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- Anna-Karin Hultgård Ekwall
Anna-Karin Hultgård Ekwall
Universitetslektor, adjungerad
Avd för reumatologi och inflammationsforskningOm Anna-Karin Hultgård Ekwall
Om Anna-Karin Hultgård Ekwall
Anna-Karin Ekwall är specialistläkare i reumatologi på Sahlgrenska universitetssjukhuset sedan 2013 och docent i reumatologi och inflammation vid Göteborgs universitet sedan 2020.
Anna-Karin erhöll masterexamen i cell- och molekylärbiologi 1994 och läkarexamen 2001 vid Uppsala universitet där också doktorsavhandling om fibroblastbiologi vid inflammation, och speciellt Ménières sjukdom, lades fram 2006. Under två postdoktorala arbeten, dels vid Göteborgs universitet 2007-2011 och sedan vid University of California San Diego, USA, 2013-2014, fördjupade sig Anna-Karin i studier av ledinflammation och det aggressiva beteendet av fibroblaster i leden vid reumatoid artrit (RA).
Forskning
Anna-Karin Ekwall leder en forskningsgrupp på Avdelningen för reumatologi och inflammationsforskning som studerar stromacellers betydelse vid inflammation och reumatisk sjukdom med fokus på nya terapimål.
Läs mer om forskargruppen Stromaceller vid inflammation och reumatisk sjukdom – nya terapimål
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Circulating Baseline CXCR3+Th2 and Th17 Cell Proportions Correlate With Trabecular Bone Loss After 48 Weeks of Biological Treatment in Early Rheumatoid
Arthritis
Julia Scheffler, Christina Drevinge, Catharina Lindholm, Inger Gjertsson, Kristina Lend, Merete Lund Hetland, Mikkel Ostergaard, Till Uhlig, Marte Schrumpf Heiberg, Espen A. Haavardsholm, Michael T. Nurmohamed, Jon Lampa, Tuulikki Sokka-Isler, Dan Nordstrom, Kim Horslev-Petersen, Bjorn Gudbjornsson, Gerdur Grondal, Ronald van Vollenhoven, Hans Carlsten, Mattias Lorentzon, Anna-Karin Hultgård Ekwall, Anna Rudin, Ulrika Islander
ACR OPEN RHEUMATOLOGY - 2024 -
Cartilage destruction in early rheumatoid arthritis patients correlates with CD21−/low double-negative B
cells
Katrin Thorarinsdottir, Sarah McGrath, Kristina Forslind, Monica Leu Agelii, Anna-Karin Hultgård Ekwall, Lennart T. H. Jacobsson, Anna Rudin, Inga-Lill Mårtensson, Inger Gjertsson
Arthritis Research and Therapy - 2024 -
Methotrexate promotes the release of granulocyte-macrophage colony-stimulating factor from rheumatoid arthritis fibroblast-like synoviocytes via autocrine interleukin-1
signaling
Beatrice Bergström, Tilia Selldén, Miriam Bollmann, Mattias N D Svensson, Anna-Karin Hultgård Ekwall
ARTHRITIS RESEARCH & THERAPY - 2024 -
Dynamic Release from Acetalated Dextran Nanoparticles for Precision Therapy of
Inflammation
Gizem Erensoy, Loise Råberg, Ula von Mentzer, Luca Dirk Menges, Endri Bardhi, Anna-Karin Hultgård Ekwall, Alexandra Stubelius
ACS Applied Bio Materials - 2024 -
Correlation of Professional Antigen-Presenting Tbet+CD11c+ B Cells With Bone Destruction in Untreated Rheumatoid
Arthritis
Sarah McGrath, Kristoffer Grimstad, Katrin Thorarinsdottir, Kristina Forslind, Daniel Glinatsi, Monica Leu Agelii, Alaitz Aranburu, Timothy Sundell, Charlotte A Jonsson, Alessandro Camponeschi, Anna-Karin Hultgård Ekwall, Andreas Tilevik, Inger Gjertsson, Inga-Lill Mårtensson
ARTHRITIS & RHEUMATOLOGY - 2024 -
Radiographic airway abnormalities in untreated early rheumatoid arthritis are associated with peripheral neutrophil
activation
Tilia Selldén, Carina Kärrman Mårdh, Martin Joelsson, Jenny Vikgren, Åse (Allansdotter) Johnsson, Gunilla Larsson, D. Glinatsi, K. Stubendorff, K. Svensson, Inger Gjertsson, Anna Rudin, Anna-Carin Lundell, Anna-Karin Hultgård Ekwall
Arthritis Research & Therapy - 2023 -
Autoantibodies to Disease-Related Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid
Arthritis
E. Lonnblom, Monica Leu Agelii, Outi Sareila, L. Cheng, B. Z. Xu, J. Viljanen, I. Hafstrom, M. L. E. Andersson, G. Bergstrom, Anna-Karin Hultgård Ekwall, Anna Rudin, A. Kastbom, C. Sjowall, Lennart T. H. Jacobsson, J. Kihlberg, Inger Gjertsson, R. Holmdahl
Arthritis & Rheumatology - 2023 -
Blood PD-1+TFh and CTLA-4+CD4+ T cells predict remission after CTLA-4Ig treatment in early rheumatoid
arthritis.
Jonathan Aldridge, Kerstin Andersson, Inger Gjertsson, Anna-Karin H Ekwall, Magnus Hallström, Ronald van Vollenhoven, Anna-Carin Lundell, Anna Rudin
Rheumatology (Oxford, England) - 2022 -
Synovial fluid profile dictates nanoparticle uptake into cartilage-implications of the protein corona for novel arthritis
treatments
U. von Mentzer, T. Sellden, L. Raberg, G. Erensoy, Anna-Karin Hultgård Ekwall, A. Stubelius
Osteoarthritis and Cartilage - 2022 -
Activated low-density granulocytes in peripheral and intervillous blood and neutrophil inflammation in placentas from SLE
pregnancies.
Marit Stockfelt, Gunilla Larsson, Hanna Engström, Henri Puttonen, Henrik Zetterberg, Kaj Blennow, Christopher Sjöwall, Helena Strevens, Andreas Jönsen, Anders A Bengtsson, Maria Majczuk Sennström, Agneta Zickert, Elisabet Svenungsson, Iva Gunnarsson, Estelle Trysberg, Bo Jacobsson, Anna-Karin Hultgård Ekwall, Karin Christenson, Johan Bylund, Mattias N D Svensson, Anna-Carin Lundell
Lupus science & medicine - 2021 -
Intermediate monocytes correlate with CXCR3(+) Th17 cells but not with bone characteristics in untreated early rheumatoid
arthritis
Christina Drevinge, Julia M. Scheffler, Catalin Koro-Arvidsson, Daniel Sundh, Hans Carlsten, Inger Gjertsson, Catharina Lindholm, Mattias Lorentzon, Anna Rudin, Anna-Karin Hultgård Ekwall, Ulrika Islander
Plos One - 2021 -
Recombinant Adiponectin Induces the Production of Pro-Inflammatory Chemokines and Cytokines in Circulating Mononuclear Cells and Fibroblast-Like Synoviocytes From Non-Inflamed
Subjects
Yuan Zhang, Jonathan Aldridge, Georgios Vasileiadis, H. Edebo, Anna-Karin H Ekwall, Anna-Carin Lundell, Anna Rudin, Cristina Maglio
Frontiers in Immunology - 2021 -
T helper cells in synovial fluid of patients with rheumatoid arthritis primarily have a Th1 and a CXCR3(+)Th2
phenotype
Jonathan Aldridge, Anna-Karin H Ekwall, Linda Mark, Beatrice Bergström, Kerstin Andersson, Inger Gjertsson, Anna-Carin Lundell, Anna Rudin
Arthritis Research & Therapy - 2020 -
Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis
reversal.
Mattias N D Svensson, Martina Zoccheddu, Shen Yang, Gyrid Nygaard, Christian Secchi, Karen M Doody, Kamil Slowikowski, Fumitaka Mizoguchi, Frances Humby, Rebecca Hands, Eugenio Santelli, Cristiano Sacchetti, Kuninobu Wakabayashi, Dennis J Wu, Christopher Barback, Rizi Ai, Wei Wang, Gary P Sims, Piotr Mydel, Tsuyoshi Kasama, David L Boyle, Francesco Galimi, David Vera, Michel L Tremblay, Soumya Raychaudhuri, Michael B Brenner, Gary S Firestein, Costantino Pitzalis, Anna-Karin H Ekwall, Stephanie M Stanford, Nunzio Bottini
Science advances - 2020 -
Active conventional treatment and three different biological treatments in early rheumatoid arthritis: phase IV investigator initiated, randomised, observer blinded clinical
trial
M. L. Hetland, E. A. Haavardsholm, Anna Rudin, D. Nordstrom, M. Nurmohamed, B. Gudbjornsson, J. Lampa, K. Horslev-Petersen, T. Uhlig, G. Grondal, M. Ostergaard, M. S. Heiberg, J. Twisk, K. Lend, S. Krabbe, L. H. Hyldstrup, J. Lindqvist, Anna-Karin H Ekwall, K. L. Gron, M. Kapetanovic, F. Faustini, R. Tuompo, T. Lorenzen, G. Cagnotto, E. Baecklund, O. Hendricks, D. Vedder, T. Sokka-Isler, T. Husmark, M. K. A. Ljosa, E. Brodin, T. Ellingsen, A. Soderbergh, M. Rizk, A. R. Olsson, P. Larsson, L. Uhrenholt, S. A. Just, D. J. Stevens, T. B. Laurberg, G. Bakland, I. C. Olsen, R. van Vollenhoven, Nord Star Study Grp Nord Star Study Grp
Bmj-British Medical Journal - 2020 -
The Rheumatoid Arthritis Risk Gene AIRE Is Induced by Cytokines in Fibroblast-Like Synoviocytes and Augments the Pro-inflammatory
Response
Beatrice Bergström, Christina Lundqvist, Georgios Vasileiadis, Hans Carlsten, Olov Ekwall, Anna-Karin H Ekwall
Frontiers in Immunology - 2019 -
Methotrexate inhibits effects of platelet-derived growth factor and interleukin-1β on rheumatoid arthritis fibroblast-like
synoviocytes
Beatrice Bergström, Hans Carlsten, Anna-Karin H Ekwall
Arthritis Research and Therapy - 2018 -
LBH Gene Transcription Regulation by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid
Arthritis
D. Hammaker, J. W. Whitaker, K. Maeshima, D. L. Boyle, Anna-Karin H Ekwall, W. Wang, G. S. Firestein
Arthritis & Rheumatology - 2016 -
The rheumatoid arthritis risk gene LBH regulates growth in fibroblast-like
synoviocytes
Anna-Karin H Ekwall, John W. Whitaker, Deepa Hammaker, William D. Bugbee, Wei Wang, Gary S. Firestein
Arthritis and Rheumatology - 2015 -
The O-glycomap of Lubricin, a Novel Mucin Responsible for Joint Lubrication, Identified by Site-specific Glycopeptide
Analysis
Liaqat Ali, Sarah A. Flowers, Chunsheng Jin, E. P. Bennet, Anna-Karin H Ekwall, Niclas G. Karlsson
Molecular & Cellular Proteomics - 2014 -
Fms-like tyrosine kinase 3 ligand controls formation of regulatory T cells in autoimmune
arthritis.
Mattias Svensson, Sofia E M Andersson, Malin Erlandsson, Ing-Marie Jonsson, Anna-Karin H Ekwall, Karin Andersson, Anders Nilsson, Li Bian, Mikael Brisslert, Maria Bokarewa
PloS one - 2013 -
Human Synovial Lubricin Expresses Sialyl Lewis x Determinant and Has L-selectin Ligand
Activity
Chunsheng Jin, Anna-Karin H Ekwall, Johan Bylund, Lena Björkman, R. P. Estrella, J. M. Whitelock, T. Eisler, Maria Bokarewa, Niclas G. Karlsson
Journal of Biological Chemistry - 2012 -
The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid
arthritis.
Anna-Karin H Ekwall, Thomas Eisler, Christian Anderberg, Chunsheng Jin, Niclas G. Karlsson, Mikael Brisslert, Maria Bokarewa
Arthritis research & therapy - 2011 -
Resistin and insulin/insulin-like growth factor signaling in rheumatoid
arthritis.
Elisabeth Almer Boström, Mattias Svensson, Sofia E M Andersson, Ing-Marie Jonsson, Anna-Karin H Ekwall, Thomas Eisler, Leif E Dahlberg, Ulf Smith, Maria Bokarewa
Arthritis and rheumatism - 2011 -
SURVIVIN IS AN ESSENTIAL MEDIATOR OF ARTHRITIS INTERACTING WITH UROKINASE
SIGNALLING.
M Baran, LN Möllers, Sofia E M Andersson, Ing-Marie Jonsson, Anna-Karin H Ekwall, Jan Bjersing, Andrej Tarkowski, Maria Bokarewa
Journal of cellular and molecular medicine - 2009