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Joakim Ek
Senior Lecturer
Department of Physiology-
Prediction of adverse maternal and perinatal outcomes associated with pre-eclampsia and hypertensive disorders of pregnancy: a systematic review and
meta-analysis
Valentina Bucher, Alexandra Roddy Mitchell, Pia Gudmundsson, Jessica Atkinson, Nicole Wallin, Joline Asp, Maria Sennstrom, Karin Hilden, Camilla Edvinsson, C. Joakim Ek, Roxanne Hastie, Catherine Cluver, Lina Bergman
ECLINICALMEDICINE - 2024 -
Maternal n-3 enriched diet reprograms the offspring neurovascular transcriptome and blunts inflammation induced by endotoxin in the
neonate
Tetyana Chumak, Amandine Jullienne, C. Joakim Ek, Maryam Ardalan, Pernilla Svedin, Ryan Quan, Arjang Salehi, Sirus Salari, Andre Obenaus, Zinaida S. Vexler, Carina Mallard
JOURNAL OF NEUROINFLAMMATION - 2024 -
Novel biomarkers of preterm brain injury from blood transcriptome in sheep model of intrauterine
asphyxia
C. Joakim Ek, Mårten Alkmark, Ana A. Baburamani, Veena G. Supramaniam, Sanjana Sood, Rossella Melchiotti, Emanuele de Rinaldis, Henrik Hagberg, Carina Mallard
PEDIATRIC RESEARCH - 2024 -
Treatment with RNase alleviates brain injury but not neuroinflammation in neonatal
hypoxia/ischemia
Rozita H Anderberg, E. Axel Andersson, Valentina Bucher, Klaus T. Preissner, Carina Mallard, C. Joakim Ek
JOURNAL OF NEUROSCIENCE RESEARCH - 2024 -
Elevated circulating adiponectin levels do not prevent anxiety-like behavior in a PCOS-like mouse
model
Manisha Samad, C. Joakim Ek, Stina Börchers, Jean-Philippe Krieger, Elisabet Stener-Victorin, Karolina P Skibicka, Ingrid Wernstedt Asterholm, Anna Benrick
SCIENTIFIC REPORTS - 2024 -
Two different isoforms of osteopontin modulate myelination and axonal
integrity
Gisela M A Nilsson, Amin Mottahedin, Aura Zelco, V. M. Lauschke, C. Joakim Ek, Juan Song, Maryam Ardalan, Sha Hua, Xiaoli Zhang, Carina Mallard, Henrik Hagberg, J. W. Leavenworth, Xiaoyang Wang
Faseb Bioadvances - 2023 -
Proteomics identifies lipocalin-2 in neonatal inflammation associated with cerebrovascular alteration in mice and preterm
infants
Giacomo Gravina, Maryam Ardalan, Tetyana Chumak, Anders K. Nilsson, C. Joakim Ek, H. Danielsson, Pernilla Svedin, Milos Pekny, Marcela Pekna, Karin Sävman, Ann Hellström, Carina Mallard
iScience - 2023 -
Alpha1-antitrypsin protects the immature mouse brain following hypoxic-ischemic
injury
Shan Zhang, W. D. Li, Y. R. Xu, Tao Li, C. Joakim Ek, X. L. Zhang, Yafeng Wang, J. Song, Changlian Zhu, Xiaoyang Wang
Frontiers in Cellular Neuroscience - 2023 -
The Alpha 7 Nicotinic Acetylcholine Receptor Does Not Affect Neonatal Brain
Injury
Maria Hammarlund, C. Joakim Ek, Sukaina Akar, Alma Karlsson, Bagmi Pattanaik, Filip Mjörnstedt, Pernilla Svedin, Maryam Ardalan, Eridan Rocha-Ferreira, Carina Mallard, Maria E Johansson
Biomedicines - 2022 -
Temporal brain transcriptome analysis reveals key pathological events after germinal matrix hemorrhage in neonatal
rats
Juan Song, Gisela M A Nilsson, Y. R. Xu, Aura Zelco, Eridan Rocha-Ferreira, Yafeng Wang, X. L. Zhang, Shan Zhang, C. Joakim Ek, Henrik Hagberg, Changlian Zhu, Xiaoyang Wang
Journal of Cerebral Blood Flow and Metabolism - 2022 -
Microbial and human transcriptome in vaginal fluid at midgestation: Association with spontaneous preterm
delivery.
Tove Wikström, Sanna Abrahamsson, Johan Bengtsson-Palme, C. Joakim Ek, Pihla Kuusela, Elham Rekabdar, Peter Lindgren, Ulla-Britt Wennerholm, Bo Jacobsson, Lil Valentin, Henrik Hagberg
Clinical and translational medicine - 2022 -
Maternal n-3 Polyunsaturated Fatty Acid Enriched Diet Commands Fatty Acid Composition in Postnatal Brain and Protects from Neonatal Arterial Focal
Stroke
Tetyana Chumak, M. J. Lecuyer, Anders K. Nilsson, J. Faustino, Maryam Ardalan, Pernilla Svedin, Ulrika Sjöbom, C. Joakim Ek, A. Obenaus, Z. S. Vexler, Carina Mallard
Translational Stroke Research - 2022 -
Adipose Tissue-Breast Cancer Crosstalk Leads to Increased Tumor Lipogenesis Associated with Enhanced Tumor
Growth.
Peter Micallef, Yanling Wu, Marco Bauzá-Thorbrügge, Belén Chanclón, Milica Vujičić, Eduard Peris, C. Joakim Ek, Ingrid Wernstedt Asterholm
International journal of molecular sciences - 2021 -
Viral mimetic triggers cerebral arteriopathy in juvenile brain via neutrophil elastase and
NETosis
A. Rayasam, A. Jullienne, Tetyana Chumak, J. Faustino, J. Szu, M. Hamer, C. Joakim Ek, Carina Mallard, A. Obenaus, Z. S. Vexler
Journal of Cerebral Blood Flow and Metabolism - 2021 -
Function and Biomarkers of the Blood-Brain Barrier in a Neonatal Germinal Matrix Haemorrhage
Model
-
Circulating tight-junction proteins are potential biomarkers for blood-brain barrier function in a model of neonatal hypoxic/ischemic brain
injury
E. Axel Andersson, Carina Mallard, C. Joakim Ek
Fluids and Barriers of the CNS - 2021 -
Vancomycin Is Protective in a Neonatal Mouse Model of Staphylococcus epidermidis-Potentiated Hypoxic-Ischemic Brain
Injury
Jacqueline Lai, Pernilla Svedin, C. Joakim Ek, Amin Mottahedin, Xiaoyang Wang, O. Levy, A. Currie, T. Strunk, Carina Mallard
Antimicrobial Agents and Chemotherapy - 2020 -
A Model of Germinal Matrix Hemorrhage in Preterm Rat
Pups.
Masako Jinnai, Gabriella Koning, Gagandeep Singh-Mallah, Andrea Jonsdotter, Anna-Lena Leverin, Pernilla Svedin, Syam Nair, Satoru Takeda, Xiaoyang Wang, Carina Mallard, C. Joakim Ek, Eridan Rocha-Ferreira, Henrik Hagberg
Frontiers in cellular neuroscience - 2020 -
The molecular anatomy and functions of the choroid plexus in healthy and diseased
brain
I. Kratzer, C. Joakim Ek, H. Stolp
Biochimica et Biophysica Acta - Biomembranes - 2020 -
Staphylococcus epidermidis Sensitizes Perinatal Hypoxic-Ischemic Brain Injury in Male but Not Female
Mice
Giacomo Gravina, Pernilla Svedin, Maryam Ardalan, O. Levy, C. Joakim Ek, Carina Mallard, Jacqueline Lai
Frontiers in Immunology - 2020 -
N-acetylcysteine inhibits bacterial lipopeptide-mediated neutrophil transmigration through the choroid plexus in the developing
brain
Amin Mottahedin, S. Blondel, C. Joakim Ek, Anna-Lena Leverin, Pernilla Svedin, Henrik Hagberg, Carina Mallard, J. F. Ghersi-Egea, N. Strazielle
Acta Neuropathologica Communications - 2020 -
Choroid plexus transcriptome and ultrastructure analysis reveals a TLR2-specific chemotaxis signature and cytoskeleton remodeling in leukocyte
trafficking
Amin Mottahedin, C. Joakim Ek, Katarina Truvé, Henrik Hagberg, Carina Mallard
Brain Behavior and Immunity - 2019 -
Magnesium induces preconditioning of the neonatal brain via profound mitochondrial
protection.
Gabriella Koning, Anna-Lena Leverin, Syam Nair, Leslie Schwendimann, C. Joakim Ek, Ylva Carlsson, Pierre Gressens, Claire Thornton, Xiaoyang Wang, Carina Mallard, Henrik Hagberg
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 2019 -
Dysmaturation of Somatostatin Interneurons Following Umbilical Cord Occlusion in Preterm Fetal
Sheep
Maryam Ardalan, Pernilla Svedin, A. A. Baburamani, V. G. Supramaniam, C. Joakim Ek, Henrik Hagberg, Carina Mallard
Frontiers in Physiology - 2019 -
Peripheral myeloid cells contribute to brain injury in male neonatal
mice
Peter L P Smith, Amin Mottahedin, Pernilla Svedin, Carl-Johan Mohn, Henrik Hagberg, C. Joakim Ek, Carina Mallard
Journal of Neuroinflammation - 2018 -
The myth of the immature barrier systems in the developing brain: role in perinatal brain
injury
Carina Mallard, C. Joakim Ek, Z. S. Vexler
Journal of Physiology-London - 2018 -
Serum concentrations of the axonal injury marker neurofilament light protein are not influenced by blood-brain barrier
permeability
Marie Kalm, Martina Boström, Åsa P Sandelius, Yohanna Eriksson, C. Joakim Ek, Kaj Blennow, Thomas Björk-Eriksson, Henrik Zetterberg
Brain Research - 2017 -
Systemic activation of Toll-like receptor 2 suppresses mitochondrial respiration and exacerbates hypoxic-ischemic injury in the developing
brain
Amin Mottahedin, Pernilla Svedin, Syam Nair, Carl-Johan Mohn, Xiaoyang Wang, Henrik Hagberg, C. Joakim Ek, Carina Mallard
Journal of Cerebral Blood Flow and Metabolism - 2017 -
γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in
mice
Xiaoli Zhang, Eridan Rocha-Ferreira, Tao Li, Regina Vontell, Darakhshan Jabin, Sha Hua, Kai Zhou, Arshed Nazmi, Anna-Maj Albertsson, Kristina Sobotka, C. Joakim Ek, Claire Thornton, Henrik Hagberg, Carina Mallard, Jianmei W. Leavenworth, Changlian Zhu, Xiaoyang Wang
Journal of Neuroinflammation - 2017 -
Effect of Neuroinflammation on Synaptic Organization and Function in the Developing Brain: Implications for Neurodevelopmental and Neurodegenerative
Disorders
Amin Mottahedin, Maryam Ardalan, Tetyana Chumak, Ilse Riebe, C. Joakim Ek, Carina Mallard
Frontiers in Cellular Neuroscience - 2017 -
TLR2-mediated leukocyte trafficking to the developing
brain.
Amin Mottahedin, Peter L P Smith, Henrik Hagberg, C. Joakim Ek, Carina Mallard
Journal of leukocyte biology - 2017 -
Immune responses in perinatal brain
injury.
Jacqueline Lai, Eridan Rocha-Ferreira, Xiaoyang Wang, C. Joakim Ek, Henrik Hagberg, Carina Mallard
Brain, behavior, and immunity - 2017 -
Radiation induces progenitor cell death, microglia activation, and blood-brain barrier damage in the juvenile rat
cerebellum
K. Zhou, Martina Boström, C. Joakim Ek, T. Li, C. C. Xie, Y. R. Xu, Y. Y. Sun, K. Blomgren, C. L. Zhu
Scientific Reports - 2017 -
GSK3β inhibition protects the immature brain from hypoxic-ischaemic insult via reduced STAT3
signalling
Barbara D'angelo, C. Joakim Ek, Yanyan Sun, Changlian Zhu, Mats Sandberg, Carina Mallard
Neuropharmacology - 2016 -
The blood-tendon barrier: Identification and characterisation of a novel tissue barrier in tendon blood
vessels
C. Lehner, R. Gehwolf, C. Joakim Ek, S. Korntner, H. Bauer, H. C. Bauer, A. Traweger, H. Tempfer
European Cells and Materials - 2016 -
Delayed astrocytic contact with cerebral blood vessels in FGF-2 deficient mice does not compromise permeability properties at the developing blood-brain
barrier
N. R. Saunders, K. M. Dziegielewska, K. Unsicker, C. Joakim Ek
Developmental Neurobiology - 2016 -
Melatonin reduces excitotoxic blood-brain barrier breakdown in neonatal
rats
R. Moretti, A. Zanin, J. Pansiot, D. Spiri, L. Manganozzi, I. Kratzer, G. Favero, A. Vasiljevic, V. E. Rinaldi, I. Pic, D. Massano, I. D'Agostino, Ana A Baburamani, M. A. La Rocca, L. F. Rodella, R. Rezzani, C. Joakim Ek, N. Strazielle, J. F. Ghersi-Egea, P. Gressens, L. Titomanlio
Neuroscience - 2015 -
Staphylococcus epidermidis Bacteremia Induces Brain Injury in Neonatal Mice via Toll-like Receptor 2-Dependent and -Independent
Pathways
Dan Bi, Lili Qiao, Ilana Bergelson, C. Joakim Ek, Luqi Duan, Xiaoli Zhang, Anna-Maj Albertsson, Matthew Pettengill, Kenny Kronforst, Jana Ninkovic, Donald Goldmann, Anders Janzon, Henrik Hagberg, Xiaoyang Wang, Carina Mallard, Ofer Levy
The Journal of infectious diseases - 2015 -
Brain barrier properties and cerebral blood flow in neonatal mice exposed to cerebral
hypoxia-ischemia
C. Joakim Ek, Barbara D'angelo, Ana A Baburamani, C. Lehner, Anna-Lena Leverin, Peter L P Smith, Holger Nilsson, Pernilla Svedin, Henrik Hagberg, Carina Mallard
Journal of Cerebral Blood Flow and Metabolism - 2015 -
Expression of tight junction proteins and transporters for xenobiotic metabolism at the blood-CSF barrier during development in the nonhuman primate (P.
hamadryas)
C. Joakim Ek, Barbara D'angelo, C. Lehner, P. Nathanielsz, C. Li, Carina Mallard
Reproductive Toxicology - 2015 -
Transcriptomal changes and functional annotation of the developing non-human primate choroid
plexus
C. Joakim Ek, P. Nathanielsz, C. Li, Carina Mallard
Frontiers in Neuroscience - 2015 -
Innate defence regulator peptide 1018 protects against perinatal brain
injury.
Hayde Bolouri, Karin Sävman, Wei Wang, Anitha Thomas, Norbert Maurer, Edie Dullaghan, Christopher D Fjell, C. Joakim Ek, Henrik Hagberg, Robert E W Hancock, Kelly Brown, Carina Mallard
Annals of neurology - 2014 -
Perinatal Hypoxia-Ischemia Reduces alpha 7 Nicotinic Receptor Expression and Selective alpha 7 Nicotinic Receptor Stimulation Suppresses Inflammation and Promotes Microglial Mox
Phenotype
Sansan Hua, C. Joakim Ek, Carina Mallard, Maria E Johansson
Biomed Research International - 2014 -
Targeting the vasculature for cerebroprotection in the immature
brain.
Henrik Hagberg, C. Joakim Ek
Experimental neurology - 2014 -
Age-Dependent Transcriptome and Proteome Following Transection of Neonatal Spinal Cord of Monodelphis domestica (South American Grey Short-Tailed
Opossum)
N. R. Saunders, N. M. Noor, K. M. Dziegielewska, B. J. Wheaton, S. A. Liddelow, D. L. Steer, C. Joakim Ek, M. D. Habgood, M. J. Wakefield, H. Lindsay, J. Truettner, R. D. Miller, A. I. Smith, W. D. Dietrich
Plos One - 2014 -
Expression of the Nrf2-system at the blood-CSF barrier is modulated by neonatal inflammation and
hypoxia-ischemia
Barbara D'angelo, C. Joakim Ek, Mats Sandberg, Carina Mallard
Journal of Inherited Metabolic Disease - 2013 -
Mechanisms That Determine the Internal Environment of the Developing Brain: A Transcriptomic, Functional and Ultrastructural
Approach
S. A. Liddelow, K. M. Dziegielewska, C. Joakim Ek, M. D. Habgood, H. Bauer, H. C. Bauer, H. Lindsay, M. J. Wakefield, N. Strazielle, I. Kratzer, K. Mollgard, J. F. Ghersi-Egea, N. R. Saunders
Plos One - 2013 -
Regulation of Toll-Like Receptors in the Choroid Plexus in the Immature Brain After Systemic Inflammatory
Stimuli
Linnea Stridh, C. Joakim Ek, Xiaoyang Wang, Holger Nilsson, Carina Mallard
Translational Stroke Research - 2013 -
Vulnerability of the developing brain to hypoxic-ischemic damage: Contribution of the cerebral vasculature to injury and
repair?
Ana A Baburamani, C. Joakim Ek, David W. Walker, Margie Castillo-Melendez
Frontiers in Physiology - 2012 -
Barriers in the developing brain and
Neurotoxicology
C. Joakim Ek, K. M. Dziegielewska, M. D. Habgood, N. R. Saunders
Neurotoxicology - 2012 -
Pathological Changes in the White Matter after Spinal Contusion Injury in the
Rat
C. Joakim Ek, M. D. Habgood, R. Dennis, K. M. Dziegielewska, Carina Mallard, B. Wheaton, N. R. Saunders
Plos One - 2012