Abhishek Niroula
Associate Senior Lecturer
Department of Medical Biochemistry and Cell biologyAbout Abhishek Niroula
Abhishek Niroula is Assistant Professor of Data-driven precision medicine and diagnostics at the Institute of Biomedicine, University of Gothenburg and a data-driven life science (DDLS) fellow in precision medicine and diagnostics. My research focuses on the mechanisms of cancer development in blood. We study clonal hematopoiesis (CH) defined by somatic genetic variants in blood cells of hematologically healthy individuals. The frequency of CH is common in the elderly population and it is associated with a higher risk of blood cancer, mortality, and several chronic diseases (e.g., cardiovascular, kidney, liver, and pulmonary diseases). We study how CH originates, evolves, and leads to diseases, including cancer. Our projects involve analysis of large scale DNA sequencing data and integration with multi-omics data.
Open positions: We are looking for bioinformatics Masters students, PhD students, and postdocs to join our team. If you are interested, please send us an email.
Selected publications
- Distinction of lymphoid and myeloid clonal hematopoiesis. Niroula A, Sekar A, Murakami MA, et al. Nat Med (2021). doi: doi.org/10.1038/s41591-021-01521-4
- Functional dissection of inherited non-coding variation influencing multiple myeloma risk. Ajore R, Niroula A, Pertesi M, et al. Nat Commun (2022). doi: doi.org/10.1038/s41467-021-27666-x
- MPRAscore: robust and non-parametric analysis of massively parallel reporter assays. Ajore R, Niroula A, Nilsson B. Bioinformatics (2019). doi: doi.org/10.1093/bioinformatics/btz591