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Ulf Smith

Researcher

Ulf Smith
Researcher
ulf.smith@medic.gu.se
+46 31-342 1104
0706-553518

Postal Address: Su sahlgrenska, 41345 Göteborg
Visiting Address: Lundberglab för diabetesforskning Vita stråket 12, Uppgång L vån 6 , 41345 Göteborg


Department of Molecular and Clinical Medicine at Institute of Medicine (More Information)
SU Sahlgrenska
413 45 Göteborg
Fax: +46 31823762
Visiting Address: Blå stråket 5 B Wallenberglab/SU , 413 45 Göteborg

About Ulf Smith

Professor, Principal Investigator, MD, PhD, FRCP

Ulf Smith is Professor of Internal Medicine and Director of the Lundberg Laboratory for Diabetes Research at the Sahlgrenska Academy, University of Gothenburg, Sweden. He has held many administrative positions including Chair of the Institute of Medicine, Chief-of-Medicine and Executive Medical Director of the Sahlgrenska University Hospital. He has been member of the Scientific Board of the Sahlgrenska Academy and Dean of Research of the Academy.

Professor Smith is a diabetologist and his research is focused on the pathogenesis of Type 2 diabetes and its complications. He has published around 500 scientific papers in the field and received many honors for his work including being a Fogarty Scholar at the NIH, Bethesda, USA.

Professor Smith is Past President of the European Association for the Study of Diabetes and Chair of the European Foundation for the Study of Diabetes. He is also Past President of the Alliance for Biomedical Research in Europe. He is chairman/member of several Scientific Advisory Boards. He has currently a position as member of the European Commission Scientific Panel for Health at the European Commission.

For information of group members and their work, please visit the website for the Lundberg Laboratory for Diabetes Research.

Main research

For information of group members and their work, please visit the website for the Lundberg Laboratory for Diabetes Research.

Group members

For information of group members and their work, please visit the website for the Lundberg Laboratory for Diabetes Research. Group members

Key Publications

Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Mannerås Holm L, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A and Smith U.
Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance.
Sci Rep. DOI: 10.1038/srep43515, (2017)

Lee S, Zhang C, Kilicarslan M, Piening BD, Bjornson E, Hallström BM, Groen AK, Ferrannini E, Laakso M, Snyder M, Blüher M, Uhlen M, Nielsen J, Smith U, Serlie M, Borén J and Mardinoglu A.
Integrated network analysis reveals an association between plasma mannose levels and insulin resistance.
Cell Metab. 24:172-184. (2016)

Smith U.
Abdominal obesity – a marker of ectopic fat accumulation.
J Clin Invest. 125(5):1790-1792. (2015)

Gustafson B, Hammarstedt A, Hedjazifar S, Hoffman JM, Svensson P-A, Grimsby J, Rondinone C and Smith U.
BMP4 and BMP antagonists regulate human white and beige adipogenesis.
Diabetes.
64:1670-1681. (2015)

Yore MM, Syed IS, Moraes-Vieira PM, Zhang T, Herman MA, Homan E.A, Patel R.T, Lee J, Chen S, Peroni O.D, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A and Kahn BB.
Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects.
Cell. 159(2):318-332. (2014)

Hammarstedt A, Hedjazifar S, Jenndahl L, Gogg S, Grünberg J, Gustafson B, Klimcakova E, Stich V, Langin D, Laakso M and Smith U.
WISP2 Regulates Preadipocyte Commitment and PPAR gamma Activation by BMP4.
Proc Natl Acad Sci USA. 110:2563-2568. (2013)

Isakson P, Hammarstedt A, Gustafson B and Smith U.
Impaired preadipocytes differentiation in human abdominal obesity – role of Wnt, TNFalpha and inflammation.
Diabetes. 58:1550-1557. (2009)

Eliasson B, Taskinen M-R and Smith U.
Long-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance.
Circulation. 94:878-881. (1996)

Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson P-A, Smith U and Kahn BB.
Retinol binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.
N Engl J Med. 354:2552-2563. (2006)

Rondinone CM, Wang L-M, Lönnroth P, Wesslau C, Pierce JH and Smith U.
Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus.
Proc Natl Acad Sci USA. 94:4171-4175. (1997)

Latest publications

Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects.
Ismail Syed, Jennifer Lee, Odile D Peroni, Mark M Yore, Pedro M Moraes-Vieira et al.
Cell metabolism, Journal article 2018
Journal article

Integrative Personal Omics Profiles during Periods of Weight Gain and Loss
B. D. Piening, W. Y. Zhou, K. Contrepois, H. Rost, G. J. G. Urban et al.
Cell Systems, Journal article 2018
Journal article

Systems biology in hepatology: approaches and applications
A. Mardinoglu, Jan Borén, Ulf Smith, M. Uhlen, J. Nielsen
Nature Reviews Gastroenterology & Hepatology, Journal article 2018
Journal article

CCN5/WISP2 and metabolic diseases
J. R. Grunberg, Johannes Elvin, A. Paul, Shahram Hedjazifar, Ann Hammarstedt et al.
Journal of Cell Communication and Signaling, Journal article 2018
Journal article

Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes
A. Mardinoglu, Silvia Gogg, L. A. Lotta, A. Stancakova, Annika Nerstedt et al.
Ebiomedicine, Journal article 2018
Journal article

TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β
M. Romero, A. Sabaté-Pérez, V. A. Francis, I. Castrillón-Rodriguez, Á Díaz-Ramos et al.
Nature Cell Biology, Journal article 2018
Journal article

Showing 81 - 90 of 159

2009

Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men
Jenny Kindblom, Claes Ohlsson, O. Ljunggren, M. K. Karlsson, Åsa Tivesten et al.
Journal of bone and mineral research, Journal article 2009
Journal article

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics
H. Koutnikova, M. Laakso, L. Lu, R. Combe, J. Paananen et al.
PLoS Genet, Journal article 2009
Journal article

Does diabetes therapy influence the risk of cancer?
Ulf Smith, E. A. Gale
Diabetologia, Journal article 2009
Journal article

2008

Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies
B. Friedrich, P. Weyrich, A. Stancakova, J. Wang, J. Kuusisto et al.
PLoS One, Journal article 2008
Journal article

Showing 81 - 90 of 159

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Utskriftsdatum: 2019-11-13