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Marc Pilon
Professor
Institutionen för kemi och molekylärbiologiOm Marc Pilon
FORSKNINGSOMRÅDER
ADIPONEKTINRECEPTORER: HUR FUNKAR DEM? Funktion och reglering av adiponektinreceptorer. Adiponektin är ett hormon som produceras av adipocyter och som reglerar insulinkänslighet. Dess receptorer har sju transmembrandomäner med en omvänd struktur i förhållande till GPCRer; för närvarande är dock dessa receptorers signalering inte väl känd. Vi studerar en mutant av dessa receptorer i C. elegans för att klargöra hur de signalerar. Detta arbete har potential att leda till identifiering av nya mål för farmaceutisk behandling av metabolt syndrom, samt ge upphov till nya kunskaper om hormonreglering och metabolism.
Länk: Pilon LAB
UTBILDNING
BIO555 Genetics
BIO906 Cell and molecular biology
BIO213 Cell and developmental biology
BIO426 Evolutionary ecology
BIO442 Molecular evolution
KMG045 Drug development (Chalmers)
KMG042 Molecular methods (Chalmers)
UPPDRAG
Ansvarig för doktorandutbildning
Google Scholar: Marc Pilon
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Aging AdipoR2-deficient mice are hyperactive with enlarged brains excessively rich in saturated fatty
acids
Mario Ruiz, Ranjan Devkota, Per-Olof Bergh, Ali Moussavi Nik, Sebastian Sköldheden, Jorge Mondejar-Duran, Maximilian Tufvesson-Alm, Mohammad Bohlooly-Y, Diego Sanchez, Peter Carlsson, Marcus Henricsson, Elisabeth Jerlhag, Jan Borén, Marc Pilon
The FASEB Journal - 2024 -
Regulation of meiotic telomere dynamics through membrane fluidity promoted by
AdipoR2-ELOVL2
Jingjing Zhang, Mario Ruiz, Per-Olof Bergh, Marcus Henricsson, Nena Stojanovic, Ranjan Devkota, Marius Henn, Mohammad Bohlooly-Y, Abrahan Hernandez-Hernandez, Manfred Alsheimer, Jan Borén, Marc Pilon, Hiroki Shibuya
NATURE COMMUNICATIONS - 2024 -
AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane
fluidity
Mario Ruiz, Ranjan Devkota, Delaney Kaper, Hanna Ruhanen, Kiran Busayavalasa, Uros Radovic, Marcus Henricsson, Reijo Käkelä, Jan Borén, Marc Pilon
Journal of Biological Chemistry - 2023 -
Striking membrane defects in AdipoR-deficient
cells
Mario Ruiz, Dimitra Panagaki, Johanna L Höög, Marc Pilon
Journal of lipid research - 2023 -
PAQR proteins and the evolution of a superpower: Eating all kinds of fats Animals rely on evolutionarily conserved membrane homeostasis proteins to compensate for dietary
variation
Marc Pilon, Mario Ruiz
Bioessays - 2023 -
Elevated Adipocyte Membrane Phospholipid Saturation Does Not Compromise Insulin
Signaling
Henrik Palmgren, Kasparas Petkevicius, Stefano Bartesaghi, Andrea Ahnmark, Mario Ruiz, Ralf Nilsson, Lars Loefgren, Matthew S. Glover, Anne-Christine Andreasson, Liselotte Andersson, Cécile Becquart, Michael Kurczy, Bengt Kull, Simonetta Wallin, Daniel Karlsson, Sonja Hess, Marcello Maresca, Mohammad Bohlooly-Y, Xiao-Rong Peng, Marc Pilon
DIABETES - 2023 -
Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart
function.
Marion Laudette, Malin Lindbom, Muhammad Arif, Mathieu Cinato, Mario Ruiz, Stephen Doran, Azra Miljanovic, Mikael Rutberg, Linda Andersson, Martina Klevstig, Marcus Henricsson, Per-Olof Bergh, Entela Bollano, Nay Aung, J. Gustav Smith, Marc Pilon, Tuulia Hyötyläinen, Matej Orešič, Rosie Perkins, Adil Mardinoglu, Malin Levin, Jan Borén
Cardiovascular research - 2023 -
Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and
embryogenesis.
Mario Ruiz, Ranjan Devkota, Dimitra Panagaki, Per-Olof Bergh, Delaney Kaper, Marcus Henricsson, Ali Nik, Kasparas Petkevicius, Johanna L Höög, Mohammad Bohlooly-Y, Peter Carlsson, Jan Borén, Marc Pilon
Nature communications - 2022 -
A small molecule screen for paqr-2 suppressors identifies Tyloxapol as a membrane fluidizer for C. elegans and mammalian
cells
Mario Ruiz, Emma Svensk, Elinor Einarsson, Erik Podda Grahn, Marc Pilon
Biochimica Et Biophysica Acta-Biomembranes - 2022 -
TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic
steatohepatitis
K. Petkevicius, Henrik Palmgren, M. S. Glover, A. Ahnmark, A. C. Andreasson, K. Madeyski-Bengtson, H. Kawana, E. L. Allman, Delaney Kaper, M. Uhrbom, L. Andersson, L. Aasehaug, J. Forsstrom, S. Wallin, I. Ahlstedt, R. Leke, D. Karlsson, H. Gonzalez-King, L. Lofgren, R. Nilsson, G. Pellegrini, N. Kono, J. Aoki, S. Hess, G. Sienski, Marc Pilon, M. Bohlooly-Y, M. Maresca, X. R. Peng
Nature Communications - 2022 -
Paradigm shift: the primary function of the "Adiponectin Receptors" is to regulate cell membrane
composition
Marc Pilon
Lipids in Health and Disease - 2021 -
A genetic titration of membrane composition in Caenorhabditis elegans reveals its importance for multiple cellular and physiological
traits
Ranjan Devkota, Delaney Kaper, Rakesh Bodhicharla, Marcus Henricsson, Jan Borén, Marc Pilon
Genetics - 2021 -
Treatment with HIV-protease inhibitor nelfinavir identifies membrane lipid composition and fluidity as a therapeutic target in advanced multiple
myeloma
Lenka Besse, Andrej Besse, Sara C. Stolze, Amin Sobh, Esther A. Zaal, Alwin J.Van Der Ham, Mario Ruiz, Santosh Phuyal, Lorina Buchler, Marc Sathianathan, Bogdan I. Florea, Jan Borén, Marcus Ståhlman, Julia Huber, Arnold Bolomsky, Heinz Ludwig, J. Thomas Hannich, Alex Loguinov, Bart Everts, Celia R. Berkers, Marc Pilon, Hesso Farhan, Christopher D. Vulpe, Herman S. Overkleeft, Christoph Driessen
Cancer Research - 2021 -
Palmitic acid causes increased dihydroceramide levels when desaturase expression is directly silenced or indirectly lowered by silencing
AdipoR2
Mario Ruiz, Marcus Henricsson, Jan Borén, Marc Pilon
Lipids in Health and Disease - 2021 -
The C. elegans PAQR-2 and IGLR-2 membrane homeostasis proteins are uniquely essential for tolerating dietary saturated
fats
Ranjan Devkota, Marcus Henricsson, Jan Borén, Marc Pilon
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids - 2021 -
Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty
acids
Mario Ruiz, H. Palmgren, Marcus Henricsson, Ranjan Devkota, H. Jaiswal, M. Maresca, M. Bohlooly-Y, X. R. Peng, Jan Borén, Marc Pilon
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids - 2021 -
Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR
proteins
Kiran Busayavalasa, Mario Ruiz, Ranjan Devkota, Marcus Ståhlman, Rakesh Bodhicharla, Emma Svensk, N. O. Hermansson, Jan Borén, Marc Pilon
Plos Genetics - 2020 -
The Caenorhabditis elegans homolog of human copper chaperone Atox1, CUC-1, aids in distal tip cell
migration
X. L. Zhang, S. Blockhuys, Ranjan Devkota, Marc Pilon, P. Wittung-Stafshede
Biometals - 2020 -
Control of membrane lipid homeostasis by lipid-bilayer associated sensors: A mechanism conserved from bacteria to
humans.
Diego de Mendoza, Marc Pilon
Progress in lipid research - 2019 -
Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and
fluidity
Mario Ruiz, Rakesh Bodhicharla, Marcus Ståhlman, Emma Svensk, Kiran Busayavalasa, H. Palmgren, H. Ruhanen, Jan Borén, Marc Pilon
Elife - 2019 -
AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of
adiponectin
Mario Ruiz, Marcus Ståhlman, Jan Borén, Marc Pilon
Journal of Lipid Research - 2019 -
Membrane Fluidity Is Regulated Cell Nonautonomously by Caenorhabditis elegans PAQR-2 and Its Mammalian Homolog
AdipoR2
Rakesh Bodhicharla, Ranjan Devkota, Mario Ruiz, Marc Pilon
Genetics - 2018 -
Membrane fluidity is regulated by the C-elegans transmembrane protein FLD-1 and its human homologs
TLCD1/2
Mario Ruiz, Rakesh Bodhicharla, Emma Svensk, Ranjan Devkota, Kiran Busayavalasa, Henrik Palmgren, Marcus Ståhlman, Jan Borén, Marc Pilon
eLife - 2018 -
FRAP: A Powerful Method to Evaluate Membrane Fluidity in Caenorhabditis
elegans
Ranjan Devkota, Marc Pilon
Bio-Protocol - 2018 -
The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty
acids.
Ranjan Devkota, Emma Svensk, Mario Ruiz, Marcus Ståhlman, Jan Borén, Marc Pilon
PLoS genetics - 2017 -
Myosin Storage Myopathy in C. elegans and Human Cultured Muscle
Cells
Martin Dahl-Halvarsson, M. Pokrzywa, Manish Rauthan, Marc Pilon, H. Tajsharghi
Plos One - 2017 -
Revisiting the membrane-centric view of
diabetes
Marc Pilon
Lipids in Health and Disease - 2016 -
Caenorhabditis elegans PAQR-2 and IGLR-2 protect against glucose toxicity by modulating membrane lipid
composition
Emma Svensk, Ranjan Devkota, Marcus Ståhlman, Parmida Ranji, Manish Rauthan, Fredrik Magnusson, Sofia Hammarsten, Maja Johansson, Jan Borén, Marc Pilon
PLoS Genetics - 2016 -
Leveraging the withered tail tip phenotype in C. elegans to identify proteins that influence membrane
properties
Emma Svensk, Jana Biermann, Sofia Hammarsten, Fredrik Magnusson, Marc Pilon
WORM - 2016 -
A chemical screen to identify inducers of the mitochondrial unfolded protein response in C.
elegans
Manish Rauthan, Marc Pilon
WORM - 2015 -
A Mutation in Caenorhabditis elegans NDUF-7 Activates the Mitochondrial Stress Response and Prolongs Lifespan via ROS and
CED-4
Manish Rauthan, Parmida Ranji, Ragda Abukar, Marc Pilon
G3-Genes Genomes Genetics - 2015 -
Loss of HMG-CoA Reductase in C-elegans Causes Defects in Protein Prenylation and Muscle
Mitochondria
Parmida Ranji, Manish Rauthan, Christophe Pitot, Marc Pilon
Plos One - 2014 -
Developmental genetics of the Caenorhabditis elegans
pharynx
Marc Pilon
Wiley Interdisciplinary Reviews: Developmental Biology - 2014 -
PAQR-2 Regulates Fatty Acid Desaturation during Cold Adaptation in C.
elegans
Emma Svensk, Marcus Ståhlman, Carl-Henrik Andersson, Maja Johansson, Jan Borén, Marc Pilon
Plos Genetics - 2013 -
The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate
pathway.
Manish Rauthan, Parmida Ranji, Nataly Aguilera Pradenas, Christophe Pitot, Marc Pilon
Proceedings of the National Academy of Sciences of the United States of America - 2013 -
The mevalonate pathway in C.
Elegans.
Manish Rauthan, Marc Pilon
Lipids in health and disease - 2011 -
The Adiponectin Receptor Homologs in C-elegans Promote Energy Utilization and
Homeostasis
Emma Svensson, L. Olsen, Catarina Mörck, Christian Brackmann, Annika Enejder, N. J. Faergeman, Marc Pilon
PLoS ONE - 2011 -
Genetics of extracellular matrix remodeling during organ growth using the Caenorhabditis elegans pharynx
model.
Gholamali Jafari, Jan Burghoorn, Takehiro Kawano, Manoj Mathew, Catarina Mörck, Claes Axäng, Michael Ailion, James H Thomas, Joseph G Culotti, Peter Swoboda, Marc Pilon
Genetics - 2010 -
Hot water treatment prevents Aphelenchoides besseyi damage to Polianthes tuberosa crops in the Mekong Delta of
Vietnam
Nguyen Thi Thu Cuc, Nguyen Thanh Son, Tran Minh Trung, Nguyen van Trang, Lam Minh Dang, Marc Pilon
Crop Protection - 2010 -
C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators, and enhances many axon guidance defective
mutants.
Catarina Mörck, Vivekanand Vivekanand, Gholamali Jafari, Marc Pilon
BMC developmental biology - 2010 -
Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis
elegans
Catarina Mörck, L. Olsen, C. Kurth, Annelie Persson, N. J. Storm, Emma Svensson, John-Olov Jansson, Marika Hellqvist, Annika Enejder, N. J. Faergeman, Marc Pilon
Proceedings of the National Academy of Sciences - 2009 -
Developmental genetics of the C. elegans pharyngeal neurons NSML and
NSMR.
Claes Axäng, Manish Rauthan, David H. Hall, Marc Pilon
BMC Developmental Biology - 2008 -
Fishing lines, time-delayed guideposts and other tricks used by developing pharyngeal neurons in C.
elegans.
Marc Pilon
Developmental Dynamics - 2008 -
Development of the Caenorhabditis elegans pharynx, with emphasis on its nervous
system.
Marc Pilon, Catarina Mörck
Acta Pharmacol. Sin. - 2008 -
CARS microscopy for the monitoring of lipid storage in C.
elegans
Annika Enejder, Christian Brackmann, Claes Axäng, Madeleine Åkeson, Marc Pilon
Proc. Soc. Photo-Opt. Instrum. Eng. - 2008 -
The twisted pharynx phenotype in C.
elegans.
Claes Axäng, Manish Rauthan, David H. Hall, Marc Pilon
BMC Developmental Biology - 2007 -
Caloric restriction and autophagy in Caenorhabditis
elegans
C Mörck, Marc Pilon
Autophagy - 2007 -
Aphelenchoides besseyi as a parasite of Polianthes tuberosa in the Mekong
Delta.
Nguyen Thi Thu Cuc, Marc Pilon
Journal of Nematology - 2007 -
Monitoring of lipid storage in Caenorhabditis elegans using coherent anti-Stokes Raman scattering (CARS)
microscopy
Thomas Hellerer, Claes Axäng, Christian Brackmann, Per Hillertz, Marc Pilon, Annika Enejder
Proceedings of the National Academy of Sciences of the USA - 2007 -
The C-elegans M3 neuron guides the growth cone of its sister cell M2 via the Kruppel-like zinc finger protein
MNM-2
Manish Rauthan, C Mörck, Marc Pilon
Developmental Biology - 2007 -
Dihydroxyacetone-induced death is accompanied by advanced glycation endproduct formation in selected proteins of Saccharomyces cerevisiae and Caenoehabditis
elegans.
Mikael Molin, Marc Pilon, Anders Blomberg
Proteomics - 2007 -
C. elegans feeding defective mutants have shorter body lengths and increased
autophagy
Catarina Mörck, Marc Pilon
BMC Developmental Biology - 2006 -
CARS microscopy for the monitoring of fat deposition mechanisms in a living
organism
Annika Enejder, Thomas Hellerer, Per Hillertz, Christian Brackmann, Claes Axäng, Marc Pilon
Multiphoton Microscopy in the Biomedical Sciences, A. Periasamy, and P. T. C. So, eds., Proc. Soc. Photo-Opt. Instrum. Eng. - 2006 -
Misexpression of acetylcholinesterases in the C. elegans pha-2 mutant accompanies ultrastructural defects in pharyngeal muscle
cells
Catarina Mörck, Claes Axäng, Mattias Goksör, Marc Pilon
Developmental Biology - 2006 -
Caloric restriction and autophagy in C.
elegans.
Catarina Mörck, Marc Pilon
Autophagy - 2006 -
Development of Caenorhabditis elegans pharynx, with emphasis on its nervous
system
Marc Pilon, C. Mörck
Acta Pharmacologica Sinica - 2005 -
The amazing world of
nematodes.
Marc Pilon
Trends in Parasitology - 2005 -
A Caenorhabditis elegans model of the myosin heavy chain IIa E706R
mutation.
Homa Tajsharghi, Marc Pilon, Anders Oldfors
Annals of Neurology - 2005 -
pha-2 encodes the C. elegans ortholog of the homeodomain protein HEX and is required for the formation of the pharyngeal
isthmus.
Catarina Mörck, Manish Rauthan, Fredrik Wågberg, Marc Pilon
Developmental Biology - 2004 -
A genetic analysis of axon guidance in the C. elegans
pharynx.
Catarina Mörck, Claes Axäng, Marc Pilon
Developmental Biology - 2003 -
A genetic analysis of axon guidance in the C elegans
pharynx
Catarina Mörck, Claes Axäng, Marc Pilon
Developmental Biology - 2003