University of Gothenburg
Institute of Biomedicine
  2. Institute of Biomedicine
  3. About us
  4. Department of Infectious Diseases
  5. Joakim Larsson group
  6. Publications

Publications

Publications (1994-)

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Please click here for a compilation of my publications by Google scholar, including citation metrics and many full-text links.

2024

  • Kieffer N, Bohm ME, Berglund F, Marathe NP, Gillings MP, Larsson DGJ. (2024). Identification of Novel FosX Family Determinants from Diverse Environmental Samples. Journal of Global Antimicrobial Resistance. Accepted for publication. Preprint available at bioRxiv. https://doi.org/10.1101/2024.11.04.621841
     

  • Parras-Moltó M, Lund D, Ebmeyer S, Larsson DGJ, Johnning A, Kristiansson E. (2024). The transfer of antibiotic resistance genes between evolutionary distant bacteria. Submitted for publication. Preprint available at bioRxiv. https://doi.org/10.1101/2024.10.22.619579
     

  • Lund D, Parras-Moltó M, Inda-Díaz JS, Ebmeyer S, Larsson DGJ, Johnning A, Kristiansson E. (2024). Genetic compatibility and ecological connectivity drive the dissemination of antibiotic resistance genes. Submitted for publication. Preprint available at bioRxiv.  https://doi.org/10.1101/2024.10.15.617735
     

  • Munthe C, Larsson DGJ. (2024). Environmental dimensions of the ethics of antimicrobial resistance. Submitted for publication. Preprint available at ResearchGate.  DOI:10.13140/RG.2.2.24616.79362/2
     

  • World Health Organization. (2024). Guidance on wastewater and solid waste management for manufacturing of antibiotics. 98 pp. Geneva. ISBN 978-92-4-009725-4. https://www.who.int/publications/i/item/9789240097254 (Joakim Larsson was lead consultant).
     
  • World Health Organization. (2024). Evidence synthesis for deriving PNECs for resistance selection. Background document to “Guidance on wastewater and solid waste management for manufacturing of antibiotics”. 21 pp. Geneva. https://www.who.int/publications/i/item/9789240097254 (Joakim Larsson was lead consultant).
     
  • Garner E, Maile-Moskowitz A, Angeles L, Flach C-F, Aga D, Nambi I, Larsson DGJ, Buergmann H, Zhang T, Vikesland P, Pruden A. (2024).  Metagenomic profiling of internationally sourced sewage influents and effluents yields insight into selecting targets for antibiotic resistance monitoring. Environmental Science & Technology. https://doi.org/10.1021/acs.est.4c03726
     
  • Bertagnolio S, Dobreva Z, Centner CM, Olaru ID et al (283 coauthors including Larsson DGJ). (2024). WHO global research priorities for antimicrobial resistance in human health. The Lancet Microbe. https://doi.org/10.1016/S2666-5247(24)00134-4
     
  • He Z, Dechesne A, Schreiber F, Zhu YG, Larsson DGJ, Smets BF. (2024). Understanding Stimulation of Conjugal Gene Transfer by Nonantibiotic Compounds: How Far Are We? Environmental Science & Technology. 58:9017-9030. https://doi.org/10.1021/acs.est.3c0606
     
  • Peters AC, Larsson DGJ, Laxminarayan R, Munthe C. (2024). Barriers and Pathways to Environmental Surveillance of Antibiotic Resistance in Middle-and-Low Income Settings: A Qualitative Exploratory Key Expert Study. Global Health Action. 17(1):2343318. https://doi.org/10.1080/16549716.2024.2343318
     

  • Camacho JB, Nilsson J, Larsson DGJ, Flach CF. (2024). Evaluation of culture conditions for sewage-based surveillance of antibiotic resistance in Klebsiella pneumoniae. Journal of Global Antimicrobial Resistant. 37:122-128.  https://doi.org/10.1016/j.jgar.2024.03.005

2023

  • Berglund F, Rodríguez-Molina D, Gradisteanu Pircalabioru D, Blaak H,  Chifiriuc M, Czobor Barbu I, Flach CF, Gheorghe-Barbu I,  Măruțescu L, Popa M, de Roda Husman A, Wengenroth L, Schmitt H, Larsson DGJ. (2023). The resistome and microbiome of wastewater treatment plant workers – The AWARE study. Environment International, 180. https://doi.org/10.1016/j.envint.2023.108242
     
  • Lund D, Coertze RD, Parras-Moltó M, Berglund F, Flach C-F, Johnning A, Larsson DGJ, Kristiansson E. (2023). Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogens. Communications Biology. 6:812.  https://doi.org/10.1038/s42003-023-05174-6  
     
  • Malmqvist E, Fumagalli D, Munthe C, Larsson DGJ. (2023). Pharmaceutical pollution from human use and the Polluter Pays Principle. Public Health Ethics, phad012. https://doi.org/10.1093/phe/phad012
     
  • Marutescu LG, Popa M, Gheorghe-Barbu I, Barbu IC, Rodríguez-Molina D, Berglund F, Blaak H, Flach C-F, Kemper MA, Spießberger B, Wengenroth L, Larsson DGJ, Nowak D, Radon K, de Roda Husman AM, Wieser A, Schmitt H, Gradisteanu Pircalabioru G, Vrancianu CO. Chifiriuc MC. (2023). Wastewater treatment plants, an “escape gate” for ESCAPE pathogens. Frontiers in Microbiology. 14:1193907. https://doi.org/10.3389/fmicb.2023.1193907
     
  • Larsson DGJ, Gaze WH, Laxminarayan R, Topp E. (2023). AMR, One Health and the environment. Nature Microbiology. https://doi.org/10.1038/s41564-023-01351-9. Read-only link: https://rdcu.be/c8MpY
     
  • Huijbers P, Bobis Camacho J, Hutinel M, Larsson DGJ, Flach CF. (2023). Sampling considerations for wastewater surveillance of antibiotic resistance in fecal bacteria. International Journal of Environmental Research and Public Health. 20(5):4555 https://doi.org/10.3390/ijerph20054555
     
  • Berglund F, Ebmeyer S, Kristiansson E, Larsson DGJ. (2023). Evidence for wastewaters as environments where mobile antibiotic resistance genes emerge. Communications Biology 6: 321.https://doi.org/10.1038/s42003-023-04676-7
     
  • Ågerstrand M, Josefsson H, Wernersson AS, Larsson DGJ. (2023). Opportunities to tackle antibiotic resistance development in the aquatic environment through the Water Framework Directive. Ambio 52:941-951. https://doi.org/10.1007/s13280-022-01828-7.Read-only link: https://rdcu.be/c4Ghz

2022

  • Larsson DGJ, Flach CF, Laxminarayan R. (2022). Sewage surveillance of antibiotic resistance holds both opportunities and challenges. Nature Reviews Microbiology 21:213-214. https://doi.org/10.1038/s41579-022-00835-5. Read-only link: rdcu.be/c01Yz
    ​​​
  • ​​Munk P, Brinch C, Møller F, Petersen T, Hendriksen R, Seyfarth A, Kjeldgaard J, Svendsen C, van Bunnik B, Berglund F, Global Sewage Surveillance Consortium, Larsson DGJ, Koopmans M, Woolhouse M, Aarestrup F. (2022) Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance. Nature Communications. 13:7251. 
    https://doi.org/10.1038/s41467-022-34312-7
     
  • Guzman-Otazo J, Joffré E, Agramont J, Mamani N, Jutkina J, Boulund F, Hu YOO, Jumilla-Lorenz D, Farewell A, Larsson DGJ, Flach CF, Iñiguez Rojas V, Sjöling Å. (2022). Conjugative transfer of multi-drug resistance IncN plasmids from environmental waterborne bacteria to Escherichia coli.  Frontiers in Microbiology.

    13:997849. https://doi.org/10.3389/fmicb.2022.997849
     

  • Bourgard C, Hernández DR, Rudenko A, Rutgersson C, Palm M, Larsson DGJ, Farewell A, Grøtli M, Sunnerhagen P. (2022). Development of dicationic bisguanidine-arylfuran derivatives as potent agents against Gram-negative bacteria. Antibiotics. 11(8):1115. https://doi.org/10.3390/antibiotics11081115
     
  • Riquelme MVP, Garner E, Gupta S, Metch J, Zhu N, Blair MF, Arango-Argoty G, Maile-Moskowitz A, Li A-D, Flach CF, Aga DS, Nambi IM, Larsson DGJ, Bürgmann H, Zhang T, Pruden A, Vikesland PJ. (2022). Demonstrating a comprehensive wastewater-based surveillance approach that differentiates globally sourced resistomes. Environmental Science & Technology. 56(21):14982–14993. https://doi.org/10.1021/acs.est.1c08673
     
  • Han Z, Feng H, Luan X, Shen Y, Deng L, Larsson DGJ, Gillings M, Zhang Y, Yang M. (2022). Three-year consecutive field application of erythromycin fermentation residue following hydrothermal treatment: Cumulative effect on soil antibiotic resistance genes. Engineering. 15:78-88. https://doi.org/10.1016/j.eng.2022.05.011
     
  • Rodríguez-Molina D, Berglund F, Blaak H, Flach CF, Kemper M, Marutescu L, Gradisteanu LP, Popa M, Spießberger B, Wengenroth L, Chifiriuc MC, Larsson DGJ, Nowak D, Radon K, de Roda Husman AM, Wieser A, Schmitt H. (2022). International travel as a risk factor for carriage of extended-spectrum β-lactamase-producing Escherichia coli in a large sample of European individuals - The AWARE Study. International Journal of Environmental Research and Public Health. 19(8):4758. https://doi.org/10.3390/ijerph19084758
     
  • Kieffer N, Ebmeyer S, Larsson DGJ. (2022). Evidence for Pseudoxanthomonas mexicana as the recent origin of the blaAIM-1 carbapenemase gene. International Journal of Antimicrobial Agents. 59:106571. https://doi.org/10.1016/j.ijantimicag.2022.106571
     
  • Lund D, Kieffer N, Parras-Moltó M, Ebmeyer S, Berglund F, Johnning A, Larsson DGJ, Kristiansson E. (2022). Large-scale characterization of the macrolide resistome reveals high diversity and several new pathogen-associated genes. Microbial Genomics. 8:000770. https://doi.org/10.1099/mgen.0.000770
     
  • Dai D, Brown C, Bürgmann HD, Larsson DGJ, Nambi I, Zhang T, Flach CF, Pruden A, Vikesland PJ. (2022). Long-read metagenomic sequencing reveals shifts in associations of antibiotic resistance genes with mobile genetic elements from sewage to activated sludge. Microbiome. 10:20. https://doi.org/10.1186/s40168-021-01216-5. A video describing the main findings of the study can be found here: https://doi.org/10.21203/rs.3.rs-1667200/v1.
     
  • Ebmeyer S, Coertze RD, Berglund F, Kristiansson E, Larsson DGJ. (2022). GEnView: a gene-centric, phylogeny-based comparative genomics pipeline for bacterial genomes and plasmids. Bioinformatics. 38:1727. https://doi.org/10.1093/bioinformatics/btab855
     
  • Hutinel M, Larsson DGJ, Flach CF. (2022). Antibiotic resistance genes of emerging concern in municipal and hospital wastewater from a major Swedish city. Science of the Total Environment. 812:151433. https://doi.org/10.1016/j.scitotenv.2021.151433
     
  • Larsson DGJ, Flach CF. (2022). Antibiotic resistance in the environment. Nature Reviews Microbiology. 20:257. https://doi.org/10.1038/s41579-021-00649-x  Read-only link: https://rdcu.be/cAQBC

2021

  • Malmqvist E, Fumagalli D, Munthe C, Larsson DGJ. (2021). Pharmaceutical pollution from human use and the Polluter Pays Principle. https://doi.org/10.1093/phe/phad012
    ​​​
  • Schar D, Zhao C, Wang Y, Larsson DGJ, Gilbert M, Van Boeckel T. (2021). Twenty-year trends in antimicrobial resistance from aquaculture and fisheries in Asia. Nature Communications. 12:5384. https://doi.org/10.1038/s41467-021-25655-8
     
  • Rodriguez-Molina D, Berglund F, Blaak H, Flach CF, Kemper M, Marutescu L, Gradisteanu GP, Popa M, Spießberger B, Weinmann T, Wengenroth L, Chifiriuc MC, Larsson DGJ, Nowak D, Radon K, Roda de Husman AM, Wieser A, Schmitt H. (2021). Carriage of ESBL-producing Enterobacterales in wastewater treatment plant workers and surrounding residents - The AWARE Study.European Journal of Clinical Microbiology & Infectious Diseases.
    https://doi.org/10.1007/s10096-021-04387-z
     
  • Flach CF, Hutinel M, Razavi M, Åhrén C, Larsson DGJ. (2021). Monitoring of hospital sewage shows both promise and limitations as an early-warning system for carbapenemase-producing Enterobacterales in a low-prevalence setting. Water Research. 200:117261. https://doi.org/10.1016/j.watres.2021.117261
     
  • Hutinel M, Fick J, Larsson DGJ, Flach CF. (2021). Investigating the effects of municipal and hospital wastewaters on horizontal gene transfer. Environmental Pollution. 276:116733. https://doi.org/10.1016/j.envpol.2021.116733
     
  • Kraupner N, Hutinel M, Schumacher K, Gray DA, Genheden M, Fick J, Flach CF, Larsson DGJ. (2021). Evidence for selection of multi-resistant E. coli by hospital effluent. Environment International. 150:106436. https://doi.org/10.1016/j.envint.2021.106436
     
  • Årdal C, Baraldi E, Beyer P, Lacotte Y, Larsson DGJ, Ploy M-C, Røttingen J-A, Smith I. (2021). Supply chain transparency and the availability of essential medicines. Bulletin of the World Health Organization 99:319. https://doi.org/10.2471/BLT.20.267724
     
  • Wengenroth L, Berglund F, Blaak H, Chifiriuc MC, Flach CF, Pircalabioru GG, Larsson DGJ, Marutescu L, van Passel M, Popa M, Radon K, de Roda Husman AM, Rodríguez-Molina D, Weinmann T, Wieser A, Schmitt H. (2021). Antibiotic resistance in wastewater treatment plants and transmission risks for employees and residents: The Concept of the AWARE Study. Antibiotics, 10(5):478. https://doi.org/10.3390/antibiotics10050478
     
  • Ebmeyer S, Kristiansson E, Larsson DGJ. (2021). A framework for identifying the recent origins of mobile antibiotic resistance genes. Communications Biology. 4:8. https://doi.org/10.1038/s42003-020-01545-5
     
  • Cerveny D, Grabic R, Grabicová K, Randák T, Larsson DGJ, Johnson AC, Jürgens MD, Tysklind M, Lindberg RH, Fick J. (2021). Neuroactive drugs and other pharmaceuticals found in blood plasma of wild European fish. Environment International. 146:106188. https://doi.org/10.1016/j.envint.2020.10618


2020

  • Karkman A, Berglund F, Flach CF, Kristiansson E, Larsson DGJ. (2020). Predicting clinical resistance prevalence using sewage metagenomic data. Communications Biology. 3:711. https://doi.org/10.1038/s42003-020-01439-6
     
  • Nijsingh N, Larsson DGJ, de Fine Licht K, Munthe C. (2020). Justifying Antibiotic Resistance Interventions: Uncertainty, Precaution and Ethics. Chapter 22, pp 357-375 In: E. Jamrozik, M. Selgelid (eds.), Ethics and Drug Resistance: Collective Responsibility for Global Public Health, Public Health Ethics Analysis 5. Springer, Cham, https://doi.org/10.1007/978-3-030-27874-8_22
     
  • Berglund F, Böhm M, Martinsson A, Ebmeyer S, Österlund T, Johnning A, Larsson DGJ, Kristiansson E. (2020). Comprehensive screening of genomic and metagenomic data reveals a large diversity of tetracycline resistance genes. Microbial Genomics. 6. https://doi.org/10.1099/mgen.0.000455
     
  • Medlicott K, Wester A, Gordon B, Montgomery M, Tayler E, Sutherland D, Schmoll O, De Souza M, Koo-Oshima S, DaBalogh K, Pinto Ferreira J, Erlacher-Vindel E, Clayton H, Graham D, Larsson DGJ, Medema G, Roda de Husman AM, Schmitt H, Yang M, Zhang Y. (2020). Technical Brief on water, sanitation, hygiene and wastewater management to prevent infections and reduce the spread of antimicrobial resistance. Report number: ISBN: 978-92-4-000641-6Affiliation: World Health Organization WHO. https://www.who.int/water_sanitation_health/publications/wash-wastewater-management-to-prevent-infections-and-reduce-amr/en/
     
  • Nieuwenhuijse DF, Oude Munnink BB, Phan MV, the Global Sewage Surveillance project consortium*, Munk P, Venkatakrishnan S, Aarestrup FM, Cotton M, Koopmans MPG. (2020). Setting a baseline for global urban virome surveillance in sewage. Scientific Reports. 10:13748. https://doi.org/10.1038/s41598-020-69869-0 *DGJ Larsson is one of the listed authors in the consortium.
     
  • Kieffer N, Ebmeyer S, Larsson DGJ. (2020). The class A carbapenemases BKC-1 and GPC-1 both originate from the bacterial genus Shinella. Antimicrobial Agents and Chemotherapy. 64:e01263-20. https://doi.org/10.1128/AAC.01263-20
     
  • Kraupner N, Ebmeyer S, Hutinel M, Fick J, Flach CF, Larsson DGJ. (2020). Selective concentrations for trimethoprim resistance in aquatic environments. Environment International. 144:106083. https://doi.org/10.1016/j.envint.2020.106083
     
  • Berglund F, Johnning A, Larsson, DGJ Kristiansson, E. (2020). An updated phylogeny of the metallo-beta-lactamases. Journal of Antimicrobial Chemotherapy. 75:dkaa392. https://doi.org/10.1093/jac/dkaa392
     
  • Razavi M, Flach CF, Kristiansson E, Larsson DGJ. (2020). The association between insertion sequences and antibiotic resistance genes. mSphere. 5:e00418-20. https://doi.org/10.1128/mSphere.00418-20
     
  • Näslund J, Asker N, Fick J, Larsson DGJ, Norrgren L. (2020). Naproxen affects multiple organs in fish but is still an environmentally better alternative to diclofenac.  Aquatic Toxicology. 227:105583. https://doi.org/10.1016/j.aquatox.2020.105583
     
  • Zhang T, Fukuda K, Topp E, Zhu Y-G, Smalla K, Tiedje JM, Larsson DGJ. (2020). Editorial: The Environmental Dimension of Antibiotic Resistance. FEMS Microbiology Ecology, 96(8): fiaa130. https://doi.org/10.1093/femsec/fiaa130
     
  • Leiros H-K S, Thomassen A M, Samuelsen Ø, Flach CF, Kotsakis S D, Larsson DGJ. (2020). Structural insight to the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10. FEBS Open Bio. 10(9):1821-1832. https://doi.org/10.1002/2211-5463.12935
     
  • Fröhlich C, Sörum V, Huber S, Samuelsen Ö, Berglund F, Kristiansson E, Kotsakis S, Marathe NP, Larsson DGJ, Leiros H-K S. (2020). Structural and biochemical characterization of the environmental metallo-β-lactamases MYO-1, ECV-1 and SHD-1. Journal of Antimicrobial Chemotherapy. 75 (9): 2554-2563 dkaa175. https://doi.org/10.1093/jac/dkaa175
     
  • Böhm M-E, Razavi M, Flach CF, Larsson DGJ. (2020). A novel, integron-regulated class C β-lactamase. Antibiotics. 9(3):123. https://doi.org/10.3390/antibiotics9030123
     
  • Eckert EM, Di Cesare A, Fontaneto D, Berendonk TU, Bürgmann H, Cytryn E, Fatta-Kassinos D, Franzetti A, Larsson DGJ, Manaia CM, Pruden A, Singer AC, Udikovic-Kolic N, Corno G. (2020). Every fifth published metagenome is not available to science. PloS Biology. 18(4):3000698. https://doi.org/10.1371/journal.pbio.3000698
     
  • Huijbers PMSC, Larsson DGJ, Flach CF. (2020). Surveillance of antibiotic resistant Escherichia coli in human populations through urban wastewater in ten European countries. Environmental Pollution. 261:114200. https://doi.org/10.1016/j.envpol.2020.114200.
     
  • Böhm M-E, Razavi M, Marathe NP, Flach CF, Larsson DGJ. (2020). Discovery of a novel integron-borne aminoglycoside resistance gene present in clinical pathogens by screening environmental bacterial communities. Microbiome. 8(1):41. https://doi.org/10.1186/s40168-020-00814-z
     
  • Laxminarayan R, Van Boeckel T, Frost I, Kariuki S, Khan E, Limmathurotsakul D, Larsson DGJ, Levy-Hara G, Mendelson M, Outterson K, Peacock S, Zhu Y-G. (2020). The Lancet Infectious Diseases Commission on antimicrobial resistance: six years later. Lancet Infectious Diseases. 20:(4) e51-e60. https://doi.org/10.1016/S1473-3099(20)30003-7
     
  • Rutgersson C, Ebmeyer S, Lassen SB, Karkman A, Fick J, Kristiansson K, Brandt KK, Flach CF, Larsson DGJ. (2020). Long-term application of Swedish sewage sludge on farmland does not cause clear changes in the soil bacterial resistome. Environment International. 137:105339. https://doi.org/10.1016/j.envint.2019.105339

2019

  • Marathe NP, Salvà-Serra F, Karlsson R, Larsson DGJ, Moore ERB, Svensson-Stadler L, Jakobsson HE. (2019). Scandinavium goeteborgense gen. nov, sp. nov, a new member of the family Enterobacteriaceae isolated from a wound infection, carries a novel quinolone-resistance gene variant. Frontiers in Microbiology. 10:2511. https://doi.org/10.3389/fmicb.2019.02511
     
  • Nijsingh N, Munthe C, Larsson DGJ. (2019) Managing pollution from antibiotics manufacturing: charting actors, incentives and disincentives. Environmental Health 18:95. https://doi.org/10.1186/s12940-019-0531-1
     
  • Ebmeyer S, Kristiansson E, Larsson DGJ. (2019). The mobile FOX AmpC beta-lactamases originated in Aeromonas allosaccharophila. International Journal of Antimicrobial Agents. 54:798. https://doi.org/10.1016/j.ijantimicag.2019.09.017
     
  • Munthe C, Nijsingh N, de Fine Lich K, Larsson DGJ. (2019). The Ethics of Antibiotic Resistance: Towards an Agenda for Feasible and Justified Global Health Policy. Bioethics. 33:731. https://doi.org/10.1111/bioe.12655
     
  • Monjas L, Fodran P, Kollback J, Cassani C, Olsson T, Genheden M, Larsson DGJ, Wallentin C-J. (2019). Synthesis and biological evaluation of truncated derivatives of abyssomicin C as antibacterial agents. Beilstein Journal of Organic Chemistry. 15:1468. https://doi.org/10.3762/bjoc.15.147
     
  • Marathe NP, Berglund F, Razavi M, Pal C, Dröge J, Samant S, Kristiansson E, Larsson DGJ. (2019). Sewage effluent from an Indian hospital harbors novel carbapenemases and integron-borne antibiotic resistance genes. Microbiome. 7:97. https://doi.org/10.1186/s40168-019-0710-x
     
  • Huijbers PMC, Flach CF, Larsson DGJ. (2019). A conceptual framework for the environmental surveillance of antibiotics and antibiotic resistance. Environment International. 130:104880. https://doi.org/10.1016/j.envint.2019.05.074
     
  • Hutinel M, Huijbers PMC, Fick J, Åhrén C, Larsson DGJ, Flach CF. (2019). Population-level surveillance of antibiotic resistance in Escherichia coli through sewage analysis. Euro Surveillance. 24:1800497. https://doi.org/10.2807/1560-7917.ES.2019.24.37.1800497
     
  • Hendriksen RS, Munk P, Niage P, van Bunnik B, Larsson DGJ,(ca 100 co-authors). (2019). Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage. Nature Communications. 10:1124. https://doi.org/10.1038/s41467-019-08853-3
     
  • Berglund F, Österlund T, Boulund F, Marathe NP, Larsson DGJ, Kristiansson E. (2019). Identification and reconstruction of novel antibiotic resistance genes from metagenomes. Microbiome. 7:52. https://doi.org/10.1186/s40168-019-0670-1
     
  • Munthe C, Nijsingh N, de Fine Licht K, Larsson DGJ. (2019). Health-related research ethics and social value: antibiotic resistance intervention research and pragmatic risks. Bioethics, 33:335. https://doi.org/10.1111/bioe.12580
     
  • Ebmeyer S, Kristiansson E, Larsson DGJ. (2019). CMY-1/MOX-family AmpC beta-lactamases MOX-1, MOX-2 and MOX-9 were mobilized independently from three Aeromonas species. Journal of Antimicrobials and Chemotherapy. 74:1202. https://doi.org/10.1093/jac/dkz025
     
  • Karkman A, Pärnänen K, Larsson DGJ. (2019). Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments. Nature Communications. 80:10. https://doi.org/10.1038/s41467-018-07992-3
     
  • Ebmeyer S, Kristiansson E, Larsson DGJ. (2019). PER extended-spectrum beta-lactamases originate from Pararheinheimera spp. International Journal of Antimicrobial Agents. 53:158. https://doi.org/10.1016/j.ijantimicag.2018.10.019

2018

  • Aga D, Davies J, Gandra S, Kasprzyk B, Larsson DGJ, McLain J, Singer A, Snape J, Slijkhuis H, Sweetman A, Voulvoulis N. (2018). Antimicrobial manufacturing waste. Pages 30-45. In: Initiatives for Addressing Antimicrobial Resistance in the Environment: Current Situation and Challenges. https://wellcome.ac.uk/sites/default/files/antimicrobial-resistance-environment-report.pdf
     
  • Sahlin S, Larsson DGJ, Ågerstrand M. (2018). Ciprofloxacin EQS data overview. ACES report number 15. https://www.aces.su.se/aces/wp-content/uploads/2018/11/Ciprofloxacin-EQS-data-overview-2018.pdf
     
  • Kotsakis S, Flach CF, Razavi M, Larsson DGJ. (2018). Characterization of the first OXA-10 natural variant with increased carbapenemase activity. Antimicrobial Agents and Chemotherapy. 63:e01817-18. https://doi.org/10.1128/AAC.01817-18
     
  • Pärnänen K, Karkman A, Hultman J, Lyra C, Bengtsson-Palme J, Larsson DGJ, Rautava S, Salminen S, Kumar H, Satokari R, Isolauri E, Virta M. (2018). Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements. Nature Communications. 9:3891. https://doi.org/10.1038/s41467-018-06393-w
     
  • Flach CF, Genheden M, Fick J, Larsson DGJ. (2018). A comprehensive screening of E. coli isolates from Scandinavia’s largest sewage treatment plant indicates no selection for antibiotic resistance. Environmental Science & Technology. 52:11419. https://doi.org/10.1021/acs.est.8b03354
     
  • Wang H, Sikora P, Rutgersson C, Lindh M, Brodin T, Björlenius B, Larsson DGJ, Norder H. (2018). Differential removal of human pathogenic viruses from sewage by conventional and ozone treatments. International Journal of Hygiene and Environmental Health. 221:479. https://doi.org/10.1016/j.ijheh.2018.01.012
     
  • Pohl J, Björlenius B, Brodin T, Carlsson G, Fick J, Larsson DGJ, Norrgren L, Stefan Örn S. (2018). Effects of ozonated sewage effluent on reproduction and behavioral endpoints in zebrafish (Danio rerio). Aquatic Toxicology. 200:93. https://doi.org/10.1016/j.aquatox.2018.04.014
     
  • Larsson DGJ, Andremont A, Bengtsson-Palme J, Koefoed Brandt K, de Roda Husman AM, Fagerstedt P, Fick J, Flach CF, Gaze WH, Kuroda M, Kvint K, Laxminarayan R, Manaia CM, Nielsen KM, Plant L, Ploy MC, Segovia C, Simonet P, Smalla K, Snape J, Topp E, van Hengel A, Verner-Jeffreys DW, Virta MPJ, Wellington EM, Wernersson AS. (2018). Critical knowledge gaps and research needs related to the environmental dimensions of antibiotic resistance. Environment International. 117:132. https://doi.org/10.1016/j.envint.2018.04.041
     
  • Kraupner N, Ebmeyer S, Bengtsson-Palme J, Fick J, Kristiansson E, Flach CF, Larsson DGJ. (2018). Selective concentration for ciprofloxacin resistance in Escherichia coli grown in complex aquatic bacterial biofilms. Environment International. 116:255. https://doi.org/10.1016/j.envint.2018.04.029
     
  • Topp E, Larsson DGJ, Miller D, Van den Eede C, Virta M. (2018). Antimicrobial resistance and the environment: Assessment of advances, gaps and recommendations for agriculture, aquaculture and pharmaceutical manufacturing. FEMS Microbiology Ecology. 93:fix185. https://doi.org/10.1093/femsec/fix185
     
  • Larsson DGJ. (2018). Risks of using the natural defense of commensal bacteria as antibiotics call for research and regulation. International Journal of Antimicrobial Agents. 51:277. https://doi.org/10.1016/j.ijantimicag.2017.12.018
     
  • Bengtsson-Palme J, Gunnarsson L, Larsson DGJ. (2018). Can branding and price of pharmaceuticals guide informed choices towards improved pollution control during manufacturing? Journal of Cleaner Production. 171:137. https://doi.org/10.1016/j.jclepro.2017.09.247
     
  • Marathe NP, Janzon A, Kotsakis SD, Flach CF, Razavi M, Berglund F, Kristiansson E, Larsson DGJ. (2018). Functional metagenomics reveals a novel carbapenem-hydrolyzing mobile beta-lactamase from Indian river sediments contaminated with antibiotic production waste. Environment International. 112:279. http://doi.org/10.1016/j.envint.2017.12.036
     
  • Bengtsson-Palme J, Larsson DGJ. (2018). Protection goals must guide risk assessment for antibiotics. Environment International. 111:352. https://doi.org/10.1016/j.envint.2017.10.019
     
  • Jutkina J, Marathe NP, Flach CF, Larsson DGJ. (2018). Antibiotics and common antibacterial biocides stimulate horizontal transfer of resistance at low concentrations. Science of the Total Environment. 616-617:172. https://doi.org/10.1016/j.scitotenv.2017.10.312
     
  • Bengtsson-Palme J, Kristiansson E, Larsson DGJ. (2018). Environmental factors influencing the development and spread of antibiotic resistance. FEMS Microbiology Reviews. 42:fux053. https://doi.org/10.1093/femsre/fux053

2017

  • Razavi M, Marathe NP, Gillings M, Flach CF, Kristiansson E, Larsson DGJ. (2017). Discovery of the fourth mobile sulfonamide resistance gene. Microbiome. 5:160. https://doi.org/10.1186/s40168-017-0379-y
     
  • Berglund F, Marathe NP, Österlund T, Bengtsson-Palme J, Kotsakis S, Flach CF, Larsson DGJ, Kristiansson E. (2017). Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data. Microbiome. 5:134. https://doi.org/10.1186/s40168-017-0353-8
     
  • Boulund F, Berglund F, Flach CF, Bengtsson-Palme J, Marathe NP, Larsson DGJ, Kristiansson E. (2017). Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets. BMC Genomics. 18:682. https://doi.org/10.1186/s12864-017-4064-0
     
  • Marathe NP, Pal C, Gaikwad SS, Jonsson V, Kristiansson E, Larsson DGJ. (2017). Untreated urban waste contaminates Indian river sediments with resistance genes to last resort antibiotics. Water Research. 124:388. https://doi.org/10.1016/j.watres.2017.07.060
     
  • Bengtsson-Palme J, Larsson DGJ, Kristiansson E. (2017). Using metagenomics to investigate human and environmental resistomes. Journal of Antimicrobials and Chemotherapy. 72:2690. https://doi.org/10.1093/jac/dkx199
     
  • Näslund J, Fick J, Asker N, Ekman E, Larsson DGJ, Norrgren L. (2017). Diclofenac affects kidney histopathology in the three-spined stickleback (Gasterosteus aculeatus) at low µg/L concentrations. Aquatic Toxicology. 189:87. https://doi.org/10.1016/j.aquatox.2017.05.017
     
  • Flach CF, Pal C, Svensson CJ, Kristiansson E, Östman M, Bengtsson-Palme J, Tysklind M, Larsson DGJ. (2017). Does antifouling paint select for antibiotic resistance? Science of the Total Environment. 590–591:461. https://doi.org/10.1016/j.scitotenv.2017.01.213
     
  • Hao X*, Li X*, Pal C*, Hobman J, Rosen BP, Larsson DGJ, Saquib Q, Alwathnani HA, Zhu Y-G, Rensing C. (2017). Bacterial resistance to arsenic protects against protist killing. Biometals. 30:307. https://doi.org/10.1007/s10534-017-0003-4 (*-co-first authors).
     
  • Pal C, Asiani K, Arya S, Rensing C, Stekel DJ, Larsson DGJ, Hobman JL. (2017). Metal resistance and its association with antibiotic resistance. Advances in Microbial Physiology. 70:261. https://doi.org/10.1016/bs.ampbs.2017.02.001

2016

  • Marathe NP, Shetty SA, Shouche YS, Larsson DGJ. (2016). Limited bacterial diversity within a treatment plant receiving antibiotic-containing waste from bulk drug production. PloS One 11:e0165914. https://doi.org/10.1371/journal.pone.0165914

     
  • Bengtsson-Palme J, Larsson DGJ. (2016). Why limit antibiotic pollution? The role of environmental selection in antibiotic resistance development. APUA Newsletter, 34:6
     
  • Pal C, Bengtsson-Palme J, Kristiansson E, Larsson DGJ. (2016). The structure and diversity of human, animal and environmental resistomes. Microbiome. 4:54. https://doi.org/10.1186/s40168-016-0199-5
     
  • Bengtsson-Palme J, Hammarén R, Pal C, Östman M, Björlenius B, Flach CF, Fick J, Kristiansson E, Tysklind M, Larsson DGJ. (2016). Elucidating selection processes for antibiotic resistance in sewage treatment plants using metagenomics. Science of the Total Environment. 572:697. https://doi.org/10.1016/j.scitotenv.2016.06.228
     
  • De Roda Husman A-M, Larsson DGJ. (2016). Risk assessment and risk management of antimicrobial resistance in the environment. AMR control 2016:104 Global Health Dynamics, UK. 
     
  • Rönnerstrand B, Jagers S, Larsson DGJ. (2016). Who worries about antibiotic resistance? (In Swedish). In: Ekvilibrium (Eds. Henrik Oscarsson, Jonas Ohlsson and Maria Solevid). SOM-institutet, University of Gothenburg. ISBN 978-91-89673-35-9.
     
  • Larsson DGJ, Svennerholm A-M. (2016). The role of antibacterial agents in the development of antibiotic resistance (in Swedish). Läkartidningen 2016;113:D44E.
     
  • Bengtsson-Palme J, Larsson DGJ. (2016) Time to limit antibiotic pollution. The medicine maker, April:17 (opinion paper) (pdf)
     
  • Lundström SV, Östman M, Bengtsson-Palme J, Rutgersson C, Thoudal M, Sircar T, Blanck H, Eriksson KM, Tysklind M, Flach CF, Larsson DGJ. (2016) Minimal selective concentrations of tetracycline in complex aquatic bacterial biofilms. Science of the Total Environment. 553:587. https://doi.org/10.1016/j.scitotenv.2016.02.103
     
  • Jutkina J, Rutgersson C, Flach CF, Larsson DGJ. (2016). An assay for determining minimal concentrations of antibiotics that drive horizontal transfer of resistance. Science of the Total Environment. 548–549:131. https://doi.org/10.1016/j.scitotenv.2016.01.044
     
  • Bengtsson-Palme J, Larsson DGJ. (2016). Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation. Environment International. 86:140. https://doi.org/10.1016/j.envint.2015.10.015

2015

  • Johnning A, Kristiansson E, Fick J, Weijdegård B, Larsson DGJ. (2015). Resistance mutations in gyrA and parC are common in Escherichia communities of both fluoroquinolone-polluted and uncontaminated aquatic environments. Frontiers in Microbiology. 6:1355. https://doi.org/10.3389/fmicb.2015.01355
     
  • Pal C, Bengtsson-Palme J, Kristiansson E, Larsson DGJ. (2015). Co-occurrence of resistance genes to antibiotics, biocides and metals reveals novel insights into their co-selection potential. BMC Genomics. 16:964. https://doi.org/10.1186/s12864-015-2153-5
     
  • Johnning A, Kristiansson E, Martin A, Marathe NP, Shouche YS, Johansson A, Larsson DGJ. (2015). Quinolone resistance mutations in the faecal microbiota of Swedish travellers to India. BMC Microbiology. 15:235. https://doi.org/10.1186/s12866-015-0574-6
     
  • Bengtsson-Palme J, Angelin M, Huss M, Kjellqvist S, Kristiansson E, Palmgren H, Larsson DGJ, Johansson A. (2015). The human gut microbiome as a transporter of antibiotic resistance genes between continents. Antimicrobial Agents and Chemotherapy. 59:6551. https://doi.org/10.1128/AAC.00933-15
     
  • Sandegren L, Salin K, Larsson DGJ. (2015). The environmental dimension of antibiotic resistance. In: Uppsala Health Summit – a world without antibiotics. Post-conference report. Pp 17-21. www.uppsalahealthsummit.se.
     
  • Flach CF, Johnning A, Nilsson I, Smalla K, Kristiansson E, Larsson DGJ. (2015). Isolation of novel IncA/C and IncN fluoroquinolone resistance plasmids from an antibiotic-polluted lake. Journal of Antimicrobial Chemotherapy. 70:2709. https://doi.org/10.1093/jac/dkv167
     
  • Bylander A, Gunnarsson L, Shao R, Billig H, Larsson DGJ. (2015). Progesterone-mediated effects on gene expression and oocyte-cumulus complex transport in the mouse fallopian tube. Reproductive Biology and Endocrinology. 13:40. https://doi.org/10.1186/s12958-015-0038-8
     
  • Ågerstrand M, Berg C, Björlenius B, Breitholtz M, Brunström B, Fick J, Gunnarsson L, Larsson DGJ, Sumpter JP, Tysklind M, Rudén C. (2015). Improving environmental risk assessment of human pharmaceuticals. Environmental Science & Technology. 49:5336. https://doi.org/10.1021/acs.est.5b00302
     
  • Bengtsson-Palme J, Hartmann M, Eriksson KM, Pal C, Thorell K, Larsson DGJ, Nilsson RH. (2015). METAXA2 – Improved Identification and Taxonomic Classification of Small and Large Subunit rRNA in Metagenomic Data, Molecular Ecology Resources. 15:1403 https://doi.org/10.1111/1755-0998.12399
     
  • Carney Almroth BM, Gunnarsson LM, Cuklev F, Fick J, Kristiansson E, Larsson DGJ. (2015). Waterborne beclomethasone diproprionate affects the physiology of fish while its metabolite beclomethasone is not taken up. Science of the Total Environment. 511:37. https://doi.org/10.1016/j.scitotenv.2014.12.016
     
  • Bengtsson-Palme J, Larsson DGJ. (2015). Antibiotic resistance genes in the environment: prioritizing risks. Nature Review Microbiology. 13:396. https://doi.org/10.1038/nrmicro3399-c-1
     
  • Larsson DGJ, Sandegren L. (2015). The environmental dimension of antibiotic resistance. In: Uppsala Health Summit – a world without antibiotics. Pre-conference report. Pp 16-19 www.uppsalahealthsummit.se.
     
  • Wernersson A-S et al (in total 46 authors). (2015). The European technical report on aquatic effect-based monitoring tools under the water framework directive. Environmental Sciences Europe. 27:7 https://doi.org/10.1186/s12302-015-0039-4

2014

  • Bengtsson-Palme J, Boulund F, Fick J, Kristiansson E, Larsson DGJ. (2014). Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India. Frontiers in Microbiology. 5:648. https://doi.org/10.3389/fmicb.2014.00648
     
  • Rutgersson C, Fick J, Marathe N, Kristiansson E, Janzon A, Angelin M, Johansson A, Shouche Y, Flach CF, Larsson DGJ. (2014). Fluoroquinolones and qnr genes in sediment, water, soil and human fecal flora in an environment polluted by manufacturing discharges. Environ Sci Technol 48:7825. https://doi.org/10.1021/es501452a
     
  • Grabicova K, Lindberg RH, Östman M, Grabic R, Randak T, Larsson DGJ, Fick J. (2014). Tissue-specific bioconcentration of antidepressants in fish exposed to effluent from a municipal sewage treatment plant. Science of the Total Environment. 488-489:46. https://doi.org/10.1016/j.scitotenv.2014.04.052
     
  • Brown JN, Samuelsson L, Bernardi G, Gooneratne R, Larsson DGJ. (2014). Aqueous and Lipid NMR Metabolomic Profiling of the Earthworm Aporrectodea caliginosa shows Potential as Indicators for Studying the Effects of Differing Landuses. Environmental Toxicology and Chemistry. 33:2313. https://doi.org/10.1002/etc.2680
     
  • Pal C, Bengtsson-Palme J, Rensing C, Kristiansson E, Larsson DGJ. (2014). BacMet: antibacterial biocide and metal resistance genes database. Nucleic Acids Research. 42:D737. https://doi.org/10.1093/nar/gkt1252
     
  • Graham DW, Collignon P, Davies J, Larsson DGJ, Snape J. (2014). Underappreciated role of regionally poor water quality on globally increasing antibiotic resistance. Environmental Science & Technology. 48:11746. https://doi.org/10.1021/es504206x
     
  • Larsson DGJ. (2014). Pollution from drug manufacturing: review and perspectives. Philosophical Transactions of the Royal Society B Biological Sciences. 369:20130571 https://doi.org/10.1098/rstb.2013.0571
     
  • Kookana RS, Williams M, Boxall AB, Larsson DGJ, Gaw S, Choi K, Yamamoto H, Shashidhar T, Zhu Y-G, Carriquiriborde P. (2014). Potential ecological footprints of active pharmaceutical ingredients: an examination of risk factors in low-, middle-, and high-income countries. Philosophical Transactions of the Royal Society B Biological Sciences. 369:20130586. https://doi.org/10.1098/rstb.2013.0586
     
  • Larsson DGJ. (2014). Antibiotics and antibiotic resistance in the external environment (in Swedish). Chapter in a popular science book on Antibiotic resistance (Antibiotika - boten och hoten) within the publication series “Formas fokuserar”. ISBN 978-91-540-6082-5. Pp 63-72
     
  • Larsson DGJ. (2014). Antibiotics in the environment. Upsala Journal of Medical Sciences. 119:108. https://doi.org/10.3109/03009734.2014.896438
     
  • Larsson DGJ, Greko C. (2014). Great drugs in the wrong place: risks for environmental effects and resistance promotion (in Swedish). Läkartidningen 111:619 Online copy available here.
     
  • Larsson DGJ, Lööf L. (2014). Läkemedel i miljön. In: Läkemedelsboken 2014, edited and produced by the Swedish Medical Products Agency. Pp 1267-1279 Also available at www.lakemedelsboken.se
     
  • Selvaraj KK, Shanmugam G, Sampath S, Larsson DGJ, Ramaswamy BR. (2013). GC-MS determination of bisphenol A and alkylphenol ethoxylates in the river water from India and their ecotoxicological risk assessment. Ecotoxicology and Environmental Safety. 99:13. https://doi.org/10.1016/j.ecoenv.2013.09.006

2013

  • Flach CF, Boulund F, Kristiansson E, Larsson DGJ. (2013). Functional verification of computationally predicted qnr genes. Annals of Clinical Microbiology and Antimicrobials. 12:34. https://doi.org/10.1186/1476-0711-12-34
     
  • Johnning A, Moore ERB, Svensson-Stadler L, Shouche YS, Larsson DGJ, Kristiansson E. (2013). Acquired genetic mechanisms of a multiresistant bacterium isolated from a treatment plant receiving wastewater from antibiotic production. Applied and Environmental Microbiology. 79:7256. https://doi.org/10.1128/AEM.02141-13
     
  • Marathe NP, Regina VR, Walujkar SA, Charan SS, Moore ERB, Charan SS, Moore ERB, Larsson DGJ, Shouche YS. (2013). A treatment plant receiving waste water from multiple bulk drug manufacturers is a reservoir for highly multi-drug resistant integron-bearing bacteria. PLoS ONE. 8:e77310. https://doi.org/10.1371/journal.pone.0077310
     
  • Shanmugam G, Sampath S, Selvaraj KK, Larsson DGJ, Ramaswamy BR. (2013). Non-steroidal anti-inflammatory drugs in Indian rivers. Environmental Science and Pollution Research. 21:921. https://doi.org/10.1007/s11356-013-1957-6
     
  • Bylander A, Lind K, Goksör M, Billig H, Larsson DGJ. (2013). The classical progesterone receptor mediates the rapid reduction of fallopian tube ciliary beat frequency by progesterone. Reproductive Biology and Endocrinology. 11:33. https://doi.org/10.1186/1477-7827-11-33
     
  • Kristiansson E, Österlund T, Gunnarsson G, Arne G, Larsson DGJ, Nerman O. (2013). A novel method for cross-species gene expression analysis. BMC Bioinformatics. 14:70. https://doi.org/10.1186/1471-2105-14-70
     
  • Asker N, Kristiansson E, Albertsson E, Larsson DGJ, Förlin L. (2013). Hepatic transcriptome profiling indicates differential mRNA expression of apoptosis and immune related genes in eelpout (Zoarces viviparus) caught at Göteborg harbor, Sweden. Aquatic Toxicology. 130–131:58. https://doi.org/10.1016/j.aquatox.2012.12.017
     
  • Rutgersson C, Gunnarsson L, Kristiansson E, Larsson DGJ. (2013). Oral exposure to industrial effluent with exceptionally high levels of drugs does not indicate acute toxic effects in rats. Environmental Toxicology and Chemistry. 32:577. https://doi.org/10.1002/etc.2105
     
  • Beijer K, Gao K, Jönsson M, Larsson DGJ, Brunström B, Brandt I. (2013). Effluent from drug manufacturing affects cytochrome P450 1 regulation and function in fish. Chemosphere 90:1149. https://doi.org/10.1016/j.chemosphere.2012.09.023
     
  • Kullgren A, Jutfelt F, Fontanillas R, Sundell K, Samuelsson LM, Wiklander K, Kling P, Koppe W, Larsson DGJ, Björnsson B-T, Jönsson E. (2013). The impact of temperature on the metabolome and endocrine metabolic signaling in Atlantic salmon (Salmo salar). Comparative Biochemical and Physiology Part A: Molecular and Integrative Physiology. 164:44. https://doi.org/10.1016/j.cbpa.2012.10.005
     
  • Ashbolt NJ, Amézquita A, Backhaus T, Borriello SP, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, Lawrence J, Larsson DGJ, McEwen SA, Ryan JJ, Schönfeld J, Silley P, Snape JR, van den Eede C, Topp E. (2013). Human health risk assessment (HHRA) for environmental development and transfer of antibiotic resistance. Environmental Health Perspectives. 121:993.https://doi.org/10.1289/ehp.1206316
     
  • Pruden A, Larsson DGJ*, Amézquita A, Collignon P, Brandt KK, Graham DW, Lazorchak JR, Suzuki S, Silley P, Snape JR, Topp E, Zhang T, Zhu Y-G. (2013). Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment. Environmental Health Perspectives. 121:878. https://doi.org/10.1289/ehp.1206446. *corresponding author and shared first author.
     
  • Finley RL, Collignon P, Larsson DGJ, McEwen SA, Li X-Z, Gaze WH, Wright GD, Reid-Smith R, Timinouni M, Ryan JJ, Woodland C, Graham DW, Topp E. (2013). The scourge of antibiotic resistance: the important role of the environment. Clinical Infectious Diseases. 57:704. https://doi.org/10.1093/cid/cit355
     
  • Gaze WH, Krone SM, Larsson DGJ, Li XZ, Robinson JA, Simonet P, Smalla K, Timinouni M, Topp E, Wellington EM, Wright GD, Zhu YG. (2013). Influence of humans on evolution and mobilization of environmental antibiotic resistome. Emerging Infectious Diseases. 19. https://doi.org/10.3201/eid1907.120871

2012

  • Boulund F, Johnning A, Pereira MB, Larsson DGJ, Kristiansson E. (2012). A novel method to discover fluoroquinolone antibiotic resistance (qnr) genes in fragmented nucleotide sequences. BMC Genomics. 13:695. https://doi.org/10.1186/1471-2164-13-695
  • Albertsson A, Rad A, Sturve J, Larsson DGJ, Förlin L. (2012). Carbonyl reductase mRNA abundance and enzymatic activity as potential biomarkers of oxidative stress in marine fish. Marine Environmental Research. 80:56. https://doi.org/10.1016/j.marenvres.2012.07.001
     
  • Cuklev F, Fick J, Cvijovic M, Kristiansson E, Förlin L, Larsson DGJ. (2012). Does ketoprofen or diclofenac pose the lowest risk to fish? Journal of Hazardous Materials. 229-230:100. https://doi.org/10.1016/j.jhazmat.2012.05.077
     
  • Boxall ABA, Rudd MA, Brooks BW, Caldwell DJ, Choi K, Hickmann S, Innes E, Ostapyk K, Staveley JP, Verslycke T, Ankley GT, Beazley KF, Belanger SE, Berninger JP, Carriquiriborde P, Coors A, DeLeo PC, Dyer SD, Gagné F, Giesy JP, Hallstrom L, Karlsson M, Larsson DGJ, Lazorchak JM, Mastrocco F, McLaughlin A, McMaster ME, Meyerhoff RD, Parrott J, Snape JR, Murray-Smith R, Servos MR, Sibley PK, Straub JO, Szabo ND, Topp E, Tetreault GR, Trudeau VL, Van Der Kraak G. (2012). Pharmaceuticals and personal care products in the environment: what are the big questions? Environmental Health Perspectives. 120:1221. https://doi.org/10.1289/ehp.1104477
     
  • Svahn S, Göransson U, El-Seedi H, Bohlin L, Larsson DGJ, Olsen B, Chryssanthou E. (2012). Antimicrobial activity of filamentous fungi isolated from highly antibiotic-contaminated river sediment. Infection Ecology & Epidemiology. 2:11591. https://doi.org/10.3402/iee.v2i0.11591
     
  • Cuklev F, Kristiansson E, Gunnarsson L, Cvijovic M, Rutgersson C, Fick J, Grabic R, Björlenius B, Larsson DGJ. (2012). Global hepatic gene expression in fish exposed to sewage effluents: A comparison of different treatment technologies. Science of the total environment. 427-428:106. https://doi.org/10.1016/j.scitotenv.2012.04.009
     
  • Roos V, Gunnarsson L, Fick J, Larsson DGJ, Rudén C. (2012). Prioritising pharmaceuticals for environmental risk assessment: Towards adequate and feasible first-tier selection. Science of the Total Environment. 421-422:102 https://doi.org/10.1016/j.scitotenv.2012.01.039 Recognized by the Society of Toxicology in 2013 to be among the “Top 10 Papers Advancing the Science of Risk Assessment in 2012”.
     
  • Gunnarsson L, Kristiansson E, Larsson DGJ. (2012). Environmental Comparative Pharmacology: Theory and application. In: Emerging Topics in Ecotoxicology, 1, 4:85 Human Pharmaceuticals in the Environment - Current and Future Perspectives. Eds: B Brooks, D Huggett. Springer Verlag. ISBN 978-1-4614-3419-1. https://doi.org/10.1007/978-1-4614-3473-3_5
     
  • Janzon A, Kristiansson K, Larsson DGJ. (2012). Environmental microbial communities living under very high antibiotic selection pressure. Invited book chapter in: Antimicrobial Resistance in the Environment. First Edition. Eds. Montforts HMM, Keen PL. Wiley & Blackwell. Pp 483-501.
     
  • Larsson DGJ. (2012). Utsläpp från läkemedelsindustri påverkar miljön - Antibiotikautsläpp riskerar också vår egen hälsa. Invited review in Swedish. Läkartidningen, 109:750
     
  • Brandt I, Breitholtz M, la Cour Jansen J, Liljelund K, Larsson DGJ, Rudén C, Tysklind M. (2012). Pharmaceuticals in a Healthy Environment. ISBN: 978-91-978836-2-7. Elanders, Sverige AB Stockholm. 71pp.

2011

  • Cuklev F, Kristiansson K, Fick J, Asker N, Förlin L, Larsson DGJ. (2011). Diclofenac in fish - blood plasma levels similar to human therapeutic levels affect global hepatic gene expression. Environmental Toxicology and Chemistry. 30:2126 https://doi.org/10.1002/etc.599
     
  • Lennquist A, Asker N, Kristiansson E, Brenthel A, Björnsson B-T, Kling P, Larsson DGJ, Förlin L. (2011). Physiology and mRNA expression in rainbow trout (Oncorhynchus mykiss) after long-term exposure to the new antifoulant medetomidine. Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology. 154:234. https://doi.org/10.1016/j.cbpc.2011.06.002
     
  • Kristiansson E, Fick J, Janzon A, Grabic R, Rutgersson C, Weijdegård B, Söderström H, Larsson DGJ. (2011). Pyrosequencing of antibiotic-contaminated river sediments reveals high levels of resistance and gene transfer elements. PLoS ONE 6:e17038. https://doi.org/10.1371/journal.pone.0017038. Highlighted in Nature (2011). https://doi.org/10.1038/news.2011.46
     
  • Holmberg A, Fogel J, Albertsson E, Fick J, Brown JN, Paxéus N, Förlin L, Johnsson J, Larsson DGJ. (2011). Does waterborne citalopram affect the aggressive and sexual behaviour of rainbow trout and guppy? Journal of Hazardous Materials. 187:596. https://doi.org/10.1016/j.jhazmat.2011.01.055
     
  • Samuelsson LM, Björlenius B, Förlin L, Larsson DGJ. (2011). Reproducible 1H NMR-based metabolomic responses in fish exposed to different sewage effluents in two separate studies. Environmental Science & Technology. 45:1703. https://doi.org/10.1021/es104111x
     
  • Ramaswamy BR, Shanmugam G, Velu G, Rengarajan B, Larsson DGJ. (2011). GC-MS analysis and ecotoxicological risk assessment of triclosan, carbamazepine and parabens in Indian rivers. Journal of Hazardous Materials. 186:1586. https://doi.org/10.1016/j.jhazmat.2010.12.037
     
  • Larsson DGJ, Lööf L. (2011). Läkemedel i miljön. Invited book chapter (In Swedish) in “Läkemedelsboken 2011-2012”, edited and produced by the Swedish Medical Products Agency. Pp 1182-1193. Also available at www.lakemedelsboken.se

2010

  • Kullgren A, Samuelsson L, Larsson DGJ, Björnsson Th, Jönsson Bergman E. (2010). A metabolomics approach to elucidate effects of food deprivation in juvenile rainbow trout (Oncorhynchus mykiss). American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 299: R1440. https://doi.org/10.1152/ajpregu.00281.2010
     
  • Fick J, Lindberg RH, Tysklind M, Larsson DGJ. (2010). Predicted critical environmental concentrations for 500 pharmaceuticals. Regulatory Toxicology and Pharmacology. 58:516. https://doi.org/10.1016/j.yrtph.2010.08.025
     
  • Bylander A, Nutu M, Wellander R, Goksör M, Billig H, Larsson DGJ. (2010). Rapid effects of progesterone on ciliary beat frequency in the mouse fallopian tube. Reproductive Biology and Endocrinology. 8:48. https://doi.org/10.1186/1477-7827-8-48
     
  • Fick J, Lindberg RH, Parkkonen J, Arvidsson B, Larsson DGJ. (2010). Therapeutic levels of levonorgestrel detected in blood plasma of fish: results from screening rainbow trout exposed to treated sewage effluents. Environmental Science & Technology. 44:2661. https://doi.org/10.1021/es903440m
     
  • Albertsson E, Larsson DGJ, Förlin L. (2010). Induction of hepatic carbonyl reductase/20β-hydroxysteroid dehydrogenase mRNA in rainbow trout downstream from sewage treatment works – possible roles of aryl hydrocarbon receptor agonists and oxidative stress. Aquatic Toxicology. 97:243. https://doi.org/10.1016/j.aquatox.2009.11.007
     
  • Friberg PA, Larsson DGJ, Billig H. (2010). Transcriptional effects of progesterone receptor antagonist in rat granulosa cells. Molecular and Cellular Endocrinology. 315:121. https://doi.org/10.1016/j.mce.2009.09.030
     
  • Cuklev F, Gunnarsson L, Larsson DGJ. (2010). Genomics as a guide to assess environmental risks of pharmaceuticals. In: Towards sustainable pharmacy in a healthy society. Pp 58-71. ISBN 978-91-978836-0-3.
     
  • Fick J, Grabic R, Lindberg RH, Larsson DGJ, Tysklind M. (2010). Bioconcentration of pharmaceuticals. In: Towards sustainable pharmacy in a healthy society. Pp 36-45. ISBN 978-91-978836-0-3.
     
  • Larsson DGJ. (2010). Release of active pharmaceutical ingredients from manufacturing sites – need for new management strategies. Integrated Environmental Assessment and Management. 6:184. https://doi.org/10.1002/ieam.20


2009 and before

  • Kristiansson E, Asker N, Förlin L, and Larsson DGJ. (2009). Characterization of the Zoarces viviparus liver transcriptome using massively parallel pyrosequencing. BMC Genomics. 10:345. https://doi.org/10.1186/1471-2164-10-345
     
  • Nutu M, Weijdegård B, Thomas P, Thurin-Kjellberg A, Billig H, Larsson DGJ. (2009). Distribution and hormonal regulation of membrane progesterone receptors beta and gamma in ciliated epithelial cells of mouse and human fallopian tubes. Reproductive Biology and Endocrinology. 7:89. http://doi.org/10.1186/1477-7827-7-89
     
  • Gunnarsson L, Kristiansson E, Rutgersson C, Sturve J, Fick J, Förlin L, Larsson DGJ. (2009). Pharmaceutical industry effluent diluted 1:500 affects global gene expression, CYP1A activity and plasma phosphate in fish. Environmental Toxicology and Chemistry. 28:2639. https://doi.org/10.1897/09-120.1
     
  • Gunnarsson L, Adolfsson-Erici M, Björlenius B, Rutgersson C, Förlin L, Larsson DGJ. (2009). Comparison of six different sewage treatment technologies - reduction of estrogenic substances and effects on gene expression in exposed male fish. Science of the Total Environment. 407:5235. https://doi.org/10.1016/j.scitotenv.2009.06.018
     
  • Fick J, Söderström H, Lindberg RH, Chau DNP, Tysklind M, Larsson DGJ. (2009). Contamination of surface, ground, and drinking water from pharmaceutical production. Environmental Toxicology and Chemistry. 28:2522. https://doi.org/10.1897/09-073.1
     
  • Larsson DGJ, Fick J. (2009). Transparency throughout the production chain – a way to reduce pollution from the manufacturing of pharmaceuticals. Regulatory Toxicology and Pharmacology. 53:161. https://doi.org/10.1016/j.yrtph.2009.01.008. Highlighted in Nature (2009). 457:640. https://doi.org/10.1038/457640a)
     
  • Carlsson G, Örn S, Larsson DGJ. (2009). Effluent from bulk drug production is toxic to aquatic vertebrates. Environ Toxicol Chem. 28:2656 doi:10.1897/08-524.1 Highlighted in Nature (2009). 457:640. https://doi.org/10.1038/457640a
     
  • Friberg PA, Larsson DGJ, Billig H. (2009). Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis. Biology of Reproduction. 80:1160 https://doi.org/10.1095/biolreprod.108.073932
     
  • Rudén C, Brandt I, Breitholtz M, Fick J, la Cour Jansen J, Larsson DGJ, Tysklind M. (2009). Feminized Fish and Vulnerable Vultures – Pharmaceuticals as Environmental Pollutants Require Novel Testing Approches. Pp 148-165. In: A healthy future – Pharmaceuticals in a Sustainable Society. Eds Bengtsson B-E et al. Apoteket AB, Stockholm Sweden. ISBN:2184-01. Available in both English and Swedish.
     
  • Gunnarsson L, Jauhiainen A, Kristiansson E, Nerman O, Larsson DGJ. (2008). Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environmental Science & Technology. 42:5807. https://doi.org/10.1021/es8005173. Highlighted in Environmental Science & Technology (2008). 42:5382. https://doi.org/10.1021/es801614k and received the “AstraZeneca Award for the best publication in risk assessment, modeling and theoretical studies” in 2008.
     
  • Larsson DGJ. (2008). Drug production facilities – an overlooked discharge source for pharmaceuticals to the environment. In Kümmerer K, ed, Pharmaceuticals in the Environment. Sources, Fate, Effects, and Risks. Springer-Verlag Berlin, Heidelberg, pp 37–42. https://doi.org/10.1007/978-3-540-74664-5
     
  • Samuelsson LM, Larsson DGJ. (2008). Contributions from metabolomics to fish research. Molecular Biosystems. 4:974. https://doi.org/10.1039/B804196B
     
  • Larsson DGJ, de Pedro C, Paxéus N. (2007). Effluent from drug manufactures contains extremely high levels of pharmaceuticals. Journal of Hazardous Materials. 148:751. http://doi.org/10.1016/j.jhazmat.2007.07.008. Highlighted in Nature (2009). 457:640. https://doi.org/10.1038/457640a)
     
  • Brown JN, Paxéus N, Förlin L, Larsson DGJ. (2007). Variations in bioconcentration of human pharmaceuticals from sewage effluents into fish blood plasma. Environmental Toxicology and Pharmacology. 24:267.https://doi.org/10.1016/j.etap.2007.06.005
     
  • Albertsson E, Kling P, Gunnarsson L, Larsson DGJ, Förlin L. (2007). Proteomic analyses indicate induction of hepatic carbonyl reductase/20β-hydroxysteroid dehydrogenase B in rainbow trout exposed to sewage effluent. Ecotoxicology and Environmental Safety. 68:33 https://doi.org/10.1016/j.ecoenv.2007.02.003
     
  • Gunnarsson L, Kristiansson E, Förlin L, Nerman O, Larsson DGJ. (2007). Sensitive and robust gene expression changes in fish exposed to estrogen: a microarray approach. BMC Genomics. 8:149. https://doi.org/10.1186/1471-2164-8-149
     
  • Friberg PA, Larsson DGJ, Rung E, Billig H. (2007). Apoptotic effects of a progesterone receptor antagonist on rat granulosa cells are not mediated via reduced protein isoprenylation. Molecular Reproduction & Development. 74:1317. https://doi.org/10.1002/mrd.20711
     
  • Nutu M, Weijdegård B, Thomas P, Bergh C, Thurin-Kjellberg A, Pang Y, Billig H, Larsson DGJ. (2007). Membrane progesterone receptor gamma: tissue distribution and expression in ciliated cells in the fallopian tube. Molecular Reproduction & Development. 74:843. https://doi.org/10.1002/mrd.20685
     
  • Tyler CR, Filby A, Iguchi T, Kramer V, Larsson DGJ, van Aggelen G, van Leeuwen C, Viant M, Tillitt D. (2007). Application of genomics to tiered testing. In: Molecular biology and risk assessment: evaluation of the potential roles of genomics in regulatory ecotoxicology (ed. Ankley G). Society of Environmental Toxicology and Chemistry. CRC Press, New York pp33-62.
     
  • Carvan MJ, Gallagher E, Goksoyr A, Hahn M, Larsson DGJ, Wirgin I. (2007). Fish models in toxicology: a roundtable discussion. Zebrafish. 4:9. https://doi.org/10.1089/zeb.2006.9998
     
  • Larsson DGJ, Fredriksson S, Sandblom E, Paxéus N, Axelsson M. (2006). Is heart rate in fish a sensitive indicator to evaluate acute effects of β-blockers in surface water? Environmental Toxicology and Pharmacology. 22:338 https://doi.org/10.1016/j.etap.2006.05.002
     
  • Samuelsson L, Förlin L, Karlsson G, Adolfsson-Erici M, Larsson DGJ. (2006). Using NMR metabolomics to identify responses of an environmental estrogen in blood plasma of fish. Aquatic Toxicology. 78:341. https://10.0.3.248/j.aquatox.2006.04.008
     
  • Larsson DGJ, Adolfsson-Erici M, Thomas P. (2006). Characterization of putative ligands for a fish gonadal androgen receptor in pulp mill effluent. Environmental Toxicology and Chemistry. 25:269. https://doi.org/10.1897/05-177R.1
     
  • Rung E, Friberg PA, Shao R, Larsson DGJ, Nielsen E.C, Svensson P.-A, Carlsson B, Carlsson L.M.S, Billig H. (2005). Progesterone receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro. Biology of Reproduction. 72:538 https://doi.org/10.1095/biolreprod.104.033878
     
  • Larsson J, Norrgren L, Förlin L. (2005). (English revised version 2006). Hormones and Endocrine disrupting substances in the Environment.Chapter 6, p 84-103. (Invited review) In: Environment and Pharmaceuticals (ed. Wall T.). Apoteksbolaget, Stockholm. Available in English or Swedish from Apoteksbolaget AB, Sweden.
     
  • Goksøyr A, Arukwe A, Larsson DGJ, Cajaraville M.P, Hauser L, Nilsen B.M, Lowe D, Matthiessen P. (2003). Molecular/cellular processes and the impact on reproduction. In: Effects of pollution on fish. Blackwell Science Ltd. pp 179-220. ISBN 0-632-06406-4.
     
  • Larsson DGJ, Sperry T, Thomas P. (2002). Regulation of androgen receptors in Atlantic croaker brains by testosterone and estradiol. General and Comparative Endocrinology. 128:224. https://doi.org/10.1016/S0016-6480(02)00503-8
     
  • Larsson DGJ, Förlin L. (2002). Male-biased sex ratios of fish embryos near a pulp mill: Temporary recovery after a short-term shutdown. Environmental Health Perspectives. 110:739. https://doi.org/10.1289%2Fehp.02110739
     
  • Larsson DGJ, Kinnberg K, Sturve J, Stephensen E, Skön M, Förlin L. (2002). Studies of masculinization, detoxification and oxidative stress responses in guppies (Poecilia reticulata) exposed to effluent from a pulp mill. Ecotoxicology and Environmental Safety. 52:13. https://doi.org/10.1006/eesa.2001.2139
     
  • Larsson DGJ, Mayer I, Hyllner SJ, Förlin L. (2002). Seasonal variations of vitelline envelope proteins, vitellogenin and reproductive steroids in male and female eelpout (Zoarces viviparus). General and Comparative Endocrinology. 125:184 https://doi.org/10.1006/gcen.2001.7740
     
  • Larsson DGJ. (2000). PhD-Thesis: Endocrine disruption in fish: sex ratios, secondary sex characters and estrogen-induced proteins. Göteborg University. ISBN 91-628-4104-1
     
  • Larsson DGJ, Hällman H, Förlin L. (2000). More male fish embryos near a pulp mill. Environmental Toxicology and Chemistry. 19:2911. https:doi.org/10.1002/etc.5620191210
     
  • Livingstone DR, Mitchelmore CS, Peters LD, O’Hara SCM, Shaw J, Chesman B, MacEvoy J, Ronisz D, Larsson DGJ, Förlin, L. (2000). Development of hepatic CYP1A and blood vitellogenin in eel (Anguilla anguilla) for use as biomarkers in the Thames estuary, UK. Marine Environmental Research. 50:367. https://doi.org/10.1016/S0141-1136(00)00060-X
     
  • Larsson DGJ, Adolfsson-Erici M, Parkkonen J, Pettersson, M, Berg H, Olsson P.-E, Förlin L. (1999). Ethinyloestradiol - an undesired fish contraceptive? Aquatic Toxicology. 45:91 https://doi.org/10.1016/S0166-445X(98)00112-X
     
  • Ronisz D, Larsson DGJ, Förlin, L. (1999). Seasonal variations in the activities of selected hepatic biotransformation and antioxidant enzymes in eelpout (Zoarces viviparus). Comparative Biochemistry and Physiology part C: Pharmacology, Toxicology and Endocrinology. 124:271. https://doi.org/10.1016/S0742-8413(99)00074-2
     
  • Norrgren L, Blom A, Andersson PL, Börjesson H, Larsson DGJ, Olsson PE. (1999). Effects of potential xenoestrogens (DEHP, nonylphenol and PCB) on sexual differentiation in juvenile Atlantic salmon (Salmo salar). Aquatic Ecosystem Health and Management. 2:311. https://doi.org/10.1016/S1463-4988(99)00043-3
     
  • Larsson DGJ, Mylonas CC, Zohar Y, Crim LW. (1997). Gonadotropin releasing hormone-analogue (GnRH-A) induces multiple ovulations of high-quality eggs in a cold-water batch-spawning teleost, the yellowtail flounder (Pleuronectes ferrugineus). Canadian Journal of Fisheries an Aquatic Sciences. 54:1957. https://doi.org/10.1139/f97-102
     
  • Hyllner SJ, Fernàndez-Palacios Barber H, Larsson DGJ, Haux C. (1995). Amino acid composition and endocrine control of vitelline envelope proteins in European sea bass (Dicentrarchus labrax) and gilthead sea bream (Sparus aurata). Molecular Reproduction and Development. 41:339. https://doi.org/10.1002/mrd.1080410309
     
  • Larsson DGJ, Hyllner SJ, Haux C. (1994). Induction of vitelline envelope proteins by estradiol-17 beta in 10 teleost species. General and Comparative Endocrinology. 96:445. https://doi.org/10.1006/gcen.1994.1201
     
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