius, Lars Fändriks, Robert J Unwin
Life sciences - 2021 -
Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie
diet.
Ville Wallenius, Erik Elias, Erik Elebring, Bauke Haisma, Anna Casselbrant, Pierre Larraufie, Emma Spak, Frank Reimann, Carel W le Roux, Neil G Docherty, Fiona M Gribble, Lars Fändriks
Gut - 2020 -
The impact of age and luminal preservation on the development of intestinal preservation injury in
rats
John M. Söfteland, Anna Casselbrant, Levent Akyürek, Mats Hellström, Mihai Oltean
Transplantation - 2020 -
Glycocholic acid and butyrate synergistically increase vitamin D-induced calcium uptake in Caco-2 intestinal epithelial cell
monolayers
Anna Casselbrant, Lars Fändriks, Ville Wallenius
Bone Reports - 2020 -
Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse
macrophages.
Rebecka Isaksson, Anna Casselbrant, Erik Elebring, Mathias Hallberg, Mats Larhed, Lars Fändriks
European journal of pharmacology - 2020 -
Proteomic Approach to the Potential Role of Angiotensin II in Barrett
Dysplasia
Svein-Olav Bratlie, Ville Wallenius, Anders Edebo, Lars Fändriks, Anna Casselbrant
Proteomics - Clinical Applications - 2019 -
The human duodenal mucosa harbors all components for a local renin angiotensin
system.
Emma Spak, Peter Hallersund, Anders Edebo, Anna Casselbrant, Lars Fändriks
Clinical science (London, England : 1979) - 2019 -
Intestinal Preservation Injury: A Comparison Between Rat, Porcine and Human
Intestines.
John Mackay Søfteland, Anna Casselbrant, Ali-Reza Biglarnia, Johan Linders, Mats Hellström, Antonio Pesce, Arvind M. Padma, Lucian Petru Jiga, Bogdan Hoinoiu, Mihai Ionac, Mihai Oltean
International journal of molecular sciences - 2019 -
GM1 ganglioside-independent intoxication by Cholera
toxin
Jakob Cervin, Amberlyn M Wands, Anna Casselbrant, Han Wu, Soumya Krishnamurthy, Aleksander Cvjetkovic, Johanna Estelius, Benjamin Dedic, Anirudh Sethi, Kerri-Lee Wallom, Rebecca E Riise, Malin Bäckström, Ville Wallenius, Frances M Platt, Michael Lebens, Susann Teneberg, Lars Fändriks, Jennifer J Kohler, Ulf Yrlid
PLoS Pathogens - 2018 -
Luminal Polyethylene Glycol Alleviates Intestinal Preservation Injury Irrespective of Molecular
Size
Anna Casselbrant, John M. Söfteland, Mats Hellström, Mantas Malinauskas, Mihai Oltean
Journal of Pharmacology and Experimental Therapeutics - 2018 -
Effects of fixation on electrophysiology and structure of human jejunal
villi
Anna Casselbrant, Herbert F Helander
Microscopy Research and Technique - 2018 -
A sequential assessment of the preservation injury in porcine
intestines
Mihai Oltean, L. Jiga, Mats Hellström, John M. Söfteland, M. Papurica, T. Hoinoiu, M. Ionac, Anna Casselbrant
Journal of Surgical Research - 2017 -
Support for involvement of the renin-angiotensin system in dysplastic Barrett's
esophagus
Svein-Olav Bratlie, Anna Casselbrant, Anders Edebo, Lars Fändriks
Scandinavian Journal of Gastroenterology - 2017 -
The renin–angiotensin system in Barrett’s
esophagus
Svein-Olav Bratlie, Anders Edebo, Anna Casselbrant, Herbert F Helander, Lars Fändriks
Scandinavian Journal of Gastroenterology - 2016 -
Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass
surgery
Anna Casselbrant, Erik Elias, Lars Fändriks, Ville Wallenius
Surgery for Obesity and Related Diseases - 2015 -
Luminal solutions protect mucosal barrier during extended
preservation.
Mihai Oltean, Mats Hellström, Catalin Ciuce, Changlian Zhu, Anna Casselbrant
The Journal of surgical research - 2015 -
Local expression of AP/AngIV/IRAP and effect of AngIV on glucose-induced epithelial transport in human jejunal
mucosa
Mantas Malinauskas, Ville Wallenius, Lars Fändriks, Anna Casselbrant
Journal of the renin-angiotensin-aldosterone system - 2015 -
Angiotensin II exerts dual actions on sodium-glucose transporter 1-mediated transport in the human jejunal
mucosa
Anna Casselbrant, Mantas Malinauskas, Hanns-Ulrich Marschall, Ville Wallenius, Lars Fändriks
Scandinavian Journal of Gastroenterology - 2015 -
Angiotensin IV and the human esophageal mucosa: An exploratory study in healthy subjects and gastroesophageal reflux disease
patients.
Eleonora Björkman, Anders Edebo, Lars Fändriks, Anna Casselbrant
Journal of the renin-angiotensin-aldosterone system : JRAAS - 2015 -
The muscular expression of RAS in patients with
achalasia.
Anna Casselbrant, Srdjan Kostic, Hans Lönroth
Journal of the renin-angiotensin-aldosterone system : JRAAS - 2015 -
Oxidative and nitrosative stress enzymes in relation to nitrotyrosine in Helicobacter pylori -infected
humans
Anders Elfvin, Anders Edebo, Peter Hallersund, Anna Casselbrant, Lars Fändriks
World Journal of Gastrointestinal Pathophysiology - 2014 -
Angiotensin IV induced contractions in human jejunal wall musculature in
vitro
Malinauskas Mantas, Stankevičius Edgaras, Anna Casselbrant
Peptides - 2014 -
Bone mineral density and expression of vitamin D receptor-dependent calcium uptake mechanisms in the proximal small intestine after bariatric
surgery
Erik Elias, Anna Casselbrant, Malin Werling, K Abegg, RP Vincent, J Alaghband-Zadeh, Torsten Olbers, Carel W le Roux, Lars Fändriks, Ville Wallenius
British Journal of Surgery - 2014 -
Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease: functionality of esophageal mucosa exposed to bile salt and trypsin in
vitro
Eleonora Björkman, Anders Edebo, Mihai Oltean, Anna Casselbrant
Scandinavian Journal of Gastroenterology - 2013 -
The renin-angiotensin system in the esophageal mucosa of healthy subjects and patients with reflux
disease
Eleonora Björkman, Anders Edebo, Anna Casselbrant, Herbert F Helander, Svein-Olav Bratlie, Vieth Michael, Lars Fändriks
Scandinavian Journal of Gastroenterology - 2013 -
Antibodies to kidney endothelial cells contribute to a "leaky" glomerular barrier in patients with chronic kidney
diseases.
Nidia Maritza Hernandez, Anna Casselbrant, Meghnad Joshi, Bengt R Johansson, Suchitra Sumitran-Holgersson
American journal of physiology. Renal physiology - 2012 -
In vitro assessment of epithelial electrical resistance in human esophageal and jejunal mucosae and in Caco-2 cell
layers.
Eleonora Björkman, Anna Casselbrant, Sören Lundberg, Lars Fändriks
Scandinavian journal of gastroenterology - 2012 -
Intraluminal Polyethylene Glycol Stabilizes Tight Junctions and Improves Intestinal Preservation in the
Rat
Mihai Oltean, Meghnad Joshi, Eleonora Björkman, S Oltean, Anna Casselbrant, Gustaf Herlenius, Michael Olausson
American Journal of Transplantation - 2012 -
Expression of reactive oxygen species in reflux
disease
Emma Andreasson, Anna Casselbrant
Gastrointestinal Endoscopy - 2011 -
Angiotensin II receptor expression and relation to Helicobacter pylori-infection in the stomach of the Mongolian
gerbil.
Peter Hallersund, Herbert F Helander, Anna Casselbrant, Anders Edebo, Lars Fändriks, Anders Elfvin
BMC gastroenterology - 2010 -
Changes in the mucosa of the Roux-limb after gastric bypass
surgery.
Emma Spak, Per Björklund, Herbert F Helander, Michael Vieth, Torsten Olbers, Anna Casselbrant, Hans Lönroth, Lars Fändriks
Histopathology - 2010 -
Angiotensin II receptors are expressed and functional in human esophageal
mucosa.
Anna Casselbrant, Anders Edebo, Peter Hallersund, Emma Spak, Herbert F Helander, Claes Jönson, Lars Fändriks
American journal of physiology. Gastrointestinal and liver physiology - 2009 -
Expression of protease-activated-receptor 2 (PAR-2) in human esophageal
mucosa.
Kamuran Inci, Anders Edebo, Lars Olbe, Anna Casselbrant
Scandinavian journal of gastroenterology - 2009 -
Angiotensin II-induced contractions in human jejunal wall musculature in
vitro.
Emma Spak, Anna Casselbrant, Torsten Olbers, Hans Lönroth, Lars Fändriks
Acta physiologica (Oxford, England) - 2008 -
Actions by angiotensin II on esophageal contractility in
humans
Anna Casselbrant, Anders Edebo, Johanna Wennerblom, Hans Lönroth, Herbert F Helander, M. Vieth, L. Lundell, Lars Fändriks
Gastroenterology - 2007 -
Acid challenge to the esophageal mucosa: effects on local nitric oxide formation and its relation to epithelial
functions
Mogens Bove, M. Vieth, Anna Casselbrant, Lars Ny, L. Lundell, Magnus Ruth
Dig Dis Sci - 2005 -
The Nitric Oxide and Renin-angiotensin II Systems in the Human
Esophagus
Anna Casselbrant
2005 -
Oesophageal intraluminal nitric oxide facilitates the acid-induced oesophago-salivary
reflex
Anna Casselbrant, Anders Pettersson, Lars Fändriks
Scand J Gastroenterol - 2003 -
Effects of Dietary Nitrate on Oesophageal Motor Function and Gastro-Oesophageal Acid Exposure in Healthy Volunteers and Reflux
Patients
Mogens Bove, Lars Lundell, Lars Ny, Anna Casselbrant, Lars Fändriks, A Pettersson, Magnus Ruth
Digestion - 2003 -
Sources of Intra-Oesophageal Nitric Oxide Production Following Intraluminal Acid
Exposure
Anna Casselbrant, Anders Pettersson, Magnus Ruth, Mogens Bove, Lars Lundell, Lars Fändriks
Scandinavian Journal of Gastroenterology - 2002 -
Angiotensin II type 2 receptor-mediated duodenal mucosal alkaline secretion in the
rat
Berndt Johansson, Mathias Holm, Sara Ewert, Anna Casselbrant, Anders Pettersson, Lars Fändriks
American Journal of Physiology - Gastrointestinal and Liver Physiology - 2001 -
Dynamic Involvement of the Inducible Type of Nitric Oxide Synthase in Acid-Induced Duodenal Mucosal Alkaline Secretion in the
Rat
Mathias Holm, Theresa L Powell, Anna Casselbrant, Berndt Johansson, Lars Fändriks
Digestive Diseases and Sciences - 2001 -
Effects of hypovolaemia on acid-induced duodenal mucosal damage in the
rat.
B Johansson, Anna Casselbrant, M Holm, Charlotte Von Bothmer, Bengt R Johansson, Lars Fändriks
Acta Physiologica Scandinavica - 2001 -
Tonometric assessment of jejunal mucosal nitric oxide formation in anaesthetized
pigs
Johan Snygg, Anna Casselbrant, Anders Pettersson, Mathias Holm, Lars Fändriks, Anders Åneman
Acta Physiologica Scandinavica - 2000 -
Infiltration and Lysis of Tumour Cell Aggregates by Adherent lnterleukin-2-Activated Natural Killer Cells Is Distinct from Specific
Cytolysis
Bengt R Johansson, Martin Unger, Per Albertsson, Anna Casselbrant, Ulf Nannmark, Marianne Hokland
Natural immunity - 1996