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Johan Spetz
Researcher
Department of Medical Radiation Sciences-
Synergistic antitumor effects of Lorlatinib and 177Lu-octreotide combination treatment in a high-risk neuroblastoma xenograft mouse
model
Arman Romiani, Daniella Pettersson, Klara Simonsson, Hana Bakr, Dan E. Lind, Anikó Kovács, Johan Spetz, Ruth H. Palmer, Bengt Hallberg, Khalil Helou, Eva Forssell-Aronsson
Therapeutics - 2024 -
Comparison of 177Lu-octreotate and 177Lu-octreotide for treatment in human neuroblastoma-bearing
mice
Arman Romiani, Klara Simonsson, Daniella Pettersson, Amin Al-awar, Nishte Rassol, Hana Bakr, Dan E. Lind, Ganesh Umapathy, Johan Spetz, Ruth H. Palmer, Bengt Hallberg, Khalil Helou, Eva Forssell-Aronsson
Heliyon - 2024 -
Late age- and dose-related effects on the proteome of thyroid tissue in rats after 131I
exposure.
Malin Druid, Emman Shubbar, Johan Spetz, Toshima Z Parris, Britta Langen, Charlotte Ytterbrink, Evelin Berger, Khalil Helou, Eva Forssell-Aronsson
Radiation - 2024 -
Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking
BAX.
Rumani Singh, Stacey Yu, Marwa Osman, Zintis Inde, Cameron Fraser, Abigail H Cleveland, Nicole Almanzar, Chuan Bian Lim, Gaurav N Joshi, Johan Spetz, Xingping Qin, Sneh M Toprani, Zachary Nagel, Matthew C Hocking, Robert A Cormack, Torunn I Yock, Jeffrey W Miller, Zhi-Min Yuan, Timothy Gershon, Kristopher A Sarosiek
Cancer research - 2023 -
Targeting TBK1 to overcome resistance to cancer
immunotherapy.
Yi Sun, Or-Yam Revach, Seth Anderson, Emily A Kessler, Clara H Wolfe, Anne Jenney, Caitlin E Mills, Emily J Robitschek, Thomas G R Davis, Sarah Kim, Amina Fu, Xiang Ma, Jia Gwee, Payal Tiwari, Peter P Du, Princy Sindurakar, Jun Tian, Arnav Mehta, Alexis M Schneider, Keren Yizhak, Moshe Sade-Feldman, Thomas LaSalle, Tatyana Sharova, Hongyan Xie, Shuming Liu, William A Michaud, Rodrigo Saad-Beretta, Kathleen B Yates, Arvin Iracheta-Vellve, Johan Spetz, Xingping Qin, Kristopher A Sarosiek, Gao Zhang, Jong Wook Kim, Mack Y Su, Angelina M Cicerchia, Martin Q Rasmussen, Samuel J Klempner, Dejan Juric, Sara I Pai, David M Miller, Anita Giobbie-Hurder, Jonathan H Chen, Karin Pelka, Dennie T Frederick, Susanna Stinson, Elena Ivanova, Amir R Aref, Cloud P Paweletz, David A Barbie, Debattama R Sen, David E Fisher, Ryan B Corcoran, Nir Hacohen, Peter K Sorger, Keith T Flaherty, Genevieve M Boland, Robert T Manguso, Russell W Jenkins
Nature - 2023 -
Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure to
I-131
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Scientific Reports - 2022 -
Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced
toxicities.
Johan Spetz, Mary H C Florido, Cameron S Fraser, Xingping Qin, Jonathan Choiniere, Stacey J Yu, Rumani Singh, Max Friesen, Lee L Rubin, Joe-Elie Salem, Javid J Moslehi, Kristopher A Sarosiek
Science advances - 2022 -
Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3
mimetics.
Cameron S Fraser, Johan Spetz, Xingping Qin, Adam Presser, Jonathan Choiniere, Chendi Li, Stacey Yu, Frances Blevins, Aaron N Hata, Jeffrey W Miller, Gary A Bradshaw, Marian Kalocsay, Vaishali Sanchorawala, Shayna Sarosiek, Kristopher A Sarosiek
Nature communications - 2022 -
Age and sex effects across the blood proteome after ionizing radiation exposure can bias biomarker screening and risk
assessment
Britta Langen, Egor Vorontsov, Johan Spetz, J. Swanpalmer, Carina Sihlbom, Khalil Helou, Eva Forssell-Aronsson
Scientific Reports - 2022 -
Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19
severity.
Zintis Inde, Ben A Croker, Clarence Yapp, Gaurav N Joshi, Johan Spetz, Cameron Fraser, Xingping Qin, Le Xu, Brian Deskin, Elisa Ghelfi, Gabrielle Webb, Aaron F Carlin, Yanfang Peipei Zhu, Sandra L Leibel, Aaron F Garretson, Alex E Clark, Jason M Duran, Victor Pretorius, Laura E Crotty-Alexander, Chendi Li, Jamie Casey Lee, Chhinder Sodhi, David J Hackam, Xin Sun, Aaron N Hata, Lester Kobzik, Jeffrey Miller, Jin-Ah Park, Douglas Brownfield, Hongpeng Jia, Kristopher A Sarosiek
Science advances - 2021 -
Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3
mimetics.
Veerle W Daniels, Jason J Zoeller, Nick van Gastel, Kelley E McQueeney, Salma Parvin, Danielle S Potter, Geoffrey G Fell, Vinícius G Ferreira, Binyam Yilma, Rajat Gupta, Johan Spetz, Patrick D Bhola, Jennifer E Endress, Isaac S Harris, Emanuel Carrilho, Kristopher A Sarosiek, David T Scadden, Joan S Brugge, Anthony Letai
Science signaling - 2021 -
Neuroblastoma xenograft models demonstrate the therapeutic potential of
Lu-177-octreotate
Arman Romiani, Johan Spetz, Emman Shubbar, Dan E. Lind, Bengt Hallberg, Ruth H. Palmer, Eva Forssell-Aronsson
BMC Cancer - 2021 -
Preface: Life through death-Key role of cellular suicide for colonial and organismal
homeostasis.
Johan Spetz, Lorenzo Galluzzi
International review of cell and molecular biology - 2020 -
Preface: Life through death-Key role of cellular suicide for colonial and organismal
homeostasis.
Johan Spetz, Lorenzo Galluzzi
International review of cell and molecular biology - 2020 -
Preface: Life through death-Key role of cellular suicide for colonial and organismal
homeostasis.
Johan Spetz, Lorenzo Galluzzi
International review of cell and molecular biology - 2020 -
Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I
exposure.
Malin Larsson, Nils Rudqvist, Johan Spetz, Emman Shubbar, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
PloS one - 2020 -
Biodistribution of I-131 in mice is influenced by circadian
variations
Charlotte Andersson, Mikael Elvborn, Johan Spetz, Britta Langen, Eva Forssell-Aronsson
Scientific Reports - 2020 -
Increased therapeutic effect on medullary thyroid cancer using a combination of radiation and tyrosine kinase
inhibitors
Viktor Sandblom, Johan Spetz, Emman Shubbar, Mikael Montelius, Ingun Ståhl, John Swanpalmer, Ola Nilsson, Eva Forssell-Aronsson
PLoS ONE - 2020 -
Proteomic expression analysis of rat thyroid tissue 12 months after low-intermediate 131I
exposure
Malin Larsson, Emman Shubbar, Johan Spetz, Britta Langen, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
ERRS 2020 - 2020 -
T Cells and Regulated Cell Death: Kill or Be
Killed.
Johan Spetz, Adam G Presser, Kristopher A Sarosiek
International review of cell and molecular biology - 2019 -
Transcriptional effects of Lu-177-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude
mice
Johan Spetz, Britta Langen, Nils Rudqvist, Toshima Z Parris, Emman Shubbar, Johanna Dalmo, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
Ejnmmi Research - 2019 -
Gemcitabine potentiates the anti-tumour effect of radiation on medullary thyroid
cancer.
Viktor Sandblom, Johan Spetz, Emman Shubbar, Mikael Montelius, Ingun Ståhl, John Swanpalmer, Ola Nilsson, Eva Forssell-Aronsson
PloS One - 2019 -
Multiparametric MR for non-invasive evaluation of tumour tissue histological characteristics after radionuclide
therapy.
Mikael Montelius, Oscar Jalnefjord, Johan Spetz, Ola Nilsson, Eva Forssell-Aronsson, Maria Ljungberg
NMR in biomedicine - 2019 -
Tyrosine kinase inhibitors can potentially increase the effect from radiation therapy on medullary thyroid
cancer
Viktor Sandblom, Johan Spetz, Emman Shubbar, Mikael Montelius, Ingun Ståhl, John Swanpalmer, Ola Nilsson, Eva Forssell-Aronsson
Gothenburg Cancer Meeting. 6-7th May 2019 - 2019 -
Tyrosinkinashämmare kan öka effekten från strålbehandling av medullär
tyreoideacancer
Viktor Sandblom, Johan Spetz, Emman Shubbar, Mikael Montelius, Ingun Ståhl, John Swanpalmer, Ola Nilsson, Eva Forssell-Aronsson
Nationellt möte om sjukhusfysik - 2019 -
Long-term effects in thyroid and plasma
after internal low dose exposure with 131I in
rat
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Gothenburg Cancer Meeting - 2019 -
Low-dose exposure of 131I in young rat thyroid tissue and
plasma
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
European Radiation Protection Week - 2019 -
Chronotherapy: a possible way to optimze 131I-based
therapy?
Charlotte Andersson, Mikael Elvborn, Johan Spetz, Britta Langen, Eva Forssell-Aronsson
European Radiation Protection Week, Stockholm, Sweden, 2019, 14-18 October - 2019 -
Radiolabeled somatostatin analogue binding and internalization in human tumor cell
lines
Sofia Saadati, Johan Spetz, Viktor Sandblom, Emil Schüler, Ruth H. Palmer, Bengt Hallberg, Khalil Helou, Eva Forssell-Aronsson
Gothenburg Cancer Meeting 2019, Gothenburg, Sweden - 2019 -
Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and
Treatment.
Johan Spetz, Javid Moslehi, Kristopher Sarosiek
Current treatment options in cardiovascular medicine - 2018 -
Comparison of in vivo MRS and ex vivo HR-MAS MRS for assessment of metabolite content in the GOT1 small intestine neuroendocrine tumour
model
Mikael Montelius, Johan Spetz, Diana Bernin, Oscar Jalnefjord, Maria Ljungberg, Eva Forssell-Aronsson
Joint Annual Meeting ISMRM-ESMRMB, 26-21 June 2018, Paris - 2018 -
Molecular targeting of various human tumor cell lines with
177Lu-octreotate
Sofia Saadati, Johan Spetz, Viktor Sandblom, Emil Schüler, Ruth H. Palmer, Bengt Hallberg, Khalil Helou, Eva Forssell-Aronsson
Annual Congress of the European Association of Nuclear Medicine October 13 - 17, 2018 Düsseldorf, Germany - 2018 -
Vandetanib may act as radiosensitiser for 177Lu-octreotate treatment of medullary thyroid
cancer
Viktor Sandblom, Johan Spetz, Emman Shubbar, Ingun Ståhl, John Swanpalmer, Eva Forssell-Aronsson
2nd European Congress of Medical Physics. Physica Medica Vol. 52, Suppl. 1, pp. 62-63 - 2018 -
Deconvolution of expression microarray data reveals I-131-induced responses otherwise undetected in thyroid
tissue
Britta Langen, Nils Rudqvist, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
Plos One - 2018 -
Radiation biomarker screening in blood plasma: the relevance of age and sex
bias
Britta Langen, Johan Spetz, John Swanpalmer, Carina Sihlbom, Khalil Helou, Eva Forssell-Aronsson
64th Annual Meeting of the Radiation Research Society, Chicago, IL, USA, Sep 23–26, 2018. - 2018 -
Better therapeutic results after fractionated administration of Lu-177-octreotate in mice bearing human
neuroblastoma
Arman Romiani, Johan Spetz, Emman Shubbar, Ruth H. Palmer, Bengt Hallberg, Eva Forssell-Aronsson
The European Association of Nuclear Medicine (EANM) - 2018 -
Optimization of treatment of neuroendocrine tumors with radiolabeled somatostatin
analogues
Eva Forssell-Aronsson, Johan Spetz, Viktor Sandblom, Britta Langen, Khalil Helou, Bo Wängberg, Ola Nilsson
Global Academics Programs Conference, Stockholm, May 15-17, 2018. - 2018 -
Time-dependent transcriptional response of GOT1 human small intestine neuroendocrine tumor after 177Lu-octreotate
therapy
Johan Spetz, Nils Rudqvist, Britta Langen, Toshima Z Parris, Johanna Dalmo, Emil Schüler, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
Nuclear Medicine and Biology - 2018 -
Identification of Potential MR-Derived Biomarkers for Tumor Tissue Response to 177Lu-Octreotate Therapy in an Animal Model of Small Intestine Neuroendocrine
Tumor.
Mikael Montelius, Johan Spetz, Oscar Jalnefjord, Evelin Berger, Ola Nilsson, Maria Ljungberg, Eva Forssell-Aronsson
Translational oncology - 2018 -
Transcriptional response to 131I exposure of rat thyroid
gland
Nils Rudqvist, Johan Spetz, Emil Schüler, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
PLoS ONE - 2017 -
Hedgehog inhibitor sonidegib potentiates 177Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude
mice
Johan Spetz, Britta Langen, Nils Rudqvist, Toshima Z Parris, Khalil Helou, Ola Nilsson, Eva Forssell-Aronsson
BMC Cancer - 2017 -
Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor
GOT1.
Johanna Dalmo, Johan Spetz, Mikael Montelius, Britta Langen, Yvonne Arvidsson, Henrik Johansson, Toshima Z Parris, Khalil Helou, Bo Wängberg, Ola Nilsson, Maria Ljungberg, Eva Forssell-Aronsson
EJNMMI Research - 2017 -
Multiparametric MRI with spatiotemporal evaluation reveals potential therapy response biomarkers for 177Lu-octreotate therapy of mice with human neuroendocrine
tumor
Mikael Montelius, Johan Spetz, Oscar Gustafsson, Evelin Berger, Ola Nilsson, Maria Ljungberg, Eva Forssell-Aronsson
ISMRM 25th Annual Meeting. 22-27 April 2017, Honolulu, Hawaii, USA - 2017 -
Combination therapy of medullary thyroid cancer using radiation and
vandetanib
Viktor Sandblom, Johan Spetz, Emman Shubbar, John Swanpalmer, Eva Forssell-Aronsson
European Journal of Nuclear Medicine and Molecular Imaging. Annual Congress of the European Association of Nuclear Medicine October 21 – 25, 2017 Vienna, Austria. Vol. 44, Suppl. 2. EP-0792 - 2017 -
In vitro screening for Lu-177-octreotate uptake in human tumor cell
lines
Johan Spetz, Viktor Sandblom, Emil Schüler, Ruth H. Palmer, Bengt Hallberg, Khalil Helou, Eva Forssell-Aronsson
Cancerfondens Planeringsgrupp för Onkologisk Radionuklidterapi höstmöte 2017 - 2017 -
Internal exposure of 131I – potential biomarkers and functional analysis for long-term effects in
thyroid
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
European Journal of Nuclear Medicine and Molecular Imaging. 44 (Suppl. 2) - 2017 -
Therapeutic potential of Lu-177-octreotate for neuroblastoma – preclinical
studies
Arman Romiani, Johan Spetz, Emil Schüler, Haiying Wang, Ruth H. Palmer, Bengt Hallberg, Eva Forssell-Aronsson
NOPHO 35th Annual meeting 2017 19 - 23 May, Stockholm, Sweden - 2017 -
Age and sex: important variables in biomarker discovery for radiotherapy and risk
estimation.
Britta Langen, Johan Spetz, Toshima Z Parris, John Swanpalmer, Carina Sihlbom, Khalil Helou, Eva Forssell-Aronsson
Swedish Cancer Society planning group for oncological radionuclide therapy - 2017 -
Dose-response study of Lu-177-octreotate in nude mice bearing human
neuroblastoma
Arman Romiani, Johan Spetz, Ruth H. Palmer, Bengt Hallberg, Eva Forssell-Aronsson
63rd Annual Meeting of the Radiation Research Society, Cancun, Mexico - 2017 -
Binding and internalization of 177Lu-octreotate in human tumor cell lines of different
origin
Sofia Saadati, Johan Spetz, Viktor Sandblom, Emil Schüler, Ruth H. Palmer, Bengt Hallberg, Khalil Helou, Eva Forssell-Aronsson
63rd Annual Meeting of the Radiation Research Society, Cancun, Mexico - 2017 -
Sex-dependent absorbed doses from 131I in male and female
mice
Mikael Elvborn, Charlotte Andersson, Johan Spetz, Britta Langen, Eva Forssell-Aronsson
63rd Annual Meeting of the Radiation Research Society, Cancun, Mexico - 2017 -
Circadian rhythm: a factor influencing biodistribution of 131I in
mice
Charlotte Andersson, Mikael Elvborn, Johan Spetz, Britta Langen, Eva Forssell-Aronsson
63rd Annual Meeting of the Radiation Research Society, Cancun, Mexico - 2017 -
Age and sex bias in biomarker discovery for radiotherapy and risk
estimation
Britta Langen, Johan Spetz, Toshima Z Parris, John Swanpalmer, Carina Sihlbom, Khalil Helou, Eva Forssell-Aronsson
63rd Annual Meeting of the Radiation Research Society, Cancun, Mexico - 2017 -
Proteomic analysis as a tool for discovery and assessment of biomarkers for therapeutic response in GOT1 tumors in vivo after 177Lu‑octreotate
therapy
Johan Spetz, Evelin Berger, Mikael Montelius, Eva Forssell-Aronsson
RRS 63nd annual meeting, October 15-18, 2017, Cancun, Mexico - 2017 -
Lutetium-177-octreotate treatment of small intestine neuroendocrine tumors - Radiation biology as basis for
optimization
Johan Spetz
2017 -
Multiparametric MR for assessment of tissue characteristics of small intestine neuroendocrine tumour evaluated by histological
correlations
Mikael Montelius, Oscar Gustafsson, Johan Spetz, Ola Nilsson, Eva Forssell-Aronsson, Maria Ljungberg
ISMRM 2017, #118, Honolulu, USA - 2017 -
Multiparametric MRI (mpMRI) for spatiotemporal characterization of tumor tissue response to radionuclide
treatment
Mikael Montelius, Johan Spetz, Maria Ljungberg, Eva Forssell-Aronsson
62nd Annual International Meeting Radiation Research Society, Waikoloa, HI, USA, October 16-19, 2016 - 2016 -
New insights on risk assessment in thyroid cancer radiotherapy: out-of-field transcriptomic effects can show high similarity with direct
exposure
Britta Langen, Nils Rudqvist, Johan Spetz, John Swanpalmer, Khalil Helou, Eva Forssell-Aronsson
4th Swedish Cancer Research Meeting - 2016 -
The relevance of non-targeted effects for risk assessment related to thyroid
irradiation
Britta Langen, Nils Rudqvist, Johan Spetz, John Swanpalmer, Khalil Helou, Eva Forssell-Aronsson
Swedish Cancer Fund's planning group for oncological radionuclide therapy - 2016 -
Treatment of medullary thyroid cancer using a combination of radiation and
gemcitabine
Viktor Sandblom, Johan Spetz, John Swanpalmer, Eva Forssell-Aronsson
62nd Annual International Meeting Radiation Research Society 2016. Big Island, Hawaii, USA, October 16-19, 2016 - 2016 -
Non-targeted transcriptomic effects upon thyroid irradiation: similarity between in-field and out-of-field responses varies with tissue
type
Britta Langen, Nils Rudqvist, Johan Spetz, John Swanpalmer, Khalil Helou, Eva Forssell-Aronsson
Scientific Reports - 2016 -
The potential of Lu-177-octreotate as a therapeutic alternative for metastatic
neuroblastoma
Arman Romiani, Johan Spetz, Emil Schüler, Wan Haiying, Ruth H. Palmer, Bengt Hallberg, Eva Forssell-Aronsson
62nd Annual International Meeting Radiation Research Society, Waikoloa, HI, USA, October 16-19, 2016 - 2016 -
Transcriptome and proteome analysis for potential biomarker discovery of long-term effects in rat thyroid and blood tissue after I-131
exposure
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
SweRays Workshop, Stockholm, Sweden, Aug 25-26 - 2016 -
Investigation of potential synergistic effects of combining gemcitabine with irradiation for medullary thyroid
cancer
Viktor Sandblom, Johan Spetz, John Swanpalmer, Eva Forssell-Aronsson
Swedish Cancer Society autumn meeting, Uppsala, Sweden. - 2016 -
Gemcitabine potentiates the anti-tumour effect of radiation therapy on medullary thyroid
cancer
Viktor Sandblom, Johan Spetz, John Swanpalmer, Eva Forssell-Aronsson
4th Swedish Cancer Research Meeting, 7-8 november 2016, Gothenburg, Sweden. - 2016 -
The influence of biological sex on thyroid cancer treatment risk
assessment
Mikael Elvborn, Charlotte Andersson, Johan Spetz, Britta Langen, Eva Forssell-Aronsson
Swedish Cancer Research Meeting, Gothenburg, 2016, November 7-8 - 2016 -
Sex-dependence in absorbed dose from I-131 in
mice
Mikael Elvborn, Charlotte Andersson, Johan Spetz, Britta Langen, Eva Forssell-Aronsson
Höstmöte med Cancerfondens Planeringsgrupp för Onkologisk Radionuklidterapi, Uppsala, 2016, November 24-25 - 2016 -
Exposure of rats to 131I - potential biomarkers of long-term effects and cancer induction in the
thyroid
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Swedish Cancer Society autumn meeting, Uppsala, Sweden. - 2016 -
Exposure of rats to 131I - potential biomarkers of long-term effects and cancer induction in the
thyroid
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
4th Swedish Cancer Research Meeting, 7-8 november 2016, Gothenburg, Sweden - 2016 -
Potential biomarkers for long-term effects in thyroid tissue after 131I exposure in
rats
Malin Larsson, Nils Rudqvist, Johan Spetz, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
62nd Annual International Meeting Radiation Research Society, Waikoloa, HI, USA, October 16-19, 2016 - 2016 -
Biodistribution of Lu-177-octreotate in nude mice with human neuroblastoma
tumors
Arman Romiani, Johan Spetz, Emil Schüler, Wan Haiying, Ruth H. Palmer, Bengt Hallberg, Eva Forssell-Aronsson
The 4th Swedish Cancer Research Meeting, Gothenburg, Sweden, November 7-8, 2016 - 2016 -
Diurnal variations in biodistribution of the radionuclide I-131 in
mice
Charlotte Andersson, Mikael Elvborn, Johan Spetz, Britta Langen, Eva Forssell-Aronsson
Swedish Cancer Research Meeting, Gothenburg, 2016, November 7-8 - 2016 -
Diurnal variations in biodistribution of the radionuclide I-131 in
mice
Charlotte Andersson, Mikael Elvborn, Johan Spetz, Britta Langen, Eva Forssell-Aronsson
Swedish Cancer Fund's planning group for oncological radionuclide therapy, Uppsala, Sweden, Nov 24-25, 2016 - 2016 -
The influence of circadian rhythm on the biodistribution of
I-131
Charlotte Andersson, Mikael Elvborn, Johan Spetz, Britta Langen, Eva Forssell-Aronsson
Swedish Radiation Research Association for Young Scientists Workshop, Stockholm, 2016, August 25-26 - 2016 -
Comparative in vivo study of the biodistribution of Lu-177-octreotate in three neuroblastoma cell
lines
Arman Romiani, Johan Spetz, Emil Schüler, Wan Haiying, Ruth H. Palmer, Bengt Hallberg, Eva Forssell-Aronsson
The Swedish Cancer Society’s planning group for Oncological Radiotherapy, Uppsala, Sweden, November 24-25, 2016 - 2016 -
Spatial proteomic analysis of GOT1 human small intestine neuroendocrine tumor in nude mice following 177Lu-octreotate
therapy
Johan Spetz, Mikael Montelius, Maria Ljungberg, Khalil Helou, Eva Forssell-Aronsson
62nd Annual International Meeting Radiation Research Society, Waikoloa, HI, USA, October 16-19, 2016 - 2016 -
Proteomic analysis reveals spatial differences in response of GOT1 tumors in vivo after 177Lu octreotate
therapy
Johan Spetz, Mikael Montelius, Maria Ljungberg, Khalil Helou, Eva Forssell-Aronsson
SweRays Workshop, Stockholm, Sweden, Aug 25-26 - 2016 -
The influence of biological sex on the biodistribution of I-131 in
mice
Mikael Elvborn, Britta Langen, Johan Spetz, Eva Forssell-Aronsson
SweRays Workshop, Stockholm, Sweden, Aug 25-26 - 2016 -
Thyroid irradiation and non-targeted effects: in-field and out-of-field responses on the transcriptomic level show tissue-specific
similarity
Britta Langen, Nils Rudqvist, Johan Spetz, John Swanpalmer, Khalil Helou, Eva Forssell-Aronsson
SweRays Workshop, Stockholm, Sweden, Aug 25-26 - 2016 -
Transcriptomic analysis of non-targeted effects following thyroid irradiation: similarity between in-field and out-of-field responses shows
tissue-specificity
Britta Langen, Nils Rudqvist, Johan Spetz, John Swanpalmer, Khalil Helou, Eva Forssell-Aronsson
62nd Annual International Meeting Radiation Research Society, Waikoloa, HI, USA, October 16-19, 2016 - 2016 -
External irradiation of the thyroid results in nontargeted transcriptional response in the kidneys and
liver
Eva Forssell-Aronsson, Britta Langen, Nils Rudqvist, Johan Spetz, John Swanpalmer, Khalil Helou
The 14th Congress of the International Radiation Protection Association (IRPA), Cape Town, South Africa - 2016 -
Transcriptional response in normal mouse tissues after i.v. 211At administration - response related to absorbed dose, dose rate, and
time
Britta Langen, Nils Rudqvist, Toshima Z Parris, Emil Schüler, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
EJNMMI Research - 2015 -
Binding and internalization of Lu-177-octreotate in two neuroblastoma cell lines and initial biodistribution studies in
animals
Arman Romiani, Johan Spetz, Emil Schüler, Wan Haiying, Ruth H. Palmer, Bengt Hallberg, Eva Forssell-Aronsson
Cancerfondens planeringsgrupp för onkologisk radionuklidterapi, Höstmöte, Linköping, Sweden, November 25-27, 2015 - 2015 -
Biokinetics and radiobiological effects of low dose exposure from radiohalogens in rodents (joint oral
presentation)
Johan Spetz, Britta Langen
Joint Japan Sweden Radioecology Workshop, Gothenburg, Sweden, September 1-2 - 2015 -
Combination therapy of medullary thyroid cancer (MTC) using 177Lu-octreotate and
gemcitabine
Viktor Sandblom, Johan Spetz, Eva Forssell-Aronsson
Cancerfondens planeringsgrupp för onkologisk radionuklidterapi, Höstmöte, Linköping, Sweden, November 25-27, 2015 - 2015 -
Biomarker gene discovery for radionuclide exposure and the impact of circadian variation and data
convolution
Britta Langen, Nils Rudqvist, Toshima Z Parris, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
Cancerfondens planeringsgrupp för onkologisk radionuklidterapi, Höstmöte, Linköping, Sweden, November 25-27, 2015 - 2015 -
Transcriptional effects of 177Lu-octreotate therapy on GOT1 tumor in nude mice using conventional and priming treatment
schedules
Johan Spetz, Johanna Dalmo, Nils Rudqvist, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
15th International Congress of Radiation Research, Kyoto, Japan, May 25-29 - 2015 -
Gene expression signature in mouse thyroid tissue after 131I and 211At
exposure
Eva Forssell-Aronsson, Nils Rudqvist, Johan Spetz, Emil Schüler, Britta Langen, Toshima Z Parris, Khalil Helou
Cancerfondens riksplaneringsgrupp för onkologisk radionuklidterapi, Höstmöte, Linköping, Sweden, November 25-27, 2015 (invited) - 2015 -
Gene expression signature in mouse thyroid tissue after 131I and 211At
exposure
Nils Rudqvist, Johan Spetz, Emil Schüler, Britta Langen, Toshima Z Parris, Khalil Helou, Eva Forssell-Aronsson
EJNMMI Research - 2015 -
Transcriptomic effects on GOT2 tumor in nude mice ̶ comparison between 177Lu-octreotate and external beam
treatments
Johan Spetz, Britta Langen, Toshima Z Parris, Emil Schüler, John Swanpalmer, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
Cancerfondens riksplaneringsgrupp för onkologisk radionuklidterapi. Vintermöte, Umeå, Sverige, Jan 22-23 - 2015 -
Hedgehog inhibitor Sonidegib potentiates 177Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude
mice
Johan Spetz, Nils Rudqvist, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
Cancerfondens riksplaneringsgrupp för onkologisk radionuklidterapi, Höstmöte, Linköping, Sweden, November 25-27, 2015 - 2015 -
Transcriptional Response in Mouse Thyroid Tissue after 211At Administration: Effects of Absorbed Dose, Initial Dose-Rate and Time after
Administration
Nils Rudqvist, Johan Spetz, Emil Schüler, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
PLoS ONE - 2015 -
Proteomic analysis of normal mouse thyroids after 131I
administration
Toshima Z Parris, Nils Rudqvist, Britta Langen, Johan Spetz, Emil Schüler, Khalil Helou, Eva Forssell-Aronsson
15th International Congress of Radiation Research, Kyoto, Japan, May 25-29 - 2015 -
Identification of Dbp as a candidate biomarker gene of low-level 131I exposure that affects thyroid
function
Nils Rudqvist, Johan Spetz, Emil Schüler, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
15th International Congress of Radiation Research, Kyoto, Japan, May 25-29 - 2015 -
Data convolution and circadian rhythm impact identification of biomarker genes for ionizing radiation exposure in vivo: concept study on 131I exposure in mouse
thyroid
Britta Langen, Nils Rudqvist, Toshima Z Parris, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
15th International Congress of Radiation Research, Kyoto, Japan, May 25-29 - 2015 -
Relationships between transcriptional regulation profiles of 27 genes commonly regulated in mice after 131I and 211At
exposure
Nils Rudqvist, Johan Spetz, Toshima Z Parris, Emil Schüler, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Swedish Radiation Research Association for Young Scientists (Swe-Rays) workshop, Malmoe, Sweden, August 20-22, 2014 - 2014 -
Genetic signatures detected in thyroid tissue in mice after 131I and 211At
exposure
Nils Rudqvist, Toshima Z Parris, Britta Langen, Emil Schüler, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
60th Annual Meeting of the Radiation Research Society, Las Vegas, NV, USA, September 20-24, 2014 - 2014 -
Transcriptional Relationships and Biological Functions of 27 Genes Commonly Regulated in Thyroid Tissue in Mice after 131I and 211At
Exposure
Nils Rudqvist, Johan Spetz, Toshima Z Parris, Emil Schüler, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
27th Annual Congress on European Association of Nuclear Medicine, Gothenburg, Sweden, October 18-22, 2014 - 2014 -
Optimization of 177Lu-octreotate treatment of neuroendocrine
tumours
Eva Forssell-Aronsson, Johan Spetz, Britta Langen, Johanna Dalmo, Maria Larsson, Mikael Montelius, Nils Rudqvist, Toshima Z Parris, Yvonne Arvidsson, Maria Ljungberg, Khalil Helou, Ola Nilsson, Bo Wängberg
3rd Swedish Cancer Research Meeting, Stockholm, Sweden, September 2-3, 2014 - 2014 -
Biokinetics of radiolabeled octreotide and MIBG in patients with metastatic pheochromocytoma and
paragangliomas
Johan Spetz, Viktor Sandblom, Ola Nilsson, Bo Wängberg, Eva Forssell-Aronsson
International Symposium on Pheochromocytoma and Paraganglioma, Kyoto, Japan, September 17-20, 2014 - 2014 -
Time- and dose rate-related effects of internal (177)Lu exposure on gene expression in mouse kidney
tissue.
Emil Schüler, Nils Rudqvist, Toshima Z Parris, Britta Langen, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
Nuclear medicine and biology - 2014 -
Treatment of patients with metastatic pheochromocytoma and paragangliomas using radiolabeled somatostatin analogues and
MIBG
Johan Spetz, Viktor Sandblom, Ola Nilsson, Bo Wängberg, Eva Forssell-Aronsson
27th Annual Congress on European Association of Nuclear Medicine, Gothenburg, Sweden, October 18-22, 2014 - 2014 -
Transcriptional response of GOT1 midgut carcinoid in nude mice following 177Lu-octreotate
treatment
Johan Spetz, Johanna Dalmo, Nils Rudqvist, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
27th Annual Congress on European Association of Nuclear Medicine, Gothenburg, Sweden, October 18-22, 2014 - 2014 -
Radiolabelled pharmaceuticals MIBG and octreotate for treatment of metastatic pheochromocytoma and
paraganglioma
Viktor Sandblom, Johan Spetz, Ola Nilsson, Bo Wängberg, Eva Forssell-Aronsson
SweRays Workshop, Malmö, Sweden, Aug 20-22, 2014 - 2014 -
Combination therapy with hedgehog inhibitor LDE225 increases efficacy of 177Lu-octreotate therapy on GOT1 tumors in nude
mice
Johan Spetz, Britta Langen, Nils Rudqvist, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
27th Annual Congress on European Association of Nuclear Medicine, Gothenburg, Sweden, October 18-22, 2014 - 2014 -
Effects of internal irradiation from 177Lu-octreotate on transcriptional expression in GOT1 midgut carcinoid in nude
mice
Johan Spetz, Johanna Dalmo, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
SweRays Workshop, Malmö, Sweden, Aug 20-22 - 2014 -
Hedgehog inhibitor LDE225 increases efficacy of 177Lu-octreotate therapy on GOT1 tumors in nude
mice
Johan Spetz, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
60th Annual Meeting of the Radiation Research Society, Las Vegas, USA, September 20-24, 2014 - 2014 -
Fractionated 177Lu-octreotate therapy of human GOT1 tumors in nude mice increases treatment efficacy, possibly via SSTR
up-regulation
Johan Spetz, Britta Langen, Johanna Dalmo, Nils Rudqvist, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
3rd Swedish Cancer Research Meeting, Stockholm, Sweden, September 2-3, 2014 - 2014 -
Biodistribution of 177Lu-octreotate in H69-bearing nude mice- comparison between neuroendocrine tumor
models
Johanna Dalmo, Johan Spetz, Viktor Sandblom, Britta Langen, Bo Wängberg, Ola Nilsson, Eva Forssell-Aronsson
SweRays Workshop, Malmö, Sweden, Aug 20-22, 2014 - 2014 -
Priming administration before the main administration of 177Lu-octreotate increases the therapeutic effect in nude mice bearing human carcinoid tumor
GOT1
Johanna Dalmo, Johan Spetz, Mikael Montelius, Britta Langen, Yvonne Arvidsson, Henrik Johansson, Toshima Z Parris, Khalil Helou, Bo Wängberg, Ola Nilsson, Maria Ljungberg, Eva Forssell-Aronsson
27th Annual Congress on European Association of Nuclear Medicine, Gothenburg, Sweden, October 18-22, 2014 - 2014 -
Increased therapeutic effect of fractionated 177Lu-octreotate administration on nude mice bearing human carcinoid tumor
GOT1.
Johanna Dalmo, Johan Spetz, H Johansson, Esmaeil Mehrara, Ola Nilsson, Bo Wängberg, Eva Forssell-Aronsson
SweRays Workshop, Uppsala, Aug 21-23, 2013 - 2013 -
Radionuclide therapy via SSTR - future aspects from experimental animal
studies.
Eva Forssell-Aronsson, Johan Spetz, Håkan Ahlman
Neuroendocrinology - 2013 -
Increased therapeutic response from fractionated 177 Lu-octreotate therapy of GOT1 tumors in nude
mice.
Johan Spetz, Johanna Dalmo, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
Cancerfondens planeringsgrupp för onkologisk radionuklidterapi. Höstmöte, Göteborg, Sverige, Nov 13-15. - 2013 -
Combination therapy of GOT 1 tumours in nude mice using 177 Lu-octreotate and the hedgehog inhibitor
LDE225.
Johan Spetz, Johanna Dalmo, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
SweRays Workshop, Uppsala, Sweden, Aug 21-25, 2013. - 2013 -
Fractionated 177Lu-octreotate therapy of GOT1 tumors in nude mice increases treatment efficacy, possibly via SSTR
up-regulation
Johan Spetz, Johanna Dalmo, Britta Langen, Toshima Z Parris, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
59th Annual Meeting of the Radiation Research Society, New Orleans, USA, September 15-19, 2013 - 2013 -
Early transcriptional regulation following low-activity 211 At exposure in mouse and related systemic physiological
aspects.
Britta Langen, Nils Rudqvist, Toshima Z Parris, Emil Schüler, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
SWERays Workshop, Uppsala, Sweden, Aug 21-23. - 2013 -
Short-term study of transcriptional regulation following low-dose astatine -211 exposure in
mouse.
Britta Langen, Nils Rudqvist, Toshima Z Parris, Emil Schüler, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson
SNMMI , Vancouver , Canada. - 2013 -
Biodistribution and dosimetry of free (211)at, (125)i(-) and (131)i(-) in
rats.
Johan Spetz, Nils Rudqvist, Eva Forssell-Aronsson
Cancer biotherapy & radiopharmaceuticals - 2013 -
Regulation of gene expression in GOT1 midgut carcinoid in nude mice following injection with
177Lu-octreotate
Johan Spetz, Britta Langen, Toshima Z Parris, Nils Rudqvist, Khalil Helou, Ola Nilsson, Håkan Ahlman, Eva Forssell-Aronsson
25th Annual Congress on European Association of Nuclear Medicine, Milano, Italy, October 27-31, 2012 - 2012 -
Effects of internal irradiation from 177Lu-octreotate on gene expression in GOT1 midgut carcinoid in nude
mice
Johan Spetz, Britta Langen, Toshima Z Parris, Nils Rudqvist, Khalil Helou, Ola Nilsson, Håkan Ahlman, Eva Forssell-Aronsson
58th Annual Meeting of the Radiation Research Society, San Juan, Puerto Rico, September 30 - October 3, 2012 - 2012 -
Specific binding and uptake of 131I-MIBG and 111In-octreotide in malignant paraganglioma - tools for choice of radionuclide
therapy
Johan Spetz, Johanna Dalmo, Ola Nilsson, Bo Wängberg, Håkan Ahlman, Eva Forssell-Aronsson
Hormone and Metabolic Research - 2012 -
Biodistribution of 177Lu-octreotate and 111In-minigastrin in GOT2 (human MTC) animal
model
Johanna Dalmo, Nils Rudqvist, Johan Spetz, Peter Laverman, Ola Nilsson, Håkan Ahlman, Eva Forssell-Aronsson
Swedish Radiation Research Association for Young Scientists (Swe-Rays) workshop, Stockholm, Sweden, August 30-31, 2012 - 2012 -
Biodistribution of 177Lu-octreotate and 111In-minigastrin in female nude mice transplanted with human medullary thyroid carcinoma
GOT2.
Johanna Dalmo, Nils Rudqvist, Johan Spetz, Peter Laverman, Ola Nilsson, Håkan Ahlman, Eva Forssell-Aronsson
Oncology reports - 2012 -
Uptake of radiolabelled meta-iodobenzylguanidine and octreotide - tumor/blood values and in vitro studies as tools for choice of radionuclide
therapy
Johan Spetz, Johanna Dalmo, Ola Nilsson, Bo Wängberg, Håkan Ahlman, Eva Forssell-Aronsson
3rd International Symposium on Pheochromocytoma and Paraganglioma, Paris - 2011 -
Biodistribution and dosimetry of free 211At, 125I- and 131I- in
rats
Johan Spetz, Nils Rudqvist, Eva Forssell-Aronsson
European Association of Nuclear Medicine Congress. Birmingham - 2011 -
Biodistribution and dosimetry of free 211At, 125I- and 131I- in
rats
Johan Spetz, Nils Rudqvist, Eva Forssell-Aronsson
Cancerfondens planeringsgrupp för onkologisk nuklidterapi samt Svensk förening för isotopterapi, Lund, Sweden, November 18-19, 2010 - 2010