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Maria Johansson
Professor
Department of PhysiologyAssistant Head of Department
Institute of Neuroscience and PhysiologyAbout Maria Johansson
Ongoing research / projects
- Cholinergic anti-inflammatory pathway and its role in cardiovascular disease
- Dietary effects on the immune system
Teaching
Circulatory Physiology
Research interests
Cardiovascular research and dietary effects on the immune system
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The alpha 7 nicotinic acetylcholine receptor agonist PHA 568487 dampens inflammation in PBMCs from patients with newly discovered coronary artery
disease.
Filip Mjörnstedt, Rebecka Wilhelmsson, Marcus A Ulleryd, Maria Hammarlund, Göran Bergström, Anders Gummesson, Maria E Johansson
American journal of physiology. Heart and circulatory physiology - 2024 -
Alpha 7 Nicotinic Acetylcholine Receptor Agonist PHA 568487 Reduces Acute Inflammation but Does Not Affect Cardiac Function or Myocardial Infarct Size in the Permanent Occlusion
Model.
Filip Mjörnstedt, Azra Miljanovic, Rebecka Wilhelmsson, Malin Levin, Maria E Johansson
International journal of molecular sciences - 2024 -
The Alpha 7 Nicotinic Acetylcholine Receptor Does Not Affect Neonatal Brain
Injury
Maria Hammarlund, C. Joakim Ek, Sukaina Akar, Alma Karlsson, Bagmi Pattanaik, Filip Mjörnstedt, Pernilla Svedin, Maryam Ardalan, Eridan Rocha-Ferreira, Carina Mallard, Maria E Johansson
Biomedicines - 2022 -
Cardiovagal Function Measured by the Deep Breathing Test: Relationships With Coronary
Atherosclerosis
G. Engstrom, V. Hamrefors, A. Fedorowski, A. Persson, Maria E Johansson, E. Ostenfeld, I. Goncalves, H. Markstad, L. S. B. Johnson, M. Persson, J. Carlson, P. G. Platonov
Journal of the American Heart Association - 2022 -
Somatic ablation of IKKβ in liver and leukocytes is not tolerated in obese mice but hepatic IKKβ deletion improves fatty liver and insulin
sensitivity.
Vagner Ramon Rodrigues Silva, Angela Molinaro, Andrea Usseglio Gaudi, Emanuel Fryk, Claudia Sardi, Maria Hammarlund, Filip Mjörnstedt, Maria E Johansson, Barbara Becattini, Per-Anders Jansson, Giovanni Solinas
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2022 -
Polymorphisms in alpha 7 nicotinic acetylcholine receptor gene, CHRNA7, and its partially duplicated gene, CHRFAM7A, associate with increased inflammatory response in human peripheral mononuclear
cells
Bagmi Pattanaik, Maria Hammarlund, Filip Mjörnstedt, Marcus A Ulleryd, W. Zhong, M. Uhlen, Anders Gummesson, Göran Bergström, Maria E Johansson
Faseb Journal - 2022 -
The selective alpha7 nicotinic acetylcholine receptor agonist AR‑R17779 does not affect ischemia-reperfusion brain injury in
mice.
Maria Hammarlund, Vladimer Darsalia, Filip Mjörnstedt, Bagmi Pattanaik, Carina Mallard, Eridan Rocha-Ferreira, Cesare Patrone, Maria E Johansson
Bioscience reports - 2021 -
Weight gain and neuroadaptations elicited by high fat diet depend on fatty acid
composition.
Louise Adermark, Saray Gutierrez, Oona Lagström, Maria Hammarlund, Valentina Licheri, Maria E Johansson
Psychoneuroendocrinology - 2021 -
Bis(maltolato)oxovanadium(IV) Induces Angiogenesis via Phosphorylation of
VEGFR2
L. Parma, H. A. B. Peters, Maria E Johansson, Saray Gutiérrez, H. Meijerink, S. de Kimpe, M. R. de Vries, P. H. A. Quax
International Journal of Molecular Sciences - 2020 -
Spleen proteomics data from high fat diet fed
mice.
Sara L Svahn, Bagmi Pattanaik, Louise Grahnemo, Saray Gutiérrez, Intawat Nookaew, John-Olov Jansson, Maria E Johansson
Data in brief - 2020 -
RNA sequencing data describing transcriptional changes in aorta of ApoE-/mice after alpha 7 nicotinic acetylcholine receptor (alpha 7nAChR)
stimulation
Marcus A Ulleryd, Filip Mjörnstedt, Dimitra Panagaki, Li Jin Yang, Kajsa Engevall, Saray Gutiérrez, Y. X. Wang, Li-Ming Gan, Holger Nilsson, E. Michaelsson, Maria E Johansson
Data in Brief - 2020 -
Dietary Polyunsaturated Fatty Acids Promote Neutrophil Accumulation in the Spleen by Altering Chemotaxis and Delaying Cell
Death
Sara L Svahn, Saray Gutiérrez, Marcus A Ulleryd, I. Nookaew, Veronica Osla, Fredrik Beckman, Staffan Nilsson, Anna Karlsson, John-Olov Jansson, Maria E Johansson
Infection and Immunity - 2019 -
Effects of Omega-3 Fatty Acids on Immune
Cells.
Saray Gutiérrez, Sara L Svahn, Maria E Johansson
International journal of molecular sciences - 2019 -
Stimulation of alpha 7 nicotinic acetylcholine receptor (α7nAChR) inhibits atherosclerosis via immunomodulatory effects on myeloid
cells.
Marcus A Ulleryd, Filip Mjörnstedt, Dimitra Panagaki, Li Jin Yang, Kajsa Engevall, Saray Gutiérrez, Yixin Wang, Li-Ming Gan, Holger Nilsson, Erik Michaëlsson, Maria E Johansson
Atherosclerosis - 2019 -
Testosterone is an endogenous regulator of BAFF and splenic B cell
number
Anna S K Wilhelmson, Marta Lantero Rodriguez, Alexandra Stubelius, Per Fogelstrand, Inger Johansson, M. B. Buechler, S. Lianoglou, V. N. Kapoor, Maria E Johansson, Johan Bourghardt Fagman, A. Duhlin, P. Tripathi, Alessandro Camponeschi, B. T. Porse, A. G. Rolink, Hans Nissbrandt, S. J. Turley, Hans Carlsten, Inga-Lill Mårtensson, M. C. I. Karlsson, Åsa Tivesten
Nature Communications - 2018 -
Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal
muscle.
Urszula Chursa, Esther Nuñez Durán, Emmelie Cansby, Manoj Amrutkar, Silva Sütt, Marcus Ståhlman, Britt-Marie Olsson, Jan Borén, Maria Johansson, Fredrik Bäckhed, Bengt R Johansson, Carina Sihlbom, Margit Mahlapuu
Diabetologia - 2017 -
The association between autonomic dysfunction, inflammation and atherosclerosis in men under investigation for carotid
plaques.
Marcus A Ulleryd, Ulrica Prahl, Johannes Börsbo, Caroline Schmidt, Staffan Nilsson, Göran Bergström, Maria Johansson
PloS one - 2017 -
Dietary Omega-3 Fatty Acids Increase Survival and Decrease Bacterial Load in Mice Subjected to Staphylococcus aureus-Induced
Sepsis
Sara L Svahn, Marcus A Ulleryd, Louise Grahnemo, Marcus Ståhlman, Jan Borén, Staffan Nilsson, John-Olov Jansson, Maria E Johansson
Infection and Immunity - 2016 -
Increased Intimal Hyperplasia After Vascular Injury in Male Androgen Receptor-Deficient
Mice
Anna S K Wilhelmson, Johan Bourghardt Fagman, Inger Johansson, Zhiyuan V. Zou, Axel G Andersson, Elin Svedlund Eriksson, Maria E Johansson, Per Lindahl, Per Fogelstrand, Åsa Tivesten
Endocrinology - 2016 -
Six Tissue Transcriptomics Reveals Specific Immune Suppression in Spleen by Dietary Polyunsaturated Fatty
Acids
Sara L Svahn, Leif Väremo, Britt G. Gabrielsson, Eduard Peris, Intawat Nookaew, Louise Grahnemo, Ann-Sofie Sandberg, Ingrid Wernstedt Asterholm, John-Olov Jansson, Jens B. Nielsen, Maria E Johansson
PLoS ONE - 2016 -
Dietary polyunsaturated fatty acids increase survival and decrease bacterial load during septic S. aureus infection, and improve neutrophil function in
mice
Sara L Svahn, Louise Grahnemo, Vilborg Palsdottir, Intawat Nookaew, Karl Wendt, Britt G. Gabrielsson, Erik Scheele, Anna Benrick, Niklas Andersson, Staffan Nilsson, Maria E Johansson, John-Olov Jansson
Infection and Immunity - 2015 -
Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE(-/-)
Mice
Marcus A Ulleryd, Evelina Bernberg, Li Jin Yang, Göran Bergström, Maria E Johansson
Biomed Research International - 2014 -
Perinatal Hypoxia-Ischemia Reduces alpha 7 Nicotinic Receptor Expression and Selective alpha 7 Nicotinic Receptor Stimulation Suppresses Inflammation and Promotes Microglial Mox
Phenotype
Sansan Hua, C. Joakim Ek, Carina Mallard, Maria E Johansson
Biomed Research International - 2014 -
alpha 7 Nicotinic Acetylcholine Receptor Is Expressed in Human Atherosclerosis and Inhibits Disease in Mice-Brief
Report
Maria E Johansson, Marcus A Ulleryd, Angelina I Bernardi, A. M. Lundberg, Annica Andersson, L. Folkersen, Linda Fogelstrand, Ulrika Islander, Z. Q. Yan, G. K. Hansson
Arteriosclerosis Thrombosis and Vascular Biology - 2014 -
Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic
mice
Maria E Johansson, X. Y. Zhang, K. Edfeldt, A. M. Lundberg, Malin Levin, Jan Borén, W. Li, X. M. Yuan, L. Folkersen, P. Eriksson, U. Hedin, H. Low, D. Sviridov, F. J. Rios, G. K. Hansson, Z. Q. Yan
European Journal of Immunology - 2014 -
Exendin-4 Reduces Ischemic Brain Injury in Normal and Aged Type 2 Diabetic Mice and Promotes Microglial M2
Polarization
V. Darsalia, Sansan Hua, M. Larsson, Carina Mallard, D. Nathanson, T. Nystrom, A. Sjoholm, Maria E Johansson, C. Patrone
Plos One - 2014 -
Rats with adenine-induced chronic renal failure develop low-renin, salt-sensitive hypertension and increased aortic
stiffness
Lisa Nguy, Maria E Johansson, Elisabeth Grimberg, Jaana Lundgren, T. Teerlink, Mattias Carlström, J. O. Lundberg, Holger Nilsson, Gregor Guron
American Journal of Physiology-Regulatory Integrative and Comparative Physiology - 2013 -
Toll-like receptor-3 activation increases the vulnerability of the neonatal brain to
hypoxia-ischemia.
Linnea Stridh, Amin Mottahedin, Maria E Johansson, Raul Chavez Valdez, Frances Northington, Xiaoyang Wang, Carina Mallard
The Journal of neuroscience : the official journal of the Society for Neuroscience - 2013 -
Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes
atherosclerosis
A. M. Lundberg, D. F. Ketelhuth, Maria E Johansson, N. Gerdes, S. Liu, M. Yamamoto, S. Akira, G. K. Hansson
Cardiovascular Research - 2013 -
Social disruption stress increases IL-6 levels and accelerates atherosclerosis in ApoE-/-
mice.
Evelina Bernberg, Marcus A Ulleryd, Maria E Johansson, Göran Bergström
Atherosclerosis - 2012 -
Vascular function in rats with adenine-induced chronic renal
failure.
Lisa Nguy, Holger Nilsson, Jaana Lundgren, Maria E Johansson, Tom Teerlink, Peter G Scheffer, Gregor Guron
American journal of physiology. Regulatory, integrative and comparative physiology - 2012 -
Rip2 deficiency leads to increased atherosclerosis despite decreased
inflammation.
Malin Levin, Pernilla Jirholt, Anna Wramstedt, Maria E Johansson, Anna M Lundberg, Maria Gustafsson Trajkovska, Marcus Ståhlman, Per Fogelstrand, Mikael Brisslert, Linda Fogelstrand, Zhong-Qun Yan, Göran K Hansson, Harry Björkbacka, Sven-Olof Olofsson, Jan Borén
Circulation research - 2011 -
Identification of a danger-associated peptide from apolipoprotein B100 (ApoBDS-1) that triggers innate proatherogenic
responses
D. F. Ketelhuth, F. J. Rios, Y. Wang, H. Liu, Maria E Johansson, G. N. Fredrikson, U. Hedin, M. Gidlund, J. Nilsson, G. K. Hansson, Z. Q. Yan
Circulation - 2011 -
Nuclear factor {kappa}B-mediated transactivation of telomerase prevents intimal smooth muscle cell from replicative senescence during vascular
repair
D. X. Bu, Maria E Johansson, J. Ren, D. W. Xu, F. B. Johnson, K. Edfeldt, Z. Q. Yan
Arterioscler Thromb Vasc Biol - 2010 -
High-salt diet combined with elevated angiotensin II accelerates atherosclerosis in apolipoprotein E-deficient
mice.
Maria E Johansson, Evelina Bernberg, Irene J Andersson, Peter Bie, Ole Skøtt, Li-Ming Gan, Göran Bergström
Journal of hypertension - 2009 -
Repeated exposure to stressors do not accelerate atherosclerosis in ApoE-/-
mice
Evelina Bernberg, Irene J Andersson, Sofia Tidstrand, Maria E Johansson, Göran Bergström
Atherosclerosis - 2009 -
T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic
mice
A. Sultan, D. Strodthoff, A. K. Robertson, G. Paulsson-Berne, J. Fauconnier, P. Parini, M. Ryden, N. Thierry-Mieg, Maria E Johansson, A. V. Chibalin, J. R. Zierath, P. Arner, G. K. Hansson
Circ Res - 2009 -
Effects of social isolation and environmental enrichment on atherosclerosis in ApoE-/-
mice
Evelina Bernberg, Irene J Andersson, Li-Ming Gan, Andrew Stuart Naylor, Maria E Johansson, Göran Bergström
Stress - 2008 -
Hyperinsulinemic rats are normotensive but sensitized to angiotensin
II.
Maria E Johansson, Irene J Andersson, Camilla Alexanderson, Ole Skøtt, Agneta Holmäng, Göran Bergström
American Journal of Physiology. Regulatory Integrative and Comparative Physiology (USA) - 2008 -
Blood pressure is the major driving force for plaque formation in aortic-constricted ApoE-/-
mice
Maria E Johansson, Anna Wickman, O. Skott, Li-Ming Gan, Göran Bergström
Journal of Hypertension - 2006 -
Endothelial dysfunction in growth hormone transgenic
mice
Irene Andersson, Maria E Johansson, Anna Wickman, Mohammad Bohlooly-Yeganeh, Natalia Klintland, Kenneth Caidahl, Maria Gustafsson, Jan Borén, Li-Ming Gan, Göran Bergström
Clinical Science - 2006 -
Angiotensin II and vascular disease. Studies in rats and atherosclerosis-prone
mice
Maria E Johansson
2006 -
Angiotensin II, type 2 receptor is not involved in the angiotensin II-mediated pro-atherogenic process in ApoE-/-
mice
Maria Johansson, Anna Wickman, Sharyn M. Fitzgerald, Li-Ming Gan, Göran Bergström
J Hypertens - 2005 -
Haemodynamically significant plaque formation and regional endothelial dysfunction in cholesterol-fed ApoE-/-
mice
Maria E Johansson, Ulrika Hägg Samuelsson, Johannes Wikström, Anna Wickman, Göran Bergström, Li-Ming Gan
Clinical Science - 2005 -
Gene expression profile and aortic vessel distensibility in voluntarily exercised spontaneously hypertensive rats: potential role of heat shock
proteins
Ulrika Hägg Samuelsson, Maria E Johansson, Julia Grönros, Andrew Stuart Naylor, Ingibjörg H Jonsdottir, Göran Bergström, Per-Arne Svensson, Li-Ming Gan
Physiol Genomics - 2005 -
Expression of progesterone receptor (PR) A and B isoforms in mouse granulosa cells: stage-dependent PR-mediated regulation of apoptosis and cell
proliferation.
Linus Ruijin Shao, Emilia Markström, P. Anders Friberg, Maria Johansson, Håkan Billig
Biology of reproduction - 2003