- Hem
- Om universitetet
- Hitta person
- Simon Lind
Simon Lind
Postdoktor
Avd för medicinsk kemi och cellbiologiOm Simon Lind
Postdoctoral student especially interested in G protein-coupled receptors and their downstream signaling cascade. During my PhD., I worked on innate immunity focusing on GPCR signaling and activation patterns of GPCRs expressed in human neutrophil. My work generated novel concepts on GPCR activation including new allosteric modulation properties as well as discovering new biased ligands. However, my lack of knowledge in structure biology led me to apply for a postdoc at Linda Johansson’s lab which has extensive experience in GPCR structural biology. Here my goal is to bridge the gap between receptor signaling and structure biology to get a broader area of expertise.
-
The allosterically modulated FFAR2 is transactivated by signals generated by other neutrophil
GPCRs
Simon Lind, K. L. Granberg, Huamei Forsman, Claes Dahlgren
Plos One - 2023 -
The ketone body acetoacetate activates human neutrophils through
FFAR2.
Jonas Mårtensson, Lena Björkman, Simon Lind, Moa Viklund, Linjie Zhang, Saray Gutierrez, Claes Dahlgren, Martina Sundqvist, Xin Xie, Huamei Forsman
Journal of leukocyte biology - 2023 -
An increase in the cytosolic concentration of free calcium ions activates the neutrophil NADPH-oxidase provided that the free fatty acid receptor 2 has been allosterically
modulated.
Simon Lind, Yanling Wu, Martina Sundqvist, Huamei Forsman, Claes Dahlgren
Cellular signalling - 2023 -
Structural Determinants in the Staphylococcus aureus-Derived Phenol-Soluble Modulin α2 Peptide Required for Neutrophil Formyl Peptide Receptor
Activation
Moa Viklund, Johanna Fredriksson, André Holdfeldt, Simon Lind, H. Franzyk, Claes Dahlgren, Martina Sundqvist, Huamei Forsman
Journal of Immunology - 2022 -
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated
functions.
Claes Dahlgren, Simon Lind, Jonas Mårtensson, Lena Björkman, Yanling Wu, Martina Sundqvist, Huamei Forsman
Immunological reviews - 2022 -
Phenol-soluble modulin α and β display divergent roles in mice with staphylococcal septic
arthritis.
Zhicheng Hu, Pradeep Kumar Kopparapu, Patrick Ebner, Majd Mohammad, Simon Lind, Anders Jarneborn, Claes Dahlgren, Michelle Schultz, Megshree Deshmukh, Rille Pullerits, Mulugeta Nega, Minh-Thu Nguyen, Ying Fei, Huamei Forsman, Friedrich Götz, Tao Jin
Communications biology - 2022 -
Free Fatty Acid Receptor 2 - A G protein coupled receptor with unique signaling properties in
neutrophils
Simon Lind
2022 -
Allosteric receptor modulation uncovers an FFA2R antagonist as a positive orthosteric modulator/agonist in
disguise.
Simon Lind, Dagny Olofsson Hoffmann, Huamei Forsman, Claes Dahlgren
Cellular signalling - 2021 -
Multiple ligand recognition sites in free fatty acid receptor 2 (FFA2R) direct distinct neutrophil activation
patterns.
Simon Lind, André Holdfeldt, Jonas Mårtensson, Kenneth L Granberg, Huamei Forsman, Claes Dahlgren
Biochemical pharmacology - 2021 -
Neutrophil Signaling That Challenges Dogmata of G Protein-Coupled Receptor Regulated
Functions
Claes Dahlgren, André Holdfeldt, Simon Lind, Jonas Mårtensson, Michael Gabl, Lena Björkman, Martina Sundqvist, Huamei Forsman
ACS Pharmacology and Translational Science - 2020 -
The PAR4-derived pepducin P4Pal10 lacks effect on neutrophil GPCRs that couple to Gαq for signaling but distinctly modulates function of the Gαi-coupled FPR2 and
FFAR2
André Holdfeldt, Simon Lind, Camilla Hesse, Claes Dahlgren, Huamei Forsman
Biochemical Pharmacology - 2020 -
Interdependent allosteric free fatty acid receptor 2 modulators synergistically induce functional selective activation and desensitization in
neutrophils
Simon Lind, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, T. P. Kenakin, Lena Björkman, Huamei Forsman, Claes Dahlgren
Biochimica Et Biophysica Acta-Molecular Cell Research - 2020 -
Functional selective ATP receptor signaling controlled by the free fatty acid receptor 2 through a novel allosteric modulation
mechanism.
Simon Lind, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, Lena Björkman, Huamei Forsman, Claes Dahlgren
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2019 -
Identification of Residues Critical for FPR2 Activation by the Cryptic Peptide Mitocryptide-2 Originating from the Mitochondrial DNA-Encoded Cytochrome
b.
Simon Lind, Michael Gabl, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, Kodai Nishino, Claes Dahlgren, Hidehito Mukai, Huamei Forsman
Journal of immunology (Baltimore, Md. : 1950) - 2019 -
Functional and signaling characterization of the neutrophil FPR2 selective agonist
Act-389949
Simon Lind, Martina Sundqvist, R. Holmdahl, Claes Dahlgren, Huamei Forsman, P. Olofsson
Biochemical Pharmacology - 2019 -
Mitocryptides from Human Mitochondrial DNA-Encoded Proteins Activate Neutrophil Formyl Peptide Receptors: Receptor Preference and Signaling
Properties.
Michael Gabl, Martina Sundqvist, André Holdfeldt, Simon Lind, Jonas Mårtensson, Karin Christenson, Takayuki Marutani, Claes Dahlgren, Hidehito Mukai, Huamei Forsman
Journal of immunology - 2018