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- Jan Holgersson
Jan Holgersson
Professor/ Chief Physician
Department of Laboratory Medicine-
Tocilizumab in chronic active antibody-mediated rejection: rationale and protocol of an in-progress randomized controlled open-label multi-center trial (INTERCEPT
study)
Lillian Streichart, Marie Felldin, Jana Ekberg, Lars Mjörnstedt, Per Lindner, Annette Lennerling, Verena Brocker, Johan Molne, Jan Holgersson, Kristien Daenen, Lars Wennberg, Tomas Lorant, Seema Baid-Agrawal
Trials - 2024 -
Including the liver in the visceral allograft: Impact on donor-specific anti-HLA antibodies and long-term
outcomes
Dace Abele, Markus Gäbel, Mihai Oltean, Jonas Varkey, Johan Mölne, Nils Ekwall, Helena Borg, Hanna Jacobsson, Jan Holgersson, Gustaf Herlenius
HUMAN IMMUNOLOGY - 2024 -
Heart transplantation in patients bridged with mechanical circulatory support: outcome comparison with matched
controls
Sven-Erik Bartfay, Emanuele Bobbio, Sorosh Esmaily, Niklas Bergh, Jan Holgersson, Göran Dellgren, Entela Bollano, Kristjan Karason
Esc Heart Failure - 2023 -
Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut
bacteria
B. Shuoker, M. J. Pichler, Chunsheng Jin, H. Sakanaka, H. Y. Wu, A. M. Gascuena, Jining Liu, T. S. Nielsen, Jan Holgersson, E. N. Karlsson, N. Juge, S. Meier, J. P. Morth, Niclas G. Karlsson, M. A. Hachem
Nature Communications - 2023 -
Sulfation of O-glycans on Mucin-type Proteins From Serous Ovarian Epithelial
Tumors.
Kristina A Thomsson, Varvara Vitiazeva, Constantina Mateoiu, Chunsheng Jin, Jining Liu, Jan Holgersson, Birgitta Weijdegård, Karin Sundfeldt, Niclas G. Karlsson
Molecular & cellular proteomics : MCP - 2021 -
Decrease of core 2 O-glycans on synovial lubricin in osteoarthritis reduces galectin-3 mediated
crosslinking.
Sarah A. Flowers, Kristina A Thomsson, Liaqat Ali, Shan Huang, Yolanda H. Mthembu, Suresh C Regmi, Jan Holgersson, Tannin A Schmidt, Ola Rolfson, Lena Björkman, Martina Sundqvist, Anna Karlsson-Bengtsson, Gregory D Jay, Thomas Eisler, Roman Krawetz, Niclas G. Karlsson
The Journal of biological chemistry - 2020 -
Recombinant mucin-type proteins carrying LacdiNAc on differentO-glycan core chains fail to supportH.
pyloribinding
Yolanda H. Mthembu, Chunsheng Jin, Médea Padra, Jining Liu, J. O. Edlund, H. Y. Ma, János T Padra, S. Oscarson, T. Boren, Niclas G. Karlsson, Sara K. Lindén, Jan Holgersson
Molecular Omics - 2020 -
Identification by mass spectrometry and immunoblotting of xenogeneic antigens in theN- andO-glycomes of porcine, bovine and equine heart
tissues
Chunsheng Jin, Reeja Maria Cherian, Jining Liu, Heribert Playà-Albinyana, C. Galli, Niclas G. Karlsson, Michael Breimer, Jan Holgersson
Glycoconjugate Journal - 2020 -
The Structural Complexity and Animal Tissue Distribution of N-Glycolylneuraminic Acid (Neu5Gc)-Terminated Glycans. Implications for Their Immunogenicity in Clinical
Xenografting
Michael Breimer, Jan Holgersson
Frontiers in Molecular Biosciences - 2019 -
Glyco-engineered cell line and computational docking studies reveals enterotoxigenic Escherichia coli CFA/I fimbriae bind to Lewis a
glycans
Lynda Mottram, Jining Liu, Sonali Chavan, Joshua Tobias, Ann-Mari Svennerholm, Jan Holgersson
Scientific Reports - 2018 -
The aldehyde dehydrogenase cord blood potency assay excludes early apoptotic
cells
Sofia Frändberg, S. Li, Cecilia Boreström, Jan Holgersson, Lars Palmqvist
Transfusion - 2018 -
Concentration of the CDCP1 protein in human cord plasma may serve as a predictor of hematopoietic stem and progenitor cell
content
Sofia Frändberg, Julia Asp, B. Waldner, Jan Holgersson, Lars Palmqvist
Stem Cell Research - 2018 -
Influence of Glycosylation on Interfacial Properties of Recombinant Mucins: Adsorption, Surface Forces, and
Friction
J. X. An, Chunsheng Jin, A. Dedinaite, Jan Holgersson, Niclas G. Karlsson, P. M. Claesson
Langmuir - 2017 -
Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated
Adherence
J. A. Bugaytsova, O. Bjornham, Y. A. Chernov, P. Gideonsson, S. Henriksson, M. Mendez, R. Sjostrom, J. Mahdavi, A. Shevtsova, Dag Ilver, K. Moonens, Macarena P Quintana-Hayashi, R. Moskalenko, C. Aisenbrey, G. Bylund, A. Schmidt, A. Aberg, K. Brannstrom, V. Koniger, S. Vikstrom, L. Rakhimova, A. Hofer, J. Ogren, H. Liu, M. D. Goldman, J. M. Whitmire, J. Aden, J. Younson, C. G. Kelly, R. H. Gilman, A. Chowdhury, A. K. Mukhopadhyay, G. B. Nair, K. S. Papadakos, B. Martinez-Gonzalez, D. N. Sgouras, L. Engstrand, M. Unemo, D. Danielsson, S. Suerbaum, S. Oscarson, L. A. Morozova-Roche, A. Olofsson, G. Grobner, Jan Holgersson, A. Esberg, N. Stromberg, M. Landstrom, A. M. Eldridge, B. A. Chromy, L. M. Hansen, J. V. Solnick, Sara K. Lindén, R. Haas, A. Dubois, D. S. Merrell, S. Schedin, H. Remaut, A. Arnqvist, D. E. Berg, T. Boren
Cell Host & Microbe - 2017 -
Recombinant Mucin-Type Fusion Proteins with a Gal alpha 1,3Gal Substitution as Clostridium difficile Toxin A
Inhibitors
Reeja Maria Cherian, Chunsheng Jin, Jining Liu, Niclas G. Karlsson, Jan Holgersson
Infection and Immunity - 2016 -
Recombinant Mucin-Type Fusion Proteins with a Galα1,3Gal Substitution as Clostridium difficile Toxin A
Inhibitors.
Reeja Maria Cherian, Chunsheng Jin, Jining Liu, Niclas G. Karlsson, Jan Holgersson
Infection and immunity - 2016 -
High quality cord blood banking is feasible with delayed clamping practices. The eight-year experience and current status of the national Swedish Cord Blood
Bank.
Sofia Frändberg, Berit Waldner, Jan Konar, Lennart Rydberg, Anders Fasth, Jan Holgersson
Cell and tissue banking - 2016 -
A positive pre-transplant endothelial precursor cell crossmatch does not imply reduced long-term kindney graft
function
Markus Gäbel, Ayeda AlMahri, Lennart Rydberg, Jan Holgersson, Michael Breimer
SOJ Immunology - 2015 -
O-glycan repertoires on a mucin-type reporter protein expressed in CHO cell pools transiently transfected with O-glycan core enzyme
cDNAs.
Jining Liu, Chunsheng Jin, Reeja Maria Cherian, Niclas G. Karlsson, Jan Holgersson
Journal of biotechnology - 2015 -
Chemokine-Mediated Robust Augmentation of Liver Engraftment: A Novel
Approach.
Meghnad Joshi, Mihai Oltean, Pradeep B Patil, David Hallberg, Marika Kleman, Jan Holgersson, Michael Olausson, Suchitra Sumitran-Holgersson
Stem cells translational medicine - 2015 -
A Panel of Recombinant Mucins Carrying a Repertoire of Sialylated O-Glycans Based on Different Core Chains for Studies of Glycan Binding
Proteins.
Reeja Maria Cherian, Chunsheng Jin, Jining Liu, Niclas G. Karlsson, Jan Holgersson
Biomolecules - 2015 -
Immunotoxicological effects of streptozotocin and alloxan: In vitro and in vivo
studies
R. A. H. Diab, M. Fares, M. Abedi-Valugerdi, M. Kumagai-Braesch, Jan Holgersson, M. Hassan
Immunology Letters - 2015 -
The first clinical uterus transplantation trial: a six-month
report.
Mats Brännström, Liza Johannesson, Pernilla Dahm-Kähler, Anders Enskog, Johan Mölne, Niclas Kvarnström, César Diaz-Garcia, Ash Hanafy, Cecilia Lundmark, Janusz Marcickiewicz, Markus Gäbel, Klaus Groth, Randa Racho El-Akouri, Saskia Eklind, Jan Holgersson, Andreas Tzakis, Michael Olausson
Fertility and sterility - 2014 -
Shiga-like toxin binds with high avidity to multivalent O-linked blood group P1 determinants on mucin-type fusion
proteins
Reeja Maria Cherian, S. Gaunitz, A. Nilsson, Jining Liu, Niclas G. Karlsson, Jan Holgersson
Glycobiology - 2014 -
A comparison of the humoral immune response induced by a recombinant human protein in wild type mice and in transgenic mice expressing the
protein
Britta Granath, Jan Holgersson, Karin Cederbrant, Ann Lövgren, Nina Brenden
British Journal of Pharmaceutical Research - 2014 -
Comparison of a brush-with-anchor and a train-of-brushes mucin on poly(methyl methacrylate) surfaces: adsorption, surface forces, and
friction.
Junxue An, Andra Dėdinaitė, Anki Nilsson, Jan Holgersson, Per M Claesson
Biomacromolecules - 2014 -
Rat islets are not rejected by anti-islet antibodies in mice treated with costimulation
blockade.
Randa A H Diab, Moustapha Hassan, Annika Tibell, Jan Holgersson, Makiko Kumagai-Braesch
Xenotransplantation - 2014 -
Multipotent mesenchymal stromal cells synergize with costimulation blockade in the inhibition of immune responses and the induction of foxp3+ regulatory T
cells.
Tohru Takahashi, Annika Tibell, Karin Ljung, Yu Saito, Anna Gronlund, Cecilia Osterholm, Jan Holgersson, Torbjörn Lundgren, Bo-Göran Ericzon, Matthias Corbascio, Makiko Kumagai-Braesch
Stem cells translational medicine - 2014 -
Molecular Deciphering of the ABO System as a Basis for Novel Diagnostics and Therapeutics in ABO Incompatible
Transplantation.
Jan Holgersson, Lennart Rydberg, Michael Breimer
International Reviews of Immunology - 2014 -
Avian influenza H5 hemagglutinin binds with high avidity to sialic acid on different O-linked core structures on mucin-type fusion
proteins
Stefan Gaunitz, Jining Liu, Anki Nilsson, Niclas G. Karlsson, Jan Holgersson
Glycoconjugate Journal - 2014 -
Mass spectrometric analysis of O-linked oligosaccharides from various recombinant expression
systems
Diarmuid T. Kenny, S. Gaunitz, Catherine A Hayes, A. Gustafsson, M. Sjöblom, Jan Holgersson, Niclas G. Karlsson
Methods in Molecular Biology - 2013 -
Engineering of therapeutic and diagnostic O-glycans on recombinant mucin-type immunoglobulin fusion proteins expressed in CHO
cells.
Linda Lindberg, Jining Liu, Jan Holgersson
Glycosylation Engineering of Biopharmaceuticals. Methods and Protocols. Part 1 - 2013 -
The outcome of the endothelial precursor cell crossmatch test in lymphocyte crossmatch positive and negative patients evaluated for living donor kidney
transplantation
M. Alheim, Ayeda AlMahri, J. Nilsson, G. Tyden, Jan Holgersson
Human Immunology - 2013 -
Mucin-type proteins produced in the Trichoplusia ni and Spodoptera frugiperda insect cell lines carry novel O-glycans with phosphocholine and sulfate
substitutions
S. Gaunitz, Chunsheng Jin, A. Nilsson, Jining Liu, Niclas G. Karlsson, Jan Holgersson
Glycobiology - 2013 -
Mucin-type fusion proteins with blood group A or B determinants on defined O-glycan core chains produced in glycoengineered Chinese hamster ovary cells and their use as immunoaffinity
matrices
L. Lindberg, J. N. Liu, S. Gaunitz, A. Nilsson, T. Johansson, Niclas G. Karlsson, Jan Holgersson
Glycobiology - 2013 -
Secretion and expression dynamics of a GFP-tagged mucin-type fusion protein in high cell density Pichia pastoris bioreactor
cultivations
Magnus Sjöblom, Linda Lindberg, Jan Holgersson, Ulrika Rova
Advances in Bioscience and Biotechnology - 2012 -
Mannosylated mucin-type immunoglobulin fusion proteins enhance antigen-specific antibody and T lymphocyte
responses.
Gustaf Ahlén, Lena Strindelius, Tomas Johansson, Anki Nilsson, Nathalie Chatzissavidou, Magnus Sjöblom, Ulrika Rova, Jan Holgersson
PloS one - 2012 -
Detection of complement-fixing and non-fixing antibodies specific for endothelial precursor cells and lymphocytes using flow
cytometry.
Ayeda AlMahri, Jan Holgersson, M Alheim
Tissue antigens - 2012 -
Adsorption of chain type-specific ABO antibodies on Sepharose-linked A and B
tetrasaccharides
Linda Lindberg, Katarina Theinert, Jining Liu, Jan Holgersson
Transfusion - 2012 -
Fetal liver-derived mesenchymal stromal cells augment engraftment of transplanted
hepatocytes.
Meghnad Joshi, Pradeep B Patil, Zhong He, Jan Holgersson, Michael Olausson, Suchitra Sumitran-Holgersson
Cytotherapy - 2012 -
Human Gastric Mucins Differently Regulate Helicobacter pylori Proliferation, Gene Expression and Interactions with Host
Cells.
Emma C Skoog, Åsa Sjöling, Nazanin Navabi, Jan Holgersson, Samuel B Lundin, Sara K. Lindén
PLoS One - 2012 -
Pichia pastoris-produced mucin-type fusion proteins with multivalent O-glycan substitution as targeting molecules for mannose-specific receptors of the immune
system.
Anki Gustafsson, Magnus Sjöblom, Lena Strindelius, Tomas Johansson, Tilly Fleckenstein, Nathalie Chatzissavidou, Linda Lindberg, Jonas Ångström, Ulrika Rova, Jan Holgersson
Glycobiology - 2011 -
Refined analysis of antigen-specific antibody responses--a new one-step tool in immunogenicity
studies.
Britta Granath, Jan Holgersson, Nina Brenden
European journal of pharmaceutical sciences - 2011 -
Antigen-binding specificity of anti-αGal reagents determined by solid-phase glycolipid-binding assays. A complete lack of αGal glycolipid reactivity in α1,3GalT-KO pig small
intestine.
Mette Diswall, Anki Gustafsson, Jan Holgersson, Mauro S Sandrin, Michael Breimer
Xenotransplantation - 2011 -
Is there a clinical need for a diagnostic test allowing detection of chain type-specific anti-A and
anti-B?
L Lindberg, S M Johansson, J Liu, P Grufman, Jan Holgersson
Transfusion - 2011 -
Cytotoxic crossmatch analysis before allo-SCT is a poor diagnostic tool for prediction of
rejection.
J. Mattsson, A Nordlander, M Remberger, M Uhlin, Jan Holgersson, O Ringdén, D Hauzenberger
Bone marrow transplantation - 2010 -
Characterization and engraftment of long-term serum-free human fetal liver cell
cultures.
Setara Begum, Meghnad Joshi, M Ek, Jan Holgersson, Marika I Kleman, Suchitra Sumitran-Holgersson
Cytotherapy - 2010 -
Effect of triple costimulation blockade on islet allograft survival in sensitized
mice.
R Diab, T Iwata, M Corbascio, A Tibell, H Ekberg, Jan Holgersson, M Kumagai-Braesch
Transplantation proceedings - 2010 -
A flow cytometric crossmatch test for simultaneous detection of antibodies against donor lymphocytes and endothelial precursor
cells.
M Alheim, S M Johansson, D Hauzenberger, P Grufman, Jan Holgersson
Tissue antigens - 2010 -
Anticarbohydrate antibody repertoires in patients transplanted with fetal pig islets revealed by glycan
arrays
Ola Blixt, Makiko Kumagai-Braesch, Annika Tibell, Carl Gustaf Groth, Jan Holgersson
American Journal of Transplantation - 2009 -
Core saccharide dependence of sialyl Lewis X
biosynthesis
Jonas Löfling, Jan Holgersson
Glycoconjugate Journal - 2009 -
Multicenter evaluation of a novel endothelial cell crossmatch test in kidney
transplantation.
Michael Breimer, Lennart Rydberg, Annette M Jackson, Donna P Lucas, Andrea A Zachary, Joseph K Melancon, Jon Von Visger, Ronald Pelletier, Susan L Saidman, Winfred W Williams, Jan Holgersson, Gunnar Tydén, Göran K Klintmalm, Sonnya Coultrup, Suchitra Sumitran-Holgersson, Per Grufman
Transplantation - 2009 -
Downregulation of tissue factor (TF) by RNA interference induces apoptosis and impairs cell survival of primary endothelium and tumor
cells
Cecilia Osterholm, Shushun Li, Henrik Ekberg, Ulla Hedner, Jan Holgersson
Cell and Tissue Research - 2008 -
Studies of Lewis antigens and H. pylori adhesion in CHO cell lines engineered to express Lewis b
determinants.
Jonas Löfling, Mette Diswall, Sara Eriksson, Thomas Borén, Michael Breimer, Jan Holgersson
Glycobiology - 2008 -
A case of acute vascular rejection caused by endothelial-reactive non-HLA
antibodies.
Jan Holgersson, Elzafir Elsheikh, Per Grufman, Suchitra Sumitran-Holgersson, Gunnar Tydén
Clinical transplants - 2007 -
Carbohydrate-dependent inhibition of Helicobacter pylori colonization using porcine
milk
A. Gustafsson, A. Hultberg, R. Sjostrom, I. Kacskovics, Michael Breimer, T. Boren, L. Hammarstrom, Jan Holgersson
Glycobiology - 2006 -
Characteristics of protein-carbohydrate interactions as a basis for developing novel carbohydrate-based antirejection
therapies
Jan Holgersson, A. Gustafsson, Michael Breimer
Immunology and cell biology - 2005 -
Anti-pig antibody adsorption efficacy of {alpha}-Gal carrying recombinant P-selectin glycoprotein ligand-1/immunoglobulin chimeras increases with core 2 {beta}1, 6-N-acetylglucosaminyltransferase
expression
J. Liu, A. Gustafsson, Michael Breimer, A. Kussak, Jan Holgersson
Glycobiology - 2005 -
Carbohydrate phenotyping of human and animal milk
glycoproteins
A. Gustafsson, I. Kacskovics, Michael Breimer, L. Hammarstrom, Jan Holgersson
Glycoconjugate journal - 2005 -
Alpha-Gal epitopes in animal tissue glycolipids and
glycoproteins.
Lennart Rydberg, Jan Holgersson, Samuelsson, Michael Breimer
Subcellular biochemistry , alpha 1, 3 galactosyltransferase, alpha-Gal epitopes and the natural anti-Gal antibody.(eds Galili, Avila) - 1999 -
alpha-Gal epitopes in animal tissue glycoproteins and
glycolipids.
Lennart Rydberg, Jan Holgersson, B E Samuelsson, Michael Breimer
Sub-cellular biochemistry - 1999 -
Biochemical and enzymatic characterization of blood group ABH and related histo-blood group glycosphingolipids in the epithelial cells of porcine small
intestine.
Annika E. Bäcker, Michael Breimer, B E Samuelsson, Jan Holgersson
Glycobiology - 1997 -
The blood group B type-4 heptaglycosylceramide is a minor blood group B structure in human B kidneys in contrast to the corresponding A type-4 compound in A kidneys. Structural and in vitro biosynthetic
studies.
Jan Holgersson, Annika E. Bäcker, Michael Breimer, Mikael Gustafsson, Per-Åke Jovall, Hasse Karlsson, W Pimlott, Bo Samuelsson
Biochimica et biophysica acta - 1992 -
Characterisation of the anti-A antibody response following an ABO incompatible (A2 to O) kidney
transplantation.
Lennart Rydberg, Michael Breimer, Jan Holgersson, Karl-Anders Karlsson, Per-Georg Nyholm, I Pascher, Lola Svensson, Bo Samuelsson
Molecular immunology - 1992 -
Blood group type glycosphingolipids of human kidneys. Structural characterization of extended globo-series
compounds.
Jan Holgersson, Per-Åke Jovall, Bo Samuelsson, Michael Breimer
Glycoconjugate journal - 1991 -
Glycosphingolipids of human large intestine: detailed structural characterization with special reference to blood group compounds and bacterial receptor
structures.
Jan Holgersson, Per-Åke Jovall, Michael Breimer
Journal of biochemistry - 1991 -
Structural characterization of non-acid glycosphingolipids in kidneys of single blood group O and A
pigs.
Jan Holgersson, Per-Åke Jovall, Bo Samuelsson, Michael Breimer
Journal of biochemistry - 1990 -
The distribution of blood group glycosphingolipids in human large intestine as investigated by mass
spectrometry.
Jan Holgersson, W Pimlott, Samuelsson, Michael Breimer
Advances of mass spectrometry. (eds Longerialle P) - 1989 -
ABO blood grouping on erythrocytes and antigen expression in different
organs.
A Ulfvin, Michael Breimer, Jan Holgersson, J Vinas, BE Samuelsson
Monoclonal antibodies against human red blood cell and related antigens. - 1988