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- André Holdfeldt
André Holdfeldt
Postdoktor
Avdelningen för Laboratoriemedicin-
Structural Determinants in the Staphylococcus aureus-Derived Phenol-Soluble Modulin α2 Peptide Required for Neutrophil Formyl Peptide Receptor
Activation
Moa Viklund, Johanna Fredriksson, André Holdfeldt, Simon Lind, H. Franzyk, Claes Dahlgren, Martina Sundqvist, Huamei Forsman
Journal of Immunology - 2022 -
5-fluorouracil treatment of patient-derived scaffolds from colorectal cancer reveal clinically critical
information
Simona Salerno, Anders Ståhlberg, André Holdfeldt, Elinor Bexe-Lindskog, Göran Landberg
Journal of Translational Medicine - 2022 -
GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by beta-arrestin recruiting GPR84
agonists
Johanna Fredriksson, André Holdfeldt, Jonas Mårtensson, Lena Björkman, T. C. Moller, E. Mullers, Claes Dahlgren, Martina Sundqvist, Huamei Forsman
Biochimica Et Biophysica Acta-Molecular Cell Research - 2022 -
Multiple ligand recognition sites in free fatty acid receptor 2 (FFA2R) direct distinct neutrophil activation
patterns.
Simon Lind, André Holdfeldt, Jonas Mårtensson, Kenneth L Granberg, Huamei Forsman, Claes Dahlgren
Biochemical pharmacology - 2021 -
Neutrophil Function and Signaling Induced by Ligands for the Formyl Peptide Receptor
2
André Holdfeldt
2021 -
Neutrophil Signaling That Challenges Dogmata of G Protein-Coupled Receptor Regulated
Functions
Claes Dahlgren, André Holdfeldt, Simon Lind, Jonas Mårtensson, Michael Gabl, Lena Björkman, Martina Sundqvist, Huamei Forsman
ACS Pharmacology and Translational Science - 2020 -
The PAR4-derived pepducin P4Pal10 lacks effect on neutrophil GPCRs that couple to Gαq for signaling but distinctly modulates function of the Gαi-coupled FPR2 and
FFAR2
André Holdfeldt, Simon Lind, Camilla Hesse, Claes Dahlgren, Huamei Forsman
Biochemical Pharmacology - 2020 -
Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor
endocytosis
Martina Sundqvist, André Holdfeldt, S. C. Wright, T. C. Moller, Esther Siaw, K. Jennbacken, H. Franzyk, M. Bouvier, Claes Dahlgren, Huamei Forsman
Biochimica Et Biophysica Acta-Molecular Cell Research - 2020 -
Interdependent allosteric free fatty acid receptor 2 modulators synergistically induce functional selective activation and desensitization in
neutrophils
Simon Lind, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, T. P. Kenakin, Lena Björkman, Huamei Forsman, Claes Dahlgren
Biochimica Et Biophysica Acta-Molecular Cell Research - 2020 -
Data showing effects of a PI3K-delta inhibitor on neutrophil superoxide production during FPR2 activation and
reactivation
André Holdfeldt, Martina Sundqvist, Claes Dahlgren, Huamei Forsman
Data in Brief - 2020 -
Functional selective ATP receptor signaling controlled by the free fatty acid receptor 2 through a novel allosteric modulation
mechanism.
Simon Lind, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, Lena Björkman, Huamei Forsman, Claes Dahlgren
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2019 -
Identification of Residues Critical for FPR2 Activation by the Cryptic Peptide Mitocryptide-2 Originating from the Mitochondrial DNA-Encoded Cytochrome
b.
Simon Lind, Michael Gabl, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, Kodai Nishino, Claes Dahlgren, Hidehito Mukai, Huamei Forsman
Journal of immunology (Baltimore, Md. : 1950) - 2019 -
Functional characteristics of circulating granulocytes in severe congenital neutropenia caused by ELANE
mutations
Q. Liu, Martina Sundqvist, W. Y. Li, André Holdfeldt, L. Zhang, Lena Björkman, Johan Bylund, Claes Dahlgren, C. Wang, X. D. Zhao, Huamei Forsman
Bmc Pediatrics - 2019 -
Staphylococcus aureus-Derived PSMα Peptides Activate Neutrophil FPR2 but Lack the Ability to Mediate β-Arrestin Recruitment and
Chemotaxis.
Martina Sundqvist, Karin Christenson, André Holdfeldt, Karin Jennbacken, Thor C Møller, Claes Dahlgren, Huamei Forsman
Journal of immunology - 2019 -
Structure-Function Characteristics and Signaling Properties of Lipidated Peptidomimetic FPR2 Agonists: Peptoid Stereochemistry and Residues in the Vicinity of the Headgroup Affect
Function
André Holdfeldt, S. L. Skovbakke, Michael Gabl, C. Nielsen, Claes Dahlgren, H. Franzyk, Huamei Forsman
ACS Omega - 2019 -
Neutrophil priming that turns natural FFA2R agonists into potent activators of the superoxide generating
NADPH-oxidase
Jonas Mårtensson, André Holdfeldt, Martina Sundqvist, Michael Gabl, T. P. Kenakin, Lena Björkman, Huamei Forsman, Claes Dahlgren
Journal of leukocyte biology - 2018 -
Lack of Receptor for Advanced Glycation End products leads to less severe staphylococcal skin infection but more skin abscesses and prolonged wound
healing.
Manli Na, Majd Mohammad, Ying Fei, Wanzhong Wang, André Holdfeldt, Huamei Forsman, Abukar Ali, Rille Pullerits, Tao Jin
The Journal of infectious diseases - 2018 -
Mitocryptides from Human Mitochondrial DNA-Encoded Proteins Activate Neutrophil Formyl Peptide Receptors: Receptor Preference and Signaling
Properties.
Michael Gabl, Martina Sundqvist, André Holdfeldt, Simon Lind, Jonas Mårtensson, Karin Christenson, Takayuki Marutani, Claes Dahlgren, Hidehito Mukai, Huamei Forsman
Journal of immunology - 2018 -
The Role of Formyl Peptide Receptors for Immunomodulatory Activities of Antimicrobial Peptides and
Peptidomimetics
S. L. Skovbakke, André Holdfeldt, Huamei Forsman, Johan Bylund, H. Franzyk
Current Pharmaceutical Design - 2018 -
Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor
FFA2R.
Martina Sundqvist, Karin Christenson, André Holdfeldt, Michael Gabl, Jonas Mårtensson, Lena Björkman, Regis Dieckmann, Claes Dahlgren, Huamei Forsman
Biochimica et biophysica acta - 2018 -
FPR2 signaling without β-arrestin recruitment alters the functional repertoire of
neutrophils.
Michael Gabl, André Holdfeldt, Martina Sundqvist, Jalal Lomei, Claes Dahlgren, Huamei Forsman
Biochemical pharmacology - 2017 -
Formyl peptide derived lipopeptides disclose differences between the receptors in mouse and men and call the pepducin concept in
question
Malene Winther, André Holdfeldt, Martina Sundqvist, Zahra Rajabkhani, Michael Gabl, Johan Bylund, Claes Dahlgren, Huamei Forsman
Plos One - 2017 -
Combining Elements from Two Antagonists of Formyl Peptide Receptor 2 Generates More Potent Peptidomimetic
Antagonists.
Sarah Line Skovbakke, André Holdfeldt, Christina Nielsen, Anna Mette Hansen, Iris Perez-Gassol, Claes Dahlgren, Huamei Forsman, Henrik Franzyk
Journal of medicinal chemistry - 2017 -
Reactivation of Gαi-coupled formyl peptide receptors is inhibited by Gαq-selective inhibitors when induced by signals generated by the platelet-activating factor
receptor.
André Holdfeldt, Agnes Dahlstrand Rudin, Michael Gabl, Zahra Rajabkhani, Gabriele M König, Evi Kostenis, Claes Dahlgren, Huamei Forsman
Journal of Leukocyte Biology - 2017 -
Formylated MHC Class lb Binding Peptides Activate Both Human and Mouse Neutrophils Primarily through Formyl Peptide Receptor
1
Malene Winther, André Holdfeldt, Michael Gabl, J. M. Wang, Huamei Forsman, Claes Dahlgren
PLoS ONE - 2016 -
The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue
Recruitment
Lena Björkman, Jonas Martensson, Malene Winther, Michael Gabl, André Holdfeldt, Martin Uhrbom, Johan Bylund, A. H. Hansen, S. K. Pandey, T. Ulven, Huamei Forsman, Claes Dahlgren
Molecular and Cellular Biology - 2016 -
The lipidated peptidomimetic Lau-[(S)-Aoc]-(Lys-βNphe)6-NH2 is a novel formyl peptide receptor 2 agonist that activates both human and mouse neutrophil
NADPH-oxidase.
André Holdfeldt, Sarah Line Skovbakke, Malene Winther, Michael Gabl, Christina Nielsen, Iris Perez-Gassol, Camilla Josephine Larsen, Ji Ming Wang, Anna Karlsson, Claes Dahlgren, Huamei Forsman, Henrik Franzyk
The Journal of biological chemistry - 2016 -
A pepducin designed to modulate P2Y2R function interacts with FPR2 in human neutrophils and transfers ATP to an NADPH-oxidase-activating ligand through a receptor cross-talk
mechanism.
Michael Gabl, André Holdfeldt, Malene Winther, Tudor I Oprea, Johan Bylund, Claes Dahlgren, Huamei Forsman
Biochimica et biophysica acta - 2016 -
The peptidomimetic Lau-(Lys-βNSpe)6-NH2 antagonizes formyl peptide receptor 2 expressed in mouse
neutrophils.
Sarah Line Skovbakke, Malene Winther, Michael Gabl, André Holdfeldt, Sara K. Lindén, Ji Ming Wang, Claes Dahlgren, Henrik Franzyk, Huamei Forsman
Biochemical pharmacology - 2016 -
Data on human neutrophil activation induced by pepducins with amino acid sequences derived from β2AR and
CXCR4.
André Holdfeldt, Malene Winther, Michael Gabl, Claes Dahlgren, Huamei Forsman
Data in brief - 2016 -
Basic characteristics of the neutrophil receptors that recognize formylated peptides, a danger-associated molecular pattern generated by bacteria and
mitochondria.
Claes Dahlgren, Michael Gabl, André Holdfeldt, Malene Winther, Huamei Forsman
Biochemical pharmacology - 2016