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- Antonio Carlesso
Antonio Carlesso
Postdoctor
Department of Pharmacology-
Mechanistic insights into ASO-RNA complexation: Advancing antisense oligonucleotide design
strategies
Johanna Horberg, Antonio Carlesso, Anna Reymer
MOLECULAR THERAPY - 2024 -
Structural dynamics of therapeutic nucleic acids with phosphorothioate backbone
modifications
Antonio Carlesso, Johanna Hörberg, Giuseppe Deganutti, Anna Reymer, Pär Matsson
NAR Genomics and Bioinformatics - 2024 -
Multiscale In Silico Study of the Mechanism of Activation of the RtcB Ligase by the PTP1B
Phosphatase
Sayyed Jalil Mahdizadeh, Michael Stier, Antonio Carlesso, Aurore Lamy, Melissa Thomas, Leif A Eriksson
JOURNAL OF CHEMICAL INFORMATION AND MODELING - 2024 -
Different binding modalities of quercetin to inositol-requiring enzyme 1 of S. cerevisiae and human lead to opposite
regulation
Sayyed Jalil Mahdizadeh, Johan Grandén, Diana Pelizzari-Raymundo, Xavier Guillory, Antonio Carlesso, Eric Chevet, Leif A Eriksson
Communications Chemistry - 2024 -
A novel IRE1 kinase inhibitor for adjuvant glioblastoma
treatment
D. Pelizzari-Raymundo, D. Doultsinos, R. Pineau, C. Sauzay, T. Koutsandreas, T. Langlais, Antonio Carlesso, E. Gkotsi, L. Negroni, T. Avril, A. Chatziioannou, E. Chevet, Leif A Eriksson, X. Guillory
iScience - 2023 -
Yeast as a tool for membrane protein production and structure
determination
Antonio Carlesso, Raquel Delgado, Oriol Ruiz Isant, Owens Uwangue, D. Valli, R. M. Bill, Kristina Hedfalk
Fems Yeast Research - 2022 -
QM/MM Well-Tempered Metadynamics Study of the Mechanism of XBP1 mRNA Cleavage by Inositol Requiring Enzyme 1 alpha
RNase
Sayyed Jalil Mahdizadeh, Emil Pålsson, Antonio Carlesso, E. Chevet, Leif A Eriksson
Journal of Chemical Information and Modeling - 2022 -
Sensor dimer disruption as a new mode of action to block the IRE1-mediated unfolded protein
response
Kosala N. Amarasinghe, D. Pelizzari-Raymundo, Antonio Carlesso, E. Chevet, Leif A Eriksson, Sayyed Jalil Mahdizadeh
Computational and Structural Biotechnology Journal - 2022 -
Peptidomimetic-based identification of FDA-approved compounds inhibiting IRE1
activity
D. Doultsinos, Antonio Carlesso, C. Chintha, J. C. Paton, A. W. Paton, A. Samali, E. Chevet, Leif A Eriksson
Febs Journal - 2021 -
Molecular modeling provides a structural basis for PERK inhibitor selectivity towards
RIPK1
C. Chintha, Antonio Carlesso, A. M. Gorman, A. Samali, Leif A Eriksson
RSC Advances - 2020 -
New insights on human IRE1 tetramer structures based on molecular
modeling
Antonio Carlesso, Johanna Hörberg, Anna Reymer, Leif A Eriksson
Scientific Reports - 2020 -
Deciphering the selectivity of inhibitor MKC9989 towards residue K907 in IRE1 alpha; a multiscale in silico
approach
Sayyed Jalil Mahdizadeh, Antonio Carlesso, Leif A Eriksson
RSC Advances - 2020 -
Pharmacological Targeting of IRE1 in
Cancer
D. P. Raymundo, D. Doultsinos, X. Guillory, Antonio Carlesso, Leif A Eriksson, E. Chevet
Trends in Cancer - 2020 -
Selective Inhibition of IRE1 Signalling mediated by MKC9989: New Insights from Molecular Docking and Molecular Dynamics
Simulations
Antonio Carlesso, Leif A Eriksson
Chemistryselect - 2019 -
Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1
inhibitors
Antonio Carlesso, C. Chintha, A. M. Gorman, A. Samali, Leif A Eriksson
Scientific Reports - 2019 -
Endoplasmic reticulum stress signalling - from basic mechanisms to clinical
applications
A. Almanza, Antonio Carlesso, C. Chintha, S. Creedican, D. Doultsinos, B. Leuzzi, A. Luis, N. McCarthy, L. Montibeller, S. More, A. Papaioannou, F. Puschel, M. L. Sassano, J. Skoko, P. Agostinis, J. de Belleroche, Leif A Eriksson, S. Fulda, A. M. Gorman, S. Healy, A. Kozlov, C. Munoz-Pinedo, M. Rehm, E. Chevet, A. Samali
Febs Journal - 2019 -
Effect of Kinase Inhibiting RNase Attenuator (KIRA) Compounds on the Formation of Face-to-Face Dimers of Inositol-Requiring Enzyme 1: Insights from Computational
Modeling
Antonio Carlesso, C. Chintha, A. M. Gorman, A. Samali, Leif A Eriksson
International Journal of Molecular Sciences - 2019 -
Modeling and exploring human IRE1 as a strategy to design novel inhibitors: a computational
approach
Antonio Carlesso
2019 -
Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase
Domain
Antonio Carlesso, C. Chintha, A. M. Gorman, A. Samali, Leif A Eriksson
ACS Omega - 2018