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Michael Breimer
Senior Advisor
Department of SurgeryAbout Michael Breimer
Michael Breimer received his MD at the Medical Faculty, Gothenburg University, in 1976. He passed his PhD examination in 1980, and became associate professor in Medical and Physiological Chemistry in 1982. In 2001, he was appointed full professor/consultant surgeon at the Department of Surgery, Sahlgrenska Academy/Sahlgrenska University Hospital, Gothenburg. He was a visiting INSERM researcher at the Institute de Biologie, Universite de Nantes, Nantes, France, in 1991-2, and visiting professor and consultant surgeon in renal transplantation surgery at Queen Elizabeth Hospital, Birmingham, UK, in 2003-4. Michael Breimer started his research in the Department of Medical and Physiological Chemistry isolating and structurally characterising blood group AB(O)H and related carbohydrate antigens. After his PhD examination, his biochemical studies relating to ABO-incompatible organ transplantation continued in the Department of Surgery. Studies of human kidneys/urinary tract revealed that human kidney contained a new type of blood group A structure. Blood group phenotypes relating to expression of ABO antigens in individual kidneys were identified. Based on A antigen expression, a hypothesis explaining why blood group A2 kidneys could be successfully transplanted to O recipients was postulated. Patients receiving ABO-incompatible kidney grafts were shown to elicit an individual specific response regarding antibody class and subclass. He was responsible for the clinical evalutation of a new blood group A/B saccharide-based immunoadsorption column. These results have been applied in clinical practice to establish ABO-incompatible renal and liver transplantation programs in Gothenburg and Birmingham, UK. The similarity between hyperacute rejection of ABO-incompatible allografts and xenografts initiated his xenotransplantation research. Carbohydrate xenoantigens and xenoantibody epitope-specificity, the removal of xenoantibodies by plasmapheresis, and antibody neutralization using soluble saccharides, were all explored. A pig kidney in vitro perfusion model was established. In 1995, he was one of the leading scientists conducting the clinical trial in which pig kidneys were connected extracorporeally to the blood circulation of volunteer dialysis patients. During more recent years, his reseach has been conducted in the field of regenerative medicine, focussed on antigen expression and immune recognition of human embryonic stem cells and bioartificial heart valves, the latter tissues being of animal origin. He has published more than 150 scientific articles in the fields of carbohydrate biochemistry, glycobiology, allo- and xeno-transplantation, and regeneratvie medicine. In the xenotransplantation field, he has undertaken several international scientific assignments, e.g., as a plenary speaker, member of editorial boards, as a Councillor of the International Xenotransplantation Association (IXA, 2000-2003 and 2013-2015). He was chairman of the organizing committee of the 8th congress of the IXA and its satellite meeting (2nd International symposium on ABO-incompatibility in transplantation) held in Gothenburg in 2005.
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Identification by mass spectrometry and immunoblotting of xenogeneic antigens in theN- andO-glycomes of porcine, bovine and equine heart
tissues
Chunsheng Jin, Reeja Maria Cherian, Jining Liu, Heribert Playà-Albinyana, C. Galli, Niclas G. Karlsson, Michael Breimer, Jan Holgersson
Glycoconjugate Journal - 2020 -
The Structural Complexity and Animal Tissue Distribution of N-Glycolylneuraminic Acid (Neu5Gc)-Terminated Glycans. Implications for Their Immunogenicity in Clinical
Xenografting
Michael Breimer, Jan Holgersson
Frontiers in Molecular Biosciences - 2019 -
Glycosphingolipids of porcine, bovine, and equine pericardia as potential immune targets in bioprosthetic heart valve
grafts
Angela Barone, John Benktander, Christy Whiddon, Chunsheng Jin, C. Galli, Susann Teneberg, Michael Breimer
Xenotransplantation - 2018 -
Is sensitization to pig antigens detrimental to subsequent
allotransplantation?
Q. Li, H. Hara, Z. Q. Zhang, Michael Breimer, Y. Wang, D. K. C. Cooper, Immunology Lettersmeeting On Advances In Transplantation Immunology Sep Aberdeen Scotland V. P. Irns Tdh, Transplantation Proceedings V. P. Lne Ry
Xenotransplantation - 2018 -
HLA and Histo-Blood Group Antigen Expression in Human Pluripotent Stem Cells and their
Derivatives
Karin Säljö, Angela Barone, Johan Mölne, Lennart Rydberg, Susann Teneberg, Michael Breimer
Scientific Reports - 2017 -
Comparison of the glycosphingolipids of human induced pluripotent stem cells and human embryonic stem
cells
Karin Säljö, Angela Barone, Dzeneta Vizlin-Hodzic, Bengt R Johansson, Michael Breimer, Keiko Funa, Susann Teneberg
Glycobiology - 2017 -
Glycosphingolipids of human embryonic stem
cells.
Michael Breimer, Karin Säljö, Angela Barone, Susann Teneberg
Glycoconjugate journal - 2017 -
Characterization of immunogenic Neu5Gc in bioprosthetic heart
valves
E. M. Reuven, S. Leviatan Ben-Arye, T. Marshanski, Michael Breimer, H. Yu, I. Fellah-Hebia, J. C. Roussel, C. Costa, M. Galiñanes, R. Mañez, T. Le Tourneau, J. P. Soulillou, E. Cozzi, X. Chen, V. Padler-Karavani
Xenotransplantation - 2016 -
Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative
Colitis.
Mattias Block, Johan Mölne, Hakon Leffler, Lars Börjesson, Michael Breimer
BioMed research international - 2016 -
A positive pre-transplant endothelial precursor cell crossmatch does not imply reduced long-term kindney graft
function
Markus Gäbel, Ayeda AlMahri, Lennart Rydberg, Jan Holgersson, Michael Breimer
SOJ Immunology - 2015 -
Recent investigations into pig antigen and anti-pig antibody
expression.
Guerard W Byrne, Christopher G A McGregor, Michael Breimer
International journal of surgery (London, England) - 2015 -
Bortezomib, C1-Inhibitor and Plasma Exchange Do Not Prolong the Survival of Multi-Transgenic GalT-KO Pig Kidney Xenografts in
Baboons.
S Le Bas-Bernardet, X Tillou, J Branchereau, N Dilek, N Poirier, M Châtelais, B Charreau, D Minault, J Hervouet, K Renaudin, C Crossan, L Scobie, Y Takeuchi, Mette Diswall, Michael Breimer, N Klar, M R Daha, P Simioni, S C Robson, M B Nottle, E J Salvaris, P J Cowan, A J F d'Apice, D H Sachs, K Yamada, I Lagutina, R Duchi, A Perota, G Lazzari, C Galli, E Cozzi, J-P Soulillou, B Vanhove, G Blancho
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 2015 -
Sialyl-lactotetra, a novel cell surface marker of undifferentiated human pluripotent stem
cells.
Angela Barone, Karin Säljö, Maria K. Blomqvist, Jan-Eric Månsson, Bengt R Johansson, Johan Mölne, John Benktander, Anders Aspegren, Petter Björquist, Michael Breimer, Susann Teneberg
Journal of Biological Chemistry - 2014 -
Characterization of acid and non-acid glycosphingolipids of porcine heart valve cusps as potential immune targets in biological heart valve
grafts.
Angela Barone, John Benktander, Susann Teneberg, Michael Breimer
Xenotransplantation - 2014 -
Tribute to Carl-Gustav Groth (1933-2014), first president of the International Xenotransplantation
Association.
David K C Cooper, Leo Buhler, Michael Breimer, Olle Korsgren, Annika Tibell, Lars Wennberg, Emanuele Cozzi, Anthony J F d'Apice, Bernhard Hering, Ian F C McKenzie, Richard N Pierson, Megan Sykes, Takaaki Kobayashi
Xenotransplantation - 2014 -
The alpha1,3GalT knockout/alpha1,2FucT transgenic pig does not appear to have an advantage over the alpha1,3GalT knockout pig with respect to glycolipid reactivity with human serum
antibodies.
Mette Diswall, John Benktander, Jonas Ångström, Susann Teneberg, Michael Breimer
Xenotransplantation - 2014 -
Molecular Deciphering of the ABO System as a Basis for Novel Diagnostics and Therapeutics in ABO Incompatible
Transplantation.
Jan Holgersson, Lennart Rydberg, Michael Breimer
International Reviews of Immunology - 2014 -
Structural Complexity of Non-acid Glycosphingolipids in Human Embryonic Stem Cells Grown under Feeder-free
Conditions.
Angela Barone, John Benktander, Jonas Ångström, Anders Aspegren, Petter Björquist, Susann Teneberg, Michael Breimer
The Journal of biological chemistry - 2013 -
Glycoproteomic identification of galectin-3 and -8 ligands in bronchoalveolar lavage of mild asthmatics and healthy
subjects.
Cecilia Cederfur, Johan Malmström, Kristian Nihlberg, Mattias Block, Michael Breimer, Leif Bjermer, Gunilla Westergren-Thorsson, Hakon Leffler
Biochimica et biophysica acta - 2012 -
Glycosphingolipid composition of epithelial cells isolated along the villus axis of small intestine of a single human
individual.
Michael Breimer, Gunnar C. Hansson, Karl-Anders Karlsson, Göran Larson, Hakon Leffler
Glycobiology - 2012 -
Norovirus GII.4 Virus-like Particles Recognize Galactosylceramides in Domains of Planar Supported Lipid
Bilayers.
Marta Bally, Gustaf E Rydell, Raphael Zahn, Waqas Nasir, Christian Eggeling, Michael Breimer, Lennart Svensson, Fredrik Höök, Göran Larson
Angewandte Chemie International Edition - 2012 -
Redefinition of the carbohydrate binding specificity of Helicobacter pylori BabA
adhesin.
John Benktander, Jonas Ångström, Michael Breimer, Susann Teneberg
The Journal of biological chemistry - 2012 -
Mobility
rethought
LH Breimer, Michael Breimer, DD Breimer
Nature - 2011 -
The structural basis of blood group A-related glycolipids in an A3 red cell phenotype and potential explanation to a serological
phenomenon
Lola Svensson, Laura Bindila, Jonas Ångström, Bo Samuelsson, Michael Breimer, Lennart Rydberg, Stephan Henry
Glycobiology - 2011 -
Erythrocyte and Porcine Intestinal Glycosphingolipids Recognized by F4 Fimbriae of Enterotoxigenic Escherichia
coli.
Annelies Coddens, Erik Valis, John Benktander, Jonas Ångström, Michael Breimer, Eric Cox, Susann Teneberg
PloS One - 2011 -
Antigen-binding specificity of anti-αGal reagents determined by solid-phase glycolipid-binding assays. A complete lack of αGal glycolipid reactivity in α1,3GalT-KO pig small
intestine.
Mette Diswall, Anki Gustafsson, Jan Holgersson, Mauro S Sandrin, Michael Breimer
Xenotransplantation - 2011 -
Gal/non-Gal antigens in pig tissues and human non-Gal antibodies in the GalT-KO
era.
Michael Breimer
Xenotransplantation - 2011 -
Structural characterization of alpha1,3-galactosyltransferase knockout pig heart and kidney glycolipids and their reactivity with human and baboon
antibodies.
Mette Diswall, Jonas Ångström, Hasse Karlsson, Carol J Phelps, David Ayares, Susann Teneberg, Michael Breimer
Xenotransplantation - 2010 -
Preoperative radiotherapy and extracellular matrix remodeling in rectal mucosa and tumour matrix metalloproteinases and plasminogen
components.
Eva Angenete, Tom Öresland, Peter Falk, Michael Breimer, Ragnar Hultborn, Marie-Louise Ivarsson
Acta oncologica - 2009 -
Recognition of blood group ABH type 1 determinants by the FedF adhesin of F18-fimbriated Escherichia
coli.
Annelies Coddens, Mette Diswall, Jonas Ångström, Michael Breimer, Bruno Goddeeris, Eric Cox, Susann Teneberg
The Journal of biological chemistry - 2009 -
Multicenter evaluation of a novel endothelial cell crossmatch test in kidney
transplantation.
Michael Breimer, Lennart Rydberg, Annette M Jackson, Donna P Lucas, Andrea A Zachary, Joseph K Melancon, Jon Von Visger, Ronald Pelletier, Susan L Saidman, Winfred W Williams, Jan Holgersson, Gunnar Tydén, Göran K Klintmalm, Sonnya Coultrup, Suchitra Sumitran-Holgersson, Per Grufman
Transplantation - 2009 -
Studies of TGF-beta(1-3) in serosal fluid during abdominal surgery and their effect on in vitro human mesothelial cell
proliferation.
Peter Falk, Maria Bergström, Ingrid Palmgren, Lena Holmdahl, Michael Breimer, Marie-Louise Ivarsson
The Journal of surgical research - 2009 -
Blood group ABO antigen expression in human embryonic stem cells and in differentiated hepatocyte- and cardiomyocyte-like
cells.
Johan Mölne, Petter Björquist, Katarina Andersson, Mette Diswall, Anders Jeppsson, Valeri Strokan, Lennart Rydberg, Michael Breimer
Transplantation - 2008 -
Studies of Lewis antigens and H. pylori adhesion in CHO cell lines engineered to express Lewis b
determinants.
Jonas Löfling, Mette Diswall, Sara Eriksson, Thomas Borén, Michael Breimer, Jan Holgersson
Glycobiology - 2008 -
Glycolipid studies in small intestine and pancreas of alpha1,3-galactosyltransferase knockout miniature swine: alpha1,3GALT-KO animals lack alphaGAL antigens and contain novel blood group H
compounds.
Mette Diswall, Jonas Ångström, H-J Schuurman, F J M F Dor, Lennart Rydberg, Michael Breimer
Transplantation proceedings - 2008 -
ABO incompatible kidney transplantation:Overview and new
strategies.
G Norden, Michael Breimer
Trends in transplantation - 2007 -
Studies on glycolipid antigens in small intestine and pancreas from alpha1,3-galactosyltransferase knockout miniature
swine.
Mette Diswall, Jonas Ångström, Frank J M F Dor, Henk-Jan Schuurman, Lennart Rydberg, Michael Breimer
Transplantation - 2007 -
Successful ABO-incompatible liver transplantation using A2
donors
Ulrika Skogsberg, Michael Breimer, Styrbjörn Friman, Lars Mjörnstedt, J. Molne, Michael Olausson, L. Rydberg, Christian T. Svalander, L. Backman
Transplantation proceedings - 2006 -
Adult ABO-incompatible liver transplantation, using A and B
donors
Ulrika Skogsberg, Michael Breimer, Styrbjörn Friman, Lars Mjörnstedt, J. Molne, Michael Olausson, L. Rydberg, Christian T. Svalander, L. Backman
Xenotransplantation - 2006 -
Surmonter les barrières classiques des groupes sanguins ABO en transplantation d
òrgane.
Michael Breimer
Actualités néphrologiques. Flammarion Médicine-Sciences. - 2006 -
ABO-incompatible live donor renal transplantation using blood group A/B carbohydrate antigen immunoadsorption and anti-CD20 antibody
treatment.
Gunnela Nordén, David Briggs, Paul Cockwell, Graham Lipkin, Lars Mjörnstedt, Johan Mölne, Andrew Ready, Lennart Rydberg, Ola Samuelsson, Christian T. Svalander, Michael Breimer
Xenotransplantation - 2006 -
Blood group A and B antigen expression in human kidneys correlated to A1/A2/B, Lewis, and secretor
status.
Michael Breimer, Johan Mölne, Gunnela Nordén, Lennart Rydberg, G. Thiel, Christian T. Svalander
Transplantation - 2006 -
Carbohydrate-dependent inhibition of Helicobacter pylori colonization using porcine
milk
A. Gustafsson, A. Hultberg, R. Sjostrom, I. Kacskovics, Michael Breimer, T. Boren, L. Hammarstrom, Jan Holgersson
Glycobiology - 2006 -
Glomerular C3c deposition and intravascular macrophage accumulation in early humoral renal allograft rejection signifies a poor short-term
outcome.
Johan Mölne, Gudrun Nyberg, Ingemar Blohmé, Lennart Rydberg, Michael Breimer, Christian T. Svalander
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 2006 -
[To have more physicians in executive functions requires changes in the curriculum of undergraduate medical
education]
Michael Breimer
Lakartidningen - 2006 -
Structural characterization of blood group A glycolipids in blood group A liver tissue in situ perfused with O blood: the dominating presence of type 1 core chain A
antigens.
Bo Samuelsson, Stefan Magnusson, Lennart Rydberg, Tore Scherstén, Michael Breimer
Xenotransplantation - 2006 -
Characteristics of protein-carbohydrate interactions as a basis for developing novel carbohydrate-based antirejection
therapies
Jan Holgersson, A. Gustafsson, Michael Breimer
Immunology and cell biology - 2005 -
Anti-pig antibody adsorption efficacy of {alpha}-Gal carrying recombinant P-selectin glycoprotein ligand-1/immunoglobulin chimeras increases with core 2 {beta}1, 6-N-acetylglucosaminyltransferase
expression
J. Liu, A. Gustafsson, Michael Breimer, A. Kussak, Jan Holgersson
Glycobiology - 2005 -
Carbohydrate phenotyping of human and animal milk
glycoproteins
A. Gustafsson, I. Kacskovics, Michael Breimer, L. Hammarstrom, Jan Holgersson
Glycoconjugate journal - 2005 -
Immunoperoxidase versus immunofluorescence in the assessment of human renal
biopsies.
Johan Mölne, Michael Breimer, Christian T. Svalander
American journal of kidney diseases : the official journal of the National Kidney Foundation - 2005 -
Expression of carbohydrate xenoantigens on porcine peripheral
nerve
S. Magnusson, V. Strokan, L. Svensson, Jan-Eric Månsson, L. Rydberg, Michael Breimer
Xenotransplantation - 2005 -
Characterization of the humoral immune response in two paediatric patients transplanted with split livers from ABO-incompatible living-related donors: appearance of cytomegalovirus-induced ABO
antibodies
Lennart Rydberg, Henry Ascher, Marie Krantz, Carola Kullberg-Lindh, Michael Olausson, Christian T. Svalander, Michael Breimer
Transfus Med - 2005 -
In vitro assessment of a new ABO immunosorbent with synthetic carbohydrates attached to
sepharose.
Lennart Rydberg, Anders Bengtsson, Ola Samuelsson, Kurt Nilsson, Michael Breimer
Transplant international : official journal of the European Society for Organ Transplantation - 2005 -
Isolation and partial characterization of Gal alpha-containing polyglycosylceramides from porcine
tissues.
Irene Leonardsson, Halina Miller-Podraza, Susann Teneberg, Michael Breimer
Xenotransplantation - 2004 -
Seventh Congress of the International Xenotransplantation Association (IXA), Glasgow, 2003: "in vitro"
highlights
Michael Breimer
Xenotransplantation - 2004 -
Commentary:In vitro highlights of the 7th Congress of the International Xenotransplantation Association,
Glasgow..
Michael Breimer
Xenotransplantation 11, 2004 - 2003 -
Release of pig leukocytes during pig kidney perfusion and characterization of pig lymphocyte carbohydrate
xenoantigens.
Stefan Magnusson, Jan-Eric Månsson, Valeri Strokan, Rainer Jussila, Takaaki Kobayashi, Lennart Rydberg, Egidio Romano, Michael Breimer
Xenotransplantation - 2003 -
Identification of target tissue glycosphingolipid receptors for uropathogenic, F1C-fimbriated Escherichia coli and its role in mucosal
inflammation
Fredrik Bäckhed, B. Alsen, N. Roche, J. Angstrom, A. von Euler, Michael Breimer, B. Westerlund-Wikstrom, Susann Teneberg, A. Richter-Dahlfors
Journal of Biological Chemistry - 2002 -
Commentary: Highlights of the 6th Congress of the International Xenotransplantation Association,
Chicago.
Michael Breimer
Xenotransplantation 9 - 2002 -
Xenotransplatation.
Michael Breimer
Transplantation (eds C. Johnsson and G Tuvesson) - 2002 -
Highlights of the 6th Congress of the International Xenotransplantation Association, Chicago,
2001.
Michael Breimer, David K C Cooper, Anthony J F d'Apice, Anthony Dorling, Ian F C McKenzie, Philip J O'Connell, Riyota Shirakura
Xenotransplantation - 2002 -
Histo-blood group A antigen expression in pig kidneys--implication for ABO incompatible pig-to-human
xenotransplantation.
Lennart Rydberg, Johan Mölne, V Strokan, Christian T. Svalander, Michael Breimer
Scandinavian journal of urology and nephrology - 2001 -
Ultrastructural identification of cells expressing Galalpha1-3Gal antigen in cultured fetal porcine isletlike cell
clusters.
V Strokan, W Bennet, Johan Mölne, O Korsgren, Michael Breimer
Transplantation proceedings - 2000 -
Distribution of the Galalpha1-3Gal antigen in cultured adult and fetal porcine pancreatic islet cells: an immunoelectron microscopic
study.
V Strokan, W Bennet, Johan Mölne, O Korsgren, Michael Breimer
Transplantation - 2000 -
Blocking of human anti-pig xenoantibodies by soluble GAL alpha 1-3Gal and Gal alpha 1-2Gal disaccharides; studies in a pig kidney in vitro perfusion
model.
Stefan Magnusson, V Strokan, Johan Mölne, K Nilsson, Lennart Rydberg, Michael Breimer
Transplant international : official journal of the European Society for Organ Transplantation - 2000 -
Ganglioside xenoantigens in pig lymphocytes and
aorta.
Stefan Magnusson, Eva Hallberg, J Mânsson, E Romano, Lennart Rydberg, V Strokan, L Svensson, Michael Breimer
Transplantation proceedings - 2000 -
Immunogenicity of Hanganutziu-Deicher antigens in pig-to-human
xenotransplantation.
T Kobayashi, A Suzuki, I Yokoyama, M Abe, S Hayashi, T Nagasaka, Y Namii, T Kato, T Tokoro, D Liu, A Nakao, H Matsuda, K Morozumi, Michael Breimer, Lennart Rydberg, C G Groth, A Tibell, O Korsgren, H Takagi
Transplantation proceedings - 2000 -
Lack of antibody production against Hanganutziu-Deicher (H-D) antigens with N-glycolylneuraminic acid in patients with porcine exposure
history.
T Kobayashi, I Yokoyama, A Suzuki, M Abe, S Hayashi, H Matsuda, K Morozumi, Michael Breimer, Lennart Rydberg, C G Groth, A Tibell, O Korsgren, H Takagi, A Nakao
Xenotransplantation - 2000 -
Ultrastructural localization of Gal alpha 1-3Gal in the pig
kidney.
V Strokan, Johan Mölne, Christian T. Svalander, Michael Breimer
Transplantation proceedings - 1999 -
Alpha-Gal epitopes in animal tissue glycolipids and
glycoproteins.
Lennart Rydberg, Jan Holgersson, Samuelsson, Michael Breimer
Subcellular biochemistry , alpha 1, 3 galactosyltransferase, alpha-Gal epitopes and the natural anti-Gal antibody.(eds Galili, Avila) - 1999 -
Xenotransplantation in
Sweden.
CG Groth, Michael Breimer
1999 -
Physiologic incompatibilities in discordant
xenotransplantation.
Michael Breimer
Transplantation proceedings - 1999 -
Xenotransplantation in
Sweden.
C G Groth, Michael Breimer
Bulletin of the World Health Organization - 1999 -
alpha-Gal epitopes in animal tissue glycoproteins and
glycolipids.
Lennart Rydberg, Jan Holgersson, B E Samuelsson, Michael Breimer
Sub-cellular biochemistry - 1999 -
Terminal alpha1-Gal is not uniformly expressed in the pig endothelial
cells.
V Strokan, U Höök, Johan Mölne, Christian T. Svalander, Michael Breimer
Proceedings of 50th Annual Meeting Scandinavian. Society for Electron Microscopy. Helsinki, Finland - 1998 -
Extracorporeal ("ex vivo") connection of pig kidneys to humans. III. Studies of plasma complement activation and complement deposition in the kidney
tissue.
Anders Bengtsson, Christian T. Svalander, Johan Mölne, Lennart Rydberg, Michael Breimer
Xenotransplantation - 1998 -
Characterisation of human natural anti-sheep
xenoantibodies.
V Strokan, Lennart Rydberg, Eva C. Hallberg, Johan Mölne, Michael Breimer
Xenotransplantation - 1998 -
Heterogeneous expression of Gal alpha1-3Gal xenoantigen in pig kidney: a lectin and immunogold electron microscopic
study.
V Strokan, Johan Mölne, Christian T. Svalander, Michael Breimer
Transplantation - 1998 -
Characterization of a mouse monoclonal IgG3 antibody to the tumor-associated globo H structure produced by immunization with a synthetic
glycoconjugate.
V Kudryashov, G Ragupathi, I J Kim, Michael Breimer, S J Danishefsky, P O Livingston, K O Lloyd
Glycoconjugate journal - 1998 -
Electrospray ionization and collision-induced dissociation time-of-flight mass spectrometry of neutral
glycosphingolipids.
A Olling, Michael Breimer, E Peltomaa, B E Samuelsson, S Ghardashkhani
Rapid communications in mass spectrometry : RCM - 1998 -
No evidence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig
kidneys.
C Patience, G S Patton, Y Takeuchi, R A Weiss, M O McClure, Lennart Rydberg, Michael Breimer
Lancet - 1998 -
Chemical and lectin-gold electron microscopical studies of the expression of the Galalpha1-determinant in the pig
aorta.
Eva C. Hallberg, V Strokan, T D Cairns, Michael Breimer, B E Samuelsson
Xenotransplantation - 1998 -
Biotinylated platelets have an impaired response to agonists as evidenced by in vitro platelet aggregation
tests.
Stefan Magnusson, M Hou, E C Hallberg, Michael Breimer, Hans Wadenvik
Thrombosis research - 1998 -
Soluble saccharides block the inhibition of agonist-induced human platelet aggregation observed after in vitro incubation of human platelet-rich plasma with porcine aortic endothelial
cells.
Stefan Magnusson, E L Romano, Eva Hallberg, Hans Wadenvik, Michael Breimer
Transplant international : official journal of the European Society for Organ Transplantation - 1998 -
An ELISA technique for quantitation of human xenoantibodies binding to pig cells: application in patients with pig kidneys extracorporeally connected to the
circulation.
Lennart Rydberg, Michael Breimer, K Nilsson, Lola Svensson, Bo Samuelsson, E Romano
Xenotransplantation - 1998 -
Studies on distribution of terminal alpha-Galactose the major human xenoantigen in pig kidney by ultracryomicrotomy and immunogold silver staining
techniques.
V Strokan, Johan Mölne, Christian T. Svalander, Michael Breimer
Proceedings of 49th Annual Meeting Scandinavian. Society for Electron Microscopy.Göteborg - 1997 -
The conceptual scientific development of the xenotransplatation project in
Göteborg.
Michael Breimer, Lennart Rydberg, S Björk, Christian T. Svalander, Mattias Aurell, Bo Samuelsson
Xenotransplantation, 2nd edition (eds Cooper, Kemp, Plat, White) - 1997 -
Biochemical and enzymatic characterization of blood group ABH and related histo-blood group glycosphingolipids in the epithelial cells of porcine small
intestine.
Annika E. Bäcker, Michael Breimer, B E Samuelsson, Jan Holgersson
Glycobiology - 1997 -
Blood group glycosphingolipid expression in kidney of an individual with the rare blood group A1 Le(a-b+) p phenotype: absence of blood group structures based on the
globoseries.
K Lindström, Per-Åke Jovall, S Ghardashkani, B E Samuelsson, Michael Breimer
Glycoconjugate journal - 1996 -
Extracorporeal ("ex vivo") connection of pig kidneys to humans. I. Clinical data and studies of platelet
destruction.
Michael Breimer, S Björck, Christian T. Svalander, Anders Bengtsson, Lennart Rydberg, K Lie-Karlsen, P O Attman, Mattias Aurell, B E Samuelsson
Xenotransplantation - 1996 -
Extracorporeal ("ex vivo") connection of pig kidneys to humans. II. The anti-pig antibody
response.
Lennart Rydberg, S Björck, E Hallberg, S Magnusson, S Sumitran, B E Samuelsson, V Strokan, Christian T. Svalander, Michael Breimer
Xenotransplantation - 1996 -
Physiological and histological characterisation of a pig kidney in vitro perfusion model for xenotransplantation
studies.
Michael Breimer, Christian T. Svalander, B Haraldsson, S Björck
Scandinavian journal of urology and nephrology - 1996 -
The expression of carbohydrate blood group antigens correlates with heat
resistance.
A Ménoret, C Otry, N Labarrière, Michael Breimer, F Piller, K Meflah, J Le Pendu
Journal of cell science - 1995 -
Natural antibodies and human
xenotransplantation.
B E Samuelsson, Lennart Rydberg, Michael Breimer, A Bäcker, M Gustavsson, J Holgersson, E Karlsson, A C Uyterwaal, T Cairns, K Welsh
Immunological reviews - 1994 -
Expression of glycolipid blood group antigens in single human kidneys: change in antigen expression of rejected ABO incompatible kidney
grafts.
A Ulfvin, A E Bäcker, H Clausen, S Hakomori, Lennart Rydberg, B E Samuelsson, Michael Breimer
Kidney international - 1993 -
Organ transplantation in Göteborg with particular reference to kidney
transplantation.
G Tufveson, L Bäckman, E Berglin, Ingemar Blohmé, Michael Breimer, Styrbjörn Friman, S Holmberg, P Lindnér, L Mjörnstedt, G Nordén
Clinical transplants - 1993 -
Serological and immunochemical characterization of anti-PP1Pk (anti-Tja) antibodies in blood group little p individuals. Blood group A type 4 recognition due to internal
binding.
Lennart Rydberg, B Cedergren, Michael Breimer, K Lindström, Per-Georg Nyholm, B E Samuelsson
Molecular immunology - 1992 -
The blood group B type-4 heptaglycosylceramide is a minor blood group B structure in human B kidneys in contrast to the corresponding A type-4 compound in A kidneys. Structural and in vitro biosynthetic
studies.
Jan Holgersson, Annika E. Bäcker, Michael Breimer, Mikael Gustafsson, Per-Åke Jovall, Hasse Karlsson, W Pimlott, Bo Samuelsson
Biochimica et biophysica acta - 1992 -
Non-acid glycosphingolipid expression in plasma of an A1 Le(a-b+) secretor human individual: identification of an ALeb heptaglycosylceramide as major blood group
component.
K Lindström, Michael Breimer, Per-Åke Jovall, B Lanne, W Pimlott, B E Samuelsson
Journal of biochemistry - 1992 -
Glycosphingolipid expression in spontaneously aborted fetuses and placenta from blood group p women. Evidence for placenta being the primary target for
anti-Tja-antibodies.
K Lindström, A E Von Dem Borne, Michael Breimer, B Cedergren, Y Okubo, Lennart Rydberg, Susann Teneberg, B E Samuelsson
Glycoconjugate journal - 1992 -
Basic biochemistry of cell surface carbohydrates and aspects of the tissue distribution of histo-blood group ABH and related
glycosphingolipids.
J Holgersson, Michael Breimer, B E Samuelsson
APMIS. Supplementum - 1992 -
Carbohydrate specificity of human immunoglobulin-M antibodies with pig lymphocytotoxic
activity.
J Holgersson, T D Cairns, E C Karlsson, A E Bäcker, Michael Breimer, D H Taube, K I Welsh, B E Samuelsson
Transplantation proceedings - 1992 -
Electron ionization-tandem mass spectrometry of glycosphingolipids. I: The identiftcation of compound-specific sequence ions in the collision-induced dissociation spectra of the immonium ions of two isomeric
hexaglycosylceramides.
J M Curtis, P J Derrick, J Holgersson, B E Samuelsson, Michael Breimer
Journal of the American Society for Mass Spectrometry - 1992 -
Characterisation of the anti-A antibody response following an ABO incompatible (A2 to O) kidney
transplantation.
Lennart Rydberg, Michael Breimer, Jan Holgersson, Karl-Anders Karlsson, Per-Georg Nyholm, I Pascher, Lola Svensson, Bo Samuelsson
Molecular immunology - 1992 -
Blood group type glycosphingolipids of human kidneys. Structural characterization of extended globo-series
compounds.
Jan Holgersson, Per-Åke Jovall, Bo Samuelsson, Michael Breimer
Glycoconjugate journal - 1991 -
Glycosphingolipids of human large intestine: detailed structural characterization with special reference to blood group compounds and bacterial receptor
structures.
Jan Holgersson, Per-Åke Jovall, Michael Breimer
Journal of biochemistry - 1991 -
Structural characterization of non-acid glycosphingolipids in kidneys of single blood group O and A
pigs.
Jan Holgersson, Per-Åke Jovall, Bo Samuelsson, Michael Breimer
Journal of biochemistry - 1990 -
Glycolipid- and glycoprotein-based blood group A antigen expression in human thrombocytes. A1/A2
difference.
J Holgersson, Michael Breimer, A Jacobsson, L Svensson, A Ulfvin, B E Samuelsson
Glycoconjugate journal - 1990 -
Blood group A glycolipid antigen biosynthesis: discrimination between biosynthesized and enzyme preparation derived blood group A antigen by mass
spectrometry.
J Holgersson, A Jacobsson, Michael Breimer, B E Samuelsson
Analytical biochemistry - 1990 -
ABO-incompatible kidney transplantation (A2 to O). Qualitative and semiquantitative studies of the humoral immune response against different blood group A
antigens.
Lennart Rydberg, Michael Breimer, H Brynger, B E Samuelsson
Transplantation - 1990 -
Blood group A glycolipid antigen expression in kidney, ureter, kidney artery, and kidney vein from a blood group A1Le(a-b+) human individual. Evidence for a novel blood group A heptaglycosylceramide based on a type 3 carbohydrate
chain.
J Holgersson, H Clausen, S Hakomori, B E Samuelsson, Michael Breimer
The Journal of biological chemistry - 1990 -
The distribution of blood group glycosphingolipids in human large intestine as investigated by mass
spectrometry.
Jan Holgersson, W Pimlott, Samuelsson, Michael Breimer
Advances of mass spectrometry. (eds Longerialle P) - 1989 -
Novel polyfucosylated N-linked glycopeptides with blood group A, H, X, and Y determinants from human small intestinal epithelial
cells.
J Finne, Michael Breimer, G C Hansson, K A Karlsson, H Leffler, J F Vliegenthart, H van Halbeek
The Journal of biological chemistry - 1989 -
Electron ionization mass spectrometry for sequence analysis of glycosphingolipid mixtures by fractional evaporation in the ion source. Mass spectrometric evidence for an eleven-sugar
glycolipid.
J Holgersson, W Pimlott, B E Samuelsson, Michael Breimer
Rapid communications in mass spectrometry : RCM - 1989 -
ABO blood grouping on erythrocytes and antigen expression in different
organs.
A Ulfvin, Michael Breimer, Jan Holgersson, J Vinas, BE Samuelsson
Monoclonal antibodies against human red blood cell and related antigens. - 1988 -
Structures of the eight- to nine-sugar glycolipids of human blood group A
erythrocytes.
Michael Breimer, H Karlsson, K A Karlsson, K Nilson, B E Samuelsson, N Strömberg
Carbohydrate research - 1988 -
Antibody response in an ABO-incompatible blood transfusion. Antigen specificity and immunoglobulin
class.
Lennart Rydberg, Michael Breimer, B E Samuelsson
Transfusion - 1988 -
Glycolipids of human large intestine: difference in glycolipid expression related to anatomical localization, epithelial/non-epithelial tissue and the ABO, Le and Se phenotypes of the
donors.
J Holgersson, N Strömberg, Michael Breimer
Biochimie - 1988 -
ABO- incompatibility and transplantation- basic facts and clinical
trials.
Michael Breimer
Imcompatibility and transplantation. Transplantation Proc. - 1987 -
Heterogeneity of anti-A and anti-B monoclonal reagents. Agglutination of some weak ABH erythrocyte variants and recognition of synthetic oligosaccharide and tissue
antigens.
P Gane, J Vellayoudom, R Mollicone, Michael Breimer, B E Samuelsson, P Rouger, G Gérard, J Le Pendu, R Oriol
Vox sanguinis - 1987 -
Blood group ABO-incompatible kidney transplantation biochemical and immunochemical studies of blood group A glycolipid antigens in human kidney and characterization of the antibody response (antigen specificity and antibody class) in O recipients receiving A2
grafts.
Michael Breimer, H Brynger, J Le Pendu, R Oriol, L Rydberg, B E Samuelsson, J Vinas
Transplantation proceedings - 1987 -
Structures of blood group glycosphingolipids of human small intestine. A relation between the expression of fucolipids of epithelial cells and the ABO, Le and Se phenotype of the
donor.
S Björk, Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
The Journal of biological chemistry - 1987 -
Blood group ABO-incompatible (A2 to O) kidney transplantation in human subjects: a clinical, serologic, and biochemical
approach.
Lennart Rydberg, Michael Breimer, B E Samuelsson, H Brynger
Transplantation proceedings - 1987 -
ABH antigens: some basic
aspects.
B E Samuelsson, Michael Breimer
Transplantation proceedings - 1987 -
The specific distribution of glycolipid-based blood group A antigens in human kidney related to A1/A2, Lewis, and secretor status of single individuals. A possible molecular explanation for the successful transplantation of A2 kidneys into O
recipients.
Michael Breimer, B E Samuelsson
Transplantation - 1986 -
Structural characterization of a blood group A heptaglycosylceramide with globo-series structure. The major glycolipid based blood group A antigen of human
kidney.
Michael Breimer, Per-Åke Jovall
FEBS letters - 1985 -
Specificity of binding of a strain of uropathogenic Escherichia coli to Gal alpha 1----4Gal-containing
glycosphingolipids.
K Bock, Michael Breimer, A Brignole, Gunnar C. Hansson, K A Karlsson, G Larson, H Leffler, B E Samuelsson, N Strömberg, C S Edén
The Journal of biological chemistry - 1985 -
The specific glycosphingolipid composition of human ureteral epithelial
cells.
Michael Breimer, Gunnar C. Hansson, H Leffler
Journal of biochemistry - 1985 -
Tissue specificity of glycosphingolipids as expressed in pancreas and small intestine of blood group A and B human
individuals.
Michael Breimer
Archives of biochemistry and biophysics - 1984 -
Blood group glycosphingolipids of human gastrointestinal
tissue.
S Björk, Michael Breimer, Gunnar C. Hansson, K-A Karlsson, H Leffler
Red cell membrane glycoconjugates and related genetics markers.(eds Catron JP, Rouger P, Salomon C) - 1983 -
Blood group glycosphingolipids of human
kidney.
Michael Breimer, Gunnar C. Hansson, G Larsson
Glycoconjugates (eds Chester, A, Heinegård D, Lundblad A, Svensson S). - 1983 -
Sequencing of large oligosaccharides by direct inlet mass spectrometry application to cell surface
glycolipids.
Michael Breimer, Gunnar C. Hansson, KA Karlsson, H Leiffler, W Pimlott, BE Samuelsson, N Strömberg, J Thurin
International Journal of Mass Spectrometry - 1983 -
Chemical and immunological identification of glycolipid-based blood group ABH and Lewis antigens in human
kidney.
Michael Breimer, K A Karlsson
Biochimica et biophysica acta - 1983 -
The preparative separation of sialic acid-containing lipids from sulphate group-containing glycolipids from small intestine of different animals. Analysis by thin-layer chromatography and detection of novel
species.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
Journal of biochemistry - 1983 -
Chemical characterization of a blood group H type pentaglycosylceramide of human small
intestine.
Michael Breimer, K A Karlsson, G Larson, J M McKibbin
Chemistry and physics of lipids - 1983 -
Structural identification of two ten-sugar branched chain glycosphingolipids of blood group H type present in epithelial cells of rat small
intestine.
Michael Breimer, K E Falk, G C Hansson, K A Karlsson
The Journal of biological chemistry - 1982 -
Glycosphingolipids of rat tissues. Different composition of epithelial and nonepithelial cells of small
intestine.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
The Journal of biological chemistry - 1982 -
Isolation and partial characterization of blood group A and H active glycosphingolipids of rat small
intestine.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
The Journal of biological chemistry - 1982 -
Characterization of a human intestinal difucosyl heptaglycosylceramide with a blood group B determinant and a type 1 carbohydrate
chain.
Michael Breimer, K A Karlsson, B E Samuelsson
The Journal of biological chemistry - 1982 -
Chemical characterization of penta-, hexa-, hepta-, octa-, and nonaglycosylceramides of rat small intestine having a globoside-like
terminus.
Jonas Ångström, Michael Breimer, K E Falk, Gunnar C. Hansson, K A Karlsson, H Leffler
The Journal of biological chemistry - 1982 -
Structural characterization of glycolipids of rat small intestine having one to eight hexoses in a linear
sequence.
Jonas Ångström, Michael Breimer, K E Falk, Gunnar C. Hansson, K A Karlsson, H Leffler, I Pascher
Archives of biochemistry and biophysics - 1982 -
Studies on differentiating epithelial cells of rat small intestine. Alterations in the lipophilic part of glycosphingolipids during cell migration from crypt villus
tip.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
Biochimica et biophysica acta - 1982 -
Glycosphingolipids of a green monkey kidney cell line (GMK AH-1). Evidence for a novel pentaglycosylceramide based on
globotetraosylceramide.
J Blomberg, Michael Breimer, K A Karlsson
Biochimica et biophysica acta - 1982 -
Sequencing of oligosaccharides by mass spectrometry applied on a 12-sugar
glycolipid.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler, W Pimlott, B E Samuelsson
FEBS letters - 1981 -
Characterization of a blood group H type pentaglycosylceramide of human pancreas based on a type 1 carbohydrate
chain.
Michael Breimer, K A Karlsson, B E Samuelsson
The Journal of biological chemistry - 1981 -
Glycosphingolipids and the differentiation of intestinal
epithelium.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
Experimental cell research - 1981 -
Blood group type glycosphingolipids from the small intestine of different animals analysed by mass spectrometry and thin-layer chromatography. A note on species
diversity.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
Journal of biochemistry - 1981 -
Separation and characterization of hematosides with different sialic acids and ceramides from rat small intestine. Different composition of epithelial cells versus non-epithelial tissue and of duodenum versus
jejunum-ileum.
Jonas Ångström, Michael Breimer, K E Falk, I Griph, Gunnar C. Hansson, K A Karlsson, H Leffler
Journal of biochemistry - 1981 -
Glycolipids of rat small intenstine with special reference to ephitelial cells in relation to
differentiation.
Michael Breimer, Gunnar C. Hansson, KA Karlsson, H Leffler
Biochemistry of cell surface glycolipids. (eds Sweeley , CC) - 1980 -
Glycolipids of rat small intestine. Characterization of a novel blood group H-active
triglycosylceramide.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
Biochimica et biophysica acta - 1980 -
Adaptation of mass spectrometry for the analysis of tumor antigens as applied to blood group glycolipids of a human gastric
carcinoma.
Michael Breimer
Cancer research - 1980 -
Human blood group A-positive and -negative strains of rat. Chemical basis as shown by fucolipids of small
intestine.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
FEBS letters - 1980 -
Demonstration of complexity of the glycosphingolipid fraction of rat small
intestine.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
Biochemical and biophysical research communications - 1980 -
Glycolipid pattern of stomach tissue of a human with the rare blood group
A,p.
Michael Breimer, B Cedergren, K A Karlsson, K Nilson, B E Samuelsson
FEBS letters - 1980 -
On the structure and function of glycosphingolipids : characterization of blood group antigens of the gastrointestinal
tract
Michael Breimer
1980 -
Glycoshingolipid characteristics of epithelial cells of intestine of several
species.
Michael Breimer, KE Falk, KA Karlsson, G Larsson, H Leffler
Glycoconjugates (eds Schauer R, Boer P, Buddecka E, Kramer MF, Vliegenhart and Wiegendt) - 1979 -
Selected ion monitoring of glycospingolipid mixtures. Identification of several blood group type glycolipids in the small intestine of an individual
rabbit.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler, W Pimlott, B E Samuelsson
Biomedical mass spectrometry - 1979 -
Structure determination of blood group type glycolipids of cat small intestine by mass
fragmentography.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler, W Pimlott, B E Samuelsson
FEBS letters - 1978 -
Presence of phytosphingosine combined with 2-hydroxy fatty acids in sphingomyelins of bovine kidney and intestinal
mucosa.
Michael Breimer, K A Karlsson, B E Samuelsson
Lipids - 1975 -
Distribution of molecular species of sphingomyelins in different parts of bovine digestive
tract.
Michael Breimer
Journal of lipid research - 1975 -
Identification of a novel hepraglycosylceramide with two fucose residues and a terminal
hexosamine.
E L Smith, J M McKibbin, Michael Breimer, K A Karlsson, I Pascher, B E Samuelson
Biochimica et biophysica acta - 1975 -
The distribution of molecular species of monoglycosylceramides (cerebrosides) in different parts of bovine digestive
tract.
Michael Breimer, K A Karlsson, B E Samuelsson
Biochimica et biophysica acta - 1974 -
Lipids in tissues of the eye. X. Molecular species of sphingomyelins from different parts of calf lens in relation to differentiation and
aging.
R M Broekhuyse, H Roelfzema, Michael Breimer, K A Karlsson
Experimental eye research - 1974