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Fredrik Hieronymus
Researcher
Department of PharmacologyAbout Fredrik Hieronymus
Clinical psychopharmacology group
Our research group focusses on assessing efficacy, tolerability, and safety of psychopharmacological treatments that are in clinical use. We are particularly interested in contrasting the specific effects of different treatments for the same conditions – e.g., different classes of antidepressants – with the goal being to improve the matching between patients and interventions so that better treatment outcomes can be achieved.
We also have a fundamental research interest in how to accurately evaluate the effects of psychopharmaceuticals in clinical and research settings. This translates into an interest in how to best construct rating scales for various psychiatric constructs, e.g., using item response theory or classical test theory. The guiding principle being that increased precision in measurement can help guide future drug discovery, e.g., by decreasing the number of participants needed to demonstrate significant effects in clinical trials and/or by increasing our understanding of the specific effects in humans of different psychopharmaceuticals.
While we primarily work with large collections of clinical trial and registry data, we also collaborate with research groups that are engaged in clinical trials of psychopharmaceuticals. Currently we are contributing to studies of psilocybin for depression in cancer patients, escitalopram in premenstrual dysphoric disorder, and a novel dopamine stabilizer as add-on treatment to SSRIs in treatment-resistant depression.
Group members
Fredrik Hieronymus, associate professor, group leader
Axel Sjöstedt, doctoral student
Helena Werin Sjögren, doctoral student
Caroline Dumitrescu, amanuensis
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A target trial emulation comparing the antidepressant effectiveness of selective serotonin reuptake inhibitors (SSRIs) highlighting the importance of patent-related confounding by
indication
Christopher Rohde, Fredrik Hieronymus, Soren Dinesen Ostergaard
ACTA PSYCHIATRICA SCANDINAVICA - 2024 -
A Novel Machine Learning Based Bias Correction Method and Its Application to Sea Level in an Ensemble of Downscaled Climate
Projections
Magnus Hieronymus, Fredrik Hieronymus
Tellus, Series A: Dynamic Meteorology and Oceanography - 2023 -
Initial severity of the Positive and Negative Syndrome Scale (PANSS)-30, its main subscales plus the PANSS-6, and the relationship to subsequent improvement and trial dropout: a pooled participant-level analysis of 18 placebo-controlled risperidone and paliperidone
trials
Fredrik Hieronymus, C. U. Correll, S. D. Ostergaard
Translational Psychiatry - 2023 -
The complex clinical response to selective serotonin reuptake inhibitors in depression: a network
perspective
L. Boschloo, Fredrik Hieronymus, Alexander Lisinski, P. Cuijpers, Elias Eriksson
Translational Psychiatry - 2023 -
The response pattern to SSRIs as assessed by the Montgomery-Åsberg Depression Rating Scale: a patient-level
meta-analysis.
Fredrik Hieronymus, Alexander Lisinski, Søren Dinesen Østergaard, Elias Eriksson
World psychiatry : official journal of the World Psychiatric Association (WPA) - 2022 -
Clinical response to SSRIs relative to cognitive behavioral therapy in depression: a symptom-specific
approach.
Lynn Boschloo, Fredrik Hieronymus, Pim Cuijpers, R J DeRubeis, S Dimidjian, B W Dunlop, D L Dunner, Elias Eriksson, U Hegerl, S Herpertz, S D Hollon, R B Jarrett, S H Kennedy, Alexander Lisinski, J Miranda, D C Mohr, G Parker, F Petrak, L C Quilty, A J Rush, Z V Segal, A D Simons, E S Weitz, J R Vittengl
World psychiatry : official journal of the World Psychiatric Association (WPA) - 2022 -
Performance of 3 Sets of Criteria for Potentially Inappropriate Prescribing in Older People to Identify Inadequate Drug
Treatment
Susanna Maria Wallerstedt, Staffan Svensson, Johan Lönnbro, Fredrik Hieronymus, J. Fastbom, M. Hoffmann, Naldy Parodi Lopez
JAMA Network Open - 2022 -
Impact of chosen cutoff on response rate differences between selective serotonin reuptake inhibitors and
placebo
Alexander Lisinski, Fredrik Hieronymus, Staffan Nilsson, Elias Eriksson
Translational Psychiatry - 2022 -
The efficacy of transcranial magnetic stimulation (TMS) for negative symptoms in schizophrenia: a systematic review and
meta-analysis
R. Lorentzen, T. D. Nguyen, A. McGirr, Fredrik Hieronymus, S. D. Ostergaard
Npj Schizophrenia - 2022 -
The efficacy of repetitive transcranial magnetic stimulation (rTMS) for bipolar depression: A systematic review and
meta-analysis
Tuan Dang Nguyen, Fredrik Hieronymus, Rasmus Lorentzen, Alexander McGirr, Søren D. Østergaard
Journal of Affective Disorders - 2021 -
Antipsychotic-placebo separation on the PANSS-6 subscale as compared to the PANSS-30: a pooled participant-level
analysis
Fredrik Hieronymus, P. Kolbae, C. U. Correll, S. D. Ostergaard
Npj Schizophrenia - 2021 -
Do side effects of antidepressants impact efficacy estimates based on the Hamilton Depression Rating Scale? A pooled patient-level
analysis
Fredrik Hieronymus, Alexander Lisinski, Elias Eriksson, S. D. Ostergaard
Translational Psychiatry - 2021 -
Low SSRI dosing in clinical practice-a register-based longitudinal
study
Alexander Lisinski, Fredrik Hieronymus, Elias Eriksson, Susanna Maria Wallerstedt
Acta Psychiatrica Scandinavica - 2021 -
Pre-diagnostic and post-diagnostic psychopharmacological treatment of 16 288 patients with bipolar
disorder
O. Kohler-Forsberg, C. Gasse, Fredrik Hieronymus, L. Petersen, R. H. Christensen, A. A. Nierenberg, S. D. Ostergaard
Bipolar Disorders - 2021 -
Southern Baltic sea level extremes: tide gauge data, historic storms and confidence
intervals
M. Hieronymus, Fredrik Hieronymus
Boreal Environment Research - 2021 -
Individual variability in treatment response to antidepressants in major depression: comparing trial-level and patient-level
analyses.
Fredrik Hieronymus, M Hieronymus, Staffan Nilsson, Elias Eriksson, S D Østergaard
Acta Psychiatrica Scandinavica - 2020 -
Item-based analysis of the effects of duloxetine in depression: a patient-level post hoc
study.
Alexander Lisinski, Fredrik Hieronymus, Jakob Näslund, Staffan Nilsson, Elias Eriksson
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 2020 -
GOOD NEWS REGARDING SSRI SAFETY IN DANISH
META-ANALYSIS.
Fredrik Hieronymus, Alexander Lisinski, Jakob Näslund, Elias Eriksson
Acta neuropsychiatrica - 2020 -
One (effect) size does not fit at all: Interpreting clinical significance and effect sizes in depression treatment
trials
Fredrik Hieronymus, Sameer Jauhar, Søren Dinesen Østergaard, Allan H. Young
Journal of Psychopharmacology - 2020 -
On the Application of Machine Learning Techniques to Regression Problems in Sea Level
Studies
M. Hieronymus, J. Hieronymus, Fredrik Hieronymus
Journal of Atmospheric and Oceanic Technology - 2019 -
Influence of baseline severity on the effects of SSRIs in depression: an item-based, patient-level post-hoc
analysis
Fredrik Hieronymus, Alexander Lisinski, Staffan Nilsson, Elias Eriksson
Lancet Psychiatry - 2019 -
How do we determine whether antidepressants are useful or not? - Authors'
reply.
Fredrik Hieronymus, Alexander Lisinski, Staffan Nilsson, Elias Eriksson
The Lancet Psychiatry - 2019 -
Acoustic white noise ameliorates reduced regional brain expression of CaMKII and ΔFosB in the spontaneously hypertensive rat model of
ADHD
Daniel Eckernäs, Fredrik Hieronymus, Thomas Carlsson, Filip Bergquist
IBRO Reports - 2019 -
On the Effects of Serotonin Reuptake Inhibitors in Major
Depression
Fredrik Hieronymus
2019 -
The alleged lack of efficacy of antidepressants in non-severe depression: a myth
debunked.
Elias Eriksson, Fredrik Hieronymus
Acta psychiatrica Scandinavica - 2018 -
Efficacy of selective serotonin reuptake inhibitors in the absence of side effects: a mega-analysis of citalopram and paroxetine in adult
depression
Fredrik Hieronymus, Alexander Lisinski, Staffan Nilsson, Elias Eriksson
Molecular Psychiatry - 2018 -
Katakam and co-workers have not shown SSRIs to be harmful and ineffective and should stop claiming that they
have.
Fredrik Hieronymus, Alexander Lisinski, Jakob Näslund, Elias Eriksson
Acta neuropsychiatrica - 2018 -
Effects of selective serotonin reuptake inhibitors on rating-scale-assessed suicidality in adults with
depression
Jakob Näslund, Fredrik Hieronymus, Alexander Lisinski, Staffan Nilsson, Elias Eriksson
British Journal of Psychiatry - 2018 -
Multiple possible inaccuracies cast doubt on a recent report suggesting selective serotonin reuptake inhibitors to be toxic and
ineffective.
Fredrik Hieronymus, Alexander Lisinski, Jakob Näslund, Elias Eriksson
Acta Neuropsychiatrica - 2018 -
Incidence of early anxiety aggravation in trials of selective serotonin reuptake inhibitors in
depression
Jakob Näslund, Fredrik Hieronymus, Johan Fredrik Emilsson, Alexander Lisinski, Staffan Nilsson, Elias Eriksson
Acta Psychiatrica Scandinavica - 2017 -
Inclusion of Flexible-Dose Trials in the Meta-Analysis of SSRI
Dose-Dependency.
Fredrik Hieronymus, Elias Eriksson
The American journal of psychiatry - 2016 -
Consistent superiority of selective serotonin reuptake inhibitors over placebo in reducing depressed mood in patients with major
depression.
Fredrik Hieronymus, Johan Fredrik Emilsson, Staffan Nilsson, Elias Eriksson
Molecular psychiatry - 2016 -
A mega-analysis of fixed-dose trials reveals dose-dependency and a rapid onset of action for the antidepressant effect of three selective serotonin reuptake
inhibitors
Fredrik Hieronymus, Staffan Nilsson, Elias Eriksson
Translational Psychiatry - 2016 -
The alleged ineffectiveness of SSRIs in depression is an artefact caused by the use of an inappropriate measure of
efficacy
Fredrik Hieronymus, Johan Fredrik Emilsson, Staffan Nilsson, Elias Eriksson
International Journal of Neuropsychopharmacology vol. 17 Supplement 1. 29th CINP World Congress of Neuropsychopharmacology, Vancouver, Canada, 22–26 June 2014 - 2014