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- Emmelie Cansby
Emmelie Cansby
Research Engineer
Department of Chemistry & Molecular Biology-
Genetic Ablation of STE20-Type Kinase MST4 Does Not Alleviate Diet-Induced MASLD Susceptibility in
Mice
Mara Caputo, Emma Andersson, Ying Xia, Wei Hou, Emmelie Cansby, Max Erikson, Dan E. Lind, Bengt Hallberg, Manoj Amrutkar, Margit Mahlapuu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 2024 -
Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic
rewiring
Ying Xia, Emma Andersson, Sumit Kumar Anand, Emmelie Cansby, Mara Caputo, Sima Kumari, R. Porosk, K. Kilk, S. Nair, Hanns-Ulrich Marschall, M. Blüher, Margit Mahlapuu
Hepatology communications. - 2023 -
STE20-type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver
biopsies
Mara Caputo, Ying Xia, Sumit Kumar Anand, Emmelie Cansby, Emma Andersson, Hanns-Ulrich Marschall, A. Konigsrainer, A. Peter, Margit Mahlapuu
Faseb Journal - 2023 -
Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced NAFLD development in
mice
Ying Xia, Emma Andersson, Mara Caputo, Emmelie Cansby, Francesca Sedda, F. Font-Girones, Johan Ruud, Yeshwant Kurhe, Bengt Hallberg, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Stefano Romeo, M. Blüher, Margit Mahlapuu
Molecular Medicine - 2023 -
Silencing of STE20-type kinase STK25 in human aortic endothelial and smooth muscle cells is
atheroprotective
Emmelie Cansby, Sima Kumari, Mara Caputo, Ying Xia, Rando Porosk, Jonathan Robinson, Hao Wang, Britt-Marie Olsson, Josefine Vallin, Julie Grantham, Ursel Soomets, L. Thomas Svensson, Carina Sihlbom, Hanns-Ulrich Marschall, Andreas Edsfeldt, Isabel Goncalves, Margit Mahlapuu
Communications Biology - 2022 -
Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic
damage
Sumit Kumar Anand, Mara Caputo, Ying Xia, Emma Andersson, Emmelie Cansby, Sima Kumari, Marcus Henricsson, R. Porosk, Katharina Keuenhof, Johanna L Höög, Syam Nair, Hanns-Ulrich Marschall, M. Bluher, Margit Mahlapuu
Journal of Lipid Research - 2022 -
GCKIII kinases in lipotoxicity: Roles in NAFLD and
beyond
Margit Mahlapuu, Mara Caputo, Ying Xia, Emmelie Cansby
Hepatology communications - 2022 -
Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic
Pathways
Yeshwant Kurhe, Mara Caputo, Emmelie Cansby, Ying Xia, Sima Kumari, Sumit Kumar Anand, B. W. Howell, Hanns-Ulrich Marschall, Margit Mahlapuu
Cellular and Molecular Gastroenterology and Hepatology - 2022 -
Silencing of STE20-type kinase MST3 in mice with antisense oligonucleotide treatment ameliorates diet-induced nonalcoholic fatty liver
disease
Mara Caputo, Yeshwant Kurhe, Sima Kumari, Emmelie Cansby, M. Amrutkar, E. Scandalis, S. L. Booten, Marcus Ståhlman, Jan Borén, Hanns-Ulrich Marschall, M. Aghajan, Margit Mahlapuu
FASEB Journal - 2021 -
STE20-type kinase TAOK3 regulates hepatic lipid
partitioning
Ying Xia, Mara Caputo, Emmelie Cansby, Sumit Kumar Anand, Silva Sütt, Marcus Henricsson, R. Porosk, H. U. Marschall, M. Bluher, Margit Mahlapuu
Molecular Metabolism - 2021 -
STE20-Type Protein Kinase MST4 Controls NAFLD Progression by Regulating Lipid Droplet Dynamics and Metabolic Stress in
Hepatocytes
Mara Caputo, Emmelie Cansby, Sima Kumari, Yeshwant Kurhe, Syam Nair, Marcus Ståhlman, Nagaraj M. Kulkarni, Jan Borén, Hanns-Ulrich Marschall, M. Bluher, Margit Mahlapuu
Hepatology Communications - 2021 -
Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney
disease.
Emmelie Cansby, Mara Caputo, Lei Gao, Nagaraj M. Kulkarni, Annika Nerstedt, Marcus Ståhlman, Jan Borén, Rando Porosk, Ursel Soomets, Matteo Pedrelli, Paolo Parini, Hanns-Ulrich Marschall, Jenny Nyström, Brian W Howell, Margit Mahlapuu
JCI insight - 2020 -
Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic
liver
Annika Nerstedt, Yeshwant Kurhe, Emmelie Cansby, Mara Caputo, Lei Gao, Egor Vorontsov, Marcus Ståhlman, Esther Nuñez Durán, Jan Borén, Hanns-Ulrich Marschall, Douglas G. Mashek, D. N. Saunders, Carina Sihlbom, A. J. Hoy, Margit Mahlapuu
Journal of Lipid Research - 2020 -
Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in
humans.
Emmelie Cansby, Nagaraj M. Kulkarni, Elin Magnusson, Yeshwant Kurhe, Manoj Amrutkar, Annika Nerstedt, Marcus Ståhlman, Carina Sihlbom, Hanns-Ulrich Marschall, Jan Borén, Matthias Blüher, Margit Mahlapuu
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2019 -
Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic
Fatty Liver Disease.
Emmelie Cansby, Esther Nuñez Durán, Elin Magnusson, Manoj Amrutkar, Sheri L Booten, Nagaraj M. Kulkarni, L Thomas Svensson, Jan Borén, Hanns-Ulrich Marschall, Mariam Aghajan, Margit Mahlapuu
Cellular and molecular gastroenterology and hepatology - 2019 -
STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of
Hypercholesterolemia
Emmelie Cansby, Elin Magnusson, Esther Nuñez Durán, M. Amrutkar, M. Pedrelli, P. Parini, Jenny M Hoffmann, Marcus Ståhlman, B. W. Howell, Hanns-Ulrich Marschall, Jan Borén, Margit Mahlapuu
Arteriosclerosis Thrombosis and Vascular Biology - 2018 -
STK25 regulates oxidative capacity and metabolic efficiency in adipose
tissue
Silva Sütt, Emmelie Cansby, A. Paul, M. Amrutkar, Esther Nuñez Durán, Nagaraj M. Kulkarni, M. Ståhlman, J. Borén, J. Laurencikiene, B. W. Howell, Sven Enerbäck, Margit Mahlapuu
Journal of Endocrinology - 2018 -
Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in
mice.
Esther Nuñez Durán, Mariam Aghajan, Manoj Amrutkar, Silva Sütt, Emmelie Cansby, Sheri L Booten, Andrew Watt, Marcus Ståhlman, Norbert Stefan, Hans-Ulrich Häring, Harald Staiger, Jan Borén, Hanns-Ulrich Marschall, Margit Mahlapuu
Hepatology communications - 2018 -
Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in
mice
Esther Nuñez Durán, Belén Chanclón, Silva Sütt, Joana Real, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Emmelie Cansby, Margit Mahlapuu
Journal of Endocrinology - 2017 -
Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal
muscle.
Urszula Chursa, Esther Nuñez Durán, Emmelie Cansby, Manoj Amrutkar, Silva Sütt, Marcus Ståhlman, Britt-Marie Olsson, Jan Borén, Maria Johansson, Fredrik Bäckhed, Bengt R Johansson, Carina Sihlbom, Margit Mahlapuu
Diabetologia - 2017 -
Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in
humans
Manoj Amrutkar, M. Kern, Esther Nuñez Durán, Marcus Ståhlman, Emmelie Cansby, Urszula Chursa, Elin Stenfeldt, Jan Borén, M. Bluher, Margit Mahlapuu
Diabetologia - 2016 -
Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes
Model
Manoj Amrutkar, Emmelie Cansby, Urszula Chursa, Esther Nuñez Durán, Belén Chanclón, Marcus Ståhlman, Vincent Fridén, Louise Mannerås Holm, Anna Wickman, Ulf Smith, Fredrik Bäckhed, Jan Borén, B. W. Howell, Margit Mahlapuu
Diabetes - 2015 -
Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and
NASH
Manoj Amrutkar, Emmelie Cansby, Esther Nuñez Durán, Carlo Pirazzi, Marcus Ståhlman, Elin Stenfeldt, Ulf Smith, Jan Borén, Margit Mahlapuu
Faseb Journal - 2015 -
Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is
maintained
Emmelie Cansby, Annika Nerstedt, Manoj Amrutkar, Esther Nuñez Durán, Ulf Smith, Margit Mahlapuu
Molecular and Cellular Endocrinology - 2014 -
Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat
diet.
Emmelie Cansby, Manoj Amrutkar, Louise Mannerås Holm, Annika Nerstedt, Azadeh Reyahi, Elin Stenfeldt, Jan Borén, Peter Carlsson, Ulf Smith, Juleen R Zierath, Margit Mahlapuu
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2013 -
Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human
hepatocytes
Annika Nerstedt, Emmelie Cansby, Manoj Amrutkar, Ulf Smith, Margit Mahlapuu
Molecular and Cellular Endocrinology - 2013 -
Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal
muscle
Annika Nerstedt, Emmelie Cansby, Christian X Andersson, M. Laakso, A. Stancakova, M. Bluher, Ulf Smith, Margit Mahlapuu
Diabetologia - 2012 -
AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3
(STAT3)
Annika Nerstedt, Aino Johansson, Christian X Andersson, Emmelie Cansby, Ulf Smith, Margit Mahlapuu
Diabetologia - 2010