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- Astrid von Mentzer
Astrid von Mentzer
Associate Senior Lecturer
Department of Microbiology and ImmunologyResearcher
Department of Microbiology and ImmunologyAbout Astrid von Mentzer
In the von Mentzer Lab, we focus on addressing the global health challenges posed by pathogenic Escherichia coli (E. coli), a major cause of diarrhoea in children and a significant contributor to infections and antibiotic resistance in both humans and animals. Our research leverages data-driven genomic approaches and machine learning to unravel the complex mechanisms behind E. coli’s ability to adapt, spread, and cause disease.
We are particularly interested in understanding the genetic factors that enable E. coli to colonise diverse hosts and environments, with a specific focus on adhesins—proteins that play a critical role in host specificity and infection. In addition, we use machine learning to identify genetic determinants that influence host transmission, helping us predict how these bacteria might spread across different populations.
Our research also employs machine learning methods to evaluate the emergence of hybrid E. coli strains, which combine traits from different pathogenic lineages, potentially leading to more virulent or resistant strains. By integrating large-scale genomic data, we aim to map the transmission dynamics of E. coli across different hosts and environments, providing insights into how these bacteria evolve and spread.
Our work not only deepens the understanding of E. coli pathogenesis and antibiotic resistance but also informs public health strategies by identifying potential targets for diagnostics, vaccine development, and interventions aimed at combating the spread of resistant strains.
Interested in joining the lab - read more at vonmentzerlab.com
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Construction of the ETECFinder database for the characterization of enterotoxigenic Escherichia coli (ETEC) and revision of the VirulenceFinder web tool at the CGE
website
Flemming Scheutz, Camilla Hald Nielsen, Astrid von Mentzer
JOURNAL OF CLINICAL MICROBIOLOGY - 2024 -
Colonization factors of human and animal-specific enterotoxigenic Escherichia coli
(ETEC)
Astrid von Mentzer, Ann-Mari Svennerholm
Trends in Microbiology - 2024 -
Circulation of enterotoxigenic Escherichia coli (ETEC) isolates expressing CS23 from the environment to clinical
settings
Carla Calderon Toledo, Astrid von Mentzer, Jorge Agramont, Kaisa Thorell, Yingshun Zhou, Miklós Szabó, Patricia Colque, Inger Kuhn, Sergio Gutiérrez-Cortez, Enrique Joffré
mSystems - 2023 -
Long-read-sequenced reference genomes of the seven major lineages of enterotoxigenic Escherichia coli (ETEC) circulating in modern
time
Astrid von Mentzer, G. A. Blackwell, D. Pickard, C. J. Boinett, E. Joffre, A. J. Page, Ann-Mari Svennerholm, G. Dougan, A. Sjoling
Scientific Reports - 2021 -
Colonization factor CS30 from enterotoxigenic Escherichia coli binds to sulfatide in human and porcine small
intestine
Astrid von Mentzer, Dani Zalem, Zofia Chrienova, Susann Teneberg
Virulence - 2020 -
Phenotypic and genomic analyses of bacteriophages targeting environmental and clinical CS3-expressing enterotoxigenic Escherichia coli (ETEC)
strains
S. Chakraborty, Astrid von Mentzer, Y. A. Begum, M. Manzur, M. Hasan, A. N. Ghosh, M. A. Hossein, A. Camilli, F. Qadri
PLoS ONE - 2018 -
An untypeable enterotoxigenic Escherichia coli represents one of the dominant types causing human
disease
Atsushi Iguchi, Astrid von Mentzer, Taisei Kikuchi, Nicholas R. Thomson
Microbial Genomics - 2017 -
Identification and characterization of the novel colonization factor CS30 based on whole genome sequencing in enterotoxigenic Escherichia coli
(ETEC)
Astrid von Mentzer, Joshua Tobias, Gudrun Wiklund, Stefan Nordqvist, M. Aslett, G. Dougan, A. Sjoling, Ann-Mari Svennerholm
Scientific Reports - 2017 -
Identification of new heat-stable (STa) enterotoxin allele variants produced by human enterotoxigenic Escherichia coli
(ETEC)
Enrique Joffre, Astrid von Mentzer, Ann-Mari Svennerholm, A. Sjoling
International Journal of Medical Microbiology - 2016 -
Stability of the Encoding Plasmids and Surface Expression of CS6 Differs in Enterotoxigenic Escherichia coli (ETEC) Encoding Different Heat-Stable (ST) Enterotoxins (STh and
STp)
Joshua Tobias, Astrid von Mentzer, Patricia Loayza Frykberg, M. Aslett, A. J. Page, Åsa Sjöling, Ann-Mari Svennerholm
Plos One - 2016 -
Whole Genome Sequencing of Enterotoxigenic Escherichia
coli
Astrid von Mentzer
2016 -
Treg-cell depletion promotes chemokine production and accumulation of CXCR3(+) conventional T cells in intestinal
tumors.
Paulina Akeus, Veronica Langenes, Jonas Kristensen, Astrid von Mentzer, Tim Sparwasser, Sukanya Raghavan, Marianne Quiding-Järbrink
European journal of immunology - 2015 -
Allele Variants of Enterotoxigenic Escherichia coli Heat-Labile Toxin Are Globally Transmitted and Associated with Colonization
Factors
Enrique Joffre, Astrid von Mentzer, M. Abd El Ghany, N. Oezguen, T. Savidge, G. Dougan, Ann-Mari Svennerholm, Åsa Sjöling
Journal of Bacteriology - 2015 -
Implications of enterotoxigenic Escherichia coli genomics for vaccine
development
Åsa Sjöling, Astrid von Mentzer, Ann-Mari Svennerholm
Expert Review of Vaccines - 2015 -
Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global
distribution
Astrid von Mentzer, T. R. Connor, L. H. Wieler, T. Semmler, A. Iguchi, N. R. Thomson, D. A. Rasko, Enrique Joffre, J. Corander, D. Pickard, Gudrun Wiklund, Ann-Mari Svennerholm, Åsa Sjöling, G. Dougan
Nature Genetics - 2014 -
Altered chemokine production and accumulation of regulatory T cells in intestinal adenomas of APC(Min/+)
mice.
Paulina Akeus, Veronica Langenes, Astrid von Mentzer, Ulf Yrlid, Åsa Sjöling, Pushpa Saksena, Sukanya Raghavan, Marianne Quiding-Järbrink
Cancer immunology, immunotherapy : CII - 2014 -
Expression of colonization factor CS5 of enterotoxigenic Escherichia coli (ETEC) is enhanced in vivo and by the bile component Na glycocholate
hydrate.
Matilda Nicklasson, Åsa Sjöling, Astrid von Mentzer, Firdausi Qadri, Ann-Mari Svennerholm
PloS one - 2012