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- Jan Holmgren
Jan Holmgren
Senior Researcher
Department of Microbiology and Immunology-
A thermostable, dry formulation inactivated Hikojima whole cell/cholera toxin B subunit oral cholera
vaccine
Manuela Terrinoni, Stefan Nordqvist, Madeleine Löfstrand, Frida Nilsson, Susanne Källgård, T. Sharma, Michael Lebens, Jan Holmgren
Vaccine - 2023 -
Safety and immunogenicity of ETVAX (R), an oral inactivated vaccine against enterotoxigenic Escherichia coli diarrhoea: a double-blinded, randomized, placebo-controlled trial amongst Finnish travellers to Benin, West
Africa
A. Kantele, M. Riekkinen, T. S. Jokiranta, S. H. Pakkanen, J. P. Pietila, A. Patjas, M. Eriksson, T. Khawaja, P. Klemets, K. Marttinen, H. Siikamaki, Anna Lundgren, Jan Holmgren, A. Lissmats, N. Carlin, Ann-Mari Svennerholm
Journal of Travel Medicine - 2023 -
Evaluating improved inactivated oral cholera vaccines for use in ending endemic cholera by 2030: opportunities and
challenges
J. Deen, Jan Holmgren, J. D. Clemens
The Lancet Infectious Diseases - 2022 -
An Update on Cholera Immunity and Current and Future Cholera
Vaccines
Jan Holmgren
Tropical Medicine and Infectious Disease - 2021 -
A phase I/II study to evaluate safety, tolerability and immunogenicity of Hillchol®, an inactivated single Hikojima strain based oral cholera vaccine, in a sequentially age descending population in
Bangladesh
F. Chowdhury, K. Ali Syed, A. Akter, T. Rahman Bhuiyan, I. Tauheed, F. Khaton, R. Biswas, J. Ferdous, H. Al Banna, A. G. Ross, N. Mc Millan, T. Sharma, V. Kanchan, A. Pal Singh, D. Gill, Michael Lebens, Stefan Nordqvist, Jan Holmgren, J. D. Clemens, F. Qadri
Vaccine - 2021 -
Immune responses against oxidized LDL as possible targets for prevention of atherosclerosis in systemic lupus
erythematosus
I. Yao Mattisson, S. Rattik, H. Björkbacka, I. Ljungcrantz, Manuela Terrinoni, Michael Lebens, Jan Holmgren, G. N. Fredrikson, B. Gullstrand, A. A. Bengtsson, J. Nilsson, M. Wigren
Vascular Pharmacology - 2021 -
Development of Hillchol (R), a low-cost inactivated single strain Hikojima oral cholera
vaccine
T. Sharma, N. Joshi, A. K. Mandyal, Stefan Nordqvist, Michael Lebens, V. Kanchan, Madeleine Löfstrand, Frida Jeverstam, M. M. Ahasan, I. Khan, M. Karim, H. Muktadir, A. Muktadir, D. Gill, Jan Holmgren
Vaccine - 2020 -
Cholera immunity and development and use of oral cholera vaccines for disease
control
F. Qadri, J. D. Clemens, Jan Holmgren
Mucosal Vaccines. Innovation for Preventing Infectious Diseases. Hiroshi Kiyono and David W. Pascual (red.) - 2020 -
Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera
vaccines
C. J. H. Davitt, S. Longet, A. Albutti, V. Aversa, Stefan Nordqvist, B. Hackett, C. P. McEntee, M. Rosa, I. S. Coulter, Michael Lebens, Joshua Tobias, Jan Holmgren, E. C. Lavelle
Mucosal Immunology - 2019 -
Requirement for Cyclic AMP/Protein Kinase A-Dependent Canonical NF kappa B Signaling in the Adjuvant Action of Cholera Toxin and Its Non-toxic Derivative
mmCT
Manuela Terrinoni, Jan Holmgren, Michael Lebens, Maximilian Larena
Frontiers in Immunology - 2019 -
Proteomic analysis of cholera toxin adjuvant-stimulated human monocytes identifies Thrombospondin-1 and Integrin-beta 1 as strongly upregulated molecules involved in adjuvant
activity
Manuela Terrinoni, Jan Holmgren, Michael Lebens, Maximilian Larena
Scientific Reports - 2019 -
An oral alpha-galactosylceramide adjuvanted Helicobacter pylori vaccine induces protective IL-1R-and IL-17R-dependent Th1
responses
S. Longet, A. Abautret-Daly, C. J. H. Davitt, C. P. McEntee, V. Aversa, M. Rosa, I. S. Coulter, Jan Holmgren, Sukanya Raghavan, E. C. Lavelle
Npj Vaccines - 2019 -
Adjuvants Enhance the Induction of Germinal Center and Antibody Secreting Cells in Spleen and Their Persistence in Bone Marrow of Neonatal
Mice
A. A. A. Pind, M. Dubik, S. Thorsdottir, A. Meinke, A. M. Harandi, Jan Holmgren, G. Del Giudice, I. Jonsdottir, S. P. Bjarnarson
Frontiers in Immunology - 2019 -
A Novel Nonantibiotic, lgt-Based Selection System for Stable Maintenance of Expression Vectors in Escherichia coli and Vibrio
cholerae
Manuela Terrinoni, Stefan Nordqvist, Susanne Källgård, Jan Holmgren, Michael Lebens
Applied and Environmental Microbiology - 2018 -
B cells treated with CTB-p210 acquire a regulatory phenotype in vitro and reduce atherosclerosis in apolipoprotein E deficient
mice
S. Rattik, P. T. Mantani, I. Y. Mattisson, I. Ljungcrantz, L. Sundius, H. Bjorkbacka, Manuela Terrinoni, Michael Lebens, Jan Holmgren, J. Nilsson, M. Wigren, G. N. Fredrikson
Vascular Pharmacology - 2018 -
Preclinical immunogenicity and protective efficacy of an oral Helicobacter pylori inactivated whole cell vaccine and multiple mutant cholera toxin: A novel and non-toxic mucosal
adjuvant
Jan Holmgren, Stefan Nordqvist, Margareta Blomquist, Frida Jeverstam, Michael Lebens, Sukanya Raghavan
Vaccine - 2018 -
Lack of Fc Gamma Receptor IIIA Promotes Rather than Suppresses Humoral and Cellular Immune Responses after Mucosal or Parenteral Immunization with Antigen and
Adjuvants
Jia-Bin Sun, Jan Holmgren, Xianghua Zhou
Scandinavian Journal of Immunology - 2017 -
Cholera
John D. Clemens, G. Balakrish Nair, Tahmeed Ahmed, Firdausi Qadri, Jan Holmgren
The Lancet - 2017 -
Deficiency in calcium-binding protein S100A4 impairs the adjuvant action of cholera
toxin
Jiabin Sun, Jan Holmgren, Maximilian Larena, Manuela Terrinoni, Yu Fang, A. R. Bresnick, Xianghua Zhou
Frontiers in Immunology - 2017 -
Thermostability of the coating, antigen and immunostimulator in an adjuvanted oral capsule vaccine
formulation
S. Longet, V. Aversa, D. O'Donnell, Joshua Tobias, M. Rosa, Jan Holmgren, I. S. Coulter, E. C. Lavelle
International Journal of Pharmaceutics - 2017 -
Surface expression of Helicobacter pylori HpaA adhesion antigen on Vibrio cholerae, enhanced by co-expressed enterotoxigenic Escherichia coli fimbrial
antigens
Joshua Tobias, Michael Lebens, S. N. Wai, Jan Holmgren, Ann-Mari Svennerholm
Microbial Pathogenesis - 2017 -
Construction and preclinical evaluation of mmCT, a novel mutant cholera toxin adjuvant that can be efficiently produced in genetically manipulated Vibrio
cholerae
Michael Lebens, Manuela Terrinoni, Stefan L. Karlsson, Maximilian Larena, Tobias Gustafsson-Hedberg, Susanne Källgård, Erik Nygren, Jan Holmgren
Vaccine - 2016 -
Preparation and preclinical evaluation of a freeze-dried formulation of a novel combined multivalent whole-cell/B-subunit oral vaccine against enterotoxigenic Escherichia coli
diarrhea
Annika Borde, Annelie Ekman, A. Larsson, N. Carlin, Jan Holmgren, Joshua Tobias
European Journal of Pharmaceutics and Biopharmaceutics - 2016 -
Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random
Process
Stefan L. Karlsson, N. Thomson, A. Mutreja, T. Connor, D. Sur, M. Ali, J. Clemens, G. Dougan, Jan Holmgren, Michael Lebens
Plos Neglected Tropical Diseases - 2016 -
A novel adjuvanted capsule based strategy for oral vaccination against infectious diarrhoeal
pathogens
C. J. H. Davitt, E. A. McNeela, S. Longet, Joshua Tobias, V. Aversa, C. P. McEntee, M. Rosa, I. S. Coulter, Jan Holmgren, E. C. Lavelle
Journal of Controlled Release - 2016 -
Helicobacter pylori Infection of the Gastric
Mucosa
Sukanya Raghavan, Jan Holmgren, Ann-Mari Svennerholm
Mucosal Immunology: Fourth Edition - 2015 -
Vaccines against Bacterial Enteric
Infections
Jan Holmgren, M. M. Levine
Mucosal Immunology: Fourth Edition - 2015 -
Cholera toxin, and the related nontoxic adjuvants mmCT and dmLT, promote human Th17 responses via cyclic AMP-protein kinase A and inflammasome-dependent IL-1
signaling
Maximilian Larena, Jan Holmgren, Michael Lebens, Manuela Terrinoni, Anna Lundgren
Journal of Immunology - 2015 -
Vaccines against enteric infections for the developing
world
Cecil Czerkinsky, Jan Holmgren
Philosophical Transactions of the Royal Society B-Biological Sciences - 2015 -
When, How, and Where can Oral Cholera Vaccines be Used to Interrupt Cholera
Outbreaks?
John Clemens, Jan Holmgren
Cholera Outbreaks - 2014 -
Development of Stable Vibrio cholerae O1 Hikojima Type Vaccine Strains Co-Expressing the Inaba and Ogawa Lipopolysaccharide
Antigens
Stefan Karlsson, Elisabeth Ax, Erik Nygren, Susanne Källgård, Margareta Blomquist, Annelie Ekman, John Benktander, Jan Holmgren, Michael Lebens
Plos One - 2014 -
Vibriocidal Antibody Responses to a Bivalent Killed Whole-Cell Oral Cholera Vaccine in a Phase III Trial in Kolkata,
India
S. Kanungo, A. L. Lopez, M. Ali, B. Manna, D. R. Kim, T. Mahapatra, Jan Holmgren, M. S. Dhingra, T. F. Weirzba, G. B. Nair, S. K. Bhattacharya, J. D. Clemens, D. Sur
Plos One - 2014 -
Expression of Cholera Toxin by El Tor Vibrio cholerae in Shallow Culture Growth
Conditions
Mayra Cobaxin, Haydee Martinez, Guadalupe Ayala, Jan Holmgren, Åsa Sjöling, Joaquin Sanchez
Microbial Pathogenesis - 2014 -
5 year efficacy of a bivalent killed whole-cell oral cholera vaccine in Kolkata, India: A cluster-randomised, double-blind, placebo-controlled
trial
S. K. Bhattacharya, D. Sur, M. Ali, S. Kanungo, Y. A. You, B. Manna, B. Sah, S. K. Niyogi, J. K. Park, B. Sarkar, M. K. Puri, D. R. Kim, J. L. Deen, Jan Holmgren, R. Carbis, M. S. Dhingra, A. Donner, G. B. Nair, A. L. Lopez, T. F. Wierzba, J. D. Clemens
Lancet. Infectious Diseases - 2013 -
Important Role for Fc gamma RIIB on B Lymphocytes for Mucosal Antigen-Induced Tolerance and Foxp3(+) Regulatory T
Cells
Jia-Bin Sun, Zou Xiang, K. G. C. Smith, Jan Holmgren
Journal of Immunology - 2013 -
Anti-bacterial and anti-toxic immunity induced by a killed whole-cell-cholera toxin B subunit cholera vaccine is essential for protection against lethal bacterial infection in mouse pulmonary cholera
model.
S S Kang, J S Yang, K W Kim, Jan Holmgren, Cecil Czerkinsky, S H Han, C-H Yun
Mucosal immunology - 2013 -
Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered alone and together with dmLT
adjuvant.
Jan Holmgren, L Bourgeois, N Carlin, J Clements, B Gustafsson, Anna Lundgren, Erik Nygren, Joshua Tobias, R Walker, Ann-Mari Svennerholm
Vaccine - 2013 -
A double mutant heat-labile toxin from Escherichia coli, LT(R192G/L211A), is an effective mucosal adjuvant for vaccination against Helicobacter pylori
infection.
Louise Sjökvist Ottsjö, Carl-Fredrik Flach, Jan Holmgren, John Clements, Sukanya Raghavan
Infection and immunity - 2013 -
Clinical trial to evaluate safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli prototype vaccine containing CFA/I overexpressing bacteria and recombinantly produced LTB/CTB hybrid
protein.
Anna Lundgren, Susannah Leach, Joshua Tobias, N Carlin, B Gustafsson, Marianne Jertborn, L Bourgeois, R Walker, Jan Holmgren, Ann-Mari Svennerholm
Vaccine - 2013 -
Vaccines against mucosal
infections.
Ann-Mari Svennerholm, Jan Holmgren
Current Opinion in Immunology - 2012 -
Mucosal Delivery Routes for Optimal Immunization: Targeting Immunity to the Right
Tissues
Cecil Czerkinsky, Jan Holmgren
Mucosal Vaccines: Modern Concepts, Strategies, and Challenges - 2012 -
Evidence for several waves of global transmission in the seventh cholera
pandemic.
Ankur Mutreja, DW Kim, Nicholas Thomson, TR Connor, JH Lee, S Kariuki, NJ Croucher, SY Choi, SR Harris, Michael Lebens, SK Niyogi, EJ Kim, T Ramamurthy, J Chun, JL Wood, JD Clemens, Cecil Czerkinsky, GB Nair, Jan Holmgren, Julian Parkhill, Gordon Dougan
Nature - 2012 -
Effect of protein release rates from tablet formulations on the immune response after sublingual
immunization
Annika Borde, Annelie Ekman, Jan Holmgren, Anette Larsson
European Journal of Pharmaceutical Sciences - 2012 -
A case for control of cholera in Africa by
vaccination.
Jan Holmgren
The Lancet infectious diseases - 2012 -
B lymphocytes treated in vitro with antigen coupled to cholera toxin B subunit induce antigen-specific Foxp3(+) regulatory T cells and protect against experimental autoimmune
encephalomyelitis.
Jia-Bin Sun, Cecil Czerkinsky, Jan Holmgren
Journal of immunology - 2012 -
Detection of human papillomavirus oncoprotein E7 in liquid-based
cytology
Maria Lidqvist, Olle Nilsson, Jan Holmgren, Sebastian Hölters, Eva Röijer, Matthias Dürst, Christian Fermér
The Journal of general virology - 2012 -
Mucosal vaccination increases local chemokine production attracting immune cells to the stomach mucosa of Helicobacter pylori infected
mice.
Carl-Fredrik Flach, Michael Mozer, Malin Sundquist, Jan Holmgren, Sukanya Raghavan
Vaccine - 2012 -
Preparation and evaluation of a freeze-dried oral killed cholera vaccine
formulation
Annika Borde, Anette Larsson, Jan Holmgren, Erik Nygren
European journal of pharmaceutics and biopharmaceutics - 2011 -
Sublingual
vaccination.
Jan Holmgren
Human vaccines - 2011 -
Efficacy of a low-cost, inactivated whole-cell oral cholera vaccine: results from 3 years of follow-up of a randomized, controlled
trial.
Jan Holmgren
PLoS neglected tropical diseases - 2011 -
Cholera toxin - a foe & a
friend
J Sanchez, Jan Holmgren
INDIAN JOURNAL OF MEDICAL RESEARCH - 2011 -
Construction of novel vaccine strains of Vibrio cholerae co-expressing the Inaba and Ogawa serotype
antigens.
Michael Lebens, Stefan Karlsson, Susanne Källgård, Margareta Blomqvist, Annelie Ekman, Erik Nygren, Jan Holmgren
Vaccine - 2011 -
New-generation vaccines against
cholera
John Clemens, S Shin, D Sur, GB Nair, Jan Holmgren
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY - 2011 -
The subcellular location of antigen expressed by adenoviral vectors modifies adaptive immunity but not dependency on cross-presenting dendritic
cells.
Petra Henning, Tobias Gustafsson, Carl-Fredrik Flach, Yeu-Jiann Hua, Anna Strömbeck, Jan Holmgren, Leif Lindholm, Ulf Yrlid
European journal of immunology - 2011 -
Construction of a non-toxigenic Escherichia coli oral vaccine strain expressing large amounts of CS6 and inducing strong intestinal and serum anti-CS6 antibody responses in
mice.
Joshua Tobias, Ann-Mari Svennerholm, Nils I A Carlin, Michael Lebens, Jan Holmgren
Vaccine - 2011 -
Impaired IFN-gamma Production after Stimulation with Bacterial Components by Natural Killer Cells from Gastric Cancer
Patients
Åsa Lindgren, Cheol H Yun, Åsa Sjöling, Camilla Berggren, Jia-Bin Sun, E Jonsson, Jan Holmgren, Ann-Mari Svennerholm, Samuel B Lundin
Experimental Cell Research - 2011 -
A truncated form of HpaA is a promising antigen for use in a vaccine against Helicobacter
pylori.
Carl-Fredrik Flach, Natascha Svensson, Margareta Blomquist, Annelie Ekman, Sukanya Raghavan, Jan Holmgren
Vaccine - 2011 -
CD8- natural killer cells are greatly enriched in the human gastrointestinal tract and have the capacity to respond to
bacteria.
Åsa Lindgren, Cheol H Yun, Anna Lundgren, Åsa Sjöling, Lena Öhman, Ann-Mari Svennerholm, Jan Holmgren, Samuel B Lundin
Journal of innate immunity - 2010 -
Intranasal Immunization With an Apolipoprotein B-100 Fusion Protein Induces Antigen-Specific Regulatory T Cells and Reduces
Atherosclerosis
Roland Klingenberg, Michael Lebens, Andreas Hermansson, Gunilla Nordin Fredrikson, Daniela Strodthoff, Mats Rudling, Daniel F. J. Ketelhuth, Norbert Gerdes, Jan Holmgren, Jan Nilsson, Goran K. Hansson
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY - 2010 -
Over-expression of major colonization factors of enterotoxigenic Escherichia coli, alone or together, on non-toxigenic E. coli
bacteria.
Joshua Tobias, Jan Holmgren, Maria Hellman, Erik Nygren, Michael Lebens, Ann-Mari Svennerholm
Vaccine - 2010 -
Construction and expression of immunogenic hybrid enterotoxigenic Escherichia coli CFA/I and CS2 colonization fimbriae for use in
vaccines.
Joshua Tobias, Ann-Mari Svennerholm, Jan Holmgren, Michael Lebens
Applied microbiology and biotechnology - 2010 -
Sublingual immunization protects against Helicobacter pylori infection and induces T and B cell responses in the
stomach.
Sukanya Raghavan, Anna Karin Ostberg, Carl-Fredrik Flach, Annelie Ekman, Margareta Blomquist, Cecil Czerkinsky, Jan Holmgren
Infection and immunity - 2010 -
Mucosally induced immunological tolerance, regulatory T cells and the adjuvant effect by cholera toxin B
subunit.
Jia-Bin Sun, C Czerkinsky, Jan Holmgren
Scandinavian journal of immunology - 2010 -
CD11c(high )dendritic cells are essential for activation of CD4+ T cells and generation of specific antibodies following mucosal
immunization.
Linda Fahlén-Yrlid, Tobias Gustafsson, Jessica Westlund, Anna Holmberg, Anna Strömbeck, Margareta Blomquist, Gordon G MacPherson, Jan Holmgren, Ulf Yrlid
Journal of immunology (Baltimore, Md. : 1950) - 2009 -
Efficacy and safety of a modified killed-whole-cell oral cholera vaccine in India: an interim analysis of a cluster-randomised, double-blind, placebo-controlled
trial.
Dipika Sur, Anna Lena Lopez, Suman Kanungo, Allison Paisley, Byomkesh Manna, Mohammad Ali, Swapan K Niyogi, Jin Kyung Park, Banawarilal Sarkar, Mahesh K Puri, Deok Ryun Kim, Jacqueline L Deen, Jan Holmgren, Rodney Carbis, Raman Rao, Thu Van Nguyen, Allan Donner, Nirmal K Ganguly, G Balakrish Nair, Sujit K Bhattacharya, John D Clemens
Lancet - 2009 -
Public health. The cholera crisis in
Africa.
S Bhattacharya, R Black, L Bourgeois, J Clemens, A Cravioto, J L Deen, Gordon Dougan, R Glass, R F Grais, M Greco, I Gust, Jan Holmgren, S Kariuki, P-H Lambert, M A Liu, I Longini, G B Nair, R Norrby, G J V Nossal, P Ogra, P Sansonetti, L von Seidlein, F Songane, Ann-Mari Svennerholm, D Steele, R Walker
Science (New York, N.Y.) - 2009 -
Robust gut associated vaccine-specific antibody-secreting cell responses are detected at the mucosal surface of Bangladeshi subjects after immunization with an oral killed bivalent V. cholerae O1/O139 whole cell cholera vaccine: comparison with other mucosal and systemic
responses.
Sohel Shamsuzzaman, Tanvir Ahmed, Kaiissar Mannoor, Yasmin Ara Begum, Pradip Kumar Bardhan, R Bradley Sack, David A Sack, Ann-Mari Svennerholm, Jan Holmgren, Firdausi Qadri
Vaccine - 2009 -
Establishment of an adult mouse model for direct evaluation of the efficacy of vaccines against Vibrio
cholerae.
Erik Nygren, Bin-Ling Li, Jan Holmgren, Stephen Attridge
Infection and immunity - 2009 -
Induction of protective immunity by vaccination against Chlamydia trachomatis using the major outer membrane protein adjuvanted with CpG oligodeoxynucleotide coupled to the nontoxic B subunit of cholera
toxin.
Chunmei Cheng, Ilham Bettahi, Maria I Cruz-Fisher, Sukumar Pal, Pooja Jain, Zhenyu Jia, Jan Holmgren, Ali M Harandi, Luis M de la Maza
Vaccine - 2009 -
Sublingual immunization with nonreplicating antigens induces antibody-forming cells and cytotoxic T cells in the female genital tract mucosa and protects against genital papillomavirus
infection.
Nicolas Cuburu, Mi-Na Kweon, Catherine Hervouet, Hye-Ran Cha, Yuk-Ying S Pang, Jan Holmgren, Konrad Stadler, John T Schiller, Fabienne Anjuère, Cecil Czerkinsky
Journal of immunology (Baltimore, Md. : 1950) - 2009 -
Enteric vaccines for the developing world: a challenge for mucosal
immunology.
C Czerkinsky, Jan Holmgren
Mucosal immunology - 2009 -
Urgent need of cholera vaccines in public health-control
programs.
John Clemens, Jan Holmgren
Future microbiology - 2009 -
Vibrio cholerae O139 capsular polysaccharide confers complement resistance in the absence or presence of antibody yet presents a productive target for cell lysis: implications for detection of bactericidal
antibodies.
Stephen Attridge, Jan Holmgren
Microbial pathogenesis - 2009 -
Differential immunogenicity of Vibrio cholerae O139 variants expressing different combinations of naturally occurring and atypical forms of the serogroup
polysaccharide.
Stephen Attridge, Gun Wallerström, Bin-Ling Li, R Morona, Jan Holmgren
Vaccine - 2009 -
Immune responses following one and two doses of the reformulated, bivalent, killed, whole-cell, oral cholera vaccine among adults and children in Kolkata, India: a randomized, placebo-controlled
trial.
Suman Kanungo, Allison Paisley, Anna Lena Lopez, Mihir Bhattacharya, Byomkesh Manna, Deok Ryun Kim, Seung Hyun Han, Stephen Attridge, Rodney Carbis, Raman Rao, Jan Holmgren, John D Clemens, Dipika Sur
Vaccine - 2009 -
B lymphocytes promote expansion of regulatory T cells in oral tolerance: powerful induction by antigen coupled to cholera toxin B
subunit.
Jia-Bin Sun, Carl-Fredrik Flach, Cecil Czerkinsky, Jan Holmgren
Journal of immunology (Baltimore, Md. : 1950) - 2008 -
Phage display for site-specific immunization and characterization of high-risk human papillomavirus specific E7 monoclonal
antibodies.
Maria Lidqvist, Olle Nilsson, Jan Holmgren, Christina Hall, Christian Fermér
Journal of immunological methods - 2008 -
Cholera immunity and cholera
vaccination
Jan Holmgren, John D Clemens
Immunity against pathogens - 2008 -
Vaccine Protection of Bangladeshi infants and young children against cholera: implications for vaccine deployment and person-to-person
transmission.
Mohammad Ali, Michael Emch, Mohammad Yunus, David Sack, Anna Lena Lopez, Jan Holmgren, John Clemens
The Pediatric infectious disease journal - 2008 -
Murine antibody responses following systemic or mucosal immunization with viable or inactivated Vibrio
cholerae.
Erik Nygren, Jan Holmgren, Stephen Attridge
Vaccine - 2008 -
Cholera toxin structure, gene regulation and pathophysiological and immunological
aspects
J. Sanchez, Jan Holmgren
Cellular and Molecular Life Sciences - 2008 -
Suppression of HIV replication in vitro by CpG and CpG conjugated to the non toxic B subunit of cholera
toxin.
Salma Nowroozalizadeh, Marianne Jansson, Jenni Adamsson, Marianne Lindblad, Eva-Maria Fenyö, Jan Holmgren, Ali M Harandi
Current HIV research - 2008 -
A randomized, placebo-controlled trial of the bivalent killed, whole-cell, oral cholera vaccine in adults and children in a cholera endemic area in Kolkata,
India.
Dilip Mahalanabis, Anna Lena Lopez, Dipika Sur, Jacqueline Deen, Byomkesh Manna, Suman Kanungo, Lorenz von Seidlein, Rodney Carbis, Seung Hyun Han, Seong Hye Shin, Stephen Attridge, Raman Rao, Jan Holmgren, John Clemens, Sujit K Bhattacharya
PLoS ONE - 2008 -
[Reply on new drugs against type 2 diabetes: important to gain experience and
knowledge]
Ake Sjöholm, Carl-David Agardh, Kerstin Brismar, Suad Efendic, Björn Eliasson, Jan W Eriksson, Anders Frid, Leif Groop, Jan Holmgren, Martin Ridderstråle, Ulf Smith
Läkartidningen - 2008 -
Depth profiling of cells and tissues by using C-60(+) and SF5+ as sputter
ions
Per Malmberg, C. Kriegeskotte, H. F. Arlinghaus, B. Hagenhoff, Jan Holmgren, Mikael Nilsson, Håkan Nygren
APPLIED SURFACE SCIENCE - 2007 -
Differential expression of intestinal membrane transporters in cholera
patients.
Carl-Fredrik Flach, Firdausi Qadri, Taufiqur Rahman Bhuiyan, N. H. Alam, Eva Jennische, Jan Holmgren, Ivar Lönnroth
FEBS letters - 2007 -
Broad up-regulation of innate defense factors during acute
cholera.
Carl-Fredrik Flach, Firdausi Qadri, Taufiqur Rahman Bhuiyan, N. H. Alam, Eva Jennische, Ivar Lönnroth, Jan Holmgren
Infection and immunity - 2007 -
Safety and immunogenicity of a reformulated Vietnamese bivalent killed, whole-cell, oral cholera vaccine in
adults.
Dang Duc Anh, Do Gia Canh, Anna Lena Lopez, Vu Dinh Thiem, Phan Thi Long, Nguyen Hong Son, Jacqueline Deen, Lorenz von Seidlein, Rodney Carbis, Seung Hyun Han, Seong Hye Shin, Stephen Attridge, Jan Holmgren, John Clemens
Vaccine - 2007 -
Sublingual immunization induces broad-based systemic and mucosal immune responses in
mice.
Nicolas Cuburu, Mi-Na Kweon, Joo-Hye Song, Catherine Hervouet, Carmelo Luci, Jia-Bin Sun, Paul Hofman, Jan Holmgren, Fabienne Anjuère, Cecil Czerkinsky
Vaccine - 2007 -
Sublingual 'oral tolerance' induction with antigen conjugated to cholera toxin B subunit generates regulatory T cells that induce apoptosis and depletion of effector T
cells
Jia-Bin Sun, C. Czerkinsky, Jan Holmgren
Scandinavian Journal of Immunology - 2007 -
Response to "questionable merits of the field trial of an oral killed whole cell cholera vaccine in Vietnam during 1998-2003" Vaccine
2007;25(8):1353-4.
Vu Dinh Thiem, Do Gia Canh, Dang Duc Anh, Jacqueline L Deen, Lorenz von Seidlein, John D Clemens, Jan Holmgren
Vaccine - 2007 -
Commentary: Ouchterlony Ö. Antigen - Antibody reactions in gels. IV. Types of reactions in coordinated systems of
diffusion
Jan Holmgren, Lars-Åke Nilsson
APMIS - 2007 -
An optimized automated assay for determination of metabolic stability using hepatocytes: assay validation, variance component analysis, and in vivo
relevance.
Lykke Jacobson, Brian Middleton, Jan Holmgren, Stefan Eirefelt, Maria Fröjd, Anders Blomgren, Lena Gustavsson
Assay and drug development technologies - 2007 -
Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in
Vietnam
Vu Dinh Thiem, Jacqueline L. Deen, Lorenz von Seidlein, Do Gia Canh, Dang Duc Anh, Jin-Kyung Park, Mohammad Ali, M. Carolina Danovaro-Holliday, Nguyen Dinh Son, Nguyen Thai Hoa, Jan Holmgren, John D. Clemens
Vaccine - 2006 -
Engineered bacterial toxin vaccines and adjuvants InSourcebook of bacterial proteins,3rded Alouf&Popoff MR (eds) (in
press).
Jan Holmgren, Ann-Mari Svennerholm
3rded Alouf J &Popoff MR - 2006 -
Cholera due to altered El Tor strains of Vibrio cholerae O1 in
Bangladesh.
G Balakrish Nair, Firdausi Qadri, Jan Holmgren, Ann-Mari Svennerholm, Ashrafus Safa, Nurul A Bhuiyan, Q Shafi Ahmad, Shah M Faruque, A S G Faruque, Yoshifumi Takeda, David A Sack
Journal of clinical microbiology - 2006 -
Oral tolerance induction with antigen conjugated to cholera toxin B subunit generates both Foxp3+CD25+ and Foxp3-CD25- CD4+ regulatory T
cells.
Jia-Bin Sun, Sukanya Raghavan, Åsa Sjöling, Samuel B Lundin, Jan Holmgren
Journal of immunology (Baltimore, Md. : 1950) - 2006 -
Oral tolerance induction by mucosal administration of cholera toxin B-coupled antigen involves T-cell proliferation in vivo and is not affected by depletion of CD25+ T
cells.
Annie George-Chandy, Susanne Hultkrantz, Sukanya Raghavan, Cecil Czerkinsky, Michael Lebens, Esbjörn Telemo, Jan Holmgren
Immunology - 2006 -
Mucosal adjuvants based on cholera toxin and Escherichia Coli heat-labile
enterotoxin.
Jan Holmgren, Cecil Czerkinsky, Ali M Harandi, Michael Lebens, Jia-Bin Sun
2006 -
Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult
volunteers
I. Stephenson, M. C. Zambon, Anna Rudin, A. Colegate, A. Podda, R. Bugarini, G. Del Giudice, A. Minutello, S. Bonnington, Jan Holmgren, K. H. Mills, K. G. Nicholson
J Virol - 2006 -
Dendritic cell-mediated induction of mucosal cytotoxic responses following intravaginal immunization with the nontoxic B subunit of cholera
toxin
Carmelo Luci, Catherine Hervouet, Deborah Rousseau, Jan Holmgren, Cecil Czerkinsky, Fabienne Anjuere
Journal of Immunology - 2006 -
Novel immunostimulatory agent based on CpG oligodeoxynucleotide linked to the nontoxic B subunit of cholera
toxin.
Jenni Adamsson, Marianne Lindblad, Annika Lundqvist, Denise Kelly, Jan Holmgren, Ali M Harandi
Journal of immunology (Baltimore, Md. : 1950) - 2006 -
CpG oligodeoxynucleotides and mobilization of innate mucosal immunity: tasks and
tactics.
Ali M Harandi, Jan Holmgren
Vaccine - 2006 -
Sublingual tolerance induction with antigen conjugated to cholera toxin B subunit induces Foxp3(+)CD25(+)CD4(+) regulatory T cells and suppresses delayed-type hypersensitivity
reactions
Jia-Bin Sun, N. Cuburu, Margareta Blomquist, Bin-Ling Li, C. Czerkinsky, Jan Holmgren
Scandinavian Journal of Immunology - 2006 -
Herd immunity conferred by killed oral cholera vaccines in Bangladesh: a
reanalysis
Mohammad Ali, Michael Emch, Lorenz von Seidlein, Mohammad Yunus, David A. Sack, Malla Rao, Jan Holmgren, John D. Clemens
Lancet - 2005 -
Natural killer cells and Helicobacter pylori infection: bacterial antigens and interleukin-12 act synergistically to induce gamma interferon
production
C. H. Yun, Anna Lundgren, Josef Azem, Åsa Sjöling, Jan Holmgren, Ann-Mari Svennerholm, Samuel B Lundin
Infect Immun - 2005 -
Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG
DNA
Jan Holmgren, Jenni Adamsson, F. Anjuere, J. Clemens, C. Czerkinsky, Kristina Eriksson, Carl-Fredrik Flach, Annie George-Chandy, Ali M Harandi, Michael Lebens, T. Lehner, Marianne Lindblad, Erik Nygren, Sukanya Raghavan, Joaquin Sanchez, M. Stanford, Jia-Bin Sun, Ann-Mari Svennerholm, Sara Tengvall
Immunol Lett - 2005 -
Cholera toxin induces a transient depletion of CD8+ intraepithelial lymphocytes in the rat small intestine as detected by microarray and
immunohistochemistry.
Carl-Fredrik Flach, Stefan Lange, Eva Jennische, Ivar Lönnroth, Jan Holmgren
Infection and immunity - 2005 -
Mucosal immunity and vaccine
design.
Cecil Czerkinsky, Ali M Harandi, Jan Holmgren
2005 -
Virulence factors, pathogenesis and vaccine protection in cholera and ETEC
diarrhea
Joaquin Sanchez, Jan Holmgren
CURRENT OPINION IN IMMUNOLOGY - 2005 -
Mucosal immunity and
vaccines
Jan Holmgren, Cecil Czerkinsky
Nature Medicine - 2005 -
CpG oligodeoxynucleotide augments HSV-2 glycoprotein D DNA vaccine efficacy to generate T helper 1 response and subsequent protection against primary genital herpes infection in
mice.
Sara Tengvall, Agnetha Josefsson, Jan Holmgren, Ali M Harandi
Journal of reproductive immunology - 2005 -
Development of pathogenicity-driven definitions of outcomes for a field trial of a killed oral vaccine against enterotoxigenic Escherichia coli in Egypt: application of an evidence-based
method
John Clemens, Stephen Savarino, Remon Abu-Elyazeed, Mohammad Safwat, Malla Rao, Thomas Wierzba, Ann-Mari Svennerholm, Jan Holmgren, Robert Frenck, Eunsik Park, Abdollah Naficy
J Infect Dis - 2004 -
Antigen-specific in vitro suppression of murine Helicobacter pylori-reactive immunopathological T cells by CD4(+)CD25(+) regulatory T
cells
Sukanya Raghavan, E. Suri-Payer, Jan Holmgren
Scandinavian Journal of Immunology - 2004 -
In vivo adjuvant-induced mobilization and maturation of gut dendritic cells after oral administration of cholera
toxin
Fabienne Anjuère, Carmelo Luci, Michael Lebens, Déborah Rousseau, Catherine Hervouet, Geneviève Milon, Jan Holmgren, Carlos Ardavin, Cecil Czerkinsky
Journal of Immunology - 2004 -
CpG DNA as a potent inducer of mucosal immunity: implications for immunoprophylaxis and immunotherapy of mucosal
infections.
Ali M Harandi, Jan Holmgren
Current opinion in investigational drugs (London, England : 2000) - 2004 -
Intranasal immunization of mice with group B streptococcal protein rib and cholera toxin B subunit confers protection against lethal
infection
Charlotte Larsson, Jan Holmgren, Gunnar Lindahl, Charlotta Bergquist
Infection and Immunity - 2004 -
Vaccination with dendritic cells pulsed in vitro with tumor antigen conjugated to cholera toxin efficiently induces specific tumoricidal CD8+ cytotoxic lymphocytes dependent on cyclic AMP activation of dendritic
cells.
Jia-Bin Sun, Kristina Eriksson, Bin-Ling Li, Marianne Lindblad, Josef Azem, Jan Holmgren
Clinical immunology (Orlando, Fla.) - 2004 -
Expression of cholera toxin under non-AKI conditions in Vibrio cholerae El Tor induced by increasing the exposed surface of
cultures
Joaquín Sánchez, Gerardo Medina, Thomas Buhse, Jan Holmgren, Gloria Soberón-Chavez
JOURNAL OF BACTERIOLOGY - 2004 -
Coupling of antigen to cholera toxin for dendritic cell vaccination promotes the induction of MHC class I-restricted cytotoxic T cells and the rejection of a cognate antigen-expressing model
tumor.
Kristina Eriksson, Jia-Bin Sun, Inger Nordström, Margareta Fredriksson, Marianne Lindblad, Bin-Ling Li, Jan Holmgren
European journal of immunology - 2004 -
Oral tolerization with peptide 336-351 linked to cholera toxin B subunit in preventing relapses of uveitis in Behcet's
disease.
M. Stanford, T Whittall, L A Bergmeier, Marianne Lindblad, Samuel B Lundin, T Shinnick, Y Mizushima, Jan Holmgren, T. Lehner
Clinical and experimental immunology - 2004 -
Orally administered CpG oligodeoxynucleotide induces production of CXC and CC chemokines in the gastric mucosa and suppresses bacterial colonization in a mouse model of Helicobacter pylori
infection.
Sukanya Raghavan, J Nyström, M Fredriksson, Jan Holmgren, Ali M Harandi
Infection and immunity - 2003 -
Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis
toxin.
Nathalie Mielcarek, Elisabeth Hultgren-Hörnquist, Bengt R Johansson, C Locht, Soman N Abraham, Jan Holmgren
Cellular Microbiology - 2001 -
Cholera toxin enhances antigen
presentation.
A K Bromander, Martin Kjerrulf, Jan Holmgren, Nils Y Lycke
Advances in experimental medicine and biology - 1995 -
Intestinal and circulating antibody-forming cells in IgA-deficient individuals after oral cholera
vaccination.
Vanda Friman, Marianne Quiding-Järbrink, L Larsson, D Ericson, J Björkander, K Theman, Jan Holmgren
Clinical and experimental immunology - 1994 -
Cholera toxin enhances alloantigen presentation by cultured intestinal epithelial
cells.
A K Bromander, Martin Kjerrulf, Jan Holmgren, Nils Y Lycke
Scandinavian journal of immunology - 1993