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Eva Millqvist
Om Eva Millqvist
Professor, överläkare och forskare inom klinisk allergologi. Mångårig erfarenhet av såväl kliniskt arbete som undervisning och forskning. Eva Millqvists forskningsområdet är luftvägsöverkänslighet och kronisk hosta.
Forskning
Icke allergisk överkänslighet i luftvägarna och kronisk refraktär hosta utan medicinsk förklaring är ett omfattande kliniskt problem då såväl diagnostik och behandlingsmöjligheter är begränsade. Hostmedicin utan klinisk effekt säljs årligen för miljarder kronor globalt och för cirka 425 miljoner kronor i Sverige.
Aktuell forskning och pågående projekt
I nuläget pågår en klinisk läkemedelsprövning i Fas II. Studien är godkänd av såväl Läkemedelsverket som övriga myndigheter. Forskargruppen har utvecklat ett hostläkemedel baserat på capsaicin (från chilifrukter) som desensitiserar (nedreglerar) så kallade TRP-receptorer (centrala för hosta) genom uttömning av neuropeptider. Metoden åstadkommer minskad hostretbarehet och minskade symptom av hosta. Framförallt är läkemedlet tänkt för patienter med kronisk refraktär hosta men kan också komma att användas för behandling av förkylningshosta.
Medarbetare inom forskningsprojekt
Eva Millqvist, MD, professor, överläkare, ansvarig för studien Ewa Ternesten Hasséus, PhD, docent, legitimerad sjuksköterska, klinisk koordinator Teet Pullerits, MD, PhD, överläkare Ewa-Lena Johansson, PhD, sjukgymnast/physiotherapist Monica Arvidsson, MD, PhD, överläkare, klinikchef Margareta Brandt Gertmo, legitimerad sjuksköterska Foteini Mazi, MD, specialistläkare i allergologi
Finansiärer
ALF-medel Regionala FoU-medel Vinnova Hjärt-Lungfonden Astma-och Allergiförbundets Forskningsfond Cancer-och Allergifonden
Samverkan
Alyn Morice, MD, PhD, professor, chefsläkare, Hull York Medical School, University of Hull, UK Surinder Birring, professor, MD, Honorary Senior Lecturer,King College Hospital, London, UK. Alastair Ross, PhD, docentvid Chalmers tekniska högskola i Göteborg Otto Savolainen, PhD, forskare vid Chalmers tekniska högskola i Göteborg. Anna-Carin Olin, professor, överläkare vid Avd för samhällsmedicin och folkhälsa vid Institutionen för medicin, Göteborgs universitet
Eva Millqvist har sedan 2017 ett pågående uppdrag för European Rerspiratory Society (ERS) att som ”co-chair” i en ”Task-force-grupp” ta fram europeiska riktlinjer vid kronisk hosta. Chair är professor Alyn Morice, Hull University UK. Uppgiften är nu i det närmaste utförd och sammanställd och publiceradi en vetenskaplig tidskrift. Dessa europeiska riktlinjer kommer också att presenteras vid ett symposium vid ERS årliga internationella konferens i Madrid oktober 2019 samt på nätet i ett så kallat ”Webinar” i december 2019.
Utvalda publikationer
- Morice AH, Millqvist E, Bieksiene K, Birring SS, Dicpinigaitis P, Ribas CD, Boon MH, Kantar A, Lai K, McGarvey L, Rigau D, Satia I, Smith J, Song WJ, Tonia T, van den Berg JWK, van Manen MJG, Zacharasiewicz A. ERS guidelines on the diagnosis and treatment of chronic cough in adults and children. Eur Respir J 2019.
- Johansson EL, Gustafsson P, Millqvist E, Ternesten-Hasseus E. Small and large airways' reactions to inhaled capsaicin in patients with chronic idiopathic cough, or asthma and in healthy control subjects. Exp Lung Res 2019; 45:55-64
- Ternesten-Hasseus E, Johansson EL, Millqvist E. Cough reduction using capsaicin. Respir Med 2015; 109:27-37.
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Consensus goals and standards for specialist cough clinics: the NEUROCOUGH international Delphi
study
Woo Jung Song, Lieven Dupont, Surinder S. Birring, Kian Fan Chung, Marta Dąbrowska, Peter Dicpinigaitis, Christian Domingo Ribas, Giovanni Fontana, Peter G. Gibson, Laurent Guilleminault, James H. Hull, Marco Idzko, Peter Kardos, Hyun Jung Kim, Kefang Lai, Federico Lavorini, Eva Millqvist, Alyn H. Morice, Akio Niimi, Sean M. Parker, Imran Satia, Jaclyn A. Smith, Jan Willem van den Berg, Lorcan P. McGarvey
ERJ Open Research - 2023 -
ERS guidelines on the diagnosis and treatment of chronic cough in adults and
children
A. H. Morice, Eva Millqvist, K. Bieksiene, S. S. Birring, P. Dicpinigaitis, C. D. Ribas, M. H. Boon, A. Kantar, K. F. Lai, L. McGarvey, D. Rigau, I. Satia, J. Smith, W. J. Song, T. Tonia, J. W. K. van den Berg, M. J. G. van Manen, A. Zacharasiewicz
European Respiratory Journal - 2020 -
Small and large airways' reactions to inhaled capsaicin in patients with chronic idiopathic cough, or asthma and in healthy control
subjects
Ewa-Lena Johansson, P. Gustafsson, Eva Millqvist, Ewa Ternesten-Hasséus
Experimental Lung Research - 2019 -
Relative frequencies of symptoms and risk factors among patients with chronic rhinosinusitis with nasal polyps using a case-control
study.
Anton Bohman, Martin Oscarsson, Kenneth Holmberg, Leif Johansson, Eva Millqvist, Salmir Nasic, Mats Bende
Acta oto-laryngologica - 2018 -
Development and validation of the self-administered Falun health instrument (SAFHI) using data from health promoted workplaces in
Sweden
O. P. Frieberg, Eva Millqvist, J. Nilsson, I. From
Scandinavian Journal of Public Health - 2018 -
Small and large airway reactions to osmotic stimuli in asthma and chronic idiopathic
cough
Ewa-Lena Johansson, Ewa Ternesten-Hasséus, P. Gustafsson, Teet Pullerits, Monica Arvidsson, Eva Millqvist
Pulmonary Pharmacology & Therapeutics - 2018 -
Physical Therapy Treatment of Impaired Chest Mobility in Patients with Airway Sensory
Hyperreactivity
Ewa-Lena Johansson, Ewa Ternesten-Hasséus, Monika Fagevik Olsén, Eva Millqvist
Physiotherapy Research International - 2017 -
TRPV1 and TRPM8 in treatment of chronic
cough
Eva Millqvist
Pharmaceuticals Policy and Law - 2016 -
Heredity of nasal
polyps.
Anton Bohman, Martin Oscarsson, Kenneth Holmberg, Leif Johansson, Eva Millqvist, Salmir Nasic, Åsa Torinsson Naluai, Mats Bende
Rhinology - 2015 -
Coping and social support in asthma and allergy: the Vasterbotten Environmental Health
Study
N. Lind, M. Nordin, E. Palmquist, A. S. Claeson, Eva Millqvist, S. Nordin
Journal of Asthma - 2015 -
Cough reduction using
capsaicin
Ewa Ternesten-Hasséus, Ewa-Lena Johansson, Eva Millqvist
Respiratory Medicine - 2015 -
A worldwide survey of chronic cough: a manifestation of enhanced somatosensory
response
A. H. Morice, A. D. Jakes, S. Faruqi, S. S. Birring, L. McGarvey, B. Canning, J. A. Smith, S. M. Parker, K. F. Chung, K. Lai, I. D. Pavord, J. van den Berg, W. J. Song, Eva Millqvist, M. J. Farrell, S. B. Mazzone, P. Dicpinigaitis, Registry Chronic Cough
European Respiratory Journal - 2014 -
Expert opinion on the cough hypersensitivity syndrome in respiratory
medicine
A. H. Morice, Eva Millqvist, M. G. Belvisi, K. Bieksiene, S. S. Birring, K. F. Chung, R. W. Dal Negro, P. Dicpinigaitis, A. Kantar, L. P. McGarvey, A. Pacheco, R. Sakalauskas, J. A. Smith
European Respiratory Journal - 2014 -
Capsaicin cough threshold test in
diagnostics
Teet Pullerits, Ewa Ternesten-Hasséus, Ewa-Lena Johansson, Eva Millqvist
Respiratory Medicine - 2014 -
Normative data for the chemical sensitivity scale for sensory hyperreactivity: the Västerbotten environmental health
study
Steven Nordin, Eva Palmquist, Mats Bende, Eva Millqvist
International Archives of Occupational and Environmental Health - 2013 -
Capsaicin sensitivity in patients with chronic cough-- results from a cross-sectional
study.
Ewa Ternesten-Hasséus, Christel Larsson, Sven Larsson, Eva Millqvist
Cough (London, England) - 2013 -
Inhalation of menthol reduces capsaicin cough sensitivity and influences inspriatory flows in chronic
cough
Eva Millqvist, Ewa Ternesten-Hasséus, Mats Bende
Respiratory Medicine - 2013 -
Respiratory movement and pain thresholds in airway environmental sensitivity, asthma and
COPD
Ewa-Lena Johansson, Ewa Ternesten-Hasséus, Monika Fagevik Olsén, Eva Millqvist
Respiratory Medicine - 2012 -
Prevalence of chronic cough in relation to upper and lower airway symptoms; the Skövde population-based
study.
Mats Bende, Eva Millqvist
Frontiers in physiology - 2012 -
Symptoms induced by environmental irritants and health-related quality of life in patients with chronic cough - a cross-sectional
study
Ewa Ternesten-Hasséus, Sven Larsson, Eva Millqvist
Cough - 2011 -
Sensitivity to environmental irritants and quality of life in
COPD
Ewa Ternesten-Hasséus, Sven Larsson, Eva Millqvist
Int J CPOD - 2011 -
Sensitivity to Environmental Irritants and Capsaicin Cough Reaction in Patients with a Positive Methacholine Provocation Test before and after Treatment with Inhaled
Corticosteroids
Y Ekstrand, Ewa Ternesten-Hasséus, Monica Arvidsson, Kerstin Löfdahl, Mona Palmqvist, Eva Millqvist
JOURNAL OF ASTHMA - 2011 -
The influence of personality traits and beliefs about medicines on adherence to asthma
treatment.
Maria Emilsson, Ina Berndtsson, Jan Lötvall, Eva Millqvist, Jesper Lundgren, Ake Johansson, Eva Brink
Primary care respiratory journal : journal of the General Practice Airways Group - 2011 -
Relationship of airway sensory hyperreactivity to asthma and psychiatric
morbidity.
Ake Johansson, Eva Millqvist, Mats Bende
Annals of allergy, asthma & immunology - 2010 -
The airway sensory hyperreactivity
syndrome.
Eva Millqvist
Pulmonary pharmacology & therapeutics - 2010 -
The idiopathic environmental intolerance symptom inventory: development, evaluation, and
application.
Maria J E Andersson, Linus Andersson, Mats Bende, Eva Millqvist, Steven Nordin
Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine - 2009 -
Attention bias and sensitization in chemical
sensitivity.
Linus Andersson, Mats Bende, Eva Millqvist, Steven Nordin
Journal of psychosomatic research - 2009 -
On the relation between capsaicin sensitivity and responsiveness to CO2: detection sensitivity and event-related brain
potentials.
L Andersson, S Nordin, Eva Millqvist, Mats Bende
International archives of occupational and environmental health - 2009 -
Attention bias and sensitization in chemical
sensitivity.
Mats Bende, Steven Nordin, Eva Millqvist, Linus Andersson
J Psychosom Res - 2009 -
Differentialdiagnostik vid astmaliknande
besvär
Eva Millqvist, Göran Wennergren
Allergi och astma. Hedlin G & Larsson K, red. Studentlitteratur - 2009 -
Down-regulation of cough sensitivity after eucapnic dry air provocation in chronic idiopathic
cough.
Ewa-Lena Johansson, Ewa Ternesten-Hasséus, Eva Millqvist
Pulmonary pharmacology & therapeutics - 2009 -
Event-related potentials in patients with olfactory
loss.
Annika Brämerson, Eva Millqvist, Bo Ydse, Jonas K Olofsson, Mats Bende, Christel Larsson
Acta oto-laryngologica - 2008 -
Voice change in seasonal allergic
rhinitis.
Eva Millqvist, Mats Bende, Moa Brynnel, Inger Johansson, Sofi Kappel, Ann-Christine Ohlsson
Journal of voice : official journal of the Voice Foundation - 2008 -
Capsaicin provocation using two different inhalation
devices.
Ewa Ternesten-Hasséus, Christel Larsson, Mats Bende, Eva Millqvist
Respiratory medicine - 2008 -
Inhaled ethanol potentiates the cough response to capsaicin in patients with airway sensory
hyperreactivity.
Eva Millqvist, Ewa Ternesten-Hasséus, Mats Bende
Pulmonary pharmacology & therapeutics - 2008 -
Dyspnea from exercise in cold air is not always
asthma.
Ewa Ternesten-Hasséus, Ewa-Lena Johansson, Mats Bende, Eva Millqvist
The Journal of asthma : official journal of the Association for the Care of Asthma - 2008 -
Prevalence and risk factors for chemical sensitivity and sensory hyperreactivity in
teenagers.
Linus Andersson, Ake Johansson, Eva Millqvist, Steven Nordin, Mats Bende
International journal of hygiene and environmental health - 2008 -
Mechanisms of increased airway sensitivity to occupational chemicals and
odors.
Eva Millqvist
Current opinion in allergy and clinical immunology - 2008 -
Prevalence of parosmia: the Skövde population-based
studies
Steven Nordin, Annika Brämerson, Eva Millqvist, Mats Bende
Rhinolgy - 2007 -
A prospective study of allergy development in 158 children and 128 adults with new extensive exposure to furred
animals
Eva Millqvist, A. Johansson, T. Månsson, Mats Bende
Clin Exp Allergy - 2007 -
Quality of life and capsaicin sensitivity in patients with airway symptoms induced by chemicals and scents: a longitudinal
study
Ewa Ternesten-Hasséus, Olle Löwhagen, Eva Millqvist
Environ Health Perspect - 2007 -
Rhinitis as a part of sensory hyperreactivity characterized by increased capsaicin cough
sensitivity
Eva Millqvist
Clin Allergy Immunol - 2007 -
Role of the upper airways in patients with chronic
cough
Eva Millqvist, Mats Bende
Curr Opin Allergy Clin Immunol. - 2006 -
Two-year follow-up with acoustic rhinometry in
children
Eva Millqvist, Mats Bende
Am J Rhinol - 2006 -
Prevalence of upper and lower airway symptoms: the Skovde population-based
study
A. Åkerlund, Eva Millqvist, D. Öberg, Mats Bende
Acta Otolaryngol. - 2006 -
Relationship between self-reported odor intolerance and sensitivity to inhaled capsaicin: proposed definition of airway sensory hyperreactivity and estimation of its
prevalence
Åke Johansson, Eva Millqvist, S. Nordin, Mats Bende
Chest. - 2006 -
Inhalation method determines outcome of capsaicin inhalation in patients with chronic cough due to sensory
hyperreactivity
Ewa Ternesten-Hasséus, Åke Johansson, Olle Löwhagen, Eva Millqvist
Pulm Pharmacol Ther - 2006 -
Prevalence and risk factors for self-reported odour intolerance: the Skovde population-based
study
Å. Johansson, Annika Brämerson, Eva Millqvist, S. Nordin, Mats Bende
Int Arch Occup Environ Health - 2005 -
Chemosensory perception and event-related potentials in self-reported chemical
hypersensitivity
Steven Nordin, Mikael Martinkauppi, Jonas Olofsson, Thomas Hummel, Eva Millqvist, Mats Bende
Int Journal of Psychophysiology - 2005 -
Changes in levels of nerve growth factor in nasal secretions after capsaicin inhalation in patients with airway symptoms from scents and
chemicals
Eva Millqvist, Ewa Ternesten-Hasséus, Arne Ståhl, M. Bende
Environ Health Perspect - 2005 -
Normative data of the chemical sensitivity
scale.
Steven Nordin, Eva Millqvist, Mats Bende
Journal of Environmental Psychology - 2004 -
A short chemical sensitivity scale for assessment of airway sensory
hyperreactivity
S. Nordin, Eva Millqvist, Olle Löwhagen, M. Bende
Int Arch Occup Environ Health - 2004 -
Relationship of airway symptoms from chemicals to capsaicin cough sensitivity in atopic
subjects
Eva Millqvist, A. Johansson, M. Bende
Clin Exp Allergy - 2004 -
The Chemical Sensitivity Scale: Psychometric properties and comparison with the noise sensitivity
scale
S Nordin, Eva Millqvist, Olle Löwhagen, M. Bende
Journal of Environmental Psychology - 2003 -
Increased capsaicin cough sensitivity in patients with multiple chemical
sensitivity.
Ewa Ternesten-Hasséus, Mats Bende, Eva Millqvist
Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine - 2002 -
Capsaicin inhalation test for identification of sensory
hyperreactivity
Å Johansson, Olle Löwhagen, Eva Millqvist, Mats Bende
Respiratory Medicine - 2002 -
Sensitivity to methacholine and capsaicin in patients with unclear respiratory
symptoms
Ewa Ternesten-Hasséus, Anne Farbrot, Olle Löwhagen, Eva Millqvist
Allergy - 2002 -
Capsaicin cough sensitivity in allergic asthmatic patients increases during the birch pollen
season.
Dan Weinfeld, Ewa Ternesten-Hasséus, Olle Löwhagen, Eva Millqvist
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology - 2002 -
Cough provocation with capsaicin is an objective way to test sensory hyperreactivity in patients with asthma-like
symptoms
Eva Millqvist
Allergy - 2000 -
Combining a beta2-agonist with a face mask to prevent exercise-induced
bronchoconstriction
Eva Millqvist, Ulf Bengtsson, Olle Löwhagen
Allergy - 2000 -
A breathing filter preventing exercise-induced
asthma
Björn Bake, Eva Millqvist, Ulf Bengtsson, O Lövhagen, Olle Löwhagen
Clin Respir Physiol - 1986 -
The Swedish winter disables
asthmatics
Eva Millqvist, Björn Bake, Ulf Bengtsson
Eur J Respir Dis Suppl - 1984 -
Prevention of cold-induced asthma by conditioning the inspired
air
Ulf Bengtsson, Eva Millqvist, Björn Bake, Olle Löwhagen
Eur J Respir Dis Suppl - 1984