New study gives a better understanding of how housekeeping takes place in cells
Normal household waste is collected and disposed of by waste collectors, and a similar process occurs in cells to remove damaged and potentially harmful proteins. A new research study in Science Advances provides a better understanding of how this is done.
Proteases are enzymes, biological catalysts, that facilitate proteolysis, decomposition of proteins into smaller parts, such as peptides or even individual amino acids.
The research was conducted using Nuclear magnetic Resonance in the advanced NMR spectroscopy infrastructure at the Swedish NMR Centre, which is hosted by the University of Gothenburg.
The study is the work of researchers from the University of Gothenburg and the Wallenberg Centre of Molecular and Translational Medicine.
The research was made possible by funding from the Knut and Alice Wallenberg Foundation (BMB), the Swedish Research Council (BMB) and an EMBO Long-term Fellowship to co-author Johannes Thomas.
Article name: Structural basis of DegP-protease temperature-dependent activation
Link to the article: https://www.science.org/doi/10.1126/sciadv.abj1816