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Kaisa Thorell
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Institutionen för kemi och molekylärbiologiUniversitetslektor, biträdande
Institutionen för kemi och molekylärbiologiOm Kaisa Thorell
Biträdande universitetslektor och DDLS-fellow i infektionsbiologi. Mitt forskningsfokus är magsäcksbakterien Helicobacter pylori där vi studerar bakteriell genomik, mikrobiell diversitet och faktorer som påverkar värd-mikrobinteraktion med relevans för utvecklingen av magsäckscancer.
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Building pangenome
graphs
Erik Garrison, Andrea Guarracino, Simon Heumos, Flavia Villani, Zhigui Bao, Lorenzo Tattini, Joerg Hagmann, Sebastian Vorbrugg, Santiago Marco-Sola, Christian Kubica, David G. Ashbrook, Kaisa Thorell, Rachel L. Rusholme-Pilcher, Gianni Liti, Emilio Rudbeck, Agnieszka A. Golicz, Sven Nahnsen, Zuyu Yang, Moses Njagi Mwaniki, Franklin L. Nobrega, Yi Wu, Hao Chen, Joep de Ligt, Peter H. Sudmant, Sanwen Huang, Detlef Weigel, Nicole Soranzo, Vincenza Colonna, Robert W. Williams, Pjotr Prins
NATURE METHODS - 2024 -
An ancient ecospecies of Helicobacter
pylori
Elise Tourrette, Roberto C. Torres, Sarah L. Svensson, Takashi Matsumoto, Muhammad Miftahussurur, Kartika Afrida Fauzia, Ricky Indra Alfaray, Ratha-Korn Vilaichone, Vo Phuoc Tuan, Difei Wang, Abbas Yadegar, Lisa M. Olsson, Zhemin Zhou, Yoshio Yamaoka, Kaisa Thorell, Daniel Falush
NATURE - 2024 -
Circulation of enterotoxigenic Escherichia coli (ETEC) isolates expressing CS23 from the environment to clinical
settings
Carla Calderon Toledo, Astrid von Mentzer, Jorge Agramont, Kaisa Thorell, Yingshun Zhou, Miklós Szabó, Patricia Colque, Inger Kuhn, Sergio Gutiérrez-Cortez, Enrique Joffré
mSystems - 2023 -
Global Antimicrobial Resistance Gene Study of Helicobacter pylori: Comparison of Detection Tools, ARG and Efflux Pump Gene Analysis, Worldwide Epidemiological Distribution, and Information Related to the Antimicrobial-Resistant
Phenotype
R. I. Alfaray, B. Saruuljavkhlan, K. A. Fauzia, R. C. Torres, Kaisa Thorell, S. R. Dewi, K. A. Kryukov, T. Matsumoto, J. Akada, R. K. Vilaichone, M. Miftahussurur, Y. Yamaoka
Antibiotics-Basel - 2023 -
The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete
genomes
Kaisa Thorell, Zilia Y. Muñoz-Ramírez, Difei Wang, Santiago Sandoval-Motta, Rajiv Boscolo Agostini, Silvia Ghirotto, Roberto C. Torres, Judith Romero-Gallo, Uma Krishna, Richard M. Peek, M. Blanca Piazuelo, Naïma Raaf, Federico Bentolila, Hafeza Aftab, Junko Akada, Takashi Matsumoto, Freddy Haesebrouck, Rony P. Colanzi, Thais F. Bartelli, Diana Noronha Nunes, Adriane Pelosof, Claudia Zitron Sztokfisz, Emmanuel Dias-Neto, Paulo Pimentel Assumpção, Ivan Tishkov, Laure Brigitte Kouitcheu Mabeku, Karen J. Goodman, Janis Geary, Taylor J. Cromarty, Nancy L. Price, Douglas Quilty, Alejandro H. Corvalan, Carolina A. Serrano, Robinson Gonzalez, Arnoldo Riquelme, Apolinaria García-Cancino, Cristian Parra-Sepúlveda, Giuliano Bernal, Francisco Castillo, Alisa M. Goldstein, Nan Hu, Philip R. Taylor, Maria Mercedes Bravo, Alvaro Pazos, Luis E. Bravo, Keith T. Wilson, James G. Fox, Vanessa Ramírez-Mayorga, Silvia Molina-Castro, Sundry Durán-Bermúdez, Christian Campos-Núñez, Manuel Chaves-Cervantes, Evariste Tshibangu-Kabamba, Ghislain Disashi Tumba, Antoine Tshimpi-Wola, Patrick de Jesus Ngoma-Kisoko, Dieudonné Mumba Ngoyi, Modesto Cruz, Celso Hosking, José Jiménez Abreu, Christine Varon, Lucie Benejat, Ousman Secka, Alexander Link, Peter Malfertheiner, Michael Buenor Adinortey, Ansumana Sandy Bockarie, Cynthia Ayefoumi Adinortey, Eric Gyamerah Ofori, Dionyssios N. Sgouras, Beatriz Martinez-Gonzalez, Spyridon Michopoulos, Sotirios Georgopoulos, Elisa Hernandez, Braulio Volga Tacatic, Mynor Aguilar, Ricardo L. Dominguez, Douglas R. Morgan, Hjördís Harðardóttir, Anna Ingibjörg Gunnarsdóttir, Hallgrímur Guðjónsson, Jón Gunnlaugur Jónasson, Einar S. Björnsson, Mamatha Ballal, Vignesh Shetty, Muhammad Miftahussurur, Titong Sugihartono, Ricky Indra Alfaray, Langgeng Agung Waskito, Kartika Afrida Fauzia, Ari Fahrial Syam, Hasan Maulahela, Reza Malekzadeh, Masoud Sotoudeh, Avi Peretz, Maya Azrad, Avi On, Valli De Re, Stefania Zanussi, Renato Cannizzaro
Nature Communications - 2023 -
Escherichia coli ST2797 Is Abundant in Wastewater and Might Be a Novel Emerging Extended-Spectrum Beta-Lactamase E.
coli
E. Paulshus, P. Colque, I. Kuhn, T. Tauhid, Y. O. O. Hu, Y. S. Zhou, Kaisa Thorell, R. Mollby, H. Sorum, Åsa Sjöling, E. Joffre
Microbiology Spectrum - 2023 -
Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious
mutations
H. A. Thorpe, E. Tourrette, K. Yahara, F. F. Vale, S. Liu, M. Oleastro, T. Alarcon, T. T. Perets, S. Latifi-Navid, Y. Yamaoka, B. Martinez-Gonzalez, I. Karayiannis, T. Karamitros, D. N. Sgouras, W. Elamin, B. Pascoe, S. K. Sheppard, J. Ronkainen, P. Aro, L. Engstrand, L. Agreus, S. Suerbaum, Kaisa Thorell, D. Falush
Nature Communications - 2022 -
Atlantic Salmon Mucins Inhibit LuxS-Dependent A. Salmonicida AI-2 Quorum Sensing in an N-Acetylneuraminic Acid-Dependent
Manner
János T Padra, Stefany Ojaimi Loibman, Kaisa Thorell, Henrik Sundh, Kristina Sundell, Sara K. Lindén
International Journal of Molecular Sciences - 2022 -
Genomic differentiation within East Asian Helicobacter
pylori
Y. You, Kaisa Thorell, L. He, K. Yahara, Y. Yamaoka, J. H. Cha, K. Murakami, Y. Katsura, Teamhp, Teamhp,, I. Kobayashi, D. Falush, J. Zhang
Microbial genomics - 2022 -
Pseudomonas boanensis sp. nov., a bacterium isolated from river water used for household purposes in Boane District,
Mozambique
Matilda Nicklasson, A. J. Martin-Rodriguez, Kaisa Thorell, S. M. Higdon, L. Neves, A. Mussagy, H. A. Rydberg, B. Hernroth, Liselott Svensson-Stadler, A. Sjoling
International Journal of Systematic and Evolutionary Microbiology - 2022 -
Complete Genome Sequence and Methylome of the Type Strain of Shewanella
algae
C. Tellgren-Roth, Kaisa Thorell, M. Y. Galperin, T. Krell, U. Romling, A. Sjoling, A. J. Martin-Rodriguez
Microbiology Resource Announcements - 2021 -
FLAME: long-read bioinformatics tool for comprehensive spliceome
characterization
Isak Holmqvist, Alan Bäckerholm, Yarong Tian, Guojiang Xie, Kaisa Thorell, Ka-Wei Tang
Rna - 2021 -
A 500-year tale of co-evolution, adaptation, and virulence:Helicobacter pyloriin the
Americas
Z. Y. Munoz-Ramirez, B. Pascoe, A. Mendez-Tenorio, E. Mourkas, S. Sandoval-Motta, G. Perez-Perez, D. R. Morgan, R. L. Dominguez, D. Ortiz-Princz, M. E. Cavazza, G. Rocha, D. M. M. Queiroz, M. Catalano, G. Z. de la Palma, C. G. Goldman, A. Venegas, T. Alarcon, M. Oleastro, F. F. Vale, K. J. Goodman, R. C. Torres, E. Berthenet, M. D. Hitchings, M. J. Blaser, S. K. Sheppard, Kaisa Thorell, J. Torres
Isme Journal - 2021 -
Global analysis of more than 50,000 SARS-CoV-2 genomes reveals epistasis between eight viral
genes.
Hong-Li Zeng, Vito Dichio, Edwin Rodríguez Horta, Kaisa Thorell, Erik Aurell
Proceedings of the National Academy of Sciences of the United States of America - 2020 -
Acinetobacter portensis sp. Nov. and acinetobacter guerrae sp. nov., isolated from raw
meat
A. Carvalheira, Lucia Gonzales-Siles, Francisco Salvà-Serra, Åsa Lindgren, L. Svensson-Stadler, Kaisa Thorell, Beatriz Piñeiro-Iglesias, Roger Karlsson, J. Silva, P. Teixeira, Edward R.B. Moore
International journal of systematic and evolutionary microbiology - 2020 -
Repeated Isolation of Extended-Spectrum-beta-Lactamase-Positive Escherichia coli Sequence Types 648 and 131 from Community Wastewater Indicates that Sewage Systems Are Important Sources of Emerging Clones of Antibiotic-Resistant
Bacteria
E. Paulshus, Kaisa Thorell, J. Guzman-Otazo, E. Joffre, P. Colque, I. Kuhn, R. Mollby, H. Sorum, A. Sjoling
Antimicrobial Agents and Chemotherapy - 2019 -
Isolates from Colonic Spirochetosis in Humans Show High Genomic Divergence and Potential Pathogenic Features but Are Not Detected Using Standard Primers for the Human
Microbiota
Kaisa Thorell, L. Inganas, A. Backhans, L. Agreus, A. Ost, M. M. Walker, N. J. Talley, L. Kjellstrom, A. Andreasson, L. Engstrand
Journal of Bacteriology - 2019 -
Whole-Genome Sequencing Redefines Shewanella
Taxonomy
Kaisa Thorell, J. P. Meier-Kolthoff, A. Sjoling, A. J. Martin-Rodriguez
Frontiers in Microbiology - 2019 -
Diarrheal bacterial pathogens and multi-resistant enterobacteria in the Choqueyapu River in La Paz,
Bolivia
J. Guzman-Otazo, Lucia Gonzales-Siles, V. Poma, Johan Bengtsson-Palme, Kaisa Thorell, Carl-Fredrik Flach, V. Iniguez, A. Sjoling
PLoS ONE - 2019 -
The speciation and hybridization history of the genus
Salmonella
A. Criscuolo, S. Issenhuth-Jeanjean, X. Didelot, Kaisa Thorell, J. Hale, J. Parkhill, N. R. Thomson, F. X. Weill, D. Falush, S. Brisse
Microbial Genomics - 2019 -
Helicobacter pylori in ancient human
remains
F. Maixner, Kaisa Thorell, L. Granehäll, B. Linz, Y. Moodley, T. Rattei, L. Engstrand, A. Zink
World journal of gastroenterology - 2019 -
Metaxa2 Database Builder: enabling taxonomic identification from metagenomic or metabarcoding data using any genetic
marker
Johan Bengtsson-Palme, Rodney T Richardson, Marco Meola, Christian Wurzbacher, Émilie D Tremblay, Kaisa Thorell, Kärt Kanger, Guillaume J Bilodeau, Reed M Johnson, Martin Hartmann, R. Henrik Nilsson
Bioinformatics (Oxford, England) - 2018 -
A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer
risk.
Elvire Berthenet, Koji Yahara, Kaisa Thorell, Ben Pascoe, Guillaume Meric, Jane M Mikhail, Lars Engstrand, Helena Enroth, Alain Burette, Francis Megraud, Christine Varon, John C Atherton, Sinead Smith, Thomas S Wilkinson, Matthew D Hitchings, Daniel Falush, Samuel K Sheppard
BMC biology - 2018 -
In vivo analysis of the viable microbiota and Helicobacter pylori transcriptome in gastric infection and early stages of
carcinogenesis.
Kaisa Thorell, Johan Bengtsson-Palme, Oscar Hsin-Fu Liu, Reyna Victoria Palacios Gonzales, Intawat Nookaew, Linda Rabeneck, Lawrence Paszat, David Y Graham, Jens Nielsen, Samuel B Lundin, Åsa Sjöling
Infection and immunity - 2017 -
Comparative Analysis of Two Helicobacter pylori Strains using Genomics and Mass Spectrometry-Based
Proteomics
Roger Karlsson, Kaisa Thorell, S. Hosseini, Diarmuid T. Kenny, Carina Sihlbom, Åsa Sjöling, A. Karlsson, I. Nookaew
Frontiers in Microbiology - 2016 -
Strategies to improve usability and preserve accuracy in biological sequence
databases
Johan Bengtsson-Palme, Fredrik Boulund, Robert Edström, Amir Feizi, Anna Johnning, Viktor Jonsson, Fredrik H. Karlsson, Chandan Pal, Mariana Buongermino Pereira, Anna Rehammar, José Sánchez, Kemal Sanli, Kaisa Thorell
Proteomics - 2016 -
Identification of a Latin American-specific BabA adhesin variant through whole genome sequencing of Helicobacter pylori patient isolates from
Nicaragua
Kaisa Thorell, Seyed Vali Hosseini, Rvpp Gonzales, Chatchai Chaotham, D. Y. Graham, L. Paszat, L. Rabeneck, Samuel B Lundin, Intawat Nookaew, Åsa Sjöling
BMC Evolutionary Biology - 2016 -
Metaxa2 Diversity Tools: Easing microbial community analysis with
Metaxa2
Johan Bengtsson-Palme, Kaisa Thorell, Christian Wurzbacher, Åsa Sjöling, R. Henrik Nilsson
Ecological Informatics - 2016 -
Metaxa2: Improved identification and taxonomic classification of small and large subunit rRNA in metagenomic
data
Johan Bengtsson-Palme, Martin Hartmann, Karl Martin Eriksson, Chandan Pal, Kaisa Thorell, D. G. Joakim Larsson, R. Henrik Nilsson
Molecular Ecology Resources - 2015 -
Multi-level characterization of host and pathogen in Helicobacter pylori-associated gastric
carcinogenesis
Kaisa Thorell
2014 -
Transcriptome signatures in Helicobacter pylori-infected mucosa identifies acidic mammalian chitinase loss as a corpus atrophy
marker
Intawat Nookaew, Kaisa Thorell, Kuntal Worah, Shugui Wang, Martin Lloyd Hibberd, Henrik Sjövall, Sven Pettersson, Jens B. Nielsen, Samuel B Lundin
BMC Medical Genomics - 2013 -
Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of
GKN3
J. H. Geahlen, C. Lapid, Kaisa Thorell, I. Nikolskiy, W. J. Huh, E. L. Oates, J. K. M. Lennerz, X. L. Tian, V. G. Weis, S. S. Khurana, Samuel B Lundin, A. R. Templeton, J. C. Mills
Physiological Genomics - 2013 -
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus
phenotype.
Jenny K Gustafsson, Anna Ermund, Daniel Ambort, Malin E V Johansson, Harriet E Nilsson, Kaisa Thorell, Hans Hebert, Henrik Sjövall, Gunnar C. Hansson
The Journal of experimental medicine - 2012 -
Verification of genes differentially expressed in neuroblastoma tumours: a study of potential tumour suppressor
genes.
Kaisa Thorell, Annika Bergman, Helena Carén, Staffan Nilsson, Per Kogner, Tommy Martinsson, Frida Abel
BMC medical genomics - 2009