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Mattias Svensson
Forskare
Institutionen för medicinAvd-/Sektionschef, bitr, inst
Avd för reumatologi och inflammationsforskningOm Mattias Svensson
Se mer information om Mattias forskning på hans engelska sida.
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Immunomodulatory Nanoparticles for Modulating Arthritis
Flares
Wade T Johnson, David McBride, Matthew Kerr, Anders Nguyen, Martina Zoccheddu, Miriam Bollmann, Xiaofu Wei, Ryan M Jones, Wei Wang, Mattias N D Svensson, Nunzio Bottini, Nisarg J Shah
ACS nano - 2023 -
Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune
Arthritis
D. A. McBride, M. D. Kerr, W. T. Johnson, Anders Nguyen, M. Zoccheddu, M. N. Yao, E. B. Prideaux, N. C. Dorn, W. Wang, Mattias N D Svensson, N. Bottini, N. J. Shah
Advanced Science - 2023 -
Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor
function.
Richard I Ainsworth, Deepa Hammaker, Gyrid Nygaard, Cecilia Ansalone, Camilla Machado, Kai Zhang, Lina Zheng, Lucy Carrillo, Andre Wildberg, Amanda Kuhs, Mattias N D Svensson, David L Boyle, Gary S Firestein, Wei Wang
Nature communications - 2022 -
Activated low-density granulocytes in peripheral and intervillous blood and neutrophil inflammation in placentas from SLE
pregnancies.
Marit Stockfelt, Gunilla Larsson, Hanna Engström, Henri Puttonen, Henrik Zetterberg, Kaj Blennow, Christopher Sjöwall, Helena Strevens, Andreas Jönsen, Anders A Bengtsson, Maria Majczuk Sennström, Agneta Zickert, Elisabet Svenungsson, Iva Gunnarsson, Estelle Trysberg, Bo Jacobsson, Anna-Karin Hultgård Ekwall, Karin Christenson, Johan Bylund, Mattias N D Svensson, Anna-Carin Lundell
Lupus science & medicine - 2021 -
Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis
reversal.
Mattias N D Svensson, Martina Zoccheddu, Shen Yang, Gyrid Nygaard, Christian Secchi, Karen M Doody, Kamil Slowikowski, Fumitaka Mizoguchi, Frances Humby, Rebecca Hands, Eugenio Santelli, Cristiano Sacchetti, Kuninobu Wakabayashi, Dennis J Wu, Christopher Barback, Rizi Ai, Wei Wang, Gary P Sims, Piotr Mydel, Tsuyoshi Kasama, David L Boyle, Francesco Galimi, David Vera, Michel L Tremblay, Soumya Raychaudhuri, Michael B Brenner, Gary S Firestein, Costantino Pitzalis, Anna-Karin H Ekwall, Stephanie M Stanford, Nunzio Bottini
Science advances - 2020 -
PTPN2 links colonic and joint inflammation in experimental autoimmune
arthritis
W. C. Hsieh, Mattias Svensson, M. Zoccheddu, M. L. Tremblay, S. Sakaguchi, S. M. Stanford, N. Bottini
Jci Insight - 2020 -
RPTP? phosphatase activity is allosterically regulated by the membrane-distal catalytic
domain
Y. T. Wen, S. Yang, K. Wakabayashi, Mattias Svensson, S. M. Stanford, E. Santelli, N. Bottini
Journal of Biological Chemistry - 2020 -
PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR
signaling.
Shen Yang, Mattias N D Svensson, Nathaniel H O Harder, Wan-Chen Hsieh, Eugenio Santelli, William B Kiosses, James J Moresco, John R Yates, Charles C King, Lin Liu, Stephanie M Stanford, Nunzio Bottini
Science signaling - 2020 -
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in
autoimmunity.
Mattias N D Svensson, Karen M Doody, Benjamin J Schmiedel, Sourya Bhattacharyya, Bharat Panwar, Florian Wiede, Shen Yang, Eugenio Santelli, Dennis J Wu, Cristiano Sacchetti, Ravindra Gujar, Gregory Seumois, William B Kiosses, Isabelle Aubry, Gisen Kim, Piotr Mydel, Shimon Sakaguchi, Mitchell Kronenberg, Tony Tiganis, Michel L Tremblay, Ferhat Ay, Pandurangan Vijayanand, Nunzio Bottini
The Journal of clinical investigation - 2019 -
Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant
ZAP70.
Meng Zhao, Mattias N D Svensson, Koen Venken, Ashu Chawla, Shu Liang, Isaac Engel, Piotr Mydel, Jeremy Day, Dirk Elewaut, Nunzio Bottini, Mitchell Kronenberg
Nature communications - 2018 -
IGF-1R signalling contributes to IL-6 production and T cell dependent inflammation in rheumatoid
arthritis.
Malin Erlandsson, Sofia Silfverswärd Lindblad, Mitra Nadali, Minna Turkkila, Mattias Svensson, Ing-Marie Jonsson, Karin Andersson, Maria Bokarewa
Biochimica et Biophysica Acta - Molecular basis of disease - 2017 -
Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in
Mice.
Stephanie M Stanford, Mattias N D Svensson, Cristiano Sacchetti, Caila A Pilo, Dennis J Wu, William B Kiosses, Annelie Hellvard, Brith Bergum, German R Aleman Muench, Christian Elly, Yun-Cai Liu, Jeroen den Hertog, Ari Elson, Jan Sap, Piotr Mydel, David L Boyle, Maripat Corr, Gary S Firestein, Nunzio Bottini
Arthritis & rheumatology (Hoboken, N.J.) - 2016 -
Impaired signaling through the Fms-like tyrosine kinase 3 receptor increases osteoclast formation and bone damage in
arthritis.
Mattias Svensson, Malin Erlandsson, Ing-Marie Jonsson, Karin Andersson, Maria Bokarewa
Journal of leukocyte biology - 2016 -
Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis
therapy.
Karen M Doody, Stephanie M Stanford, Cristiano Sacchetti, Mattias N D Svensson, Charlotte H Coles, Nikolaos Mitakidis, William B Kiosses, Beatrix Bartok, Camille Fos, Esther Cory, Robert L Sah, Ru Liu-Bryan, David L Boyle, Heather A Arnett, Tomas Mustelin, Maripat Corr, Jeffrey D Esko, Michel L Tremblay, Gary S Firestein, A Radu Aricescu, Nunzio Bottini
Science translational medicine - 2015 -
Murine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch
recombination.
Mattias Svensson, Karin Andersson, Caroline Wasén, Malin Erlandsson, Merja Nurkkala Karlsson, Ing-Marie Jonsson, Mikael Brisslert, Mats Bemark, Maria Bokarewa
Proceedings of the National Academy of Sciences of the United States of America - 2015 -
Survivin co-ordinates formation of follicular T-cells acting in synergy with
Bcl-6
Karin Andersson, Mikael Brisslert, Nicola Cavallini, Mattias Svensson, Amanda Welin, Malin Erlandsson, M. J. Ciesielski, Gergely Katona, Maria Bokarewa
Oncotarget - 2015 -
Trabecular bone loss in collagen antibody-induced
arthritis
Louise Grahnemo, Annica Andersson, Merja Nurkkala Karlsson, Alexandra Stubelius, Marie K Lagerquist, Mattias Svensson, Claes Ohlsson, Hans Carlsten, Ulrika Islander
Arthritis Research & Therapy - 2015 -
CTLA4-Ig but not anti-TNF therapy promotes staphylococcal septic arthritis in
mice.
Abukar Ali, Amanda Welin, Jan-Christoph Schwarze, Mattias Svensson, Manli Na, Anders Jarneborn, Malin Magnusson, Majd Mohammad, Jakub Kwiecinski, Elisabet Josefsson, Johan Bylund, Rille Pullerits, Tao Jin
The Journal of infectious diseases - 2015 -
IL-1 Receptor Antagonist Treatment Aggravates Staphylococcal Septic Arthritis and Sepsis in
Mice.
Abukar Ali, Manli Na, Mattias Svensson, Malin Magnusson, Amanda Welin, Jan-Christoph Schwarze, Majd Mohammad, Elisabet Josefsson, Rille Pullerits, Tao Jin
PloS one - 2015 -
Down-regulation of survivin alleviates experimental
arthritis.
Karin Andersson, Mattias Svensson, Malin Erlandsson, Ing-Marie Jonsson, Maria Bokarewa
Journal of leukocyte biology - 2015 -
S100A4 regulates the Src-tyrosine kinase dependent differentiation of Th17 cells in rheumatoid
arthritis
Mikael Brisslert, Li Bian, Mattias Svensson, R. F. Santos, Ing-Marie Jonsson, I. Barsukov, Malin Erlandsson, Karin Andersson, A. M. Carmo, Maria Bokarewa
Biochimica Et Biophysica Acta-Molecular Basis of Disease - 2014 -
Fms-like tyrosine kinase 3 ligand controls formation of regulatory T cells in autoimmune
arthritis.
Mattias Svensson, Sofia E M Andersson, Malin Erlandsson, Ing-Marie Jonsson, Anna-Karin H Ekwall, Karin Andersson, Anders Nilsson, Li Bian, Mikael Brisslert, Maria Bokarewa
PloS one - 2013 -
Expression of metastasin S100A4 is essential for bone resorption and regulates osteoclast
function.
Malin Erlandsson, Mattias Svensson, Ing-Marie Jonsson, Li Bian, Noona Ambartsumian, Sofia E M Andersson, Zhiqi Peng, Jukka Vääräniemi, Claes Ohlsson, Karin Andersson, Maria Bokarewa
Biochimica et biophysica acta - 2013 -
Activation of Fms-like tyrosine kinase 3 signaling enhances survivin expression in a mouse model of rheumatoid
arthritis.
Sofia E M Andersson, Mattias Svensson, Malin Erlandsson, Mats Dehlin, Karin Andersson, Maria Bokarewa
PloS one - 2012 -
Resistin and insulin/insulin-like growth factor signaling in rheumatoid
arthritis.
Elisabeth Almer Boström, Mattias Svensson, Sofia E M Andersson, Ing-Marie Jonsson, Anna-Karin H Ekwall, Thomas Eisler, Leif E Dahlberg, Ulf Smith, Maria Bokarewa
Arthritis and rheumatism - 2011