Toxicological Mechanisms and Chemical In Fish (CYP-lab)
Short description
We are interested in physiological and molecular mechanisms behind unwanted chemical mixture effects in fish. Our focus is on key proteins in the detoxification pathway and how they are affected by individual chemicals and mixtures. We study different chemical classes—including steroid hormones, pharmaceuticals, biocides, algae toxins, and aromatic hydrocarbons—and how they interfere with the detoxification pathway in fish liver cells. We develop new approach methodologies to reduce animal toxicity experiments. One goal is to build physiological data-based models that describe and forecast synergistic effects of pollutant mixtures. We hypothesize that identifying “bottlenecks” in detoxification can lead to alternative models to assess and predict mixture effects.
Members
Malin Celander (PhD, professor)
Annika Lindkvist (research engineer)
Flavia Bieczynski (guest investigator)
Bachelor- and Master students
Ongoing Projects
Research project funded by the Carl Trygger Foundation: “Metabolism of Common Biocides in Fish Liver Cells”. In collaboration with Dr Anne Farbrot, at the School of Public Health and Community Medicine at University of Gothenburg.
Research project funded by the Swedish Fund for Research Without Animal Experiments. “FishTox22 – Development of fish cell line-based toxtests to replace fish toxtests”. In collaboration with Professor Nicolas Bury, University of Southampton, UK and Professor Christer Hogstrand, King’s College London, UK. Read more here about the project! Länka till den Engelska versionen.
Research project funded by the Wenner-Gren Foundations. “”Chemical Interactions on the Detoxification Pathway in Fish Liver Cells Exposed to Mixtures”. In collaboration with Dr Flavia Bieczynski, Universidad Nacional del Comahue, Bariloche, Argentina.
Research project funded by Formas. ”Cell- och Matematisk-baserad Modell av PXR/AhR-medierad Metabolism i Zebrafisk” In collaboration with Dr Maja Edenius (Huvudsökande), IVL Swedish Environmental Research Institute and Professor Torbjörn Lundh, Department of Mathematics, Chalmers Technical University and University of Gothenburg.
Research project funded by Formas. “Occurrence and effects of alkylated, substituted and heterocyclic PAC s in marine coastal ecosystems”. In I collaboration with Dr Maria Granberg (PI) and Dr Kerstin Magnusson, IVL Swedish Environmental Research Institute.
Other Collaboration Partners
- Professor John Stegeman, Woods Hole Oceanographic Institution, MA, USA.
- Professor Anders Goksøyr, University of Bergen, Norway.
Ongoing Art Project
“The Coastal Shallow Bay”. A collaboration between professor Malin Celander and artist Iris Alexandrov. Read more about the art project here.
A preview of a movie in preparation.
Other Activities
- Member of the appointment board of faculty of Science and Technology at University of Gothenburg.
- Chair of the Vice Chancellor’s council for investigations of suspected deviation from good research practice at University of Gothenburg.
- Member of the National Ethics Review Appeals Board (Önep). https://www.onep.se/en/
- Chair and organizer of the 21st International Symposium Pollutant Responses In Marine Organisms(PRIMO21) that was held May 22-25 in 2022 in Gothenburg. Read more about the symposium here!
Publications
In October 2020 we published the first "CYPerModel" from the ongoing project.
Fallahi S, Minariková M, Alvord C, Alendal G, Frøysa HG, Lundh T, Celander MC. Environ. Sci. Technol. 2020, 54, 21, 13748–13758
Find more of our publications on GUP
